The Effects of Reflex Path Length on Clonus Frequency in Spastic Muscles

J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.47.10.1122 on 1 October 1984. Downloaded from

Journal ofNeurology, Neurosurgery, and Psychiatry 1984;47:1122-1124

Short report The effects of reflex path length on clonus frequency in spastic muscles

ROBERT IANSEK From the Department ofNeurology, Prince Henry's Hospital, Melbourne, Australia

SUMMARY Clinical evaluation of clonus in spastic muscles was performed by comparing reflex path length with clonus frequency for different muscles in the same patient. It was found that clonus frequency varied inversely with reflex path length (r = 0-84, p < 0-001). The findings confirm that clonus is generated by a peripheral mechanism of self re-excitation rather than a central spinal pacemaker.

Clonus is a well recognised clinical sign, usually Methods guest. Protected by copyright. occurring in spasticity. A normal, nonspastic limb may manifest clonus, but only under certain condi- Twenty-one unselected patients who were seen on the tions.' The repetitive self perpetuating movement is neurology service were used as subjects. Attempts were induced by brisk stretch of the involved muscle made to study patients with clonus in more than one mus- group, although cutaneous sensory inputs can initi- cle. No restriction was placed on the underlying pathological basis for the spasticity. Neurological examination and ate clonic movements in a susceptible limb.2 The routine nerve conduction studies were performed to underlying mechanism of clonus is poorly under- exclude an underlying neuropathy. Clonus frequency was stood and controversial. Some investigators34 have measured by use of surface electrodes and the raw EMG evidence to support the theory of a self re-excitation was recorded on photosensitive paper. The duration of circuit perpetuated by the constant stretch applied each EMG burst was halved and the mid point was used to to the contracting muscle, on a background of high estimate the interbeat time for ten successive EMG bursts gain in the motor neuron-spindle feed back loop. and then averaged to obtain the frequency. The approxi- Other investigators,25 claim that the evidence sup- mate distance of the clonic muscles from the spinal cord ports the concept of a spinal pacemaker which has was calculated as follows: (1) Ankle The distance from the medial malleolus to the been released by lesions to descending motor path- anterior superior iliac spine. ways and that abrupt spindle input, induced by (2) Knee The anterior tibial plateau to the anterior mechanical muscle stretch, switches on the spinal superior iliac spine. pacemaker to produce the clonus. (3) Forearm The lateral epicondyle to C7 vertebral This report outlines the results of an investigation spine with the limb in the anatomical position. which tested the relationship of clonus frequency http://jnnp.bmj.com/ with the distance of the contracting muscle from the Results spinal cord. The results clearly show that a linear inverse relationship does exist between clonus fre- The table summarises the results for all 21 patients. quency and reflex path length. It is concluded that Twelve patients (19 recordings) had full nerve con- such a finding provided further support for a duction velocity estimation, whereas the remainder peripheral self re-excitation mechanism, rather than (9) refused to proceed with further analysis subse- an intrinsic spinal pacemaker in the mechanism of quent to the estimation of the distal motor latency clonus. because of discomfort. No patient had either clinical on September 24, 2021 by or electrical evidence of a peripheral neuropathy. Address for reprint requests: Dr R lansek, Department of Neurol- The probable pathological basis for the spasticity ogy, Middlesex Hospital, London WIN 8AA, UK. was quite variable, as was the age. The results were Received 31 January 1984 and in revised form 5 April 1984. analysed according to which patients had had a Accepted 18 April 1984 complete and incomplete nerve conduction velocity 1122 J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.47.10.1122 on 1 October 1984. Downloaded from

The effects of reflex path length on clonus frequency in spastic muscles 1123 Table Summary ofresults Patient Provisional diagnosis Leg Thigh Arm Age (yr) Hz CMS Hz CMS Hz CMS

41 Multiple sclerosis 6-5 85 - - 23 Familial spastic paraparesis 7-2 91 - - - - 50 Stroke 6-7 90 -- 9-5 53 71 Stroke 6-1 90 - - -- 56 Stroke 6-3 84 -- 8 64 46 Multiple sclerosis 8-0 77 - - - - 23 Unknown 5-9 88 - - 7-6 54 50 Multiple sclerosis 6-5 78 -- 9-3 48 33 Cerebral cysticercosis 6-7 82 7-5 54 - - 26 Pseudobulbar palsy 7-0 88 - -- - 56 Multiple sclerosis 5-7 83 - - 8-3 47 54 Unknown 6-9 83 - - - - 22 Motor vehicle accident, head injury 6-5 85 10 54 75 Cervical cord compression 5-9 84 7-8 54 75 Brainstem stroke 5-7 81 - - - - 68 Cervical cord compression 5-0 89 - - - - 58 Vitamin B12 deficiency 7-0 78 - - - - 81 Cervical cord compression 4-4 93 - - - - 28 Syringomyelia 6-0 95 - - - - 39 Multiple sclerosis 6-9 83 -- - - 16 Herpes simplex encephalitis 7-7 82 - - - - estimation. The plot of the clonus frequency against from the spinal cord. An example of this finding is approximate distance from the spinal cord is shown shown in figure 1(b) where the raw EMG activity of in the figure for both groups of patient. Results of the gastrocnemius muscle for clonus occurring at the guest. Protected by copyright. linear regression analysis are also shown in the ankle is compared with the EMG activity of the figures for each group in the form of the line of best muscle producing clonus at the wrist. In another fit and its confidence limits. The correlation patient with widespread clonus and a pseudobulbar coefficient for the group of patients in which nerve palsy of uncertain cause, several clonic beats could conduction velocity was estimated was -0-84 (p < be induced by the performance of a jaw jerk. The 0-001) and for the total number of patients the cor- frequency in this case was 13-8 Hz compared to a relation coefficient was -0-80 (p < 0-001). It is evi- clonic frequency of 7-0 Hz at the ankle. Although, dence that a linear relationship existed between the this was not sustained clonus the finding is in agree- clonus frequency and the distance of the muscle ment with the remainder of this report, as one would predict that clonus of the jaw would be at a much NCV only Al I data faster frequency than at the ankle. r =84 r=0-80 100 P

1124 lansek quency of spastic patients with an applied sinusoidal groups consistently demonstrated faster frequencies, force of a set frequency, but rather that a beat fre- in the same patient, when compared to the frequency was set up. Such a finding, he concluded, was quency of the gastrocnemius muscle at the ankle. consistent with a central mechanism. However, Furthermore, the measurements to the anterior Stein and Lee,6 claim that beat frequencies can superior iliac spine would be an under-estimate of occur purely on a simple peripheral oscillation the distance, rather than an over-estimate compared reflex, rather than on a central mechanism and have to the upper limb measurements. proved this point mathematically. Dimitrijevic, It is concluded that clonus frequency in spastic Nathan and Sherwood2 based their conclusions on muscle is a direct consequence of reflex path length the fact that clonic motor neurons were refractory to and this finding confirms the theory of a peripheral, sensory inputs from the 1A fibres subsequent to a rather than a central mechanism for clonus. clonic contraction for a set period which coincided with the clonus frequency. Furthermore, they were unable to change the frequency by a variety of manoeuvres which would theoretically alter the fre- References quency if the mechanism was a peripheral one. The clonus in man. inexcitability of the motor neuron pool in the Dimit- Gottlieb GL, Agarwal GC. Physiological Exp Neurol 1977;54:616-21. rijevic, Nathan and Sherwood study2 was short 2 Dimitrijevic MR, Nathan PW, Sherwood AM. Clonus: enough to put a limit on the higher frequency, but The Role of Central Mechanisms. J Neurol Neurosurg not on the lower frequency of clonus. The latter Psychiatry 1980;43: 321-33. would be determined by reflex delay times. In addi- 3Szumski AJ, Burg D, Struppler A, Vehlo F. Activity of tion, none of the manoeuvres used in that study muscle spindles during muscle twitch and clonus in were assessed for their effect on the peripheral normal and spastic human subjects. Electroence- guest. Protected by copyright. reflex pathways; an example is the effect of tempera- phalogr Clin Neurophysiol 1974;37:589-97. ture change on conduction velocity. 4Hagbarth KE, Wallin G, Lofstedt L, Aquilonius SM. One criticism of the current study is that the rela- Muscle spindle activity in alternating tremor of Par- kinsonism and clonus. J Neurol Neurosurg Psychiatry tionship between reflex path length and frequency 1975;38:636-41. might be artefactual owing to an inaccurate meas- 5 Walsh EG. Clonus: Beats provoked by the application of urement of reflex path lengths. However, anatomi- a rhythmic force. J Neurol Neurosurg Psychiatry cally the reflex path length for the quadriceps 1 976;39: 266-74. femoris muscle is shorter than for the gastrocnemius 6 Stein RB, Lee RG. Tremor and Clonus. In: Brooks VB, muscle, as is the distance from the common flexor ed. Handbook of Physiology Section 1: Vol II. The muscles of the forearm at the elbow than for the Nervous System. Baltimore: Williams & Wilkins gastrocnemius muscle at the ankle. Both muscle 1981:325-43. http://jnnp.bmj.com/ on September 24, 2021 by