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A Scoping Review on Women's Responses to Contraceptive

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A Scoping Review on Women's Responses to Contraceptive Polis et al. Reproductive Health (2018) 15:114 https://doi.org/10.1186/s12978-018-0561-0 REVIEW Open Access There might be blood: a scoping review on women’s responses to contraceptive- induced menstrual bleeding changes Chelsea B. Polis* , Rubina Hussain and Amanda Berry Abstract Introduction: Concern about side effects and health issues are common reasons for contraceptive non-use or discontinuation. Contraceptive-induced menstrual bleeding changes (CIMBCs) are linked to these concerns. Research on women’s responses to CIMBCs has not been mapped or summarized in a systematic scoping review. Methods: We conducted a systematic scoping review of data on women’s responses to CIMBCs in peer-reviewed, English-language publications in the last 15 years. Investigator dyads abstracted information from relevant studies on pre-specified and emergent themes using a standardized form. We held an expert consultation to obtain critical input. We provide recommendations for researchers, contraceptive counselors, and product developers. Results: We identified 100 relevant studies. All world regions were represented (except Antarctica), including Africa (11%), the Americas (32%), Asia (7%), Europe (20%), and Oceania (6%). We summarize findings pertinent to five thematic areas: women’s responses to contraceptive-induced non-standard bleeding patterns; CIMBCs influence on non-use, dissatisfaction or discontinuation; conceptual linkages between CIMBCs and health; women’sresponsesto menstrual suppression; and other emergent themes. Women’s preferences for non-monthly bleeding patterns ranged widely, though amenorrhea appears most acceptable in the Americas and Europe. Multiple studies reported CIMBCs as top reasons for contraceptive dissatisfaction and discontinuation; others suggested disruption of regular bleeding patterns was associated with non-use. CIMBCs in some contexts were perceived as linked with a wide range of health concerns; e.g., some women perceived amenorrhea to cause a buildup of “dirty” or “blocked” blood, in turn perceived as causing blood clots, fibroids, emotional disturbances, weight gain, infertility, or death. Multiple studies addressed how CIMBCs (or menstruation) impacted daily activities, including participation in domestic, work, school, sports, or religious life; sexual or emotional relationships; and other domains. Conclusions: Substantial variability exists around how women respond to CIMBCs; these responses are shaped by individual and social influences. Despite variation in responses across contexts and sub-populations, CIMBCs can impact multiple aspects of women’slives.Women’s responses to CIMBCs should be recognized as a key issue in contraceptive research, counseling, and product development, but may be underappreciated, despite likely – and potentially substantial – impacts on contraceptive discontinuation and unmet need for modern contraception. Keywords: Contraception, Menstruation, Menstrual bleeding changes, Contraceptive non-use and discontinuation, Side effects, Health concerns, Amenorrhea * Correspondence: [email protected] Guttmacher Institute, 125 Maiden Lane, 7th Floor, New York, NY 10038, USA © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. Polis et al. Reproductive Health (2018) 15:114 Page 2 of 17 Plain English summary categories, such as self or partner opposition to contracep- Some contraceptive methods cause changes in women’s tive use, inconvenience of use, or other reasons, may be menstrual bleeding patterns. For example, a woman’s intertwined with health or side effect-related concerns. period may become lighter or heavier, longer or shorter, Therefore, it is difficult to estimate the prevalence or im- less regular, or may disappear altogether. Concerns pact of these concerns, or to disentangle which issues are about side effects and health issues – including those re- of greatest concern to women or couples, particularly on a lated to changes to menstrual bleeding patterns – may national scale. limit use of contraceptive methods. However, the re- Furthermore, while certain contraceptive side effects search on how women respond to contraceptive-induced are clinically documented, various contraceptive-induced menstrual bleeding changes (CIMBCs) has not been bodily processes may be interpreted variably by different summarized in a systematic scoping review. We col- individuals. Perceptions of contraceptive-related side ef- lected and summarized the body of evidence on women’s fects may be rooted in personal experience, knowledge responses to CIMBCs in a standardized manner. We of others’ experiences, or misinformation [9, 10]. While identified 100 studies from around the world relevant to discordance between documented and perceived side ef- this issue. We summarized what studies found regarding fects is acknowledged in the literature [11, 12], both ex- how women respond when contraceptive methods stop perienced and perceived side effects can be highly their periods or cause other non-standard bleeding pat- influential in contraceptive decision-making processes terns, and the extent to which CIMBCs make women [10, 13]. Furthermore, cultural norms and values may unhappy with their method of contraception, or stop shape tolerance (or lack thereof) and fears around vari- their method of contraception, or not use any method of ous side effects. contraception. We also summarized what the evidence Hormonal contraceptive methods and IUDs may in- suggests regarding how women think about CIMBCs in duce changes in menstrual bleeding patterns [14–16], terms of their own health, as well as other themes that which can impact willingness to try or continue using emerged from our review of studies. While women these methods, or method satisfaction [6, 17–23]. across countries and populations respond differently to Contraceptive-induced menstrual bleeding changes different CIMBCs, due to individual and social influ- (CIMBCs) may include bleeding patterns which are pre- ences, it is clear that CIMBCs impact many areas of dictable but diverge from a “typical” menstrual pattern women’s lives. It is important that researchers, medical (such as amenorrhea, commonly induced by methods providers, and contraceptive product developers such as progestin-only injectables, or heavy, prolonged recognize this as an important issue, and we offer rec- bleeding often experienced by copper IUD users [24, 25]), ommendations on how to do so. or may cause unpredictable bleeding patterns. While men- strual bleeding can be measured in straightforward clinical Background categories, there may be large ranges defined around nor- About 99 million unintended pregnancies occur annu- mal menstruation [26, 27] and these clinical definitions ally, the majority of which could be prevented through may not be in line with women’s perceptions of normal use of modern contraception [1, 2]. Concerns about side bleeding. Furthermore, women may experience CIMBCs effects and health issues are common reasons for they consider abnormal or unacceptable, but may still non-use or discontinuation of contraception among clinically fall within the range of normal. women who do not desire pregnancy [3–5]. Among In addition to inconvenience (for unpredictable bleed- married women with an unmet need for contraception ing patterns in particular), and the menstrual hygiene in 52 developing countries, 7–53% reported not using a management costs of many bleeding patterns, some in- method due to these concerns [3]. Some smaller (often dividuals may perceive changes to bleeding patterns as qualitative) studies report on women’s experiences with being tied to overall notions about their health [23, 28, 29] or fears about side effects or health concerns in relation or to physical or mental health issues [6, 9, 10, 12, to various contraceptive methods, but few large or 13, 20, 23, 29]. For example, some women fear that nationally-representative studies specifically investigate injectable-induced amenorrhea leads to permanent in- these issues in detail [6]. Some large-scale surveys (e.g., fertility, which is not supported in the literature [30]. PMA2020 and Demographic and Health Surveys (DHS)) Counseling may not always be comprehensive enough ask about reasons for contraceptive non-use and discon- to adequately prepare women to fully understand, an- tinuation, and include health concerns, fear of side ef- ticipate, or manage CIMBCs [31]. Though difficult to fects, and interference with bodily processes as broad precisely quantify (owing in part to lack of sufficiently response categories, but neither survey asks which spe- specific nationally representative data, as described cific side effects or health concerns led to non-use or above), some evidence suggests that CIMBCs are a discontinuation [7, 8]. Furthermore, other broad response central aspect of what women mean when they report Polis et al. Reproductive Health (2018) 15:114 Page 3 of 17 “side effects” or “health concerns” [32–35], and may among women
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