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Sigma Biochemical Library Index Number Compound Name Index Number Compound Name 1 L-Abrine 36 N-Acetyl-DL-methionine, 2 N-Acetyl-D-alanine Mg salt 3 N-Acetyl-DL-alanine 37 N-Acetyl-L-methionine 4 N-Acetyl-L-alanine 38 N-Acetyl-5-methyl-DL- 5 N-Acetyl-L-alanine p- tryptophan nitroanilide 39 N-Acetyl-O-methyl-L- 6 N-Acetyl-DL-C- tyrosine methyl ester allylglycine; 2-Acetamido- 40 N-Acetyl-L-3-nitro-tyrosine 4-pentenoic acid ethyl ester 7 N(a)-Acetyl-L-arginine 41 N-Acetyl-DL-norleucine 8 N-Acetyl-D-asparagine 42 N-Acetyl-D-phenylalanine 9 N(a)-Acetyl-L-asparagine 43 N-Acetyl-DL- 10 N-Acetyl-DL-aspartic acid phenylalanine 11 N-Acetyl-L-aspartic acid 44 N-Acetyl-L-phenylalanine 12 N-Acetyl-L-aspartic acid, 45 N-Acetyl-L-phenylalanine CHA salt ethyl ester 13 N-Acetyl-L-cysteine 46 N-Acetyl-DL- 14 N-6-Acetyl-dnp-L-lysine phenylalanine-b-naphthyl 15 N-Acetyl-o-fluoro-DL- ester phenyl-alanine 47 N-Acetyl-DL- 16 N-Acetyl-m-fluoro-DL- phenylalanine p- phenyl-alanine nitrophenyl ester 17 N-Acetyl-DL-glutamic acid 48 N-Acetyl-DL-proline 18 N-Acetyl-L-glutamic acid 49 N-Acetyl-L-proline 19 N-Acetyl-L-glutamine 50 N-Acetyl-DL-C- 20 N-Acetylglycine propargylglycine; 2- 21 N(a)-Acetyl-L-histidine Acetamido-4-pentynoic 22 N-Acetyl-DL- acid homocysteine thiolactone 51 N-Acetyl-DL-serine 23 N-Acetylhydroxy-L-proline 52 O-Acetyl-L-serine .HCl 24 O-Acetylhydroxy-L-proline 53 N-Acetyl-D-tryptophan 25 N-Acetyl-D-allo-isoleucine 54 N-Acetyl-DL-tryptophan 26 N-Acetyl-D-leucine 55 N-Acetyl-L-tryptophan 27 N-Acetyl-DL-leucine 56 N-Acetyl-L- 28 N-Acetyl-L-leucine tryptophanamide 29 N(a)-Acetyl-L-lysine 57 N-Acetyl-L-tryptophan 30 N(e)-Acetyl-L-lysine ethyl ester 31 N(a)-Acetyl-L-lysine-N- 58 N-Acetyl-L-tyrosinamide methylamide 59 N-Acetyl-L-tyrosine 32 N(a)-Acetyl-L-lysine 60 N-Acetyl-L-tyrosine ethyl methyl ester .HCl ester 33 N-Acetyl-D-methionine 61 N-Acetyl-L-tyrosine 34 N-Acetyl-DL-methionine hydrazide 35 N-Acetyl-DL-methionine, 62 N-Acetyl-DL-valine Ca salt 63 N-Acetyl-L-valine 64 S-Adenosyl-L-cysteine Sigma Biochemical Library, page 1 of 154 Index Number Compound Name Index Number Compound Name 65 S-Adenosyl-L-ethionine 99 DL-a-Aminobutyric acid iodide hydroxamate 66 S-Adenosyl-D- 100 a-Aminoisobutyric acid homocysteine hydroxamate 67 S-Adenosyl-L- 101 L-Arginine hydroxamate homocysteine .HCl 68 S-Adenosyl-L-methionine 102 DL-Aspartic acid b- chloride hydroxamate 69 S-Adenosyl-L-methionine 103 L-Cystine dihydroxamate iodide 104 L-Glutamic acid g- 70 S-Adenosyl-L-methionine, hydroxamate toslyate salt 105 Glycine hydroxamate 71 L-Alaninamide .HBr 106 L-Histidine hydroxamate 72 D-Alanine 107 L-Isoleucine hydroxamate 73 DL-Alanine + D-allo 74 L-Alanine 108 L-Leucine hydroxamate 75 b-Alanine 109 L-Lysine hydroxamate 76 L-Alanine 7-amido-4- .HCl methyl-coumarin, 110 DL-Methionine trifluoroacetate salt hydroxamate 77 L-Alanine benzyl ester 111 DL-Norleucine .HCl hydroxamate 78 b-Alanine benzyl ester, 112 DL-Norvaline toslyate salt hydroxamate 79 L-Alanine ethyl ester .HCl 113 DL-Phenylalanine 80 b-Alanine 4-methoxy-b- hydroxamate naphthylamide .HCl 114 DL-Serine hydroxamate 81 L-Alanine 4-methoxy-b- 115 DL-Threonine naphthylamide .HCl hydroxamate 82 b-Alanine methyl ester 116 DL-Tryptophan .HCl hydroxamate 83 DL-Alanine methyl ester 117 L-Tryptophan .HCl hydroxamate 84 L-Alanine methyl ester 118 L-Tyrosine hydroxamate .HCl 119 DL-Valine hydroxamate 85 DL-Alanine b- 120 b-Aminoadipic acid naphthylamide 121 D-a-Aminoadipic acid 86 DL-a-Alanine b- 122 L-a-Aminoadipic acid naphthylamide .HCl 123 N-(p-Aminobenzoyl)-L- 87 L-Alanine b- glutamic acid diethyl ester naphthylamide 124 D-a-Aminobutyric acid 88 L-Alanine-b- 125 DL-a-Aminobutyric acid naphthylamide .HBr 126 L-a-Aminobutyric acid 89 L-Alanine p-nitroanilide 127 DL-b-Aminobutyric acid .HCl 128 g-Aminobutyric acid 90 DL-Alaninol 129 DL-a-Aminobutyric acid 91 DL-Alaninol .HCl methyl ester .HCl 92 L-Alaninol 130 e-Aminocaproic acid 93 Albizziin 131 w-Aminocaprylic acid 94 D-Allylglycine 132 DL-a-Aminocaprylic acid 95 DL-Allylglycine 133 N(e)-DL-(2-Amino-2- 96 L-Allylglycine carboxyethyl)-L-lysine 97 DL-Alanine hydroxamate 134 L-a-(2- 98 b-Alanine hydroxamate Aminoethoxyvinyl)glycine .HCl Sigma Biochemical Library, page 2 of 154 Index Number Compound Name Index Number Compound Name 135 S-2-Aminoethyl-L-cysteine 173 L-Asparagine t-butyl ester .HCl .HCl 136 L-a-Amino-b- 174 D-Aspartic acid guandinopropionic acid 175 DL-Aspartic acid .HCl 176 DL-Aspartic acid, 137 6-Amino-1-hexyl hemimagnesium salt phosphate 177 DL-Aspartic acid, K salt 138 p-Aminohippuric acid 178 L-Aspartic acid 139 p-Aminohippuric acid, Na 179 L-Aspartic acid, salt hemimagnesium salt 140 DL-g-Amino-b- 180 L-Aspartic acid, Na salt hydroxybutyric acid 181 L-Aspartic acid, K salt 141 a-Aminoisobutyric acid 182 L-Aspartic acid di-t-butyl 142 DL-b-Aminoisobutyric acid ester .HCl 143 d-Aminolevulinic acid .HCl 183 L-Aspartic acid dibenzyl 144 d-Aminolevulinic acid ester, tosylate salt methyl ester .HCl 184 DL-Aspartic acid dimethyl 145 Aminomethylphosphonic ester .HCl acid 185 D-Aspartic acid b- 146 p-Amino-DL- hydroxamate phenylalanine 186 L-Aspartic acid b- 147 p-Amino-D-phenylalanine hydroxamate 148 p-Amino-L-phenylalanine 187 L-Aspartic acid a-(b- 149 DL-a-Aminopimelic acid naphthylamide) 150 3-Aminopropylphosphonic 188 4-Aza-DL-leucine .2HCl acid 189 O-Diazoacetyl-L-serine 151 3-Amino-L-tyrosine .2HCl 190 DL-7-Azatryptophan .H2O 152 d-Amino-N-valeric acid 191 N-Benzoyl-b-alanine 153 d-Amino-N-valeric acid 192 N-Benzoyl-DL-alanine .HCl 193 N-Benzoyl-DL-alanine 154 L-Anserine nitrate methyl ester 155 D-Arginine 194 N-Benzoyl-L-alanine 156 D-Arginine .HCl methyl ester 157 DL-Arginine .HCl 195 N-Benzoyl-d-aminovaleric 158 L-Arginine acid 159 L-Arginine .HCl 196 N(a)-Benzoyl-L- 160 L-Arginine-7-amido-4- argininamide .HCl .H2O methylcoumarin .HCl 197 N(a)-Benzoyl-DL-arginine 161 L-Arginine L-aspartate 7-amido-4- 162 L-Arginine L-glutamate methylcoumarin .HCl 163 L-Arginine 4-methoxy-b- 198 N(a)-Benzoyl-L-arginine naphthylamide .HCl 7-amido-4- 164 L-Arginine methyl ester methylcoumarin .HCl .2HCl 199 N(a)-Benzoyl-DL-arginine 165 L-Arginine b- 200 N(a)-Benzoyl-L-arginine naphthylamide .HCl 201 N(a)-Benzoyl-L-arginine 166 L-Arginine p-nitroanilide ethyl ester .HCl .2HCl 202 N(a)-Benzoyl-L-arginine 167 L-Argininic acid 4-methoxy-b- 168 Argininosuccinic acid, Ba naphthylamide .HCl salt 203 N(a)-Benzoyl-L-arginine 169 D-Asparagine .H2O methyl ester bicarbonate 170 DL-Asparagine .H2O 204 N(a)-Benzoyl-L-arginine 171 L-Asparagine anhydrous methyl ester .HCl 172 L-Asparagine .H2O Sigma Biochemical Library, page 3 of 154 Index Number Compound Name Index Number Compound Name 205 N(a)-Benzoyl-DL-arginine 240 N(a)-t-BOC-L-asparagine p-nitroanilide .HCl 241 N(a)-t-BOC-L-asparagine 206 N(a)-Benzoyl-L-arginine p-nitrophenyl ester p-nitroanilide .HCl 242 N-t-BOC-L-aspartic acid 207 N-Benzoyl-DL-leucine 243 N-t-BOC-L-aspartic acid 208 N-Benzoyl-L-leucine b- a-benzyl ester naphthylamide 244 N-t-BOC-L-aspartic acid 209 N-Benzoyl-DL- b-benzyl ester phenylalanine 245 N-t-BOC-L-aspartic acid 210 N-Benzoyl-L- b-t-butyl ester, DCHA salt phenylalanine 246 N-t-BOC-L-aspartic acid 211 N-Benzoyl-DL- b-cyclohexyl ester phenylalanine b-naphthol 247 N-t-BOC-b-benzyl-L- as-bi ester aspartic acid p-nitrophenyl 212 N-Benzoyl-L-tyrosine ethyl ester ester 248 N-t-BOC-S-benzyl-L- 213 N-Benzoyl-DL-valine cysteine 214 b-Benzyl L-aspartate 249 N-t-BOC-g-benzyl-L- 215 S-Benzyl-L-cysteine glutamic acid p- 216 S-Benzyl-L-cysteine ethyl nitrophenyl ester ester .HCl 250 N-t-BOC-g-benzyl-L- 217 S-Benzyl-L-cysteine histidine methyl ester .HCl 251 N-t-BOC-O-benzyl-L- 218 S-Benzyl-L-cysteine p- serine nitroanilide 252 N-t-BOC-O-benzyl-L- 219 g-Benzyl-L-glutamate threonine 220 N-Benzylglycine ethyl 253 N-t-BOC-O-benzyl-L- ester tyrosine 221 g-Benzyl-L-histidine 254 N-t-BOC-O-benzyl-L- 222 S-Benzyl-DL- tyrosine 2,4,5- homocysteine trichlorophenyl ester 223 5-Benzyloxy-DL- 255 N(a)-t-BOC-N(e)-CBZ-L- tryptophan lysine 224 7-Benzyloxy-DL- 256 N(a)-t-BOC-N(e)-CBZ-L- tryptophan lysine, DCHA salt 225 O-Benzyl-DL-serine 257 N(e)-t-BOC-N(a)-CBZ-L- 226 O-Benzyl-L-serine lysine, DCHA salt 227 O-Benzyl-L-tyrosine 258 N(a)-t-BOC-N(e)-CBZ-L- 228 Bestatin .HCl lysine N- 229 Betaine anhydrous hydroxysuccinimide ester 230 Betaine .H2O 259 N(e)-t-BOC-N(a)-CBZ-L- 231 Betaine .HCl lysine p-nitrophenyl ester 232 N-t-BOC-b-alanine 260 N-t-BOC-3,4-dehydro-L- 233 N-t-BOC-D-alanine proline 234 N-t-BOC-L-alanine 261 N(a)-t-BOC-O-2,6- 235 N-t-BOC-L-alanine N- dichlorobenzyl-L-tyrosine hydroxysuccinimide ester 262 N-t-BOC-epistatine 236 N-t-BOC-b-alanine p- 263 N(a)-t-BOC-N(e)-formyl-L- nitrophenyl ester lysine 237 N-t-BOC-L-alanine p- 264 N-t-BOC-D-glutamic acid nitrophenyl ester a-benzyl ester 238 N-t-BOC-L-a-aminobutyric 265 N-t-BOC-L-glutamic acid acid a-benzyl ester 239 N(a)-t-BOC-L-arginine 266 N-t-BOC-L-glutamic acid .HCl g-benzyl ester Sigma Biochemical Library, page 4 of 154 Index Number Compound Name Index Number Compound Name 267 N-t-BOC-L-glutamic acid 298 N-t-BOC-L-norleucine, g-benzyl ester DCHA salt 268 N-t-BOC-L-glutamic acid 299 N-t-BOC-L-norvaline, g-t-butyl ester DCHA salt 269 N-t-BOC-L-glutamic acid 300 N(d)-t-BOC-L-ornithine g-cyclohexyl ester 301 N-t-BOC-D-phenylalanine 270 N(a)-t-BOC-L-glutamine 302 N-t-BOC-L-phenylalanine 271 N(a)-t-BOC-L-glutamine 303 N-t-BOC-L-phenylalanine, N-hydroxysuccinimide DCHA salt ester 304 N-t-BOC-L-phenylalanine 272 N(a)-t-BOC-L-glutamine N-hydroxysuccinimide p-nitrophenyl ester ester 273 N-t-BOC-glycine 305 N-t-BOC-D-phenylalanine 274 N-t-BOC-glycine N- p-nitrophenyl
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  • TAAR1 Activation Modulates Monoaminergic Neurotransmission, Preventing Hyperdopaminergic and Hypoglutamatergic Activity

    TAAR1 Activation Modulates Monoaminergic Neurotransmission, Preventing Hyperdopaminergic and Hypoglutamatergic Activity

    TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity Florent G. Revela, Jean-Luc Moreaua, Raul R. Gainetdinovb, Amyaouch Bradaiac, Tatyana D. Sotnikovab, Roland Morya, Sean Durkina, Katrin Groebke Zbindend, Roger Norcrossd, Claas A. Meyere, Veit Metzlera, Sylvie Chaboza, Laurence Ozmena, Gerhard Trubea, Bruno Pouzeta, Bernhard Bettlerf, Marc G. Carong, Joseph G. Wettsteina, and Marius C. Hoenera,1 aNeuroscience Research, dDiscovery Chemistry, and eDiscovery Technologies, Pharmaceuticals Division, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland; bDepartment of Neuroscience and Brain Technologies, Italian Institute of Technology, 16163 Genoa, Italy; cNeuroservice, Domaine de Saint-Hilaire, 13593 Aix-en-Provence, France; fDepartment of Biomedicine, Institute of Physiology, Pharmazentrum, University of Basel, CH-4056 Basel, Switzerland; and gDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710 Edited by Richard D. Palmiter, University of Washington, Seattle, WA, and approved March 31, 2011 (received for review February 24, 2011) The trace amine-associated receptor 1 (TAAR1), activated by en- sitive to the locomotor-stimulating effect of d-amphetamine dogenous metabolites of amino acids like the trace amines and show elevated striatal release of dopamine (DA), noradren- p-tyramine and β-phenylethylamine, has proven to be an impor- aline (NA), and serotonin [5-hydroxytryptamine (5-HT)] after a d-amphetamine challenge (10, 12). Furthermore, the spontaneous tant modulator of the dopaminergic system and is considered −/− firing rate of the VTA DA neurons is augmented in Taar1 mice, a promising target for the treatment of neuropsychiatric disorders. fi To decipher the brain functions of TAAR1, a selective TAAR1 ago- and only in WT mice does pTyr decrease this ring rate (10).
  • Aldrich Raman

    Aldrich Raman

    Aldrich Raman Library Listing – 14,033 spectra This library represents the most comprehensive collection of FT-Raman spectral references available. It contains many common chemicals found in the Aldrich Handbook of Fine Chemicals. To create the Aldrich Raman Condensed Phase Library, 14,033 compounds found in the Aldrich Collection of FT-IR Spectra Edition II Library were excited with an Nd:YVO4 laser (1064 nm) using laser powers between 400 - 600 mW, measured at the sample. A Thermo FT-Raman spectrometer (with a Ge detector) was used to collect the Raman spectra. The spectra were saved in Raman Shift format. Aldrich Raman Index Compound Name Index Compound Name 4803 ((1R)-(ENDO,ANTI))-(+)-3- 4246 (+)-3-ISOPROPYL-7A- BROMOCAMPHOR-8- SULFONIC METHYLTETRAHYDRO- ACID, AMMONIUM SALT PYRROLO(2,1-B)OXAZOL-5(6H)- 2207 ((1R)-ENDO)-(+)-3- ONE, BROMOCAMPHOR, 98% 12568 (+)-4-CHOLESTEN-3-ONE, 98% 4804 ((1S)-(ENDO,ANTI))-(-)-3- 3774 (+)-5,6-O-CYCLOHEXYLIDENE-L- BROMOCAMPHOR-8- SULFONIC ASCORBIC ACID, 98% ACID, AMMONIUM SALT 11632 (+)-5-BROMO-2'-DEOXYURIDINE, 2208 ((1S)-ENDO)-(-)-3- 97% BROMOCAMPHOR, 98% 11634 (+)-5-FLUORODEOXYURIDINE, 769 ((1S)-ENDO)-(-)-BORNEOL, 99% 98+% 13454 ((2S,3S)-(+)- 11633 (+)-5-IODO-2'-DEOXYURIDINE, 98% BIS(DIPHENYLPHOSPHINO)- 4228 (+)-6-AMINOPENICILLANIC ACID, BUTANE)(N3-ALLYL)PD(II) CL04, 96% 97 8167 (+)-6-METHOXY-ALPHA-METHYL- 10297 ((3- 2- NAPHTHALENEACETIC ACID, DIMETHYLAMINO)PROPYL)TRIPH 98% ENYL- PHOSPHONIUM BROMIDE, 12586 (+)-ANDROSTA-1,4-DIENE-3,17- 99% DIONE, 98% 13458 ((R)-(+)-2,2'- 963 (+)-ARABINOGALACTAN BIS(DIPHENYLPHOSPHINO)-1,1'-
  • Synthesis of Isothiocyanates Using DMT/NMM/Tso− As a New Desulfurization Reagent

    Synthesis of Isothiocyanates Using DMT/NMM/Tso− As a New Desulfurization Reagent

    molecules Article Synthesis of Isothiocyanates Using DMT/NMM/TsO− as a New Desulfurization Reagent Łukasz Janczewski 1,* , Dorota Kr˛egiel 2 and Beata Kolesi ´nska 1 1 Faculty of Chemistry, Institute of Organic Chemistry, Lodz University of Technology, Zeromskiego 116, 90-924 Lodz, Poland; [email protected] 2 Department of Environmental Biotechnology, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, Wolczanska 171/173, 90-924 Lodz, Poland; [email protected] * Correspondence: [email protected] Abstract: Thirty-three alkyl and aryl isothiocyanates, as well as isothiocyanate derivatives from esters of coded amino acids and from esters of unnatural amino acids (6-aminocaproic, 4-(aminomethyl)benzoic, and tranexamic acids), were synthesized with satisfactory or very good yields (25–97%). Synthesis was performed in a “one-pot”, two-step procedure, in the presence of organic base (Et3N, DBU or NMM), and carbon disulfide via dithiocarbamates, with 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4- methylmorpholinium toluene-4-sulfonate (DMT/NMM/TsO−) as a desulfurization reagent. For the synthesis of aliphatic and aromatic isothiocyanates, reactions were carried out in a microwave reactor, and selected alkyl isothiocyanates were also synthesized in aqueous medium with high yields (72–96%). Isothiocyanate derivatives of L- and D-amino acid methyl esters were synthesized, under conditions without microwave radiation assistance, with low racemization (er 99 > 1), and their absolute configuration was confirmed by circular dichroism. Isothiocyanate derivatives of natural and unnatural amino acids were evaluated for antibacterial activity on E. coli and S. aureus bacterial strains, where the Citation: Janczewski, Ł.; Kr˛egiel,D.; most active was ITC 9e.
  • 1 Abietic Acid R Abrasive Silica for Polishing DR Acenaphthene M (LC

    1 Abietic Acid R Abrasive Silica for Polishing DR Acenaphthene M (LC

    1 abietic acid R abrasive silica for polishing DR acenaphthene M (LC) acenaphthene quinone R acenaphthylene R acetal (see 1,1-diethoxyethane) acetaldehyde M (FC) acetaldehyde-d (CH3CDO) R acetaldehyde dimethyl acetal CH acetaldoxime R acetamide M (LC) acetamidinium chloride R acetamidoacrylic acid 2- NB acetamidobenzaldehyde p- R acetamidobenzenesulfonyl chloride 4- R acetamidodeoxythioglucopyranose triacetate 2- -2- -1- -β-D- 3,4,6- AB acetamidomethylthiazole 2- -4- PB acetanilide M (LC) acetazolamide R acetdimethylamide see dimethylacetamide, N,N- acethydrazide R acetic acid M (solv) acetic anhydride M (FC) acetmethylamide see methylacetamide, N- acetoacetamide R acetoacetanilide R acetoacetic acid, lithium salt R acetobromoglucose -α-D- NB acetohydroxamic acid R acetoin R acetol (hydroxyacetone) R acetonaphthalide (α)R acetone M (solv) acetone ,A.R. M (solv) acetone-d6 RM acetone cyanohydrin R acetonedicarboxylic acid ,dimethyl ester R acetonedicarboxylic acid -1,3- R acetone dimethyl acetal see dimethoxypropane 2,2- acetonitrile M (solv) acetonitrile-d3 RM acetonylacetone see hexanedione 2,5- acetonylbenzylhydroxycoumarin (3-(α- -4- R acetophenone M (LC) acetophenone oxime R acetophenone trimethylsilyl enol ether see phenyltrimethylsilyl... acetoxyacetone (oxopropyl acetate 2-) R acetoxybenzoic acid 4- DS acetoxynaphthoic acid 6- -2- R 2 acetylacetaldehyde dimethylacetal R acetylacetone (pentanedione -2,4-) M (C) acetylbenzonitrile p- R acetylbiphenyl 4- see phenylacetophenone, p- acetyl bromide M (FC) acetylbromothiophene 2- -5-