REVIEW published: 24 June 2021 doi: 10.3389/fphar.2021.622498 The Use of Chinese Yang/ Qi-Invigorating Tonic Botanical Drugs/ Herbal Formulations in Ameliorating Chronic Kidney Disease by Enhancing Mitochondrial Function Jiayi Tian 1,2†, Yuqi Huang 1,2†, Tong Wu 1,2, Hsien-Da Huang 2,3, Kam Ming Ko 4*, Bao Ting Zhu 1,2* and Jihang Chen 1,2* 1Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen, China, 2School of Life and Health Sciences, The Chinese University of Hong Kong, Edited by: Shenzhen, China, 3Warshel Institute for Computational Biology, The Chinese University of Hong Kong, Shenzhen, China, 4Division Uraiwan Panich, of Life Science, The Hong Kong University of Science & Technology, Hong Kong, China Mahidol University, Thailand Reviewed by: Mingjiang Yao, Background: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality. Xiyuan Hospital, China Mitochondrial dysfunction has been implicated as a key factor in the development of CKD. Rodrigo Castaneda, According to traditional Chinese medicine (TCM) theory, many Chinese Yang/Qi- Universidad de San Carlos de Guatemala, Guatemala invigorating botanical drugs/herbal formulations have been shown to produce *Correspondence: promising outcomes in the clinical management of CKD. Experimental studies have Jihang Chen indicated that the health-promoting action of Yang/Qi invigoration in TCM is related to
[email protected] Bao Ting Zhu the up-regulation of mitochondrial energy generation and antioxidant status.
[email protected] Kam Ming Ko Objective: In this review, we aim to test whether Chinese Yang/Qi-invigorating tonic
[email protected] botanical drugs/herbal formulations can provide medical benefits in CKD and its †These authors have contributed complications.