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The Impact of Patient Information Leaflets to Prevent Hypoglycemia In The impact of patient information leaflets to prevent hypoglycemia in out-patients with type 2 diabetes mellitus El impacto de los folletos de información al paciente para prevenir la hipoglucemia en pacientes ambulatorios con diabetes mellitus tipo 2 Veintramuthu Sankar1, Abdul Sherif2, Anita Ann Sunny3, Grace Mary John2, Senthil Kumar Rajasekaran3 1 Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, India 2 Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore, India 3 Department of Endocrinology, PSG Hospitals, PSG Institute of Medical Sciences and Research, Coimbatore, India http://dx.doi.org/10.30827/ars.v60i1.7614 Artículo original ABSTRACT Original Article Hypoglycemia is a significant complication of intensive diabetes therapy, a true medical emergency, which requires prompt recognition and treatment to prevent organ and brain damage. Therefore, knowl- Correspondencia Correspondence edge about diabetes can play an important role in maintaining glycemia control and prevent hypogly- Veintramuthu Sankar cemic complications. [email protected] Aim: The aim of the study is to develop and assess the impact of patient information leaflets to prevent hypoglycemia in outpatients with type 2 diabetes mellitus and to study the effect of prescribed drugs Financiación Fundings pattern in patients. Fund granted by College management Material & Methods: This open labelled, interventional study was conducted in the endocrinology Out and the research work was approved Patient Department (OPD) in a tertiary care hospital over a period of 9 months in 55 patients. The infor- for the award of Degree of Master of pharmacy by The Tamilnadu Dr.MGR mation was provided to patients through a developed patient information leaflet and their awareness Medical University, Chennai, India and glycemic status were assessed by an internally institution developed vernacular language based validated questionnaire. The questionnaire with four different dimensions patient knowledge, glycemic Agradecimientos control, compliance and life style was quantified in the study. Acknowledgements We would like to thank PSG College of Results: The study showed statistically significant (P<0.05) improvement in knowledge and glycemic Pharmacy, Department of Endocrinology, control in male patients and in knowledge, compliance, and glycemic control for female patients. Liter- PSG Hospitals, Clinical sites, and the ate patients showed more significant improvement in knowledge, compliance, life style, and glycemic patients for their participation. We also control than illiterate patients. thank Dr Sivaram Hariharan, for his extensive English proof reading and Conclusions: Results of the study suggested that pharmacist provided patient education and awareness editing services. helped type 2 diabetic hypoglycemic patients to improve knowledge and glycaemic control. Conflicto de interés Keywords: Diabetes; Hypoglycemia; Patient Education; Consumer health information leaflets Competing interest The authors state no conflict of interest RESUMEN Received: 30.06.2018 La hipoglucemia es una complicación importante de la terapia intensiva de la diabetes, una verdadera Accepted: 09.02.2019 emergencia médica, que requiere un reconocimiento y tratamiento rápidos para prevenir el daño cere- bral y de órganos. Por lo tanto, el conocimiento sobre la diabetes puede desempeñar un papel importante en el mantenimiento del control de la glucemia y prevenir las complicaciones hipoglucémicas. Objetivo: el objetivo del estudio es desarrollar y evaluar el impacto de los folletos de información al paciente para prevenir la hipoglucemia en pacientes ambulatorios con diabetes mellitus tipo 2 y estudiar el efecto del patrón de medicamentos recetados en los pacientes. Material y métodos: Este estudio abierto de intervención abierta se realizó en el Departamento de pa- cientes ambulatorios (OPD) de endocrinología en un hospital de atención terciaria durante un período de 9 meses en 55 pacientes. La información se proporcionó a los pacientes a través de un folleto de información al paciente y su conocimiento y estado glucémico se evaluaron mediante un cuestionario validado basado en el lenguaje vernáculo desarrollado internamente en una institución. El cuestionario LICENSE 3.0 UNPORTED. Ars Pharm. 2019; 60(1): 5-14 5 Sankar V, et al. con cuatro dimensiones diferentes de conocimiento del paciente, and considering the risk factors for iatrogenic hypoglyce- control glucémico, cumplimiento y estilo de vida se cuantificó en mia5. Main measures to prevent hypoglycemia includes el estudio. drug counselling, meal plan, limiting the use of alcoholic Resultados: El estudio mostró una mejora, estadísticamente sig- beverages, and through appropriate diabetes management nificativa (P <0,05), en el conocimiento y el control glucémico en plan. The knowledge and education can also help patients pacientes masculinos y en el conocimiento, el cumplimiento y el to manage their glycemic conditions effectively along with control glucémico en pacientes femeninos. Los pacientes alfabeti- pharmacological management6-12. Many health profession- zados mostraron una mejora más significativa en el conocimiento, als rely on a verbal explanation, but this has been shown to el cumplimiento, el estilo de vida y el control glucémico que los be ineffective; patients tend to forget approximately half of pacientes analfabetos. Conclusiones: Los resultados del estudio 13 sugirieron que el farmacéutico brindó a los pacientes con hipoglu- the given information . One method of providing informa- cemia diabética tipo 2 información y conciencia para mejorar el tion is to supply a patient information leaflet. It have also conocimiento y el control glucémico. been shown to increase knowledge of drug side effects in a series of studies undertaken in the community14-15. The Palabras clave: Diabetes; hipoglucemia; Educación del paciente; present study was undertaken to develop a patient infor- Folletos de información de salud para el consumidor mation leaflet and evaluate the impact of it in education INTRODUCTION by pharmacist with respect to knowledge, compliance, life Hypoglycemia is a condition featuring lower than normal style, and glycemic control in T2DM patients with hypo- levels of blood glucose. It can be defined as “mild” if ep- glycemia. The effect of prescribed drugs pattern for the isode is self-treated; “moderate” if assisted, and “severe” management of glycemic control in patients will also be if hospitalised and assisted by physician (Diabetes Con- investigated. trol and Complications Trial, 1993). Hypoglycemia could MATERIALS AND METHODS be classified as a true medical emergency, which left un- treated may lead to organ and brain damage1. It is a sig- Study design nificant complication of intensive diabetes therapy. Severe The open labelled, interventional study was conducted in untreated hypoglycemia can cause significant economic the endocrinology outpatient department in a tertiary care and personal burden. Hence, identification and prevention hospital for a period of 9 months from June 2015 to Feb- of hypoglycemia are very important factors for prevention ruary 2016 . Institutional Ethics Committee (IEC) approval of hypoglycemic complications2. Diabetic medications, was taken before initiation of the study. including insulin and sulfonylureas, are among the most 3 common causes of hypoglycemia in diabetic subjects . Oc- Sample size calculation casional episodes of hypoglycemia with metformin are re- ported when an imbalance between food intake and dose of Sample size was calculated as 55 based on the outpatient metformin2. According to Diabetes Audit and Research in statistics of endocrinology department. Raosoft sample Tayside Scotland (DARTS) study, severe hypoglycemia was size calculator with margin of error 5%, confidence level observed in 7.3% and 0.8% of patients with Type 2 Diabetes 95%, and probability was used for calculation. A total of Mellitus (T2DM) treated with insulin and oral sulfonylurea 385 diabetic patients were screened out of which 100 hypo- respectively. The risk of hypoglycemia is highest in those glycemic patients were identified. Fifty five patients were with T2DM, who have received insulin for more than 10 included in the study based on the inclusion and exclusion years4. T2DM patients lose, on an average, three productive criteria. days following a severe hypoglycemic attack. The Action Inclusion and exclusion criteria to Control Cardiovascular Risk in Diabetes (ACCORD) Tri- al has demonstrated increased mortality rates in patients Both male and female hypoglycemic patients of age >18 who experienced episodes of hypoglycemia. Repeated years diagnosed with T2DM were included. Patients on episodes of hypoglycemia can result significant mortality Oral Hypoglycemic Agents (OHA’s) and/or insulin were which is reportedly associated with a six fold increase in included in the study. Pregnancy, lactation, psychosis, men- death. The clinical approach to minimize hypoglycemia tal retardation, active substance abuse, and significant de- while improving glycemic control includes addressing the pression patients were excluded from the study. Patients issue, applying the principles of aggressive glycemic ther- who were not willing to provide consent were excluded apy, including flexible and individualized drug regimens, from the study. 6 Ars Pharm. 2019; 60(1): 5-14 The impact of patient information leaflets to prevent hypoglycemia in out-patients with type 2 diabetes mellitus
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