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(12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 De Juan Et Al
US 200601 10428A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0110428A1 de Juan et al. (43) Pub. Date: May 25, 2006 (54) METHODS AND DEVICES FOR THE Publication Classification TREATMENT OF OCULAR CONDITIONS (51) Int. Cl. (76) Inventors: Eugene de Juan, LaCanada, CA (US); A6F 2/00 (2006.01) Signe E. Varner, Los Angeles, CA (52) U.S. Cl. .............................................................. 424/427 (US); Laurie R. Lawin, New Brighton, MN (US) (57) ABSTRACT Correspondence Address: Featured is a method for instilling one or more bioactive SCOTT PRIBNOW agents into ocular tissue within an eye of a patient for the Kagan Binder, PLLC treatment of an ocular condition, the method comprising Suite 200 concurrently using at least two of the following bioactive 221 Main Street North agent delivery methods (A)-(C): Stillwater, MN 55082 (US) (A) implanting a Sustained release delivery device com (21) Appl. No.: 11/175,850 prising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more (22) Filed: Jul. 5, 2005 bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more Related U.S. Application Data bioactive agents Subretinally; and (60) Provisional application No. 60/585,236, filed on Jul. (C) instilling (e.g., injecting or delivering by ocular ion 2, 2004. Provisional application No. 60/669,701, filed tophoresis) one or more bioactive agents into the Vit on Apr. 8, 2005. reous humor of the eye. Patent Application Publication May 25, 2006 Sheet 1 of 22 US 2006/0110428A1 R 2 2 C.6 Fig. -
Labeling and Synthesis of Estrogens and Their Metabolites
Labeling and Synthesis of Estrogens and Their Metabolites Paula Kiuru University of Helsinki Faculty of Science Department of Chemistry Laboratory of Organic Chemistry P.O. Box 55, 00014 University of Helsinki, Finland ACADEMIC DISSERTATION To be presented with the permission of the Faculty of Science of the University of Helsinki, for public criticism in Auditorium A110 of the Department of Chemistry, A. I. Virtasen Aukio 1, Helsinki, on June 18th, 2005 at 12 o'clock noon Helsinki 2005 ISBN 952-91-8812-9 (paperback) ISBN 952-10-2507-7 (PDF) Helsinki 2005 Valopaino Oy. 1 ABSTRACT 3 ACKNOWLEDGMENTS 4 LIST OF ORIGINAL PUBLICATIONS 5 LIST OF ABBREVIATIONS 6 1. INTRODUCTION 7 1.1 Nomenclature of estrogens 8 1.2 Estrogen biosynthesis 10 1.3 Estrogen metabolism and cancer 10 1.3.1 Estrogen metabolism 11 1.3.2 Ratio of 2-hydroxylation and 16α-hydroxylation 12 1.3.3 4-Hydroxyestrogens and cancer 12 1.3.4 2-Methoxyestradiol 13 1.4 Structural and quantitative analysis of estrogens 13 1.4.1 Structural elucidation 13 1.4.2 Analytical techniques 15 1.4.2.1 GC/MS 16 1.4.2.2 LC/MS 17 1.4.2.3 Immunoassays 18 1.4.3 Deuterium labeled internal standards for GC/MS and LC/MS 19 1.4.4 Isotopic purity 20 1.5 Labeling of estrogens with isotopes of hydrogen 20 1.5.1 Deuterium-labeling 21 1.5.1.1 Mineral acid catalysts 21 1.5.1.2 CF3COOD as deuterating reagent 22 1.5.1.3 Base-catalyzed deuterations 24 1.5.1.4 Transition metal-catalyzed deuterations 25 1.5.1.5 Deuteration without catalyst 27 1.5.1.6 Halogen-deuterium exchange 27 1.5.1.7 Multistep labelings 28 1.5.1.8 Summary of deuterations 30 1.5.2 Enhancement of deuteration 30 1.5.2.1 Microwave irradiation 30 1.5.2.2 Ultrasound 31 1.5.3 Tritium labeling 32 1.6 Deuteration estrogen fatty acid esters 34 1.7 Synthesis of 2-methoxyestradiol 35 1.7.1 Halogenation 35 1.7.2 Nitration of estrogens 37 1.7.3 Formylation 38 1.7.4 Fries rearrangement 39 1.7.5 Other syntheses of 2-methoxyestradiol 39 1.7.6 Synthesis of 4-methoxyestrone 40 1.8 Synthesis of 2- and 4-hydroxyestrogens 41 2. -
Pharmaceutical Appendix to the Tariff Schedule 2
Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9 -
Synthetic Modifications of Estrogens and Androgens
Synthetic Modifications of Estrogens and Androgens Somdatta Deb University of Helsinki Faculty of Science Department of Chemistry Laboratory of Organic Chemistry Finland ACADEMIC DISSERTATION To be presented with the permission of the Faculty of Scienec of the University of Helsinki for public criticism in Auditorium A110, Department of Chemistry on June 23rd, 2011, at 12 o’clock. Helsinki 2011 Supervisor Professor Kristiina Wähälä Laboratory of Organic Chemistry Department of Chemistry University of Helsinki Finland Reviewers Professor Erkki Kolehmainen Department of Chemistry University of Jyväskyla Finland Docent Salme Koskimies Adjunct. Professor University of Helsinki Opponent Professor Maria Christina das Neves Oliveira Unidade de Ciências Químicas e Radiofarmacêuticas Portugal ISBN 978-952-92-9174-8 (paperback) ISBN 978-952-10-7051-8 (PDF) Helsinki 2011 Unigrafia Acknowledgements This thesis work was carried out at the Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki. I would like to express my deep gratitude to my supervisor Prof. Kristiina Wähälä for introducing me to the fascinating field of steroid chemistry and for providing the facilities to do this work. I warmly thank emeritus professor Tapio Hase for his helpful, invaluable scientific advice during my work. Prof. Matti J. Tikkananen and his group are gratefully acknowledged for pleasant collaboration. My warmest thanks are due to all personnel in the Laboratory of Organic Chemistry, specially the members (former and present) of Phyto-Syn group for their support. They have been always there when needed. In particular I would like to thank Gudrun Silvennoinen for technical assistance and friendship. I am thankful to Dr. Ullastiina Hakala for introducing me to the field of ionic liquid. -
United States Patent (19) 11 Patent Number: 6,068,830 Diamandis Et Al
US00606883OA United States Patent (19) 11 Patent Number: 6,068,830 Diamandis et al. (45) Date of Patent: May 30, 2000 54) LOCALIZATION AND THERAPY OF FOREIGN PATENT DOCUMENTS NON-PROSTATIC ENDOCRINE CANCER 0217577 4/1987 European Pat. Off.. WITH AGENTS DIRECTED AGAINST 0453082 10/1991 European Pat. Off.. PROSTATE SPECIFIC ANTIGEN WO 92/O1936 2/1992 European Pat. Off.. WO 93/O1831 2/1993 European Pat. Off.. 75 Inventors: Eleftherios P. Diamandis, Toronto; Russell Redshaw, Nepean, both of OTHER PUBLICATIONS Canada Clinical BioChemistry vol. 27, No. 2, (Yu, He et al), pp. 73 Assignee: Nordion International Inc., Canada 75-79, dated Apr. 27, 1994. Database Biosis BioSciences Information Service, AN 21 Appl. No.: 08/569,206 94:393008 & Journal of Clinical Laboratory Analysis, vol. 8, No. 4, (Yu, He et al), pp. 251-253, dated 1994. 22 PCT Filed: Jul. 14, 1994 Bas. Appl. Histochem, Vol. 33, No. 1, (Papotti, M. et al), 86 PCT No.: PCT/CA94/00392 Pavia pp. 25–29 dated 1989. S371 Date: Apr. 11, 1996 Primary Examiner Yvonne Eyler S 102(e) Date: Apr. 11, 1996 Attorney, Agent, or Firm-Banner & Witcoff, Ltd. 87 PCT Pub. No.: WO95/02424 57 ABSTRACT It was discovered that prostate-specific antigen is produced PCT Pub. Date:Jan. 26, 1995 by non-proStatic endocrine cancers. It was further discov 30 Foreign Application Priority Data ered that non-prostatic endocrine cancers with Steroid recep tors can be stimulated with Steroids to cause them to produce Jul. 14, 1993 GB United Kingdom ................... 93.14623 PSA either initially or at increased levels. -
Stembook 2018.Pdf
The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data. -
Innovative Research of America(IRA)公司专业动物皮
中国总代:上海起福生物科技有限公司 Innovative Research of America(IRA)公司专业动物皮 下嵌入式给药专业供应商,公司专利的 Matrix-Driven Delivery 系统使药物的长期等量的释放得到了保证,释放时间可以长达 90 天,这样不仅减轻了您的负担也减少了对动物的伤害。 特点 · 丰富的产品线 大约 600 种 · 可以按客户要求定制您实验需要的药剂 · 丰富的文献引用 · 使长期稳定给药成为可能 · 减少对动物的伤害 产品选择 产品展示如下:您需要选择药物种类・缓释时间、药物剂量、包装等,具体如下 1. 知道一天需要释放的计量就可以选择药物剂量了 平均一天的放出量×缓释时间=产品药物量 2. 药物每天释放量的计算方法计算方法 产品药物剂量 缓释时间 每一天释放剂量 ÷ = 电话:4006551678 email:[email protected] QQ: 4006551678 中国总代:上海起福生物科技有限公司 使用方法 常用植入方法(所有大小颗粒全部适用) 1. 将动物脖子皮肤轻轻拉起。 2. 在动物脖子处切一个药片大小的口子。 3. 用镊子插入 2 厘米左右。 4. 用镊子将药片植入就可以了。 小颗粒用植入器具( PRECISION TROCHAR)使用植入方法(颗 粒的直径 3 毫米以下) 1. 先将药片装入小颗粒用植入器。 2. 将动物脖子皮肤轻轻拉起。 3. 用小颗粒用植入器刺穿动物皮肤,将药片植入即可。 *这种方法不需要抗生素和缝合伤口,也没有出血 *本产品使用过程中不能和其他有机溶剂或者其他液体接触和一起 使用。 电话:4006551678 email:[email protected] QQ: 4006551678 中国总代:上海起福生物科技有限公司 药品种类 大约有 600 中产品可以选择。 A B C D E F G H I K L M N O P Q R S T U V X Y Z 产品编号 释放时间 药品名称 21 天 60 天 90 天 A Acebutolol C-101 SC-101 NC-101 2 -Acetamidofluorene (2-Aaf) A-102 SA-102 NA-102 Acetarsone B-165 SB-165 NB-165 Acetazolamide D-111 SD-111 ND-111 Acetopromazine C-102 SC-102 NC-102 Acetyl-L-Carnitine V-272 SV-272 NV-272 N -Acetyl-L-Cysteine Q-212 SQ-212 NQ-212 N -Acetyl-L-Glutamine Q-272 SQ-272 NQ-272 电话:4006551678 email:[email protected] QQ: 4006551678 中国总代:上海起福生物科技有限公司 产品编号 释放时间 药品名称 21 天 60 天 90 天 N -Acetylimidazole Q-273 SQ-273 NQ-273 N -Acetylprocainamide C-106 SC-106 NC-106 cis -Aconitic Acid K-111 SK-111 NK-111 trans -Aconitic Acid K-112 SK-112 NK-112 Aconitine K-113 SK-113 NK-113 Actinomycin D (Dactinomycin) Z-110 SZ-110 NZ-110 Adenosine N-111 SN-111 NN-111 Adrenal Cortex Acetone -
A Thesis by Morry Givner Subrnitted to the Faculty of Graduate Studies
ESTROGEN METABOLISM 1N HUMAN SUBJECTS A Thesis by Morry Givner Subrnitted to the Faculty of Graduate Studies and Research in partial fulfillment of the Requirements for the degree of Master of Science. McGill University August 1956. Montreal, Quebec ACKNOWLEDGEMENTS Grateful acknowledgement is expressed to my research director, Dr. W.S. Bauld for encouragement and supervision during this course of study. The author wishes to express his gratitude to Dr. 1. G. Milne of the McGill University Clinic of The Montreal General Hospital for his co-operation in the selection of subjects and his many valuable suggestions. To Dr. E. H. Bensley, 1 wish to express my appreciation for his valuable suggestions. Finally, thanks are offered to Mrs. A. Alfh.eim for her excellent technical assistance, which was neoessary for this work. TABLE OF CONTENTS ESTROGEN EXCRETION IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTION I. Introduction: A. Reasons for the Investigation P.l B. Survey of Previous Investigations on Estrogen Metabolism P.4 C. The relationship of Estrogens to Coronary Artery Disease P.lO II. Methode: A. Experimental Procedure for the Study of Patients with Previous Myocardial Infarction P.13 B. Method for Estrogen Analysis P.13 III. Resulta P.16 IV. Discussion P.24 v. Summary P.26 Table of Contents {Contfd) ESTROGEN METABOLISM IN VARIOUS GYNECOLOGICAL AND ENDOCRINOLOGICAL DISORDERS I. Experimental P.27 ll. Discussion P.27 Ill. Summary P.28 A METHOD FOR THE DETERMINATION OF ESTRONE IN HUMAN URINE 1. Introduction P.29 ll. Methods P.29 Ill. Resulta P.32 IV. Discussion P.33 V. Summary P.33 GENERAL SUMMARY P.34 REFERENCES APPENDIX LIST OF FIGURES Figure 1. -
(12) Patent Application Publication (10) Pub. No.: US 2002/0010208A1 Shashoua Et Al
US 2002001 0208A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2002/0010208A1 Shashoua et al. (43) Pub. Date: Jan. 24, 2002 (54) DHA-PHARMACEUTICAL AGENT Related U.S. Application Data CONJUGATES OF TAXANES (63) Continuation of application No. 09/135,291, filed on (76) Inventors: Victor Shashoua, Brookline, MA (US); Aug. 17, 1998, now abandoned, which is a continu Charles Swindell, Merion, PA (US); ation of application No. 08/651,312, filed on May 22, Nigel Webb, Bryn Mawr, PA (US); 1996, now Pat. No. 5,795,909. Matthews Bradley, Layton, PA (US) Publication Classification Correspondence Address: Edward R. Gates, Esq. (51) Int. Cl." ............................................ A61K 31/337 Wolf, Greenfield & Sacks, P.C. (52) U.S. Cl. .............................................................. 514/449 600 Atlantic Avenue Boston, MA 02210 (US) (57) ABSTRACT The invention provides conjugates of cis-docosahexaenoic (21) Appl. No.: 09/846,838 acid and pharmaceutical agents useful in treating noncentral nervous System conditions. Methods for Selectively target 22) Filled: Mayy 1, 2001 ingg pharmaceuticalp agents9. to desired tissues are pprovided. Patent Application Publication Jan. 24, 2002 Sheet 1 of 14 US 2002/0010208A1 1 OO 5 O -5OO - 1 OO-9 -8 -7 -6 -5 -4 LOG-10 OF SAMPLE CONCENTRATION (MOLAR) CCRF-CEM-o- SR ----- RPM-8226----- K-562- - -A - - HL-60 (TB) -g- - MOLT4: ... O Fig. 1 1 OO 5 O -5OO -1 O O -8 -7 -6 -5 -4 -- 9 LOGo OF SAMPLE CONCENTRATION (MOLAR) A549/ATCC-o-NS326. NCEKVX 28. --Q-- NCI-H322M-...-a---Eidsf8::... NC-H522--O-- HOP-62---Fig. 2 a-- NC-H460.-------- Patent Application Publication Jan. -
Medicinal Chemistry Unit - 1 Drug Design
PAPER IV - MEDICINAL CHEMISTRY UNIT - 1 DRUG DESIGN 1.0 Introduction 1.0.1 Objectives 1.1 Development of new drugs 1.2 Procedures followed in drug design. 1.3 Concept of lead compound and lead modification. 1.4 Concept of prodrugs and soft drugs 1.5 Structure 1.5.1 Activity relationship (SAR), factors affecting bioactivity resonance, inductive effect. 1.5.2 Isosterism, bio-isosterism, spacial considerations 1.5.3 Theories of drug activity 1.5.4 Occupancy theory, rate theory, induced fit theory. 1.5.5 Quantitative structure activity relationship & History and development of QSAR. 1.6 Concepts of drug receptors 1.6.1 Elementary treatment of drug receptor interactions. 1.7 Physicochemical parameters : Lipophilicity 1.7.1 Partition coefficient 1.7.2 Electronic ionization constants 1.7.3 Steric, Shelton and surface activity parameters & redox potentials 1.7.4 Free-Wilson analysis 1.7.5 Hansch analysis 1.7.6 Relationship between Free-Wilson and Hansch analysis 1.7.7 LD-50, ED-50 (Mathematical deviations of equations excluded) 1.7.8 Let us sum up 1.7.9 Check your progress, the key 1.8 References 1.0 Introduction : The drug term is derived from drogue-a dry herb, a french word. Drug is present in medicine i.e. used to prevent and cure of different diseases by treatment. According to WHO (1966), "Drug is any substance or product i.e. used or intended to be used to explore physiological systems for the benefit of the recipient. Essential drugs satisfy the priority of healthcare needs of the public, are intended to be available of functioning Health systems at all times in excess amounts. -
LGC Product List
Uni-Asia Scientific Instrument Company Limited - Your Worldwide Laboratory Supplies Sourcing Partner Email [email protected] Website www.uniasiahk.com Please browse through our product lists or send your enquiry to [email protected] for a quotation! Bulk pricing can always be discussed! LGC Standards Product List Code Discriptions AC-SE015.040.001 Drugs of substitution STM 3/10-A SE serum, 6 x 2.5ml AC-SE015.040.002 Drugs of substitution STM 1/11-A SE serum, 6 x 2.5ml AC-SE015.040.005.003TDM Benzodiazepine in serum, lyophilised BZF 3/10-A SE for AC-SE015.040.005.004TDM Benzodiazepine in serum, lyophilised BZF 3/10-B SE for AC-SE015.040.005.005TDM Benzodiazepine in serum, lyophilised BZF 1/11– A SE for AC-SE015.040.005.006TDM Benzodiazepine in serum, lyophilised BZF 1/11– B SE for BAM-K008 Diesel oil (ISO 9377-2, ISO 16703, EN 14039), 7ml BAM-K009 Lubricating oil (ISO 9377-2, ISO 16703, EN 14039), 7ml BAM-K010 Diesel Fuel/Lubricating Oil (1:1) (ISO 9377-2, ISO 16703, BAMSUS-1R Setting-up sample for sectrometric analysis of low alloyed BCR-010 Tin ore powder - Tin; 225g BCR-017A Copper - Sulfur and phosphorous, 370g BCR-017B Copper - Sulfur and phosphorous; 50g BCR-022A Copper (electrolytic tough pitch) - Oxygen; 42g BCR-022B Copper (electrolytic tough pitch) - Oxygen; 28g BCR-024B Titanium - Oxygen and nitrogen; 10g BCR-024C Titanium - Oxygen, nitrogen; 5g BCR-032 Moroccan phosphate rock - Trace elements; 100g BCR-033 Super-phosphate - Constituents; 100g BCR-038 Fly ash from pulverised coal - Trace elements; 5g BCR-039B Pyrex glass -
Lääkeaineiden Yleisnimet (INN-Nimet) 31.12.2019
Lääkealan turvallisuus- ja kehittämiskeskus Säkerhets- och utvecklingscentret för läkemedelsområdet Finnish Medicines Agency Lääkeaineiden yleisnimet (INN-nimet) 31.12.