Genome Complexity’ Conundrum
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The Hallmarks of Cancer a Long Non-Coding RNA Point of View
review REVIEW RNA Biology 9:6, 703-719; June 2012; © 2012 Landes Bioscience The hallmarks of cancer A long non-coding RNA point of view Tony Gutschner and Sven Diederichs* Helmholtz-University-Group “Molecular RNA Biology & Cancer”; German Cancer Research Center DKFZ; Heidelberg, Germany; Institute of Pathology; University of Heidelberg; Heidelberg, Germany Keywords: non-coding RNA, ncRNA, lincRNA, gene expression, carcinogenesis, tumor biology, cancer therapy, MALAT1, HOTAIR, XIST, T-UCR Abbreviations: ALT, alternative lengthening of telomeres; AR, androgen receptor; ANRIL, antisense non-coding RNA in the INK4 locus; Bax, BCL2-associated X protein; Bcl-2, B cell CLL/lymphoma 2; Bcl-xL, B cell lymphoma-extra large; CBX, chromobox homolog; cIAP2, cellular inhibitor of apoptosis; CUDR, cancer upregulated drug resistant; EMT, epithelial- mesenchymal-transition; eNOS, endothelial nitric-oxide synthase; ER, estrogen receptor; GAGE6, G antigene 6; GAS5, growth-arrest specific 5; GR, glucocorticoid receptor; HCC, hepatocellular carcinoma; HIF, hypoxia-inducible factor; HMGA1, high mobility group AT-hook 1; hnRNP, heterogenous ribonucleoprotein; HOTAIR, HOX antisense intergenic RNA; HOX, homeobox; HULC, highly upregulated in liver cancer; lncRNA, long non-coding RNA; lincRNA, long intergenic RNA; MALAT1, metastasis associated long adenocarcinoma transcript 1; Mdm2, murine double minute 2; miRNA, microRNA; mRNA, messenger RNA; mTOR, mammalian target of rapamycin; Myc, myelocytomatosis oncogene; NAT, natural antisense transcript; ncRNA, non-coding -
Spring 2006 Volume Nine / Number One
SPRING 2006 VOLUME NINE / NUMBER ONE NON-PROFIT U.S. POSTAGE PAID PERMIT 751 SAN DIEGO, CA THE SCRIPPS RESEARCH INSTITUTE A PUBLICATION OF THE SCRIPPS RESEARCH INSTITUTE Office of Communications—TPC30 ENDEAVOR 10550 North Torrey Pines Road La Jolla, California 92037 www.scripps.edu PUBLISHER: Keith McKeown EDITOR: Mika Ono Benedyk DESIGN: Miriello Grafico PRODUCTION: Miriello Grafico Kevin Fung COVER ILLUSTRATION: Dennis Clouse PORTRAIT PHOTOGRAPHY: Martin Trailer Bruce Hibbs Jamey Stillings PRINTING: Precision Litho © 2006 All material copyrighted by The Scripps Research Institute. “While the last century has been the century of physical sciences, I believe the next century will be the century of biological sciences.” ANDREW VITERBI, PH.D. Scripps Research Supporter THE SCRIPPS RESEARCH INSTITUTE Andrew J. Viterbi Looks to the Future ENDEAVOR Inventor, entrepreneur, and Scripps Research trustee Andrew J. Viterbi, Ph.D., has spent half a century capturing and capitalizing on the physical sciences. Best known for the Viterbi Algorithm used in digital communications and other fields and a co-founder VOLUME NINE / NUMBER ONE SPRING 2006 of QUALCOMM, Inc., a leading developer and manufacturer of mobile satellite com- munications and digital wireless telephony, Viterbi nonetheless sees biological sciences as the wave of the future. “While the last century has been the century of physical sciences, I believe the next century will be the century of biological sciences,” says Viterbi. 1723 Viterbi’s interest in the biological sciences first led him to Scripps Research as a member of the Scripps Cancer Center Advisory Board. The center is dedicated to FEATURES: ALSO: quickly bringing advanced cancer treatments from the laboratory bench to the patient’s bedside through breakthrough translational research. -
Biogenesis and Transcriptional Regulation of Long Noncoding Rnas in the Human Immune System Charles F
Th eJournal of Brief Reviews Immunology Biogenesis and Transcriptional Regulation of Long Noncoding RNAs in the Human Immune System Charles F. Spurlock, III,* Philip S. Crooke, III,† and Thomas M. Aune* The central dogma of molecular biology states that DNA members of the same clade (4–7). Although some lncRNAs makes RNA makes protein. Discoveries over the last have orthologous transcripts across species leading to robust quarter of a century found that the process of DNA tran- experimental systems, this is not always the case, leaving many scription into RNA gives rise to a diverse array of func- lncRNAs explored in animal models unverified in human tional RNA species, including genes that code for protein systems. In this article, we explore the features that give rise to and noncoding RNAs. For decades, the focus has been these transcripts and highlight recent work identifying specific on understanding how protein-coding genes are regu- genomic loci that transcribe lncRNAs found in the human lated to influence protein expression. However, with immune system. the completion of the Human Genome Project and follow-up ENCODE data, it is now appreciated that lncRNA nomenclature and canonical transcription and function only 2–3% of the genome codes for protein-coding The discovery of lncRNAs would not have been possible gene exons and that the bulk of the transcribed ge- without the completion of the Human Genome Project that nome, apart from ribosomal RNAs, is at the level of provided the first drafts of a complete reference sequence and noncoding RNA genes. In this article, we focus on the refinement of DNA- and RNA-sequencing platforms capable biogenesis and regulation of a distinct class of non- of longer sequence reads and higher read depth and coverage. -
A Brief Overview of Lncrnas in Endothelial Dysfunction-Associated Diseases: from Discovery to Characterization
epigenomes Review A Brief Overview of lncRNAs in Endothelial Dysfunction-Associated Diseases: From Discovery to Characterization Rashidul Islam 1 and Christopher Lai 2,* 1 Department of Health Technology and Informatics, Hong Kong Polytechnic University, Hong Kong, China; [email protected] 2 Health and Social Sciences Cluster, Singapore Institute of Technology, Singapore 138683, Singapore * Correspondence: [email protected]; Tel.: +65-6592-1045 Received: 12 August 2019; Accepted: 7 September 2019; Published: 13 September 2019 Abstract: Long non-coding RNAs (lncRNAs) are a novel class of regulatory RNA molecules and they are involved in many biological processes and disease developments. Several unique features of lncRNAs have been identified, such as tissue-and/or cell-specific expression pattern, which suggest that they could be potential candidates for therapeutic and diagnostic applications. More recently, the scope of lncRNA studies has been extended to endothelial biology research. Many of lncRNAs were found to be critically involved in the regulation of endothelial function and its associated disease progression. An improved understanding of endothelial biology can thus facilitate the discovery of novel biomarkers and therapeutic targets for endothelial dysfunction-associated diseases, such as abnormal angiogenesis, hypertension, diabetes, and atherosclerosis. Nevertheless, the underlying mechanism of lncRNA remains undefined in previous published studies. Therefore, in this review, we aimed to discuss the current methodologies for discovering and investigating the functions of lncRNAs and, in particular, to address the functions of selected lncRNAs in endothelial dysfunction-associated diseases. Keywords: endothelial dysfunction; lncRNAs; angiogenesis; hypertension; atherosclerosis; diabetes 1. Introduction The endothelium, which is also known as the “tissue-blood barrier”, is a monolayer of endothelial cells (ECs) that lines on the outer surface of blood vessels.