Boston University Photonics Center Annual Report 2018

Letter from the Director THIS ANNUAL REPORT summarizes activities of the Boston University Photonics Center for the 2017-2018 academic year. In it, you will find quantitative and descriptive information regarding our photonics programs in education, interdisciplinary research, business innovation, and technology development.

Located at the heart of Boston University’s urban campus, the Photonics Center is an interdisciplinary hub for education, research, scholarship, innovation, and technology development associated with practical uses of light. Our nine-story building houses world-class research facilities and shared laboratories dedicated to photonics research, and sustains the work of 58 faculty members, 12 staff members, and more than 100 graduate students and postdoctoral fellows.

Over the past year, the Center achieved the three main goals of the strategic plan that our community committed itself to nearly six years ago. Our first strategic goal was to strengthen the Center’s research foundation, which we quantified succinctly as sustained grant income of $20M per year by Photonics Center researchers. At the time of our strategic plan, our annual grant income was about half that, and Center operations were substantially leveraged by a single DoD Technology Over the past Translation Contract that ended in 2011. In the years since, we have focused year, the Center our efforts on supporting and catalyzing new research grants by our faculty, and achieved the three the effort has paid off. Our average grant support over the past four years has main goals of the exceeded our target, and this year our grant income was about $21M. In myriad ways, this steep increase in grant support has strengthened our capacity to train strategic plan that students, make innovative discoveries, and impact society. Our second strategic our community goal was to focus our resources on institutional initiatives that leveraged Boston committed itself University’s other pillars of research strengths in life sciences. The launch of the to nearly six years new Neurophotonics Center, with Dave Boas at the helm, marks a watershed in our realization of that goal. The new Center is already a hive of activity, anchored ago. by a nationally prominent training program in neurophotonics, an exceptional new shared facility for research, and an inspirational and dedicated leader. Our third and final strategic goal was to use the institutional infrastructure of the Photonics Center to help win major center awards for the university. Under the leadership of David Bishop, the Director of the affiliated and co-located Materials Division research facility, the Photonics Center faculty and staff helped win the University’s first NSF Engineering Research Center (ERC) on Cellular Metamaterials. This tissue engineering ERC is headquartered in our Center, and represents exactly the kind of significant research challenge that we aspired to take on.

It has been rewarding to see our community transform itself to meet these ambitious strategic goals, and I am grateful to the staff and faculty of the Photonics Center for creating and achieving our shared vision of research excellence.

Dr. Thomas Bifano Director, Boston University Photonics Center BU Photonics Center Annual Report 2018

1 | Mission Statement

2 | Photonics Center at a Glance

2 | Highlights of FY18

4 | Photonics Center Strategic Plan

5 | Photonics Center Articles

11 | Faculty

16 | Center Leadership and Administrative Staff

16 | Organizational Chart

17 | Research Projects and Technology Development

18 | Major Projects Managed by the Center

20 | List of Current Grant Awards

27 | Publications

33 | Awards and Patents

35 | Educational Programs and Initiatives

38 | Business Innovation Center

40| Events and Programs

42 | Facilities and Equipment Mission Statement

THE BOSTON Academic and Entrepreneurial Sensors and Systems. Additionally, UNIVERSITY PHOTONICS Programs and Initiatives for Students the Center for Innovation in Point of Care Technologies for the Future of generates fundamental CENTER While the Photonics Center does not Cancer Care has promoted technology knowledge and develops innovative offer academic degrees, the faculty translation in an area of critical national technology in the field of photonics. teach a broad array of graduate and need. Going forward, it is expected that We work on challenging problems that undergraduate courses that cut across the Innovation Ecosystem, developed as are important to society, we translate traditional departmental curricula. part of the CELL-MET activities, will enabling research discoveries into useful Beyond the classroom, students engage be the primary driver for technology prototypes, and we educate future in diverse entrepreneurial activities, development. leaders in the field. including internships with companies in the Business Innovation Center, Business Innovation and This mission is executed through: opportunities for engagement/ Commercialization of Photonics networking with industry, particularly Technology • Basic research and scholarship in with members of the Industry/ photonics. University Cooperative Research Center The Photonics Center is a leader • Academic and entrepreneurial (I/UCRC) and ERC, and participation in in commercialization of photonics programs and initiatives for the annual Photonics Center Symposium. technology, an activity that is anchored students. The NSF Research Experiences for by its Business Innovation Center • Technology development for Undergraduates (REU) in Integrated (BIC). Individual tenant companies healthcare, defense, and security Nanomanufacturing (INM) completed continue to demonstrate growth, attract applications. its final no cost-extension year and business financing, and demonstrate • Business innovation and under the umbrella of the Engineering commercial potential. BIC is 100% commercialization of photonics Research Center, REU and RET occupied and currently has 10 technology. participants at BU, Florida International tenant companies. These companies University, and University of Michigan continue to be valued participants The Photonics Center community researched cellular metamaterials this in the Photonics Center community. of faculty, students, and staff past summer. The Research Experiences Preferential selection of prospective engage in numerous interdisciplinary for Teachers (RET) site in Integrated tenants that work in areas aligned with collaborations to further the field. Nanomanufacturing was awarded renewal the research and scholarship activities Below are examples of how the and will now support training for an of Photonic Center faculty creates an Photonics Center and its diverse additional three years. The RET program environment rich with opportunities for community executes each of the four focuses on providing Engineering collaboration and growth in sponsored pillars supporting our mission. support and training for middle and high research. The BIC companies have also school teachers from public schools contributed significantly to student Basic Research and Scholarship in with high percentages of low income training and mentoring. Photonics families and community college faculty members. These programs also provide Photonics Center faculty are involved BU graduate researchers diverse training in research in diverse fields of study and mentoring opportunities not often with areas of strength in biophotonics, included as part of a graduate education imaging, nanophotonics, nonlinear experience. and quantum photonics, and photonic materials and devices. The Center has Technology Development always had a strong cross-disciplinary research effort in Biomedical The Photonics Center’s technology Engineering (BME) and the strength development activities focus on emerging of collaborations between the Materials photonic applications in healthcare. group, cell engineering in BME and These activities include direct sponsored optogenetics and imaging led to strong research collaboration with research labs proposals and the eventual award of the at major corporations and the successful Engineering Research Center (ERC) on completion of seven years of operation Cellular Metamaterials in October 2017. through Phase I and a Phase II renewal of the NSF-sponsored, member- supported I/UCRC on Biophotonic

ANNUAL REPORT 2018 - 1 Highlights of FY18

BU Photonics Center Plays Meghan Foley will serve as PHOTONICS CENTER Prominent Role in $20M Financial Manager for the ERC; At a Glance Five-Year NSF ERC Proposal and Photonics Center staff Award member Beth Mathisen will serve as the Communications BU was awarded a $20M and Events Manager for the five-year National Science ERC. 58 Foundation (NSF) Engineering Faculty Members Research Center (ERC) Cellular The Photonics Center hired Metamaterials proposal on the two new staff members to topic of tissue engineering, with develop and manage processes the possibility of renewal for and data for the ERC. Nozomi an additional five years and an Ito is serving as Administrative 12 additional $20M. The first five Manager and Brenda Hugot years of the project runs from is serving in a part-time Staff Members October 1, 2017 – September capacity as Administrator for 30, 2022. The BU Photonics the ERC. Photonics Center Center staff played a prominent leadership and staff will work role in developing the proposal collaboratively with partners at 84 and planning and managing the the University of Michigan and three-day site visit during the Florida International University Funded R&D Projects proposal process. Photonics to conduct project activities. Center Professor David Bishop is serving as PI and Director of the Research has begun in ERC. Photonics Center Director the four research thrust $21M Thomas Bifano is leading the areas of Nanomechanics, Imaging Thrust area; Photonics Nantechnology, Optical Funding for R&D Center Assistant Director Engineering and Cellular for Operations and Financial Engineering, and an all hands Administration Robert Schaejbe meeting was held at the is leading the Administrative University of Michigan in May team as Administrative Director; 2018 with the CELL-MET 174 and Photonics Center Assistant team. Thrust leaders met with Director of Technical Programs consultants for the NSF to help Archival Publications Thomas Dudley is leading the develop their work and the Innovation Thrust. Photonics ERC Senior Leadership Team Center Manager for Operations met with NSF representatives and Technical Programs Helen throughout the first year of the 3 Fawcett is leading the Diversity project to ensure the project Thrust and will also manage ERC was on track for success. Shared Laboratory Facilities safety training. Photonics Center Additionally, a productive call staff member Cynthia Kowal will was held with the External develop and submit proposals Scientific Advisory Board in and manage budgets for the ERC; June 2018, and the Council Photonics Center staff member of Deans met to provide

2 - BOSTON UNIVERSITY PHOTONICS CENTER Highlights of FY18 (cont’d) guidance to the CELL-MET Training (NRT) project on through 2021. team. Year two of research and Neurophotonics completed administrative activities will its first year. The NRT is a BU Photonics Center commence in October 2018. university-wide community of Supports Renewal of doctoral students in Biology, NSF RET Site: Integrated The 21st Annual Photonics Neuroscience, Biophysics, Nanomanufacturing Center Symposium on and Engineering with focused Neurophotonics professional development The Photonics Center supported and graduate training in the renewal of the National This year, the annual Photonics Neurophotonics. NRT students Science Foundation Research Center symposium focused on were trained on Neurophotonics Experiences for Teachers Site: Neurophotonics. Photonics methods by Photonics Center Integrated Nanomanufacturing Center Professor David Boas and BU faculty throughout (INM) for another three years chaired the conference, which the year. The NRT experience and $500,000. Teachers will drew nearly 200 attendees. The includes: participate in interdisciplinary day before the symposium, Engineering laboratory research NSF NRT trainees participated • Immersive hands-on training during the summer as they in an international research experiences and lab rotations are mentored by engineering exchange with their counterparts with leading Neurophotonics faculty and graduate students. at Laval University. Later that researchers, including a boot In addition, a new component evening, Boston University camp on Neurophotonics. of this site includes several BU Neurophotonics faculty • Interdisciplinary coursework Wheelock College of Education participated in the Provost’s and dissertation. & Human Development faculty Research on Tap event • Professional development mentors and their graduate “Illuminating How the Brain mentoring. students. These mentors Works.” The next day, NRT • Seminars and NRT events. will assist with curriculum trainees presented their research • Annual symposium. development focused on at two poster sessions that • Summer school workshops, engineering integration in were part of the symposium national conferences, peer-led alignment with MA-Adapted which included all external seminars, journal club, and Next Generation of Science speakers. Invited speakers were more. Standards. It is expected that a from Columbia University, minimum of 10 middle and high Harvard University, Howard To start the program, 15 first school teachers and community Hughes Medical Institute, Laval year students completed a three- college faculty will participate University, MIT, Neuroscience day immersive boot camp. Boot each year. Center of Zurich, Rockefeller Camp is an immersive summer University, and University of academic and experiential California, San Diego. learning exercise focused on training NRT Trainees in the First Year of the NSF NRT on core tools and techniques of Neurophotonics Completed Neurophotonics. Thus far, 41 trainees have been trained as The National Science part of the program. This five- Foundation National Research year training grant will continue

ANNUAL REPORT 2018 - 3 Photonics Center Strategic Plan

CENTRAL TO THE critical review, management and Devices Directorate (SEDD) and PHOTONICS CENTER logistical support for large scale, interactions with ARL’s Enterprise STRATEGIC PLAN is an complex collaborations proposed for Multiscale Research of Materials operational model where the Center for external sponsorship, including (EMRM). operates as a centralized resource research and educational projects. – promoting, supporting, and Major successes were the award of At the Business Innovation Center, sustaining allied research centers and the National Research Traineeship located on the 6th floor of the programs across Boston University. grant on Understanding the Brain Photonics Center, Photonics Center The Center has been conducting (UtB) in FY17 and the award of the staff are implementing strategic business as an institute leading Nanosystems Engineering Research changes that align the Center more on a number of activities such as Center in FY18. The support closely with ongoing Photonics the Business Innovation Center, continues post-award with project Center member research and managing and equipping shared administration, and assistance on educational activities and with the laboratories, and administering/ compliance matters from sponsor activities of the I/UCRC and its supporting block grants and and University perspectives. The member companies. supporting affiliated units. Photonics Center provides outsized support for the CELL-MET Photonics Center staff continued Some of the affiliated units include: ERC, assuming leadership roles to pursue high-value, multi- the Nanotechnology Innovation in Inclusivity/ investigator grants Center (BUnano), the Industry/ Training, in the areas of University Cooperative Research Administration, Central to the terahertz devices, Center (I/UCRC) on Biophotonic Innovation Photonics Center plasmonics, Sensors and Systems (CBSS), the Ecosystems, and strategic plan is where quantum Center for Innovation in Point of in one of the four communications, Care Technologies for the Future Research Thrusts. the Center operates as energy of Cancer Care, the Materials a centralized resource - conservation, fiber Science and Engineering Division, The resources and promoting, supporting lasers, microscopic the Engineering Research Center expertise of the and spectroscopic on Lighting Enabled Systems Photonics Center and sustaining allied imaging and Applications (LESA) and staff are employed research centers and technologies most recently the CELL-MET to manage several programs across BU. and adaptive Engineering Research Center. With training grants that optics. Staff respect to the Materials Division, include: Research contributions to the Photonics Center has managed Experiences support proposal substantial renovations for the for Teachers, Research Experience preparation and networking with Materials Division and co-manages for Undergraduates, a substantial government, academic and industrial shared labs such as the Focused effort in Research Experiences for partners have become increasingly Ion Beam/Transmission Electron Veterans, and the National Research important to the Photonics Center’s Microscope Facility (FTF). In Traineeship grant. Additionally, strategic mission, and that role will addition to these facilities, the the Center also supports major continue to expand. Photonics Center also supports faculty awarded grants such as the several other shared labs as Department of Defense grant described in the section on facilities. on Multi-Scale Multi-Disciplinary Modeling of Electronic Materials In support of its strategic goal (MSME). MSME is a major grant of expanding core programs for involving close collaborations research support, the Photonics with the ARL’s research scientist Center provides strategic advice, at the Sensors and Electronic

4 - BOSTON UNIVERSITY PHOTONICS CENTER Photonics in the World

BU WINS $20M FOR NSF a College of Arts & Sciences professor of physics, ENGINEERING RESEARCH CENTER and head of ENG’s Division of Materials Science & GOAL IS PERSONALIZED HEART TISSUE FOR CLINICAL Engineering, will direct the center. Working with him USE will be four leaders in specific areas—or “thrusts”—of by Barbara Moran technical expertise: Thomas Bifano, an ENG professor of mechanical engineering and director of the Photonics BOSTON UNIVERSITY HAS WON A $20 Center, will direct imaging; Alice White, an ENG professor MILLION, FIVE-YEAR AWARD from the National and chair of the mechanical engineering department, Science Foundation (NSF) to create a multi-institution will direct nanomechanics; Christopher Chen, an ENG Engineering Research Center (ERC), with the goal of professor of biomedical engineering, will direct cellular synthesizing personalized heart tissue for clinical use. The engineering; and Stephen Forrest, a University of grant, which is renewable for a total of 10 years and $40 Michigan professor of materials science and engineering, million, is designed to accelerate an area of engineering will direct nanotechnology. Arvind Agarwal, a Florida research—in this case, bioengineering functional heart International University (FIU) professor of mechanical tissue—that is likely to spur societal change and economic and materials engineering, will work with White’s team to growth within a decade. advance nanomechanics methods, and will also lead FIU’s involvement in the ERC, with a crucial role in education “The goal is moving from the basic research capability and outreach. to a technology that could be disruptive,” says Kenneth Lutchen, dean of the College of Engineering and a professor of biomedical engineering, who notes that the ERC program is designed to stimulate translation of research to practice by facilitating worldwide corporate, clinical, and institutional partnerships. “The center will transform cardiovascular care by synthesizing breakthroughs in nanotechnology and manufacturing with tissue engineering and regenerative medicine,” he says.

ERC grants are extremely competitive. Of more than 200 Credit: Jeroen Eyckmans applicants, only 4—Boston University, Purdue University, the Georgia Institute of Technology, and Texas A&M University—received awards in 2017. “The awarding of The ERC will also develop areas of expertise in education, the NSF ERC is outstanding recognition of the quality diversity, administration, and outreach. Helen Fawcett, and creativity of our faculty team from across the College an ENG research assistant professor of mechanical of Engineering,” says Robert A. Brown, president of BU. engineering, will lead the diversity team. Stormy Attaway “Their efforts will help make the creation of personalized (GRS’84,’88), an ENG assistant professor of mechanical human tissue for cardiac applications a reality.” engineering, will colead the workforce development and education team with Sarah Hokanson (CAS’05), The Engineering Research Center will be housed at Professional Development & Postdoctoral Affairs Boston University, the lead institution on the grant. program director. The administration team will be led The award hits a “sweet spot” at the intersection of by Robert Schaejbe, Photonics Center assistant director BU’s strengths in biomedical engineering, photonics, of operations and financial administration. Thomas and nanotechnology, says Lutchen. David Bishop, an Dudley, Photonics Center assistant director of technical ENG professor of electrical and computer engineering, ANNUAL REPORT 2018 - 5 of the biggest problems we face. This may allow us to David Bishop solve it, not make incremental progress.”

Heart disease—including coronary heart disease, hypertension, and stroke—is the leading cause of death in the United States, according to the American Heart Association. About 790,000 people in the United States have heart attacks each year, about one every 40 seconds. Of those, about 114,000 will die. Statistics like these, and the fact that cardiovascular disease is relatively advanced in terms of regenerative medicine, led the team to target heart disease in their ERC proposal.

Scientists and engineers have been struggling to build or grow artificial organs for decades. But aside from simple, nonmoving parts, like artificial windpipes, the field has not lived up to its early promise. This is partly because organs, with their multiple cell types, have proved difficult to synthesize, and also because researchers have learned that the body’s dynamic stresses—beating hearts, stretching lungs—play a larger role in how tissues grow and perform than originally thought. “It’s humbling to have the opportunity to work on something that could be The ERC plans to accomplish four goals with the a real game changer. If we succeed cellular metamaterials it intends to build: fabricate responsive heart tissue containing muscle cells and blood we’ll save a lot of lives” vessels; understand and control the tissue using optical technologies; scale the process up to easily create multiple programs, will lead the Innovation Ecosystem team, a copies of the tissue; and personalize the product, so it group of companies and research consortia that will serve can be tailored to individual patients. The first goal will as advisors and work with the ERC to commercialize the be to create “functionalized heart tissue on a chip,” says technologies it creates. Lutchen, tissue that could be built with a specific patient’s cells and used to test new drugs and therapies. The Two partner institutions—the University of Michigan ultimate goal is to fabricate heart tissue that could replace and Florida International University—as well as six diseased or damaged muscle after a heart attack. affiliate institutions—Harvard Medical School, Columbia University, the Wyss Institute at Harvard, Argonne “It’s humbling to have the opportunity to work on National Laboratory, the École polytechnique fédérale something that could really be a game changer,” says de Lausanne in Switzerland, and the Centro Atómico Bishop. “If we succeed, we’ll save a lot of lives and add Bariloche/Instituto Balseiro in Argentina—will offer meaningful years for many people.” additional expertise in bioengineering, nanotechnology, and other areas.

“We have assembled a very competitive team from world- class institutions with a compelling vision,” says Bishop, noting that the grant is designed to move research from the lab into industry, while also creating education, job training, and employment opportunities. “This grant gives us the opportunity to define a societal problem, and then create the industry to solve it. Heart disease is one 6 - BOSTON UNIVERSITY PHOTONICS CENTER KLAPPERICH AWARDED GATES “This project takes everything we have learned in our FOUNDATION GRAND CHALLENGES lab about small scale and portable blood preparation and GRANT combines it with smart, usable design for manufacturing by Liz Sheeley and scale up,” said Klapperich. “We are very excited to get started.”

LONG-TERM HIV TREATMENT, KNOWN AS The simple sample preparation and storage system will ANTIRETROVIRAL THERAPY, has dramatically allow infected and high-risk patients in low resource changed the quality of life and longevity of infected areas to be consistently monitored. The potential to and at-risk patients. But even on this treatment, patients directly reduce transmission rates and new infections must be constantly monitored by having their blood considerably increases when doctors in low resource tested several times a year with nucleic acid amplification areas can combine the effective use of antiretroviral testing (NAAT). NAAT is sensitive and effective for early therapy and NAAT diagnostics. The new system also detection, but it is expensive and requires samples to creates more opportunities for faster diagnoses to allow be refrigerated, which can be a challenge in developing those who are newly infected to limit their exposure to countries. others and implement safe protocols to stop the virus from spreading. Professor Catherine Klapperich (BME, MSE) has devised a new, easy-to-use method called SNAPflex (System for Nucleic Acid Prep – Flexible) that prepares samples for NAAT without refrigeration and at much lower cost. The promise of the technology has been recognized by The Bill & Melinda Gates Foundation, which has awarded Klapperich, in collaboration with MakerHealth, located in Cambridge, MA, a $100,000 Grand Challenges Explorations grant to develop it.

Grand Challenges Explorations is a $100 million initiative that supports research to solve global health Catherine Klapperich and development challenges. Since its launch in 2008, the initiative has funded over 1365 projects in more The new system also creates more than 65 countries over a wide breadth of disciples, but opportunities for faster diagnoses. all within the scope of four topics, including innovations for integrated diagnostic systems and health systems strengthening to ensure effective health supply chains. If Rather than test for antibodies, NAAT looks for the successful, projects can receive follow-on funding for up presence of the virus’ genetic material, a method that to $1 million. provides more sensitive and quantitative monitoring, but one that also requires samples to be kept cold during transit to a laboratory in addition to expensive sample preparation and testing equipment. Klapperich’s storage solution is a flexible, layered plastic and paper system that looks like a roll of tape. Along the roll are a series of fluidic systems, each able to store and extract the genetic material used in NAAT. The storage card could be torn off one-by-one from the roll and then a patient would provide a small amount of blood from a finger prick onto the card. Klapperich developed two innovative liquid solutions that would extract, clean and dry the Source: Catherine Klapperich genetic material from the patient’s blood.

ANNUAL REPORT 2018 - 7 Not only is the cold-storage element of the previous veterans, “there must be a reduction in the number of process cut out, but this new device also eliminates head impacts,” says Ann McKee, director of the CTE the need to use needles, syringes and other medical Center and another study coauthor. “The continued equipment to draw and store blood samples. Laboratory focus on concussion and symptomatic recovery does not costs are also significantly lowered since the cards prepare address the fundamental danger these activities pose to the sample for processing. And because it is easy to use, human health.” medical professionals should be able to use it quickly and with little training. Klapperich’s card system can be McKee and her team first examined the brains of four manufactured using either laser cutting or stamping, both dead teenage athletes who’d suffered head injuries one, low-cost processes, because of the simple and flexible 2, 10, and 128 days before they died. They found a design. All of these factors allow the new device to be range of post-trauma pathologies, including one case of implemented quickly and economically and get patients early CTE (the disease has four stages) and two brains faster access to test results and potential treatments. with abnormal tau accumulations. When researchers compared the brains to those of four teenage athletes BU-LED STUDY: CTE MAY OCCUR WITHOUT CONCUSSION who had not suffered recent head trauma, they found that those brains did not have the same pathologies. PROGRESSIVE BRAIN DISEASE COULD BE CAUSED BY REPETITIVE HEAD INJURIES The researchers speculated that early CTE could result by Rich Barlow

A NEW BU-LED STUDY PUBLISHED in “It’s the the journal Brain suggests that chronic traumatic hits to the encephalopathy (CTE) is caused by head injuries, head, not not by concussions. The research explains why 20 concussion, percent of athletes who exhibited the early stages of that trigger the progressive brain illness postmortem never had a Chronic diagnosed concussion. Traumatic Encephalop- “It’s the hits to the head, not concussion, that trigger athy.” CTE,” says study coauthor Lee Goldstein, a School of Medicine associate professor of psychiatry, who also has an appointment at the College of Engineering. Lee Goldstein The study suggests that head injuries can cause blood vessels to leak proteins into adjacent brain tissues, from damaged brain blood vessels that leak blood inflaming them. CTE is a brain disease characterized by proteins into nearby tissue, causing inflammation of the accumulation of tau protein around the brain’s blood brain. They tested the hypothesis by exposing lab mice vessels. It is found in athletes, soldiers, and others who to two different triggers linked to CTE: repeated head have suffered repeated concussions and other brain impacts and blast exposures. trauma and is associated with dementia, mood changes, and aggression. Concussions are injuries that impair a They then scanned the mice brains and found leaky person’s functions, such as memory or balance. blood vessels, as well as persistent changes in electrical functions, possibly explaining cognitive impairment in The study’s finding is important because efforts to some people after similar injuries. protect athletes focus on preventing concussions rather than repeated hits to the head, says Christopher “The same brain pathology that we observed in Nowinski, cofounder and CEO of the Concussion teenagers after head injury was also present in head- Legacy Foundation. injured mice,” says Goldstein. “We were surprised that the brain pathology was unrelated to signs of “In order to reduce CTE risk” in athletes and military concussion.” 8 - BOSTON UNIVERSITY PHOTONICS CENTER The findings, he adds, “provide strong causal evidence” silicon, are critical components of many systems used linking head impacts to both traumatic brain injury and and developed both by the Department of Defense early CTE, “independent of concussion.” and industrial organizations. Due to the relatively small market, a single industrial organization cannot afford The researchers focused especially on capillaries, the the investment necessary to assess a priori the risks smallest “and most important blood vessels” in the associated in using materials and technologies that brain, Goldstein says, through which oxygen, nutrients, are not fully developed in a final system. As a result, and waste removal occur. “Head impact results in focal accurate modeling methodologies that can predict the disruption” of capillaries, resulting in proteins leaking performance under realistic operating and manufacturing into the brain, he says. conditions would provide invaluable information prior to the prototyping or testing phases. The researchers also used computer simulations from Lawrence Livermore National Laboratory and The Center for Semiconductor Modeling (CSM) of mechanical models from BU, both of which showed that Materials and Devices will bring together partners in triggers for concussion and CTE may be distinct. academia, government and industry to work on common BELOTTI TO LEAD ARMY RESEARCH problems enabling the pooling of resources, talent LABORATORY CENTER FOR and knowledge together to address the development SEMICONDUCTOR MODELING of semiconductor materials for niche applications. The aim is to focus on solving fundamental problems NEW COLLABORATIVE CENTER WILL AID IN STREAMLINING SEMICONDUCTOR ADVANCEMENTS in a collaborative environment to enable faster and by BU College of Engineering more efficient semiconductor material and device development. This approach intends to be an alternative to the current model in which the innovation process ELECTRONICS AND OPTOELECTRONICS at the fundamental level is performed within each DEVICES BASED ON SEMICONDUCTOR organization and it is considered proprietary. MATERIALS play a crucial role for a variety of defense, security and commercial applications. While the development of silicon electronics has reached a high level of sophistication enabled by accurate simulation tools, for other semiconductor material systems this is not the case. Many defense applications, for example, those in the electro-optical area, employ semiconductors for which simulation and design tools are much less mature and the technology associated to device fabrication still not completely understood. This introduces significant risks and delays in the development process that ultimately leads to Enrico Bellotti cost overruns. As a result, the defense and security community is investing significant resources to address The first projects the CSM will tackle is focused on this challenge. imaging systems for the infrared (IR) spectral range. These optoelectronics devices are made of compound Professor Enrico Bellotti (ECE, MSE) is the principal semiconductors and are used for space research, investigator of a new $1.25 million interdisciplinary night vision and surveillance, bio-medical imaging center that will work with collaborators from the U.S. and autonomous vehicles guidance. While some of Army Research Laboratory, industry and academia to these imaging systems already provide state of the develop new simulation and design methodologies for art performance, further improvements will require a semiconductor materials and devices. deeper understanding of the material properties and their associated technology. A variety of electronics and optoelectronic devices, fabricated using semiconductor materials other than

ANNUAL REPORT 2018 - 9 The goal of the CSM is to provide a validated modeling framework to understand the limitations of current semiconductor materials, predict the behavior of new ones and guide the technological development allowing a faster and effective development process.

10 - BOSTON UNIVERSITY PHOTONICS CENTER Faculty & Staff

Stephan Anderson Thomas Bifano David Boas Jerry Chen Professor, Radiology Professor, ME Professor, BME, ECE Assistant Professor, Biology, BME 820 Harrison Ave. 8 Saint Mary’s St., 927 610 Commonwealth Ave, 804 8 Saint Mary’s St., 827 617-638-6610 617-353-8908 617-358-1709 617-353-1276 [email protected] [email protected] [email protected] [email protected]

Research interests: Research interests: Research interests: Research interests: • Radiology • Microelectromechanical systems • Neurophotonics • Long-range cortical • Adaptive optics communications

Soumendra Basu Professor, ME, MSE Keith Brown Irving Bigio Assistant Professor, ME, MSE, Physics Ji-Xin Cheng 730 Commonwealth Ave. Professor, BME, ECE Professor, ECE, BME 110 Cummington Mall, 305 EMA 204 44 Cummington Mall, 233 8 Saint Mary’s St., 827 617-353-6728 627-353-4841 617-358-1987 [email protected] 617-353-1276 [email protected] [email protected] [email protected]

Research interests: Research interests: Research interests: • Top-down pattering and bottom- Research interests: • Environmental degradation of • Biomedical optics • Label-free microscopy materials at elevated temperatures up assembly • Medical applications of optics, • Mesoscale soft materials • Medical Photonics • Structure and stability of lasers, and spectroscopy interfaces • Scanning probe techniques

John Connor David Bishop Scott Bunch Associate Professor, MED Enrico Bellotti Professor, MSE, ME, ECE, BME, Associate Professor, ME, MSE 72 E. Concord St., R516 Professor, ECE, MSE Physics 110 Cummington Mall, 404 617-638-0339 8 Saint Mary’s St., 533 8 St. Mary’s St., 609 617-353-7706 [email protected] 617-358-1576 617-358-4080 [email protected] [email protected] [email protected] Research interests: Research interests: • Label-free virus detection Research interests: Research interests: • Experimental nanomechanics of • Identification of biomarkers of • Computational electronics • Low temperature physics 2D materials infection • Semiconductor materials • Mechanical properties of materials • Molecular transport through • Virus/host interactions at low temperatures porous graphene • MEMS and NEMS • Graphene adhesion

ANNUAL REPORT 2018 - 11 700 Albany St. 617-638-4267 [email protected]

Research interests: • Optical neurophysiology • Femtosecond laser surgery

Xue Han Luca Dal Negro Shyamsunder Erramilli Associate Professor, BME Associate Professor, ECE, MSE, Professor, Physics, BME, MSE Physics 590 Commonwealth Ave., 214 44 Cummington Mall, 521 8 St. Mary’s St., 825 617-353-6114 617-358-6189 617-358-2627 [email protected] [email protected] [email protected] Research interests: Research interests: Research interests: • Infrared and Raman microscopy • Neurotechnology • Nanophotonics • Quantum cascade laser sources • Optics of complex media Timothy Gardner • Ultrafast infrared spectroscopy Assistant Professor, Biology, BME 24 Cummington St. 617-358-1144 [email protected]

Research interests: • Mechanisms of temporal sequence perception and Allyn Hubbard production Professor, ECE, BME • Vocal learning in songbirds 8 St. Mary’s St., 329 Allison Dennis Helen Fawcett Assistant Professor, BME, MSE Research Assistant Professor, ME 617-353-2815 [email protected] 8 St. Mary’s St., 916 8 St. Mary’s St., 935 617-353-8509 857-753-1719 Research interests: [email protected] [email protected] • Auditory physiology • Neurocomputing and biosensors Research interests: Research interests: • Nanobiotechnology • Biodetection, optics, nanoscale • Flourescent biosensing lithography, and imaging • STEM outreach and development Bennett Goldberg • Quantum dot chemistry Professor Emeritus, Physics • Flourescence resonance energy transfer (FRET) [email protected]

Research interests: • Biological sensors • Semiconductor IC optic failure Guilford Jones analysis Professor Emeritus, Chemistry, MSE • Nanotubes and nano-optics [email protected] Theodore Fritz Professor Emeritus, Astronomy Research interests: Kamil Ekinci • Photochemistry Professor, ME, MSE 725 Commonwealth Ave., 501 617-353-7446 110 Cummington Mall, 408 [email protected] 617-353-8670 [email protected] Research interests: • Space plasma physics Research interests: • Magnetosphere physics Lee Goldstein • Nanophotonics, nano- • Rocket and satellite experiments Associate Professor, Psychiatry optomechanics, and optical 670 Albany St., 4th floor metrology 617-414-8361 Ajay Joshi • Nanofluidics [email protected] Associate Professor, ECE • Nanomechanics and NEMS 8 St. Mary’s St.,334 Research interests: 617-353-4840 • Alzheimers disease [email protected] • Biometals and metallomics • Molecular aging disorders Research interests: • On-chip and off-chip interconnect Christopher Gabel design Assistant Professor, MED • Computer architecture

12 - BOSTON UNIVERSITY PHOTONICS CENTER Research interests: 8 St. Mary’s St., 718 • Photonic material processing 617-358-6188 • Optical fiber fabrication, lasers, [email protected] and sensors Research interests: • Silicon photonics • First-prinicples theory and design of integrated photonic devices Catherine Klapperich Professor, BME, ME, MSE Darren Roblyer Assistant Professor, BME 44 Cummington Mall, 701A 617-358-0253 44 Cummington Mall, 231 [email protected] 617-358-1554 Theodore Moustakas [email protected] Research interests: Professor Emeritus, ECE, MSE • Nanomechanics of hydrated Research interests: biomaterials [email protected] • Diffuse optics • Microfluidic device design • Therapies in oncology • Optical functional imaging Research interests: Siddharth Ramachandran • Growth by MBE and HVPE of Professor, ECE, MSE nitride semiconductors • Amorphous semiconductors 8 St. Mary’s St., 521 617-353-9881 [email protected]

Research interests: • Micro and nano optical fibers Xi Ling • Optical physics of guided waves Assistant Professor, Chemistry, MSE Kenneth Rothschild 590 Commonwealth Ave., 273 Professor, Physics 617-358-0253 590 Commonwealth Ave, 209 [email protected] Roberto Paiella 617-353-2603 Professor, ECE, MSE [email protected] Research interests: • Nanomaterials and their hybrid 8 St. Mary’s St., 529 Research interests: structures 617-353-8883 • Biomembrane technology and • Synthesis of van der Waals [email protected] biomolecular photonics materials Bjorn Reinhard • Ion transport Research interests: Professor, Chemistry • Terahertz photonics • Plasmonics and related 8 St. Mary’s St., 727 optoelectronic device applications 617-353-8669 [email protected]

Research interests: • Micro and nano optical fibers • New optical materials

Jerome Mertz Michael Ruane Professor, BME, ECE Professor Emeritus, ECE

24 Cummington Mall, 202 [email protected] 617-358-0746 Dimitris Pavlidis [email protected] Research Professor, ECE Research interests: • Resonant cavity biosensors Research interests: 8 St. Mary’s St., 337 • Development and applications 617-353-2811 of novel optical microscopy for [email protected] Jason Ritt biological imaging Assistant Professor, BME Research interests: • High resolution imaging 24 Cummington St., 201 • Wide bandgap semiconductor 617-353-5903 materials and devices [email protected] • Circuits for high frequency Research interests: • Neuroscience of active sensing • Neurophotonic methods applied Michelle Sander to the rodent whisker tactile Assistant Professor, ECE, MSE system 8 St. Mary’s St., 534 617-358-0505 Theodore Morse [email protected] Professor Emeritus, ECE, MSE Milos Popovic Research interests: [email protected] Assistant Professor, ECE • Femtosecond lasers

ANNUAL REPORT 2018 - 13 15 St. Mary’s St., 101 617-353-1888 [email protected]

Research interests: • Electromechanical machines • Fiber optic manufacture • Biomedical devices Aaron Schmidt Brian Walsh Assistant Professor, ME, MSE Lei Tian Assistant Professor, ECE Assistant Professor, ME, ECE 110 Cummington Mall, 305 110 Cummington Mall, 303 617-353-9596 8 St. Mary’s St., 830 617-353-3414 [email protected] 617-353-1334 [email protected] [email protected] Research interests: Research interests: • Nanoscale energy transport Research interests: • Space plasma dynamics • Ultrafast laser metrology • Computational imaging and • Solar wind-planetary coupling • Laser-material interaction Alexander Sushkov sensing • Small spacecraft Assistant Professor, Physics, ECE • Gigapixel 3D microscopy • Compressive imaging 590 Comm. Ave, 213 617-353-2619 [email protected]

Research interests: • Quantum tools for precision measurements • Magnetic imaging Alice White Joshua Semeter Professor, ME, MSE, BME Professor, ECE Barry Unger 110 Cummington Mall, 107 8 St. Mary’s St., 537 Associate Professor, MET 617-358-3498 617-353-4846 [email protected] [email protected] 808 Commonwealth Ave. 617-353-0940 Research interests: Research interests: [email protected] • Ionospheric and space plasma • Nanoscale 3D printing • Mechanical metamaterials physics Research interests: • Image processing Anna Swan • High technology Associate Professor, ECE, MSE, • Venture capital businesses Physics

8 St. Mary’s St., 827 617-353-1275 [email protected]

Research interests: John White • Interactions of biomaterials with Professor, BME nanostructures Alexander Sergienko • Carbon nanotubes Professor, ECE 44 Cummington Mall, 403 Selim Unlu 617-353-2805 Professor, ECE, BME, MSE 8 St. Mary’s St.,729 [email protected] 617-353-6564 [email protected] 8 St. Mary’s St., 826 Research interests: 617-353-5067 • Mechanisms of episodic memory Research interests: [email protected] • Pathophysiology of epilepsy • Ultrafast quantum optics • Computational neuroscience • Quantum metrology Research interests: • Quantum biophotonics • Near-field optical microscopy Malvin Teich • Nanoscale imaging of biological Professor Emeritus, ECE, BME samples • Biosensors 8 St. Mary’s St., 916 617-353-1236 [email protected]

Research interests: • Quantum photonics • Neural coding Andre Sharon Professor, ME, MSE

14 - BOSTON UNIVERSITY PHOTONICS CENTER Chen Yang Lawrence Ziegler Associate Professor, Chemistry, ECE Professor, Chemistry

8 Saint Mary’s St., 829 8 St. Mary’s St., 719 617-358-4837 617-353-8663 [email protected] [email protected]

Research interests: Research interests: • Nano materials for their potential • Spontaneous resonance Raman applications in nanoscale devices studies of photodissociative and and biological applications biological chromophores

FACULTY COMMITTEES

The Photonics Center has five committees that support and serve its faculty and staff. The Photonics Center Director appoints committee chairs each year.

Ji Yi Assistant Professor, MED, BME Photonics Center Guest Speakers: Chair – Tim Weber 650 Albany St. 617-638-6599 The Distinguished Speaker Seminar Series is managed by student [email protected] leaders of the BU student chapters of the Optical Society of

Research interests: America and SPIE. With support by the Photonics Center • Novel optical techniques for early for travel and seminar expenses, students host a distinguished disease detection • Monitoring disease progression speaker of their choice each semester. and prognosis Education: Chair – Open The Education Committee investigates methods for applying and enriching education of photonics within the community and BU programs.

Xin Zhang Academic Advisory: Professor, ME, MSE, ECE, BME Chair – Dr. Thomas Bifano 8 St. Mary’s St., 921 The Academic Advisory Committee advises the Director of 617-353-2702 the Photonics Center on educational and academic issues and is [email protected] comprised of the chairs from the Center’s affiliated departments. Research interests: • Micro nanomaterials • Micro nanomechanics Space Allocation: Chair – Dr. Thomas Bifano This committee chair generates policy guidelines for space management.

Symposium: Chair – Dr. David Boas This committee chair organized the 21st annual Photonics Center Symposium that focused on neurophotonics. The symposium included external university speakers.

ANNUAL REPORT 2018 - 15 Leadership & Administrative Staff

Photonics Center Organizational Chart

Dr. Thomas Bifano Director

8 St. Mary’s St., 927 617-353-8908 [email protected]

Yvonne Cancino Brenda Hugot Paul Mak Administrative Administrator, ERC Laboratory Manager Coordinator, Business Innovation Center 8 St. Mary’s St., 918 8 St. Mary’s St., 821 617-353-1910 617-353-8869 8 St. Mary’s St.,623 [email protected] [email protected] 617-358-0480 [email protected]

Thomas Dudley Nozomi Ito Beth Mathisen Assistant Director, Administrative Communications & Technical Programs Manager, ERC Events Manager

8 St. Mary’s St., 929 8 St. Mary’s St., 917 8 St. Mary’s St., 937 617-358-4924 617-353-2442 617-353-8907 [email protected] [email protected] [email protected]

Helen Fawcett Cynthia Kowal Alexey Nikiforov Manager, Operations Senior Proposal Laboratory Manager & Technical Programs Development Administrator 8 St. Mary’s St., 831 8 St. Mary’s St., 935 617-353-9045 857-753-1719 8 St. Mary’s St., 938 [email protected] [email protected] 617-353-8656 [email protected] Robert Schaejbe Meghan Foley Assistant Director, Manager of Anlee Krupp Laboratory Manager Operations & Financial Administration Administration 8 St. Mary’s St., 933 8 St. Mary’s St., 931 8 St. Mary’s St., 928 617-358-4438 617-353-9044 [email protected] 617-358-4257 [email protected] [email protected] 16 - BOSTON UNIVERSITY PHOTONICS CENTER Research Projects & Technology Development

FACULTY MEMBERS AND STAFF OF desiring to establish a center in this field would FY18. The decision to terminate operations THE PHOTONICS CENTER continue to be directed by NSF to collaborate with CBSS. was not made lightly. The I/UCRC program be Faculty members and staff of the Photonics As the lead institution on this multi-university proved extremely beneficial in the preparation Center continue to be involved in a number of Center, BU has successfully carried out the of the ERC proposal as it laid the organizational leading-edge research activities either through mission to: ground-work for managing multi-university support of affiliated units in the Materials centers, enabled structures for the recruitment Science and Engineering Division, the • Create a national center of excellence for and structure of an Industry Advisory Board, Nanotechnology Innovation Center (BUnano), biosensor research with photonics as the developed financial infrastructure for managing the Industry/University Cooperative Research enabling technology. multiple sub-projects and membership Center (I/UCRC) on Biophotonic Sensors • Cultivate embryonic applications for contributions, and developed processes and and Systems (CBSS), and the Engineering biosensors. initiatives for networking, student mentoring, Research Center on Lighting Enabled Systems • Advance biophotonic sensor technology, and internship opportunities. and Applications (LESA) or through the providing significant commercial benefits administration of block grants from the for disease diagnosis, patient monitoring, With the award of the ERC, it became apparent National Institute of Health (NIH), National drug efficacy testing, and food and water that approximately 50% of the research Science Foundation (NSF), Department of the safety. activities of CBSS overlapped with the new Army and others. The Center has also been • Develop effective methods for technology Center and this caused conflicts in recruiting heavily involved in the Engineering Research translation, accelerating innovative new members to either of the Centers. The Center (ERC) that was awarded in October research to commercial benefit. Photonics Center found that the companies 2017. • Increase the quantity, quality and diversity desired to reap the benefits of both CBSS and of professionals prepared to work in this the ERC while only paying a single membership Industry/University Cooperative Research field. fee. The Photonics Center had a core group of Center (I/UCRC) on Biophotonic Sensors • Involve the full technology and supply CBSS members that were able to distinguish and Systems chain in a common focus of solving critical the benefits of the applications based research unmet needs in the healthcare sector using of the I/UCRC versus the forward looking The I/UCRC concept is a long-running NSF biophotonic sensing solutions. research of the ERC and although they were program designed to foster university and willing to support both Centers, the team industry collaboration and is jointly supported Now after seven successful years of leading became concerned about the sustainability of by the foundation and industry. NSF has funded CBSS, including guiding the team through CBSS with BU remaining as the lead university. several of these I/UCRC centers, each center is the award of a Phase II Center in the spring Our partner at the University of California at unique and focused on a specific theme. As the of 2017, during a very competitive renewal Davis (UCD) was offered the Directorship of title implies, CBSS is focused on biophotonic process, BU will step down as the lead and CBSS and after careful consideration declined sensors and systems, and any other university CBSS will terminate operations at the end of the opportunity. The decision was ultimately

Project PI Site Mentor Funding Commercial Potential IRIS Instrument for Label-free and Multi- Unlu BU InBios $50K YES plexed Protein Binding Measurements AO-OCT with AO via Pupil Segmentation Zawadzki UCD Iris AO $50K YES High Speed 3D Imaging with a Standard Mertz BU Thorlabs $50K YES Microscope Protein & Small Molecule Dynamic Analysis Unlu BU Scienion $77K YES in Microwell Plates Pre-clinical Study of Raman Spectroscopy Zadwadz- UCD Nikon $50K for Probing of Retina in Animal Models of ki/Chen Age Related Macular Degeneration (AMD) Computational Microscopy for 3D Cellular Tian BU Thorlabs $63K YES Imaging

ANNUAL REPORT 2018 - 17 made to terminate the Center and had the full fast volumetric microscopy technique easily Other awards with significant Photonic Center concurrence of UCD, the Industry Advisory adaptable to existing microscopes staff contributions include: Board (IAB) and the Program Manager at NSF. Computational microscopy for 3D cellular NSF NRT: Understanding the Brain (UtB): In aggregate since inception, the research imaging (Tian). This project is motivated by Neurophotonics faculty generated 182 proposals which were the need to acquire quantitative information reviewed by the IAB. The IAB reviewed and of a large quantity of samples at high speed The National Science Foundation National rank ordered the projects, selecting those to provide statistically significant data for Research Traineeship Program - Understanding to be funded. Over the life of the Center, biomedical research. Using a programmable the Brain (UtB): Neurophotonics was awarded 35 proposals were funded and completed, LED array and innovative illumination in August 2016. BU was one of two awards including seven in FY18. Each funded project strategies and forward/reverse algorithms, in the Understanding the Brain category. The had an industry mentor and was reviewed twice the team demonstrated 3D phase microscopy first year focused on developing the program during the year. The seven projects funded at high resolution without any mechanical and recruiting from within Boston University’s in FY18 are listed in the nearby table, with a scanning on highly complex cellular structures. incoming fall 2016 class and recruiting externally further narrative on the projects where the Funding for this project would likely have been for new graduate student applying for fall 2017. project PI is a BU faculty member. extended for a second year, if it were not for The first cohort (fall 2016 students) applied to the termination of CBSS. be NRT trainees in April 2016 and attended Each of the projects was assigned a mentor the first Boot Camp in July 2017. Traineeships from industry, who helped set the direction for MAJOR PROJECTS MANAGED BY form the essential core of the NRT student research and guided research to achieve results THE CENTER community and all trainees have access to the aligned with potential commercial applications. many benefits and opportunities afforded by The Center continues to administer and our traineeship grant. Our program’s emphasis IRIS Instrument for label-free and manage several large grants from proposal is on community building, collaborations, multiplexed protein binding measurements writing through post-award administration. interdisciplinary research, and professional (Unlu). This was a very application specific While a few high-profile programs such as the development opportunities for trainees. Within development, that led to an instrument NIH U54 Center for Innovation in Point of the community of trainees, a limited number that will be used by the project mentor Care Technologies for the Future of Cancer are trainees with fellowships (Fellows). The (InBios International) during their product Care and the NIH R01 Development of near fellowship provides stipend, tuition and fees development phase. InBios develops and Real-Time, Multiplexed Diagnostics for Viral from NSF for two years. Forty-one trainees manufactures highly sensitive and specific Hemorrhagic Fever have ended, several new have been accepted into the training program immunodiagnostics for infectious diseases. projects have launched. The most significant including eight fellowship recipients. More The IRIS instrument will assist InBios in of the new projects is the NSF sponsored information about the NSF NRT UtB: determining the binding affinity of proteins Engineering Research Center (ERC) for Neurophotonics can be found on the program to validate the discovery of high-affinity Directed Multiscale Assembly of Cellular website: http://www.bu.edu/neurophotonics- antibodies for new assays. The instrument will Metamaterials with Nanoscale Precision, nrt/. conduct height-map analysis of assay to arrive (CELL-MET). at real-time protein binding monitoring. An NIH U54: Center for Innovation in Point instrument was delivered to InBios where the NSF ERC: Directed Multiscale Assembly of Care Technologies for the Future of tool is being benchmarked against proteins of of Cellular Metamaterials with Nanoscale Cancer Care interest. Precision (CELL-MET) Professor Catherine Klapperich was awarded Protein and small molecule dynamic The ERC program is intended to create an a five-year U54 cooperative agreement that analysis in microwell plates (Unlu). innovative inclusive culture in engineering to started on July 1, 2012. The focus of the This is another project related to the IRIS cultivate new ideas and pursue engineering program is on identification, prototyping, and instrument and one that focused on process discovery that achieves a significant science, early clinical assessment of innovative point development of Chip and Liquid Handling. technology, and societal outcome. CELL- of care technologies for treating, screening, The instrument was also optimized for small MET has a vision to develop technologies diagnosis, and monitoring of cancers. Helen molecule detection. The industry mentor and processes to grow clinically significant Fawcett is the Technical Program Manager and (Scienion) on this project was closely involved cardiac tissue that can repair/replace damaged the Clinical Outreach Director of this grant. in defining the product requirements for this heart muscle and ultimately cure heart The Photonics Center provides financial and instrument. The realistic next step for the disease. This is a comprehensive technology administrative management of this grant. The IRIS project is commercialization and the PI is program with significant broader impacts in final one-year no cost extension closed out in exploring opportunities with the BU Office of Workforce Development, K-12 to graduate June 2018. This year, CFTCC engaged with the Technology Development. and post-graduate Training, and Technology continuing projects at Rice University and MIT Transfer and the Cultivation of an Innovation as the no-cost extension year closed out. For High Speed 3D imaging with a standard Ecosystem. Photonics Center staff play more details and information on the CFTCC, Microscope (Mertz). This project involved significant leadership roles in the research, a NIH NIBIB Point of Care Technologies modifying a standard upright microscope inclusiveness, training, administration and Resource Network member, please visit: to perform ultrafast 3D imaging. The technology transfer efforts of CELL-MET. http://www.bu.edu/cftcc/. modifications involve the use of a MEMS deformable mirror for fast focal sweeps in combination with modulated illumination intensity to achieve a simple wide-field based 18- BOSTON UNIVERSITY PHOTONICS CENTER ANNUAL REPORT 2018 - 19 LIST OF CURRENT GRANTS

Photonics faculty members received more than $21M in external funding. The following table lists funds in the fiscal year (July 1, 2017 - June 30, 2018), as reported by the Sponsored Programs office.

GRANT TITLE PI NAME SPONSOR FUNDING AMOUNT PERIOD FUNDED PROCESSING OF SOFC ANODES BASU Department of Energy 10/1/2015-7/31/2020 $600,000 FOR ENHANCED INTERMEDIATE SOUMENDRA TEMPERATURE CATALYTIC ACTIVITY AT HIGH FUEL UTILIZATION CRA: COMPUTATIONALLY- BELLOTTI University of Utah 1/1/2014-1/31/2018 $258,036 GUIDED DESIGN OF ENERGY ENRICO EFFICIENT ELECTRONIC MATERIALS (CDE3M) DARPA WIRED - BELLOTTI HRL Laboratories, LLC 6/28/2016-1/28/2019 $70,000 POLYCRISTALLINE ENRICO SEMICONDUCTORS - TASKS TA1 DARPA WIRED - COLLOIDAL BELLOTTI DRS Advanced Isr, LLC 6/28/2016-2/28/2018 $65,704 QUANTUM DOT DETECTORS - ENRICO TASKS TA1 AND TA2 CENTER FOR SEMICONDUCTOR BELLOTTI Department of Defense/ARL 9/1/2017-11/30/2022 $250,287 MODELLING ENRICO OPTICAL AND BIFANO THOMAS Regents of the University of 9/1/2017-8/31/2018 $90,305 THERMOMECHANICAL DESIGN Minnesota OF HIGH REFLECTIVITY DEFORMABLE MEMBRANES A SWALLOWED-CAPSULE BIGIO IRVING NIH/National Institute of 9/30/2017-8/31/2018 $185,157 OPTICAL SCREENING TOOL FOR Biomedical Ima HISTOLOGICAL ASSESSMENT OF THE ESOPHAGUS DEVELOPMENT OF OPTICAL BIGIO IRVING DermaSensor, Inc. 8/1/2016-2/28/2018 $47,117 INSTRUMENTS FOR SENSING SKIN DISEASE NANOSYSTEMS ENGINEERING BISHOP DAVID National Science Foundation 10/1/2017-9/30/2022 $3,600,000 RESEARCH CENTER FOR DIRECTED MULTISCALE ASSEMBLY OF CELLULAR METAMATERIALS WITH NANOSCALE PRECISION: CELL- MET MEMS DEVICES FOR DETECTING BISHOP DAVID Department of Commerce/ 1/31/2018-10/31/2018 $64,837 THE CASIMIR ENERGY NIST MICROSCOPIC IMAGING OF BOAS DAVID NIH/National Institute of 9/1/2017-6/30/2018 $1,018,192 TISSUE OXYGEN DELIVERY Biomedical Ima ALTERED BY MICROVASCULAR CHANGES GATED DIFFUSE CORRELATION BOAS DAVID General Hospital Corp d/b/a 9/25/2017-7/31/2019 $82,292 SPECTROSCOPY FOR Massachusett FUNCTIONAL IMAGING OF THE HUMAN BRAIN ESTABLISHING AN FNIRS BOAS DAVID NIH/National Institute of 1/1/2018-12/31/2021 $424,329 ECOSYSTEM FOR OPEN Neurological D SOFTWARE-HARDWARE DISSEMINATION IMPROVING HUMAN FMRI BOAS DAVID Massachusetts General 11/1/2017-7/31/2018 $36,192 THROUGH MODELING AND Hospital IMAGING MICROVASCULAR DYNAMICS CLOSED-LOOP, TIP-DIRECTED BROWN KEITH National Science Foundation 9/1/2017-8/31/2020 $8,000 NANOCHEMISTRY

20 - BOSTON UNIVERSITY PHOTONICS CENTER GRANT TITLE PI NAME SPONSOR FUNDING AMOUNT PERIOD FUNDED NEUROTECHNOLOGY HUB: CHEN JERRY University of North Carolina 10/1/2017-9/30/2018 $266,728 NEMONIC: NEXT-GENERATION at Chapel H MULTIPHOTON NEUROIMAGING CONSORTIUM

CIRCUIT MECHANISMS FOR CHEN JERRY Richard and Susan Smith 3/1/2017-2/29/2020 $100,000 LONG-RANGE COMMUNICATION Family Foundatio IN THE NEOCORTEX

ROLE FOR INTER-AREAL CHEN JERRY Whitehall Foundation, Inc. 6/12/2017-6/11/2020 $150,000 CORTICAL DYNAMICS DURING PERCEPTION HIGH-THROUGHPUT HIGH- CHENG JI-XIN NIH/National Institute of 5/1/2017-4/30/2018 $932,925 CONTENT SINGLE CELL General Medica ANALYSIS BY MULTICHANNEL STIMULATEDRAMAN FLOW CYTOMETRY IN VIVO PHOTOACTOUSTIC CHENG JI-XIN NIH/National Heart, Lung, 8/1/2017-7/31/2018 $749,622 SENSING OF LIPID LADEN and Blood Inst PLAQUE SUB MICRON IR BASED SINGLE CHENG JI-XIN Anasys Instruments 10/1/2017-3/31/2018 $100,000 CELL ANALYSIS IMPLICATIONS FOR CANCER RESEARCH VOLUMETRIC CHEMICAL CHENG JI-XIN National Science Foundation 7/1/2018-6/30/2021 $140,000 IMAGING OF CELL METABOLISM BY STIMULATED RAMAN PROJECTION MICROSECOND TIME SCALE CHENG JI-XIN Purdue University 7/1/2017-12/31/2018 $244,384 VIBRATIONAL SPECTRAL IMAGING OF LIVING SYSTEMS GENETIC PROBING OF RESIDUES CONNOR JOHN NIH/National Institute of 7/1/2018-6/30/2020 $247,500 INVOLVED IN EBOLAVIRUS Allergy & Infe GLYCOPROTEIN ENTRY DIRECTIONAL LIGHT DAL NEGRO Osram Sylvania, Inc. 8/1/2017-7/31/2018 $86,150 EMISSION FROM CONVERSION LUCA MATERIALS WITH APERIODIC NANOSTRUCTURES NANOSCALE FLUID-STRUCTURE EKINCI KAMIL National Science Foundation 7/1/2016-6/30/2019 $10,000 INTERACTION: HYDRODYNAMIC SYNCHRONIZATION OF HIGH- FREQUENCY NANOMECHANICAL OSCILLATORS A RAPID AND SENSITIVE EKINCI KAMIL NIH/National Institute of 5/22/2018-4/30/2020 $206,146 ANTIBIOTIC SUSCEPTIBILITY Allergy & Infe TEST FOR URINARY TRACT INFECTIONS A PLATFORM FOR INNOVATION GARDNER NIH/National Institute of 8/1/2016-6/30/2018 $279,458 IN MINIATURE MICROSCOPY TIMOTHY Neurological D HIGH DENSITY MICROFIBER GARDNER NIH/National Eye Institute 9/30/2016-7/31/2018 $246,813 INTERFACES FOR DEEP BRAIN TIMOTHY OPTICAL RECORDING AND STIMULATION THE SELF-TUNING BRAIN: GARDNER California Institute Of 12/12/2017-11/30/2018 $ 324,042 CELLULAR AND CIRCUIT TIMOTHY Technology MECHANISMS OF BEHAVIORAL RESILIENCE THE EYE AS WINDOW TO BRAIN GOLDSTEIN LEE Crown Philanthropies 1/1/2018-12/31/2018 $200,000 INJURY: NONINVASIVE RETINAL IMAGING TO DETECT AND MONITOR ACUTE AND CHRONIC EFFECTS OF NEUROTRAUMA

ANNUAL REPORT 2018 - 21 GRANT TITLE PI NAME SPONSOR FUNDING AMOUNT PERIOD FUNDED LMMUNOTHERAPEUTIC GOLDSTEIN LEE Pinteon Therapeutics, Inc. 1/1/2018-12/31/2019 $330,387 TARGETING OF PHOSPHORYLATED TAU PROTEOFORMS AND TREATMENT OF CHRONIC TRAUMATIC ENCEPHALOPATHY (CTE) TARGETING TAU GOLDSTEIN LEE United Neuroscience, Inc. 2/6/2018-2/5/2021 $496,202 PROTEINOPATHY FOR PREVENTION AND TREATMENT OF CHRONIC TRAUMATIC ENCEPHALOPATHY (CTE) AND RELATED TAU PROTEIN NEURODEGENERATIVE DISEASES DEVELOPMENT OF MICRORNA- HAN XUE NIH/National Institute of 9/1/2016-8/31/2018 $34,032 GUIDED NEURON TAGS Neurological D (MAGNETS) TO TARGET AND CLASSIFY NEURAL SUBTYPES IN THE LIVING BRAIN CHARATERIZE FUNCTIONAL HAN XUE NIH/National Institute of 4/15/2016-3/31/2018 $20,563 CONNECTIVITIY OF Mental Health HIPPOCAMPAL ADULT BORN NEUROGENESIS DURING CRITICAL PERIOD WABOSH - WASHINGTON AND BU JOSHI AJAY University of Washington 6/6/2018-6/5/2020 $500,677 DO OPEN SOURCE HARDWARE RAPID MOLECULAR DIAGNOSTS KLAPPERICH NIH/National Institute of 4/1/2015-3/31/2019 $409,386 FOR CHLAMYDIA AND CATHERINE Allergy & Infe GONORRHEA AT THE POINT-OF- CARE PAPER MICROFLUIDIC CHIP FOR KLAPPERICH General Hospital Corp d/b/a 5/1/2017-6/30/2018 $164,033 ISOTHERMAL AMPLIFICATION CATHERINE Massachusett AND LATERAL FLOW DETECTION OF HUMAN PAPILLOMAVIRU (HPVS) PORTABLE NUCLEIC ACID KLAPPERICH Bill and Melinda Gates 11/1/2017-4/30/2019 $100,000 PREP, STORAGE, AND SHIPPING CATHERINE Foundation DEVICE RAPID AND MULTIPLEX KLAPPERICH Mount Kenya University 11/15/2017-3/15/2018 $10,000 DIAGNOSIS OF MATERNAL CATHERINE BACTERIAL INFECTIONS HIGH DYNAMIC RANGE MERTZ JEROME NIH/National Eye Institute 9/30/2016-7/31/2018 $335,881 MULTIPHOTON MICROSCOPY FOR LARGE-SCALE IMAGING DEVELOPMENT OF LABEL- MERTZ JEROME NIH/National Institute of 6/1/2018-3/31/2020 $239,527 FREE COMPUTATIONAL FLOW General Medica CYTOMETRY FOR HIGH- THROUGHPUT MICRO-ORGANISM CLASSIFICATION ANGLE-SENSITIVE PAIELLA National Science Foundation 8/1/2017-7/31/2020 $379,953 METASURFACES FOR LENS-FREE ROBERTO COMPOUND-EYE CAMERAS IPA ASSIGNMENT - DIMITRIS PAVLIDIS National Science Foundation 11/3/2014-11/2/2018 $243,073 PAVLIDIS DIMITRIS AIM ACADEMY DESIGN/TEST POPOVIC MILOS Aim Photonics 3/13/2017-5/31/2018 $215,420 EDUCATION SCALABLE: SELF-COHERING POPOVIC MILOS Regents of the University of 3/7/2018-12/7/2018 $60,000 ADAPTIVE LIDAR ARRAY Colorado, o BUILDING-BLOCK LIGHT ENGINE

22 - BOSTON UNIVERSITY PHOTONICS CENTER GRANT TITLE PI NAME SPONSOR FUNDING AMOUNT PERIOD FUNDED (BRI) HIGH-POWER FIBER RAMACHADRAN Department of Defense/ 9/1/2014-8/31/2019 $250,000 LASERS USING INTERMODAL SIDDHARTH AFOSR NONLINEARITIES POWER-SCALABLE BLUE FIBER RAMACHADRAN Department of Defense/ONR 4/15/2017-4/14/2019 $225,000 LASERS SIDDHARTH

HIGH POWER LASERS VIA RAMACHADRAN Department of Defense/ 9/15/2017-9/14/2018 $311,506 INTERMODAL NONLINEAR SIDDHARTH AFOSR OPTICS IN FIBER MID-IR NONLINEAR FREQUENCY RAMACHADRAN Q-Peak, Inc. 12/5/2017-5/1/2018 $32,544 GENERATION IN MULTIMODE SIDDHARTH FIBERS ILLUMINATING DYNAMIC REINHARD NIH/National Cancer Institute 5/1/2014-4/30/2019 $368,325 RECEPTOR CLUSTERING IN THE BJOERN EPIDERMAL GROWTH FACTOR RECEPTOR PLASMON COUPLING REINHARD National Science Foundation 5/1/2018-4/30/2021 $156,175 CORRELATION SPECTROSCOPY BJOERN SPATIOTEMPORAL CONTROL OF RITT T JASON NIH/National Eye Institute 9/30/2016-7/31/2018 $238,166 LARGE NEURONAL NETWORKS USING HIGH DIMENSIONAL OPTIMIZATION NONLINEAR PULSE DYNAMICS SANDER National Science Foundation 7/1/2017-6/30/2020 $7,700 IN FIBER LASERS AT THE VERGE MICHELLE OF MODE-LOCKING AND IN TRANSITION REGIMES CELL MEMBRANE DYNAMICS IN SANDER Department of Defense/ 4/28/2017-4/27/2020 $118,518 INFRARED NERVE STIMULATION MICHELLE AFOSR AND BLOCKING INSTRUMENTATION PLATFORM SANDER Department of Defense/ 6/15/2018-6/14/2019 $239,147 FOR IMAGING CELL MEMBRANE MICHELLE AFOSR DYNAMICS HEAT TRANSFER ACROSS SCHMIDT National Science Foundation 8/1/2017-7/31/2020 $311,804 NANOSTRUCTURED METAL- AARON SEMICONDUCTOR INTERFACES THE NAMICS PROJECT SCHMIDT NAMICS North American 1/1/2017-5/31/2018 $11,818 AARON R&D Center - Diema THE MILLSTONE HILL GEOSPACE SEMETER Massachusetts Institute of 12/15/2012-11/30/2017 $33,904 FACILITY JOSHUA Technology INSPIRE TRACK 1: MAHALI SEMETER Massachusetts Institute of 12/1/2013-11/30/2017 $28,820 SPACE WEATHER MONITORING JOSHUA Technology EVERYWHERE MULTI-SCALE STRUCTURING OF SEMETER Department of Defense/ 9/30/2015-9/29/2018 $139,595 THE POLAR IONOSPHERE BY JOSHUA AFOSR MAGNETOSHERE-IONOSPHERE INTERACTIONS 17-HELIO17F-0035, SEMETER NASA 9/1/2017-8/31/2018 $45,000 SIMULTANEOUS MEASUREMENTS JOSHUA OF SUBSTORM ELECTRON ENERGIZATION IN THE IONOSPHERE AND THE PLASMA SHEET PARTICLE ENERGIZATION SEMETER NASA 3/16/2018-3/15/2021 $148,336 IN THE MAGNETOTAIL AND JOSHUA AURORA: COMPARATIVE STUDY USING IN SITU MEASUREMENTS AND SPATIALLY RESOLVED IONOSPHERIC SENSING

ANNUAL REPORT 2018 - 23 GRANT TITLE PI NAME SPONSOR FUNDING AMOUNT PERIOD FUNDED UNDERSTANDING THE SEMETER Jet Propulsion Laboratory 5/22/2018-9/30/2020 $20,000 IMPACTS OF DYNAMIC DRIVERS JOSHUA ON GLOBAL STORM-TIME IONOSPHERE-THERMOSPHERE (IT) SYSTEM EFRI ACQUIRE: MICROCHIP SERGIENKO University of California, San 1/1/2017-12/31/2020 $97,000 PHOTONIC DEVICES FOR ALEXANDER Diego QUANTUM COMMUNICATION OVER FIBER EFFICIENT QUANTUM SERGIENKO Department of Defense/ 12/15/2017-12/14/2019 $150,000 FREQUENCY CONVERSION FOR ALEXANDER AFOSR QUANTUM COMMUNICATION AND QUANTUM INFORMATION PROCESSING CIF: SMALL: COLLABORATIVE TIAN LEI National Science Foundation 7/1/2018-6/30/2021 $250,707 RESEARCH: SIGNAL PROCESSING FOR NONLINEAR DIFFRACTIVE IMAGING: ACQUISITION, RECONSTRUCTION, AND APPLICATIONS SBIR PHASE I: HIGH- UNLU SELIM Nanoview Diagnostics Inc. 6/1/2017-11/30/2017 $60,975 THROUGHPUT NANOPARTICLE CHARACTERIZATION FOR LIFE SCIENCE APPLICATIONS REAL TIME IN-LINE BACTERIA UNLU SELIM Physical Sciences, Inc. 8/1/2017-12/20/2017 $64,854 DETECTION FOR MILITARY MOBILE WATER TREATMENT SYSTEM INTEGRATED NANOPARTICLE UNLU SELIM Consiglio Nazionale delle 10/1/2017-9/30/2020 $850,200 ISOLATION AND DETECTION Ricerche SYSTEM FOR COMPLETE ON-CHIP ANALYSIS OF EXOSOMES CUPID CUBESAT OBSERVATORY WALSH BRIAN NASA 4/25/2016-9/30/2020 $654,183 RAPID: ANDESITE CUBESAT WALSH BRIAN National Science Foundation 11/15/2017-10/31/2018 $124,478 SOLAR WIND MAGNETOSPHERE WALSH BRIAN NASA 5/1/2018-4/30/2021 $51,020 IONOSPHERE LINK EXPLORER (SMILE) CALCIUM SIGNALING IN A WHITE JOHN University of Utah 7/1/2016-6/30/2018 $11,191 MODEL OF TEMPORAL LOBE EPILEPSY TRAINING PROGRAM IN WHITE JOHN NIH/National Institute of 7/1/2017-6/30/2018 $4,043 QUANTITATIVE BIOLOGY AND General Medica PHYSIOLOGY REU: INTEGRATED ZHANG XIN National Science Foundation 5/1/2015-4/30/2019 $20,000 NANOMANUFACTURING RET IN ENGINEERING ZHANG XIN National Science Foundation 5/1/2015-4/30/2019 $10,000 AND COMPUTER SCIENCE SITE: INTEGRATED NANOMANUFACTURING RET SITE: INTEGRATED ZHANG XIN National Science Foundation 5/1/2018-4/30/2021 $500,596 NANOMANUFACTURING METAMATERIAL-ENABLED ZHANG XIN NIH/National Institute of 7/1/2018-3/31/2021 $206,250 MAGNETIC RESONANCE Biomedical Ima IMAGING ENHANCEMENT DIATOM-ENABLED SCALABLE ZHANG XIN National Science Foundation 6/1/2018-5/31/2021 $358,142 NANOMANUFACTURING FOR PHOTONIC DEVICES COLLABORATIVE RESEARCH: ZHANG XIN National Science Foundation 6/15/2018-5/31/2021 $357,500 IMPEDANCE-ENABLED MICROFLUIDIC RENAL PROXIMAL TUBULE BIOCHIP PLATFORM

24 - BOSTON UNIVERSITY PHOTONICS CENTER GRANT TITLE PI NAME SPONSOR FUNDING AMOUNT PERIOD FUNDED DRAPER LABORATORIES ZHANG XIN Draper Laboratory, Inc. 6/1/2017-5/31/2018 $51,366 FELLOWSHIP (DAVID SUTHERLAND)

DRAPER LABORATORIES ZHANG XIN Draper Laboratory, Inc. 6/1/2017-5/31/2018 $47,376 FELLOWSHIP (MATTHEW PONSINI)

SPONSORED RESEARCH ZHANG XIN Aramco Services Company 3/1/2018-2/29/2020 $239,427 AGREEMENT WITH ARAMCO

TOTAL: $ 21,419,015

ANNUAL REPORT 2018 - 25 26 - BOSTON UNIVERSITY PHOTONICS CENTER Publications, Patents & Awards

“Mid-Infrared Transmission through M. Matsubara & E. Bellotti, “A First- BOOK CHAPTERS Germanium-Core Borosilicate Glassclad Principles Study of Carbon-related Energy Semiconductor Fibers,” Optical Materials Levels in GaN. I. Complexes Formed by L. Zhang, J. Drelich, N. Neelameggham., Express, Vol. 7, 9, p. 3107-3115, 2017. Carbon and Hydrogen, Silicon or Oxygen,” D. Guillen, N. Haque, J. Zhu, S. Basu, Journal of Applied Physics, Vol. 121, 19, p. 16, … F. Tesfaye, “Energy Technology 2017: M. Ordu, J. Guo, G. Ng Pack, P. Shah, 2017. Carbon Dioxide Management and Other S. Ramachandran, S. Basu, M. Hong, Technologies,” Springer International … S. Erramilli, “Nonlinear Optics in P. Sengupta & E. Bellotti, “Spin-Orbit Publishing, 2017. Germanium Mid-Infrared Fiber Material: Coupling Mediated Tunable Electron Heat Detuning Oscillations in Femtosecond Mid- Capacity of Quantum Wells,” Applied F. Bertazzi, M. Goano, G. Ghione, A. Infrared Spectroscopy,” AIP Advances, Vol. Physics Letters, Vol. 110, 1, p. 4, 2017. Tibaldi. P. Debernardi, & E. Bellotti, 7, 9, p. 095125, 2017. P. Sengupta, M. Matsubara, E. Bellotti & “Electron Transport” J. Piprek Handbook of J. Shi, “Intrinsic Optical Conductivity of Optoelectronic Device Modeling and Simulation, Z. Sun, S. Gopalan, U. Pal, & S. Basu, a C-2v Symmetric Topological Insulator,” p. 35-81, Boca Raton, Florida: CRC Press, “Cu1. 3Mn1. 7O4 Spinel Coatings Semiconductor Science and Technology, Vol. 32, 7, 2017. Deposited by Electrophoretic Deposition p. 8, 2017. on Crofer 22 APU Substrates for Solid T. Zhang, J. Klamkin, A. Joshi, & A. Oxide Fuel Cell Applications. Surface and W. Shain, N. Vickers, B. Goldberg, T. Coskun, “Thermal Management of Silicon Coatings Technology,” Surface and Coatings Bifano & J. Mertz, “Extended Depth- Photonic NoCs in Many-core Systems. Technology, Vol. 323, p. 49-57, 2017. of-Field Microscopy with a High-Speed Photonic Interconnects for Computing Systems Deformable Mirror,” Opt. Lett. Vol. 2, 5, p. Understanding and Pushing Design Challenges, R. Wang, U. Pal, S. Gopalan, & S. Basu, 995-998, 2017. River Publishers, 2017. “Chromium Poisoning Effects on Performance of (La, Sr) MnO3-based W. Shain, N. Vickers, A. Negash, T. D. Simon, G. Jaeger, & A. Sergienko, Cathode in Anode-Supported Solid Oxide Bifano, A. Sentenac, & J. Mertz, “Dual “Quantum Metrology, Imaging, and Fuel Cells,” Journal of the Electrochemical Fluorescence-Absorption Deconvolution Communication,” Springer, 2017. Society, Vol. 164, 7, p. F740-F747, 2017. Applied to Extended-Depth-of-Field Microscopy,” Opt. Lett., Vol. 42, 20, p. 4183- B. Walsh, “Magnetopause Plasma R. Wang, M. Würth, U. Pal, S. Gopalan, & 4186, 2017. Parameters and Asymmetries in Solar Wind S. Basu, “Roles of Humidity and Cathodic Magnetosphere Coupling” In S. Haaland, A. Current in Chromium Poisoning of Sr- G. Grillone, Z. Wang, G. Krisciunas, A. Runov, & C. Forsyth, p. 29-40, Dawn-Dusk doped LaMnO3-based Cathodes in Solid Tsai, V. Kannabiran, R. Pistey, … I. Bigio, Asymmetries in Planetary Plasma, Wiley, 2017. Oxide Fuel Cells,” Journal of Power Sources, “The Color of Cancer: Margin Guidance Vol. 360, p. 87-97, 2017. for Oral Cancer Resection Using Elastic L. Ziegler, W. Premasiri, Y. Chen, J. Scattering Spectroscopy,” Laryngoscope, Vol. Fore, & A. Brodeur, “SERS Biomedical A. Kyrtsos, M. Matsubara, & E. Bellotti, 127, 4, p. S1-S9, 2017. Applications: Diagnostics, Forensics and “Migration Mechanisms and Diffusion Metabolomics,” Frontiers and Advances Barriers of Vacancies in Ga2O3,” Physical J. Nguyen, S. Hossain, J. Cooke, J. Ellis, M. in Molecular Spectroscopy, p. 327-368, Review B, Vol. 95, 24, p. 9, 2017. Deci, I. Bigio, C. Emala, . . . S. Joshi, “Flow Amsterdam: Elsevier, 2017. Arrest Intra-Arterial Delivery of Small D. Lewis, M. Matsubara, E. Bellotti, & S. TAT-Decorated and Neutral Micelles to Sharifzadeh, “Quasiparticle and Hybrid Gliomas,” Journal of Neuro-oncology, Vol. 133, JOURNAL ARTICLES Density Functional Methods in Defect 1, p. 77-85, 2017. Studies: An Application to the Nitrogen J. Davis, K. Ludwig, K. Smith, J. Woicik, Vacancy in GaN,” Physical Review B, Vol. 96, A. Salman, U. Sharaha, E. Rodriguez-Diaz, S. Gopalan, U. Pal, & S. Basu, “Surface 23, p. 11, 2017. E. Shufan, K. Riesenberg, I. Bigio, & M. Segregation in Lanthanum Strontium Huleihel, “Detection of Antibiotic Resistant Manganite Thin Films and Its Potential M. Matsubara & E. Bellotti, “A First- Escherichia Coli Bacteria Using Infrared Effect on the Oxygen Reduction Reaction,” Principles Study of Carbon-related Energy Microscopy and Advanced Multivariate Journal of The Electrochemical Society, Vol. 164, Levels in GaN. I. Complexes Formed by Analysis,” Analyst, Vol. 142, 12, p. 2136- 10, p. F3091-F3096, 2017. Substitutional/Interstitial Carbons and 2144, 2017. Gallium/Nitrogen Vacancies,” Journal of M. Ordu, J. Guo, B. Tai, M. Hong, S. Applied Physics, Vol. 121, 19, p. 15, 2017. U. Sharaha, E. Rodriguez-Diaz, K. Erramilli, S. Ramachandran, & S. Basu, Riesenberg, I. Bigio, M. Huleihel & A. ANNUAL REPORT 2018 - 27 Salman, “Using Infrared Spectroscopy and “Evaluating Anesthetic Protocols for H. Wang, C. Magnain, R. Wang, J. Dubb, Multivariate Analysis to Detect Antibiotics’ Functional Blood Flow Imaging in the Rat A. Varjabedian, L. Tirrell, … D. Boas, Resistant Escherichia Coli Bacteria,” Eye,” J Biomed Opt, Vol. 22, 1, p. 16005, “as-PSOCT: Volumetric Microscopic Analytical Chemistry, Vol. 89, 17, p. 8782- 2017. Imaging of Human Brain Architecture and 8790, 2017. Connectivity,” Neuroimage, Vol. 165, p. 56- P. Pouliot, L. Gagnon, T. Lam, P. Avti, 68, 2018. Y. Zhu, T. Fearn, D. Chicken, M. Austwick, C. Bowen, D. Boas, M. Desjardins, I. Bigio, S. Somasundaram, C. Mosse, … F. Lesage, “Magnetic Resonance K. Xu, D. Boas, S. Sakadžic & J. LaManna, … S. Bown, “A Partially Supervised Fingerprinting Based on Realistic “Brain Tissue PO2 Measurement During Bayesian Image Classification Model with Vasculature in Mice,” Neuroimage, Vol. 149, Normoxia and Hypoxia Using Two-Photon Applications in Diagnosis of Sentinel p. 436-445, 2017. Phosphorescence Lifetime Microscopy,” Lymph Node Metastases in Breast Cancer,” Adv Exp Med Biol, Vol. 977, p. 149-153, ResearchGate, 2017. P. Rasmussen, A. Smith, S. Sakadžic, 2017. D. Boas, A. Pries, T. Secomb & L. M. Imboden, H. Han, T. Stark & D. Ostergaard, “Model-Based Inference from M. Yaseen, J. Sutin, W. Wu, D. Boas, B. Bishop, “Cryogenic Fab-on-a-Chip Sticks Microvascular Measurements: Combining Fu, H. Uhlirova, A. Devor, … S. Sakadžić, the Landing,” ACS Nano, Vol. 11, 9, p. Experimental Measurements and Model “Fluorescence Lifetime Microscopy of 8707-8716, 2017. Predictions Using a Bayesian Probabilistic NADH Distinguishes Alterations in Approach,” Microcirculation, Vol. 24, 4, 2017. Cerebral Metabolism in Vivo,” Biomed Opt J. Morrison, M. Imboden … & D. Bishop, Express, Vol. 8, 5, p. 2368-2385, 2017. “Tuning the Resonance Frequencies and A. Sajjadi, S. Isakoff, B. Deng, B. Singh, Mode Shapes in a Large Range Multi- C. Wanyo, D. Boas, Q. Fang, …, S. Carp, N. Farmakidis, & K. Brown, “Quantifying Degree of Freedom Micromirror,” Optics “Normalization of Compression-Induced Liquid Transport and Patterning Using Express, Vol. 25, 7, p. 7895-7906, 2017. Hemodynamics in Patients Responding to Atomic Force Microscopy,” Langmuir, Vol. Neoadjuvant Chemotherapy Monitored 33, 21, p. 5173-5178, 2017. C. Pollock, J. Morrison, M. Imboden, T. by Dynamic Tomographic Optical Breast Little, & D. Bishop, “Beam Shaping with Imaging,” Biomed Opt Express, Vol. 8, 2, p. Z. Huang, L. Li, X. Zhang, N. Alsharif, Tip-Tilt Varifocal Mirror for Indoor Optical 555-569, 2017. X. Wu, K. Brown, Z. Peng, … Y. Wang, Wireless Communication,” Optics Express, “Photoactuated Pens for Molecular Vol. 25, 17, p. 20274-20285, 2017. S. Sakadžic, D. Boas & S. Carp, Printing,” Advanced Materials, Vol. 30, 8, p. “Theoretical Model of Blood Flow 8, 2018. S. Erdener, J. Tang, A. Sajjadi, K. Kiliç, Measurement by Diffuse Correlation S. Kura, C. Schaffre, & D. Boas, “Spatio- Spectroscopy,” J Biomed Opt, Vol. 22, 2, p. B. Isaacofft & K. Brown, “Progress in Top- Temporal Dynamics of Cerebral Capillary 27006, 2017. Down Control of Bottom-Up Assembly,” Segments with Stalling Blood Cells,” J Cereb Nano Letters, Vol. 17, 11, p. 6508-6510, 2017. Blood Flow Metab, p. 271678X17743877, H. Schytz, F. Amin, J. Selb & D. Boas, 2017. “Non-Invasive Methods for Measuring L. Li, L. M. Encarnacao & K. Brown, Vascular Changes in Neurovascular “Polymer Nanomechanics: Separating the S. Jahani, A. Fontanta, D. Harper, J. Ellison, Headaches,” J Cereb Blood Flow Metab, p. Size Effect from the Substrate Effect in D. Boas, B. Forester, & M. Yücel, “fNIRS 271678X17724138, 2017. Nanoindentation,” Applied Physics Letters, Can Robustly Measure Brain Activity Vol. 110, 4, p. 5, 2017. During Memory Encoding and Retrieval in J. Tang, S. Erdener, B. Fu & D. Boas, Healthy Subjects,” Scientific Reports, Vol. 7, 1, “Capillary Red Blood Cell Velocimetry A. Rendos, N. Alsharif, B. Kim & K. p. 9533, 2017. by Phase-Resolved Optical Coherence Brown, “Elasticity and Failure of Liquid Tomography,” Optic Letters, Vol. 42, 19, p. Marbles: Influence of Particle Coating and K. Kisler, A. Nelson, S. V. Rege, A. 3976-3979, 2017. Marble Volume,” Soft Matter, Vol. 13, 47, p. Ramanathan, Y. Wang, D. Boas, A. Ahuja, 8903-8909, 2017. … B. Zlokovic, “Pericyte Degeneration J. Tang, S. Erdener, B. Li, B. Fu, S. Sakadzic, Leads to Neurovascular Uncoupling and A. Carp, … D. Boas, “Shear-Induced D. Akinwande, C. Brennan, S. Bunch, P. Limits Oxygen Supply to Brain,” Nat Diffusion of Red Blood Cells Measured Egberts, J. Felts, H. Gao, Y. Zhu, “A Review Neurosci, Vol. 20, 3, p. 406-416, 2017. with Dynamic Light Scattering Optical on Mechanics and Mechanical Properties Coherence Tomography,” J Biophotonics, Vol. of 2D Materials. Graphene and Beyond,” B. Li, H. Wang, B. Fu, R. Wang, S. Sakadžic 11, 2, 2018. Extreme Mechanics Letters, Vol 13, p. 42-77, & D. Boas, “Impact of Temporal 2017. Resolution on Estimating Capillary RBC- H. Wang, C. Magnain, S. Sakadžić, B. Flux with Optical Coherence Tomography,” Fischl & D. Boas, “Characterizing the D. Lloyd, X. Liu, N. Boddeti, L. Cantley, R. J Biomed Opt, Vol. 22, 1, p. 16014, 2017. Optical Properties of Human Brain Tissue Long, M. Dunn & S. Bunch, “Adhesion, with High Numerical Aperture Optical Stiffness, and Instability in Atomically Thin E. Moult, W. Choi, D. Boas, B. Baumann, Coherence Tomography,” Biomed Opt MoS2 Bubbles,” Nano Letters, Vol. 17, 9, p. A. Clermont, E. Feener & J. Fujimoto, Express, Vol. 8, 12, p. 5617-5636, 2017. 5329-5334, 2017. 28 - BOSTON UNIVERSITY PHOTONICS CENTER P. Bethge, S. Carta, D. Lorenzo, L. Egolf, Nature Communications, Vol. 8, p. 12, 2017. Cells,” Cell Stem Cell, Vol. 20, 3, p. 303, 2017. D. Goniotaki, J. Chen, L. Madisen, … F. Z. Chen, G. Wang, S. Ma, D. Jung, H. Ha, J. Wu, L. You, L. Lan, H. Lee, S. Chaudhry, Helmchen, “An R-CaMP1.07 Reporter J. Cheng, T. Altamimi, J. Lin, “NrG4 J. Cheng, R. Li, . . . J. Mei, “Semiconducting Mouse for Cell-Typespecific Expression Promotes Fuel Oxidation and a Healthy Polymer Nanoparticles for Centimeters- of a Sensitive Red Fluorescent Calcium Adipokine Profile to Ameliorate Diet- Deep Photoacoustic Imaging in the Second Indicator,” LOS One, Vol. 12, 6, p. 19, 2017. Induced Metabolic Disorders,” Molecular Near-Infrared Window,” Advanced Materials, Metabolism, Vol. 6, 8, p. 863-872, 2017. Vol. 29, 41, p. 6, 2017. J. Ni & J. Chen, “Long-Range Cortical Dynamics: A Perspective from the Mouse P. Dong & J. Cheng, “Pump-Probe H. Yang, S. Seo, S. Shin, S. Min, J. Sensorimotor Whisker System,” European Microscopy: Theory, Instrumentation, and Cheng, M. Kang, R. Yoo, . . . K. Lee, Journal of Neuroscience, Vol. 46, 8, p. 2315- Applications,” Spectroscopy, Vol. 32, 4, p. 24- “3,3’-Diindolylmethane Suppresses 2324, 2017. 36, 2017. High-Fat Diet-Induced Obesity Through Inhibiting Adipogenesis of Pre-Adipocytes J. Chen, J. Liu, I. Tevis, R. Andino, J. Hui, Y. Cao, Y. Zhang, A. Kole, P. by Targeting USP2 Activity,” Molecular C. Miller, L. Ziegler, ... M. Thuo, Wang, G. Yu, . . . J. Cheng, “Real-Time Nutrition & Food Research, Vol. 61, 10, p. 12, “Spectroscopic Evidence for the Origin Intravascular Photoacoustic- Ultrasound 2017. of Odd-Even Effects in Self assembled Imaging of Lipid-Laden Plaque in Human Monolayers and Effects of Substrate Coronary Artery at 16 Frames per Second,” C. Zhang, K. Huang, B. Rajwa, J. Li, S. Roughness,” Physical Chemistry Chemical Scientific Reports, Vol. 7, p. 11, 2017. Yang, H. Li . . . J. Cheng, “Stimulated Physics, Vol. 19, 10, p. 6989-6995, 2017. Raman Scattering Flow Cytometry for C. Karanja, W. Hong, W. Younis, H. Label-Free Single-Particle Analysis,” Optica, M. Alshaykh, C. Liao, O. Sandoval, G. Eldesouky, M. Seleem & J. Cheng, Vol. 4, 1, p. 103-109, 2017. Gitzinger, N. Forget, J. Cheng, D. Leaird, “Stimulated Raman Imaging Reveals … A. Weiner, “High-Speed Stimulated Aberrant Lipogenesis as a Metabolic Marker C. Zhang, J. Li, L. Lan & J. Cheng, Hyperspectral Raman Imaging Using Rapid for Azole-Resistant Candida Albicans,” “Quantification of Lipid Metabolism in Acousto-Optic Delay Lines,” Optics Letters, Analytical Chemistry, Vol. 89, 18, p. 9822- Living Cells through the Dynamics of Lipid Vol. 42, 8, p. 1548-1551, 2017. 9829, 2017. Droplets Measured by Stimulated Raman Scattering Imaging,” Analytical Chemistry, Y, Bai, D. Zhang, C. Li, C. Liu & J. Cheng, J. Kim, K. Dunville, J. Li, J. Cheng, Vol. 89, 8, p. 4502-4507, 2017. “Bond-Selective Imaging of Cells by Mid- T. Conley, C. Couture & W. Campbell, Infrared Photothermal Microscopy in High “Intermuscular Adipose Tissue Content and D. Zhang, W. Chen, H. Chen, H. Yu, G. Wavenumber Region,” Journal of Physical Intramyocellular Lipid Fatty Acid Saturation Kassab & J. Cheng, “Chemical Imaging Chemistry B, Vol. 121, 44, p. 10249-10255, Are Associated with Glucose Homeostasis of Fresh Vascular Smooth Muscle Cell 2017. in Middle-Aged and Older Adults,” Response by Epi-Detected Stimulated Endocrinol Metabolism, Seoul, Vol. 32, 2, p. Raman Scattering,” Journal of Biophotonics, S. Bandyopadhyay, J. Li, E. Traer, J. Tyner, 257-264, 2017. Vol. 11, 2, p. 7, 2018. A. Zhou, S. Oh, & J. Cheng, “Cholesterol Esterification Inhibition and Imatinib H. Lee & J. Cheng, “Imaging Chemistry G. Daaboul, D. Freedman, S. Scherr, E. Treatment Synergistically Inhibit Growth of Inside Living Cells by Stimulated Raman Carter, A. Rosca, D. Bernstein, S. Unlu . . BCR-ABL Mutation-Independent Resistant Scattering Microscopy,” Methods, Vol. 128, p. . J. Connor, “Enhanced Light Microscopy Chronic Myelogenous Leukemia,” PLOS 119-128, 2017. Visualization of Virus Particles from Zika One, Vol. 12, 7, p. 15, 2017. Virus to Filamentous Ebola Viruses,” PLOS H. Lee, D. Zhang, Y. Jiang, X. Wu, P. One, Vol. 12, 6, p. 15, 2017. Y. Cao, A. Kole, L. Lan, P. Wang, J. Hui, Shih, C. Liao . . . J. Cheng, “Label-Free M. Sturek & J. Cheng, “Spectral Analysis Vibrational Spectroscopic Imaging of S. Scherr, D. Freedman, K. Agans, A. Assisted Photoacoustic Imaging for Lipid Neuronal Membrane Potential,” Journal of Rosca, E. Carter, S. Unlu, M. Kuroda . . . Composition Differentiation,” Photoacoustics, Physical Chemistry Letters, Vol. 8, 9, p. 1932- J. Connor, “Disposable Cartridge Platform Vol. 7, p. 12-19, 2017. 1936, 2017. for Rapid Detection of Viral Hemorrhagic Fever Viruses,” Lab on a Chip, Vol. 17, 5, p. W. Chen, C. Qian, W. Hong, J. Cheng & C. Li, D. Zhang, M. Slipchenko & J. Cheng, 917-925, 2017. H. Yu, “Evolution of Membrane Fouling “Mid-Infrared Photothermal Imaging Revealed by Label-Free Vibrational of Active Pharmaceutical Ingredients N. Unlu, F. Kanik, E. Seymour, J. Connor Spectroscopic Imaging,” Environmental at Submicrometer Spatial Resolution,” & S. Unlu, “DNA-Directed Antibody Science & Technology, Vol. 51, 17, p. 9580- Analytical Chemistry, Vol. 89, 9, p. 4863-4867, Immobilization for Robust Protein 9587, 2017. 2017. Microarrays: Application to Single Particle Detection ‘DNA-Directed Antibody X. Chen, C. Zhang, P. Lin, K. Huang, J. J. Li, S. Condello, J. Thomes-Pepin, X. Ma, Immobilization,” Methods Mol Biology, Vol. Liang, J. Tian & J. Cheng, “Volumetric Y. Xia, T. Hurley . . . J. Cheng, “Lipid 1571, p. 187-206, 2017. Chemical Imaging by Stimulated Raman Desaturation Is a Metabolic Marker and Projection Microscopy and Tomography,” Therapeutic Target of Ovarian Cancer Stem L. Dal Negro & S. Inampudi, “Fractional ANNUAL REPORT 2018 - 29 Transport of Photons in Deterministic C. Ettinger, S. Erramilli, H. Akiyama . . . Vol. 36, 5, p. 801-814, 2017. Aperiodic Structures,” Scientific Reports, Vol. B. Reinhard, “Plasmonic Enhancement L. Delshadtehrani, S. Eldridge, S. 7, p. 15, 2017. of Selective Photonic Virus Inactivation,” Canakci, M. Egele & A. Joshi, “Nile: A Scientific Reports, Vol. 7, p. 10, 2017. Programmable Monitoring Coprocessor,” E. Penzo, S. Romano, Y. Wang, S. Dhuey, IEEE Computer Architecture Letters, p. 1-4, L. Dal Negro, V. Mocella & S. Cabrini, M. Ordu, J. Guo, G. Ng Pack, P. Shah, S. 2017. S, “Patterning of Electrically Tunable Ramachandran, M. Hong . . . S. Erramilli, Light-Emitting Photonic Structures “Nonlinear Optics in Germanium C. Katevatis, A. Fan & C. Klapperich, Demonstrating Bound States in the Mid-Infrared Fiber Material: Detuning “Low Concentration DNA Extraction and Continuum,” Journal of Vacuum Science & Oscillations in Femtosecond Mid-Infrared Recovery Using a Silica Solid Phase,” PLOS Technology B, Vol. 35, 6, p. 6, 2017. Spectroscopy,” AIP Advances, Vol. 7, 9, p. One, Vol. 12, 5, p. 14, 2017. 095125, 2017. H. Sun, J. Yin, E. Pecora, L. Dal Negro, N. Kolluri, C. Klapperich & M. Cabodi, R. Paiella & T. Moustakas, “Deep- A. Totachawattana, M. Hong, S. Erramilli “Towards Lab-on-a-Chip Diagnostics for Ultraviolet Emitting AlGaN Multiple & M. Sander, “Multiple Bifurcations with Malaria Elimination,” Lab on a Chip, Vol. 18, Quantum Well Graded-Index Separate- Signal Enhancement in Nonlinear Mid- 1, p. 75-94, 2018. Confinement Heterostructures Grown by Infrared Thermal Lens Spectroscopy,” MBE on SiC Substrates,” IEEE Photonics Analyst, Vol. 142, 11, p. 1882-1890, 2017. Q. Guo, F. Guinea, B. Deng, I. 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Gentry, Efficient and Broadband Optical Polarizers R. Gorlick, J. Berger…D. Roblyer, “In K. Cossel, J. Cleary, M. Popovic. . . R. Based on Dielectric Nanowires,” Optics vivo, Noninvasive Functional Measurements Mirin, “Room-Temperature-Deposited Express, Vol. 25, 19, p. 22897-22904, 2017. of Bone Sarcoma Using Diffuse Optical Dielectrics and Superconductors for Spectroscopic Imaging,” Journal of Biomedical Integrated Photonics,” Optics Express, Vol. A. Feizpour, D. Stelter, C. Wong, H. Optics, Vol. 22, 12, p. 9, 2017. 25, 9, p.10322, 2017. Akiyama, S. Gummuluru, T. Keyes & B. Reinhard, “Membrane Fluidity Sensing F. Teng, T. Cormier, A. Sauer-Budge, V. Stojanovič, R. Ram, M. Popovic, S. on the Single Virus Particle Level with R. Chaudhury, V. Pera, R. Istfan . . . D. Lin, S. Moazeni, M. Wade … P. Bhargava, Plasmonic Nanoparticle Transducers,” ACS Roblyer, “Wearable Near-Infrared Optical “Monolithic Silicon- Photonic Platforms Sensors, Vol. 2, 10, p. 1415-1423, 2017. Probe for Continuous Monitoring During in State-of-the-art CMOS SOI Processes,” Breast Cancer Neoadjuvant Chemotherapy Optics Express, Vol. 26, 10, p. 13106-13121, M. Ferreira, E. Castro-Camus, D. Ottaway, Infusions, Journal of Medical Optics, Vol. 22, 2018. J. Miguel Lopez-Higuera, X. Feng, B. 1, p. 8, 2017. Reinhard, W. Jin . . . Q. Quan, “Roadmap J. Demas, G. Prabhakar, T. He & S. on Optical Sensors,” Journal of Optics, Vol. A. Torjesen, R. Istfan & D. Roblyer, Ramachandran, “Wavelength-Agile High- 19, 8, p. 34, 2017. “Ultrafast Wavelength Multiplexed Broad Power Sources via Four-Wave Mixing in Bandwidth Digital Diffuse Optical Higher-Order Fiber Modes,” Optics Express, S. Lerch & B. Reinhard, “Spectral Spectroscopy for in vivo Extraction of Vol. 27, 7, p. 7455-7464, 2017. Signatures of Charge Transfer in Tissue Optical Properties,” Journal of Assemblies of Molecularly-Linked Biomedical Optics, Vol. 22, 3, p. 8, 2017. P. Gregg, P. Kristensen & S. Plasmonic Nanoparticles,” International Ramachandran, “Conservation of Orbital Journal of Modern Physics B, Vol. 31, 24, p. 15, K. Rothschild, “Structural Changes in an Angular Momentum in Air-Core Optical 2017. Anion Channelrhodopsin: Formation of the Fibers,” Optica, Vol. 4, 9, p. 1115-1116, 2017. K and L Intermediates at 80 K,” Biochemistry, M. Nazari, M. Xi, S. Lerch, M. Alizadeh, Vol. 56, 16, p. 2197-2208, 2017. A. Gulistan, S. Ghosh, S. Ramachandran C. Ettinger, H. Akiyama . . . B. Reinhard, & B. Rahman, “Efficient Strategy to “Plasmonic Enhancement of Selective A. Akosman & M. Sander, “Dual Comb Increase Higher Order Inter-Modal Stability Photonic Virus Inactivation,” Scientific Generation from a Mode-Locked Fiber of a Step Index Multimode Fiber,” Optics Reports, Vol. 7, p. 10, 2017. Laser with Orthogonally Polarized Express, Vol. 25, 24, p. 29714-29723, 2017. Interlaced Pulses,” Optics Express, Vol. 25, B. Reinhard, T. Chen, X. Wang & 16, p. 18592-18602, 2017. T. He, J. Demas & S. Ramachandran, M. Alizadeh, “Monitoring Transient “Ultra-Low Loss Dispersion Control with Nanoparticle Interactions with Liposome- H. Akbari, A. Bhatt, C. La Hoz & J. Chirped Transmissive Fiber Gratings,” Confined Plasmonic Transducers,” Semeter, “Incoherent Scatter Plasma Lines: Optics Letters, Vol. 42, 13, p. 2531-2534, Microsystems and Nanoengineering, Vol. 3. April Observations and Applications,” Space 2017. 2017. Science Reviews, Vol. 212, 1-2, p. 249-294, 2017. Y. Jung, Q. Kang, R. Sidharthan, D. Ho, X. Zhao, M. Alizadeh & B. Reinhard, S. Yoo, P. Gregg, S. Ramachandran … “Generating Optical Birefringence and H. Akbari, L. Goodwin, J. Swoboda, J. St- D. Richardson, “Optical Orbital Angular Chirality in Silicon Nanowire Dimers,” ACS Maurice & J. Semeter, “Extreme Plasma Momentum Amplifier Based on an Air- Photonics, Vol. 4, 9, p. 2265-2273, 2017. Convection and Frictional Heating of the Hole Erbium-Doped Fiber,” Journal of A. Aguirre, G. Apiou-Sbirlea, D. Roblyer & Ionosphere: ISR observations,” Journal of Lightwave Technology, Vol. 35, 3, p. 430-436, B. Tromberg, “Translational Biophotonics,” Geophysical Research-Space Physics, Vol. 122, 7, 2017. Journal of Biomedical Optics, Vol. 22, 12, p. 2, p. 7581-7598, 2017. 2017. S. Pidishety, S. Pachava, P. Gregg, S. R. McGranaghan, A. Bhatt, T. Matsuo, A. Ramachandran, G. Brambilla & B. M. Applegate & D. Roblyer, “High-Speed Mannucci, J. Semeter & S. Datta-Barua, Srinivasan, “Orbital Angular Momentum Spatial Frequency Domain Imaging with “Ushering in a New Frontier in Geospace Beam Excitation Using an All-Fiber Weakly Temporally Modulated Light,” Journal of Through Data Science,” Journal of Geophysical Fused Mode Selective Coupler,” Optics Biomedical Optics, Vol. 22, 7, p. 7, 2017. Research-Space Physics, Vol. 122, 12, p. 12586- Letters, Vol. 42, 21, p. 4347-4350, 2017. 12590, 2017. A. Leproux, T. O’Sullivan, A. Cerussi, A. D. Vitullo, C. Leary, P. Gregg, R. Smith, D. Durkin, B. Hill, N. Hylton, D. Roblyer … J. Semeter, S. Mrak, M. Hirsch, J. Swoboda, Reddy, S. Ramachandran & M. Raymer, B. Tromberg, “Performance Assessment H. Akbari, G.Starr . . . V. Pankratius, “GPS “Observation of Interaction of Spin and of Diffuse Optical Spectroscopic Imaging Signal Corruption by the Discrete Aurora: ANNUAL REPORT 2018 - 31 Precise Measurements From the Mahali Z. Wang, L. Spinoulas, K. He, L. Tian, 3, p. 2877-2888, 2017. Experiment,” Geophysical Research Letters, Vol. O. Cossairt, A. Katsaggelos & H. Chen, 44, 19, p. 9539-9546, 2017. “Compressive Holographic Video,” Optics W. Liu, M. Chiao, M. Collier, T. Cravens, Express, Vol. 25, 1, p. 250-262, 2017. M. Galeazzi, D. Koutroumpa . . . B. Walsh, N. Sivadas, J. Semeter, Y. Nishimura & “The Structure of the Local Hot Bubble,” A. Kero, “Simultaneous Measurements of L. Yeh, L. Tian & L. Waller, “Structured Astrophysical Journal, Vol. 834, 1, p. 6, 2017. Substorm-Related Electron Energization Illumination Microscopy with Unknown in the Ionosphere and the Plasma Sheet,” Patterns and a Statistical Prior,” Biomedical V. Souza, W. Gonzalez, D. Sibeck, D. Koga, Journal of Geophysical Research: Space Physics, Optics Express, Vol. 8, 2, p. 695-711, 2017. B. Walsh & O. Mendes, “Comparative Vol. 122, 2017. Study of Three Reconnection X O. Avci, M. Campana, C. Yurdakul & S. Line Models at the Earth’s Dayside J. Swoboda, J. Semeter, M. Zettergren & Unlu, “Pupil Function Engineering for Magnetopause Using in Situ Observations,” P. Erickson, “Observability of Ionospheric Enhanced Nanoparticle Visibility in Wide- Journal of Geophysical Research-Space Physics, Space-Time Structure with ISR: A Field Interferometric Microscopy,” Optica, Vol, 122, 4, p. 4228-4250, 2017. Simulation Study,” Radio Science, Vol. 52, 2, Vol. 4, 2, p. 247-254, 2017. p. 20, 2017. B. Walsh, C. Komar & Y. Pfau-Kempf, O. Avci, C. Yurdakul & S. Unlu, “Spacecraft Measurements Constraining D. Simon, C. Fitzpatrick, S, Osawa & “Nanoparticle Classification in Wide-Field the Spatial Extent of a Magnetopause A. Sergienko, “Quantum Simulation Interferometric Microscopy by Supervised Reconnection X Line,” Geophysical Research of Discrete-Time Hamiltonians Using Learning from Model,” Applied Optics, Vol. Letters, Vol. 44, 7, p. 3038-3046, 2017. Directionally Unbiased Linear Optical 56, 15, p. 4238-4242, 2017. Multiports,” Physical Review A, Vol. 95, 4, p. G. Handy, M. Taheri, J. White & A. 10, 2017. U. Aygun, O. Avci, E. Seymour, H. Urey, Borisyuk, “Mathematical Investigation S. Unlu & A. Ozkumur, “Label-Free of IP3-Dependent Calcium Dynamics D. DeMille, J. Doyle & A. Sushkov, and High-Throughput Detection of in Astrocytes,” Journal of Computational “Probing the Frontiers of Particle Physics Biomolecular Interactions Using a Flatbed Neuroscience, Vol. 42, 3, p. 257-273, 2017. with Tabletop-Scale Experiments,” Science, Scanner Biosensor,” ACS Sensors, Vol. 2, 10, Vol. 357, 6355, p. 990-994, 2017. p. 1424-1429, 2017. J. Martínez, B. Rahsepar & J. White, “Anatomical and Electrophysiological A. Garcon, D. Aybas, J. Blanchard, G. F. Ekiz-Kanik, D. Sevenler, N. Unlu, M. Clustering of Superficial Medial Entorhinal Centers, N. Figueroa, P. Graham, A. Chiari & S. Unlu, “Surface Chemistry Cortex Interneurons,” eNeuro, Vol. 4, 5, Sushkov . . . D. Budker, “The Cosmic and Morphology in Single Particle Optical 2017 Axion Spin Precession Experiment Imaging,” Nanophotonics, Vol. 6, 4, p. 713- (CASPEr): A Dark-Matter Search with 730, 2017. Y. Patel, A. George, A. Dorval, J. White, Nuclear Magnetic Resonance,” Quantum D. Christini & R. Butera, “Hard Real-Time Science and Technology, Vol.3, 1, 2017. D. Sevenler, O. Avci & S. Unlu, Closed-Loop Electrophysiology with the “Quantitative Interferometric Reflectance Real-Time eXperiment Interface (RTXI),” D. Kimball, S. Afach, D. Aybas, J. Blanchard, Imaging for the Detection and PLOS Computational Biology, Vol. 13, 5, p. 22, D. Budker, G. Centers, A. Sushkov . . . T. Measurement of Biological Nanoparticles,” 2017. Wu, “Overview of the Cosmic Axion Spin Biomedical Optics Express, Vol. 8, 6, p. 2976- Precession Experiment (CASPEr),” 2017. 2989, 2017. M. Taheri, G. Handy, A. Borisyuk & J. White, “Diversity of Evoked Astrocyte S. Rajendran, N. Zobrist, A. Sushkov, R. S. Unlu, M. Chiari & A. Ozcan, Ca2+ Dynamics Quantified through Walsworth & M. Lukin, “A Method for “Introduction to the Special Issue of Experimental Measurements and Directional Detection of Dark Matter Using Optical Biosensors,” Nanophotonics, Vol. 6, 4, Mathematical Modeling,” Front Syst Neurosci, Spectroscopy of Crystal Defects,” Physical p. 623-625, 2017. Vol. 11, 79, 2017. Review D, Vol. 96, 3, p. 9, 2017. M. Archer, M. Hartinger, B. Walsh & V. T. Lin, S. Ramadurgam & C. Yang, “Design T. Wang, D. Kimball, A. Sushkov, D. Aybas, Angelopoulos, “Magnetospheric and Solar of Contact Electrodes for Semiconductor J. Blanchard, G. Centers . . . D. Budker, Wind Dependences of Coupled Fast-Mode Nanowire Solar Energy Harvesting “Application of Spin-Exchange Relaxation- Resonances Outside the Plasmasphere,” Devices,” Nano Letters, Vol. 17, 4, p. 2118- Free Magnetometry to the Cosmic Axion Journal of Geophysical Research-Space 2125, 2017. Spin Precession Experiment,” Physics of the Physics, Vol. 122, 1, p. 212-226, 2017. Dark Universe, Vol. 19, p. 27-35, 2018. K. McNear, Y. Huang & C. Yang, S. Hoilijoki, U. Ganse, Y. Pfau-Kempf, “Understanding Cellular Internalization X. Wang, J. Christopher & A. Swan, “2D P. Cassak, B. Walsh, H. Hietala . . . M. Pathways of Silicon Nanowires,” Journal of Raman Band Splitting in Graphene: Charge Palmroth, “Reconnection Rates and X Line Nanobiotechnology, 15, 10, 2017. Screening and Lifting of the K-Point Kohn Motion at the Magnetopause: Global 2D-3V Anomaly,” Scientific Reports, Vol. 7, p. 9, 2017. Hybrid-Vlasov Simulation Results,” Journal Y. Zi, S. Suslov & C. Yang, “Understanding of Geophysical Research-Space Physics, Vol. 122, Self-Catalyzed Epitaxial Growth of III-V 32 - BOSTON UNIVERSITY PHOTONICS CENTER Nanowires Toward Controlled Synthesis,” Susceptibilities,” Analytical and Bioanalytical Selim Unlu was elected an OSA Fellow by Nano Letters, Vol. 17, 2, p. 1167-1173, 2017. Chemistry, Vol. 409, 11, p. 3043-3054, 2017. the Optical Society of America. G. Duan, J. Schalch, X. Zhao, J. Zhang, L. Ziegler, “Anomalous pH-Dependent Xin Zhang was elected as an IEEE R. Averitt & X. Zhang, “Analysis of the Surface Adsorption of p-Methyl Benzoic Fellow by the Institute of Electrical and Thickness Dependence of Metamaterial Acid: Enhancement Due to Cooperative Electronics Engineers. Absorbers at Terahertz Frequencies,” Optics Adsorption,” Journal of Physical Chemistry B, Express, Vol. 26, 3, p. 2242-2251, 2018. 2017. Xin Zhang received the Boston University Distinguished Scholar Award by the BU G, Duan, J. Schalch, X. Zhao, J. Zhang, AWARDS College of Engineering. R. Averitt & X. Zhang, “Identifying the Perfect Absorption of Metamaterial David Bishop was elected to the National Xin Zhang was elected as an AIAA Absorbers,” Physical Review B, Vol. 97, 3, p. Academy of Inventors as a Fellow. Associate Fellow by the American Institute 035128, 2017. of Aeronautics and Astronautics. Keith Brown received the Boston University G. Duan, X. Zhao & X. Zhang, “A Dean’s Catalyst Award. PATENTS Magnetically Coupled Communication and Charging Platform for Microsensors,” Jerry Chen received the Smith Award for S. Anderson, G. Duan, X. Zhang & X. Journal of Microelectromechanical Systems, Vol. Excellence in Biomedical Research. Zhao (US Patent #62/516,376) “Apparatus 26, 5, p. 1099-1109, 2017. for Improving Magnetic Resonance Jerry Chen received the Whitehall Imaging,” Issue Date: June 7, 2017. B. Pein, W. Chang, H. Hwang, J. Scherer, Foundation Research Grant Award. I. Coropceanu, X. Zhao, X. Zhang … K. D. Bishop, M. Holyoke, G. Cannel, Nelson, “Terahertz-Driven Luminescence Jerry Chen was awarded the NARSAD J. Chang & M. Imboden (US Patent and Colossal Stark Effect in CdSe-CdS Young Investigator Award from the Brain & #15274414) “Widely Tunable Cavity Filter Colloidal Quantum Dots,” Nano Letters, Vol. Behavior Research Foundation. Using Low Voltage, Large Out of Plane 17, 9, p. 5375-5380, 2017. Actuation Mems,” Issue Date: 2016. Ji-Xin Cheng was awarded the Boston D. Sutherland, X. Zhang & J. Charest, University Moustakas Chair Professorship in D. Bishop, M. Holyoke, G. Kannel, M. “Water Infused Surface Protection as Photonics and Optoelectronics Beacken, J. Chang & M. Imboden (US an Active Mechanism for Fibrin Sheath Patent #15274433) “Mems Device with Prevention in Central Venous Catheters,” Xi Ling received the Boston University Large Out-of-Plane Actuation and Low- Artificial Organs, Vol. 41, 10, p. E155-E165, Materials Science and Engineering Resistance Interconnect and Methods of 2017. Innovation award. Use,” Issue Date: 2017.

Y. Wang, G. Duan, L. Zhang, L. Ma, X. Xi Ling was awarded the Boston University L. Dal Negro (US Patent # 62/488,121) Zhao & X. Zhang, “Terahertz Dispersion University's Provost Career Development “Azimuthally-Modulated Aperiodic Phase Characteristics of Super-Aligned Multi- Professorship. Arrays for Engineered Spectral Separation,” Walled Carbon Nanotubes and Enhanced Issue Date: April 21, 2017. Transmission Through Subwavelength Milos Popovic was awarded the Boston Apertures,” Scientific Reports, Vol. 8, p. 2087, University Innovation Career Development K. Ekinci, K. Vural, S. Debbie & D. 2018. Professorship. Chuanhua, D. (US Patent # 15/669,069) “Method and Device for Antibiotic M. Wu, X. Zhao, J. Zhang, J. Schalch, Kenneth Rothschild was inducted into the Susceptibility Testing Based on Fluctuation G. Duan, K. Cremin . . . X. Zhang, “A National Academy of Inventors. of Electrical Resistance in a Microchannel.” Three-Dimensional All-Metal Terahertz Issue Date: August 4, 2017. Metamaterial Perfect Absorber,” Applied Michelle Sander received the Boston Physics Letters, Vol. 111, 5, p. 051101, 2017. University UROP Award for summer 2017 R. Meade, K. Mehta, E. Megged, J. Orcutt, and fall 2017. M. Popovic, R. Ram, . . . O. Tehar- X. Zhao, J. Schalch, J. Zhang, H. Seren, Zahav (US Patent #9,768,330) “Method G. Duan, R. Averitt & X. Zhang, Michelle Sander was elected by the Optical and Optoelectronic Structure Providing “Electromechanically Tunable Metasurface Society as an OSA Ambassador. Polysilicon Photonic Devices with Different Transmission Waveplate at Terahertz Optical Properties,” Issue Date: August 25, Frequencies,” Optica, Vol. 5, 3, p. 303-310, Joshua Semeter was elected to the National 2014. 2017. Science Foundation: Advisory Committee for the Geoscience Directorate (AC-GEO). F. Pavanello & M. Popovic (US Patent W. Premasiri, Y. Chen, P. Williamson, D. #US20170315421A1) “CMOS Compatible Bandarage, C. Pyles & L. Ziegler, “Rapid Joshua Semeter was elected to the National Optical Modulators,” Issue Date: July 1, Urinary Tract Infection Diagnostics by Academy of Sciences: Committee on Solar 2015. Surface-Enhanced Raman Spectroscopy and Space Physics (CSSP). (SERS): Identification and Antibiotic M. Popovic (US Patent ANNUAL REPORT 2018 - 33 #US20170269297A1) “Method and Apparatus for Optical Waveguide-to- Semiconductor Coupling for Integrated Photonic Circuits,” Issue Date: March 21, 2016.

D. Roblyer & A. Torjesen (US Patent #62/489,677) “High-Speed Tissue Oximetry System Employing Fast Digital Diffuse Optical Spectroscopy,” Issue Date: April 25, 2017.

T. Otchy, T. Gardner, A. White, C. Lissandrello, W. Gillis, J. Shen . . . D. Chew, D. (US Patent #62367,975) “Nerve Cuff, Methods of Fabricating the Same and Methods of Use,” Issue Date: June 2017.

34 - BOSTON UNIVERSITY PHOTONICS CENTER Educational Programs & Initiatives

NSF Research Experiences for Below are some relevant statistics regarding and Computer Engineering (ECE) at Undergraduates (REU) in Integrated the 2017 REU participants: their university/institute. Nanomanufacturing (INM) • 58% have fewer than two accredited • 25% of the applicants do not have any Engineering undergraduate or graduate Professors Xin Zhang and Helen Fawcett accredited Engineering undergraduate programs available in ME, BME, MSE led the third summer cohort (2017) of REU or graduate programs in Mechanical or ECE. participants. The student cohort arrived Engineering (ME), Biomedical • 67% female / 33% male participants at BU to move into their dorm rooms and Engineering (BME), Materials Science • All applicants have a GPA of 3.0 or start the 10-week program in June 2017. and Engineering (MSE) or Electrical higher. Summer 2017 NSF REU INM List of Projects and Participants Faculty Mentor Dept Project Title REU Participant REU Home Institution Universidad Metropolitana Gabriela Rodriguez Thomas Bifano ME Fast Volumetric Imaging of Neurons Kaila Trawitzki New Jersey Institute of Technology Linking Cell Viability and Stress Events Using a Shola Onissema James Bird ME Rowan University Microfluidic Platform Karimu BME/ Northampton Commu- ECE/ nity College, attending David Bishop ME/ Optical Micromirror Measurement Leila Chiles Temple University in fall MSE/ 2017 Physics ME/ Carnegie Mellon Keith Brown MSE/ Patterned Enzymatic Growth of Materials Deanyone Su University Physics

Florida International Uni- Douglas Densmore ECE Microfabrication of Lab on a Chip Devices Anibal Morales versity High Permeable Graphene Oxide Membranes for University of Texas El Chuanhua Duan ME Lilia Sanchez Water Desalination and Purification Paso ECE/ City College of New Michelle Sander Patterning Graphene with an Ultrafast Laser Ryan Ng MSE York

Michael Smith BME Micropatterning for Traction Measurements Jordan Dreher Norfolk State University

Computational Microscopy Using Coded Lei Tian ECE Joy Muthami University of Delaware Illumination for Biomedical Imaging

Helen Fawcett ME IRIS Microchip Process Validation Lauryn Carver University of Oklahoma BME/ ECE/ Uniformly Oriented Diatom Frustule Monolayers: Florida International Xin Zhang John Hidalgo ME/ Formation And Analysis University MSE/ Northampton Commu- ECE/ Manufacturing of Lens-Free Image Sensors for nity College, attending Roberto Paiella Lauren Strong MSE Ultrasmall Compound-Eye Cameras Temple University in fall 2017 ANNUAL REPORT 2018 - 35 • 75% of the participants are self- information on the REU INM program faculty mentors. They also participated identified Underrepresented Minorities can be found at: http://www.bu.edu/ in the final poster session alongside the (URMs), 8% are self-identified white/ photonics-reu/. REU students. RET participants were Asian. awarded certificates of participation as NSF Research Experiences for well as Professional Development Point The NSF REU INM is working alongside, Teachers (RET) in Integrated (PDP) certificates for instructional time and integrating where possible with the Nanomanufacturing as part of the RET program at an ice other REU sites on campus and the cream social. This event provided a forum Undergraduate Research Opportunities Professors Xin Zhang and Helen Fawcett where their labs could acknowledge their Program (UROP) office. More information led the third summer cohort (2017) of excellent research during the summer. about the NSF REU participants can be RET participants in the six week program, More information on the NSF RET INM found at http://www.bu.edu/photonics-reu. July 5 – August 11. program can be found at: http://www. Last year’s program included 11 discrete Teachers were recruited from high-needs bu.edu/photonics-ret/. research projects and 12 REU participants. public schools within the Massachusetts In most cases, the REU student worked STEM Pipeline network and from alongside an RET participant who joined community college faculty in surrounding BU four weeks into the start of the REU districts. Teachers were also recruited program. We were able to bring back one based on their interest in research student from the prior year’s program opportunities in nanotechnology that with funding provided by NSF REU they can integrate into their classroom supplements through the curriculum. The Directors NSF I/UCRC. The following assisted in the translation faculty and their graduate 60% of the of RET experiences into student mentors worked with teachers are sustainable STEM education the REU/RET participants female. curricula and activities at from June 5 – August 11, the teachers’ home schools 2017. through team-based development and leveraging In addition to the laboratory research, research mentors in the teacher’s REU participants spent 1.5 hours per partnering laboratory. week at brown bag seminars on topics ranging from graduate school and career Some relevant statistics about the 2017 advising, to point of care technologies RET participants are as follows: for resource limited countries and STEM. The participants also had three hours a • 60% of the schools represented are week of cleanroom and nanofabrication from communities with higher than laboratory experiences. The students and 40% low income households. teachers engaged in scientific presentations • 50% of the schools are receiving level by many of the participating faculty 3 or higher district assistance from mentors including Professors Paiella, Massachusetts. Reinhard, and Brown. Professor Klapperich • 30% of the participants are led a discussion on global technologies underrepresented minorities. in health care that was well received. At • 60% of the teachers are female. the four-week mark, when the teacher More information about the projects participants arrived, the REU participants and the teachers can be found at http:// presented their research to the teachers bu.edu/photonics-ret. The table below along with a few slides describing their identifies the project, faculty mentor, the educational background, where they came teachers and the schools from which they from, and what made them decide to came from. pursue Engineering. The program ended with a poster session combined with the In addition to laboratory research, RET NSF REU BU Chemistry program. REU participants joined the REU students at participants were awarded certificates of brown bag seminars, in cleanroom and participation at an ice cream social where nanofabrication laboratory experiences, their labs acknowledged their excellent and were involved in scientific research during the summer. More presentations by many of the participating

36 - BOSTON UNIVERSITY PHOTONICS CENTER Summer 2017 NSF RET Participants in Integrated Nanomanufacturing

Faculty Mentor Dept Project Title RET Participant RET Home Institution

Abdellah Da- North Shore Community Thomas Bifano ME Fast Volumetric Imaging of Neurons khama College

Linking Cell Viability and Stress Events James Bird ME Scott Hubeny East Boston High School Using a Microfluidic Platform

ME/ Edward M Kennedy Patterned Enzymatic Growth of Ma- Keith Brown MSE/ Kevin Robin Academy for Health terials Physics Careers

Microfabrication of Lab on a Chip Douglas Densmore ECE Amy Borges Hopkinton Middle School Devices

High Permeable Graphene Oxide Chuanhua Duan ME Membranes for Water Desalination Colleen Kelly Dorchester Academy and Purification

ECE/ Patterning Graphene with an Ultrafast Michelle Sander MSE Tanea Cezar Fuller Middle School Laser

Micropatterning for Traction Mea- Antoinette Michael Smith BME McKinley Middle School surements Barrow-Jordan

Computational Microscopy Using Lei Tian ME Coded Illumination for Biomedical Karl Yando Chelsea High School Imaging

Helen Fawcett ME IRIS Microchip Process Validation Chandler Smoak West Roxbury Academy

BME/ ECE/ Uniformly Oriented Diatom Frustule John O’Bryant School of Xin Zhang ME/ Talia Clark MSE Monolayers: Formation And Analysis Science and Math

ANNUAL REPORT 2018 - 37 Business Innovation Center

Innovation Center Facilities home-use clinical trials testing of the iLET over $1.3M. This data shows good evidence Bionic Pancreas System. This approval was for job creation and the economic benefits Located on the 6th floor of the Photonics also significant as it is the first trial to test of small business enterprises. Center building, Boston University’s Fiasp®, Novo Nordisk’s latest formulation Business Innovation Center (BIC) of fast-acting insulin using autonomous The management of the tenant companies currently hosts 10 technology companies insulin delivery. have given back to the Photonics Center that are in the early stages of business and have supported the educational growth. The goal of BIC is to accelerate Graduated BIC companies as well as and research elements of the Photonics innovation by encouraging industry current tenants continue to be the best Center mission. These companies have collaboration with faculty and providing recruiters of new businesses to the Center provided internship opportunities for educational opportunities for graduate and BIC expects to replace the departing students, mentored students and increased and undergraduate students. The mix of companies in the first few months of FY19. sponsored research opportunities. In companies includes those in life sciences, Part of the success of the BIC companies FY18, the BIC companies hired a total biotechnology, artificial intelligence, relates to the selectivity that the Photonics of 27 student interns and had five former photonics and clean energy. Center is able to maintain. There are over interns that were hired as full-time 35 Business Incubators or Innovation employees. Additionally BU graduates The theme of this group of companies for Acceleration Facilities in the Boston area, have been hired to fill critical roles at some FY18 would be “taking it to the next level.” but it is believed that BIC is the only center of the BIC companies. The interns not Four of the companies (Beta Bionics, with a charter to enhance only filled engineering/ JanaCare, nanoView Biosciences, and the education of students scientist positions as a Poly6 Technologies) closed on a Series and expand opportunities The theme of graduate student from the A or Series B round in the past year and for sponsored research. It this group of BU Questrom School of at least two more companies are looking is very clear that BIC is the Management performed companies for for their first round of equity financing. only center operating at the comprehensive market FY18 would be Two companies (nanoView and Lattice intersection of photonics/ research for Poly6 and built Automation) departed in the last month of nano-engineering and life “taking it to the out a 135 page analytical FY18, and a third company (MicroLeads), sciences, with access to next level.” report to give to investors, will depart in the first month of the specialized photonics tools. shareholders and other key new fiscal year. Each of these departing Some of the additional Poly6 stakeholders. companies are experiencing tremendous benefits and services growth and require additional staff and available to BIC companies include: facility Some of the activities supported by the facilities to support expanding operations. management, EH&S support, conference BIC companies include hosting Biomedical A company that departed in May 2017 and catering services, library resources, Engineering Senior Design projects, serving also continues to make headlines in FY18. invitations to Photonics Center conferences, as reviewers or judges on the BU School Neurala has received mention in over 200 symposia, guest lectures and all networking of Engineering’s Medical Design course publications including Fortune, TechCrunch, events, opportunities for collaboration and participating as guest lecturers in CNBC, Boston Globe, Chicago Tribune, Fox with leaders in Photonics, Nanotechnology design courses on biosensors and medical News, ABC News, Associated Press, Washington and Materials research, and a pipeline diagnostics. Six of the 10 BIC companies Post and Time; and they were named as one of talented and entrepreneurial young supported Senior Design projects and for of the 100 Most Disruptive Companies in scientist/engineers available for internships. the second year in a row, Bioventus funded the World by Disrupter Daily. student travel to present a poster at the The available space includes shared office 2018 Northeast Bioengineering Conference Some of the remaining companies are space, private office space, and wet lab in Philadelphia. demonstrating market successes that will and optical laboratory spaces. Additionally, also lead to growth. JanaCare announced BIC also has room for four companies in The management of the BIC companies earlier this year that the company entered a bio-safety level 2 (BSL-2) space, which have also been speakers or panelists at into an exclusive agreement with Siemens was partially funded by Massachusetts Life the BU College of Engineering “Lunch Healthineers to distribute their Aina Blood Sciences Center (MLSC), a quasi-public and Learn” series, the Photonics Forum Monitoring System. The Aina System is the investment agency of the Commonwealth series, the Biological Design Center’s described as the world’s first smart phone of Massachusetts. Since the BSL-2 lab is “Breakthroughs in Biotechnology” based diagnostic system for the detection state sponsored, the Center has additional seminar series, “on-hire to fire” speed and management of chronic diseases, such tracking and reporting requirements, which networking events and other training events as congestive heart failure. Beta Bionics shows the 450 square foot lab provided with BME students, and other student also announced in May, that it received employment for 17 engineers/scientists organizations (i.e. Women in Science and IDE approval from the FDA to begin providing a combined compensation of Engineering (WISE). In all situations, the 38 - BOSTON UNIVERSITY PHOTONICS CENTER speakers provided students with a practical (REU) and Research Experiences for BIC companies to the CELL-MET Industry perspective on the value of their classroom Teachers (RET) programs, Jana Care took Advisory Board. BIC is also making plans training. an undergraduate student on board starting to reserve space for spin-out companies in June and Bioventus has a teacher working that are associated with CELL-MET and The BIC companies have also continued to in their labs. This is intended to expand the to launch an effort more geared to start- engage faculty on collaborative research at research experiences beyond the academic up business incubation and enhancing the BU Charles River and Medical campuses, environment. technology translation in the associated and have supported various equipment regenerative medicine and tissue engineering initiatives such as Poly6’s support for As another example of the contributions spaces. upgrades. In addition, repair of equipment of the BIC companies to the Photonics in the BME core facility took place, and Center mission, Bioventus was an active The full list of FY18 tenants can be found Jana Care had an equipment loan agreement member of the I/UCRC on Biophotonic in the nearby table. These companies made with Professor Cabodi where a tool was Sensors and Systems; and with the launch full use of the BU facilities to continue provided that is useful in the development of CELL-MET, Bioventus and Poly6 have product development, solicit investment and of new assays. In a trial initiative for the signed on as members. Moving forward, cultivate their initial customers. Research Experiences for Undergraduates an effort will be made to recruit additional

List of FY18 Photonics Center Innovation Center Tenants

Company Name Origin Status Change Technology Market Sector Funding

John Agira Hopkins None Polymer Waveguide Energy Self-funded University

Boston Grants and Beta Bionics None Artificial Pancreas Healthcare University Venture

License from Bone Growth Corporate and Bioventus None Healthcare Pfizer Protein Private Equity

De Nova Pain-free Tattoo ClearIt New Healthcare Self-funded Start-up Removal

Diagnostics for JanaCare Harvard None Healthcare Grants Chronic Diseases

Lattice Boston Biological Design Departed Healthcare Grants Automation University Solution

Micro-Electrodes Expected to Micro-Leads Inc. Draper Labs and Implantable Healthcare Grants Depart July ‘18 Devices Reduced nanoView Biosci- Boston Grants and Footprint, Labs Photonics Healthcare ences University Venture Moved High Performance Poly6 MIT None Polymers Healthcare Grants Technologies

Snapdragon Process Flow MIT None Pharmaceutical Corporate Chemistry, Inc. Chemistry

ANNUAL REPORT 2018 - 39 Events & Programs

THE PHOTONICS CENTER offers an exciting array of events PHOTONICS SEMINAR CALENDAR and programs throughout the year to engage the community and offer Date Speaker Title enriching opportunities to BU, September 7, 2017 Professor Scott “Optical Frequency Combs: Boston area universities and local Diddams, From Lab-scale to companies. These events foster University of Colo- Chip-scale” interdisciplinary discussion and rado (Hosted by BU encourage faculty and students OSA/SPIE Student to collaborate with a variety of Chapter) professionals on fundamental September 28, 2017 Professor Shaochen “Light-based Rapid 3D research. Chen, UCSD Printing, an Enabling Technology for Soft and The Photonics Center hosts regular Precision Biomaterials” community events: The Photonics October 13, 2017 Professor Govind “Space-Time Seminars, Forums and Cafes. The Agrawal, Optics Duality in Optics” Photonics Seminars and Forums, Institute give the community opportunities to participate in technical discussions April 27, 2018 Professor Joseph “Mapping Brain Functions, in an open forum. Speakers are Culver, Washington Connections and Networks University School of with Light” selected to discuss their current Medicine (Hosted by research endeavors and the real- BU OSA/SPIE world applications of their research. Student Chapter) The Cafes bring together the faculty, students, staff, and innovation center PHOTONICS FORUM CALENDAR company employees in an informal setting for conversation and Date Speaker Presentation collaboration. The Cafes are hosted October 25, 2017 Dr. Jeffrey Peterson, “In vivo Imaging of Cancer, on the second Friday of each month Perkin Elmer Inflammation, and Toxicology from September through April in Using NIR Fluorescent the West End Lounge. Imaging Agents” January 31, 2018 Professor Ji Yi, “Big Data” in Human Boston University Neuroretinal Imaging and its Applications” February 28, 2018 Professor Ji-Xin “Killing Super Bug “MRSA” Cheng, Boston with Photons” University March 28, 2018 Professor Xi Ling, “Light-matter Interaction in Boston University Two-dimensional Van der Waals Structures” June 15, 2018 Dr. Martin Fermann, “Ultrafast Fiber Lasers: Power IMRA and Precision for the Real World”

40 - BOSTON UNIVERSITY PHOTONICS CENTER 21st Annual Photonics Center Symposium

This year, the 21st Annual Photonics Center Symposium focused on Neurophotonics. The symposium drew over 200 attendees from BU, other academic institutions, and industry. Photonics Professor David Boas chaired a popular and successful conference.

The agenda for this year’s symposium featured presentations by researchers from leading academic institutions.

The speakers included: Professor Kwanghun Chung, MIT Professor Yves De Koninck, Laval University Professor Anna Devor, UCSD Professor Maria Angela Franceschini, Harvard University/MGH Professor Fritjof Helmchen, University of Zurich Professor Elizabeth Hillman, Columbia University Professor Na Ji, Howard Hughes Medical Institute Professor Chris Xu, Cornell University Professor Alipasha Vaziri, Rockefeller University

During lunch and at the conclusion of this year’s conference, a reception and electronic poster board session was held where participants, students and speakers discussed their research in an informal setting.

ANNUAL REPORT 2018 - 41 Facilities & Equipment

PHO B24 – Upgrade HVAC Optoelectronic Processing BUILDING PROJECTS System for Temperature and Facility (OPF) Humidity Control PHO 801, 802 – Professor Ji-Xin OPF is a multi-user 2500 sq. ft. Cheng Professors Shyamsunder Erramilli facility located on the 8th floor and Lawrence Ziegler conduct of the Photonics Center. The New laboratory space for Professor research requiring strict temperature facility contains equipment for Ji-Xin Cheng, a Boston University and humidity control. This project, semiconductor and optoelectronic Photonics Center member which began in the spring, will wafer and chip fabrication. The serving in the Moustakas Chair provide a stand-alone HVAC system facility includes both a Class Professorship in Photonics and capable of meeting their needs. 100 and a Class 1000 cleanroom Optoelectronics, was completed Construction is scheduled to be and equipment facilitating in 2018. Professor Cheng has completed in the fall. photolithography, wet chemical appointments in Electrical & processing, thin film depositions, Computer Engineering and SHARED LABORATORY FACILITIES plasma etching and cleaning, Biomedical Engineering. His metallization, thermal oxidation, laboratory includes multiple optical thermal annealing, wire bonding, bays as well as wet laboratory space. The three shared labs at the and electrical characterization. Photonics Center contain a variety PHO 804, 806 – Associate of instruments and capabilities, The Class 100 cleanroom has Professor Chen Yang designed to serve the needs of capabilities for photolithography, the Photonics Center and Boston mask fabrication and nanoscale New laboratory space for Professor University community. In addition replication. Two types of photoresist Chen Yang was completed in to BU usage, the shared facilities are spinners are available for use by 2018. Professor Yang’s primary also accessible on a fee for use basis all self-users in OPF. The standard appointment is in Electrical & by current and former Business Headway Research spinner is Computer Engineering. Her Innovation Center (BIC) companies, designed to accommodate small laboratory consists primarily of outside universities, and outside chip level (5 mm x 5 mm) to six inch wet lab space with an adjoining gas companies. The Optoelectronic wafers, while the Suss Microtech room equipped with a state of the Processing Facility (OPF) includes Delta 80 is used to spin chrome on art detection system. a Class 100 photolithography glass masters that can be written cleanroom and a Class 1000 using the Heidelberg Direct Write PHO B21 – Assistant Professor cleanroom with processing and test Laser System. The laboratory Masha Kamenetska equipment for die and wafer level conveniently provides ovens and processing and measurement. The a hood for bakes to facilitate Construction on new laboratory Precision Measurement Laboratory photoresist development. Chip and space for Professor Kamenetska (PML) consists of two laboratory wafer exposure is achieved through began this spring. Professor spaces with scanning electron the UV exposure tool, the MA6 (up Kamenetska’s primary appointment and atomic force microscopy to a 6 inch square masks). A high- is in Chemistry. Her laboratory will among other analytical surface powered optical Nikon microscope include optical and wet lab space. characterization tools. The Focused provides higher resolution imaging Construction is scheduled to be Ion Beam/Transmission Electron for surface inspection. The Nanonex completed in the fall. Microscope Facility (FTF), houses NBX200 allows thermal and UV a FEI Focused Ion Beam (FIB) replication processes for nanoscale and a FEI Transmission Electron structures and can handle up to a Microscope (TEM). 3-inch wafers. 42 - BOSTON UNIVERSITY PHOTONICS CENTER Cleaning, etching or characterization testing can also be done inside the FESEM allows polymers and plastics tools are found in the Class 1000 cleanroom in OPF. The Current to be viewed without conductive cleanroom. Tools include a KLA Voltage/Capacitance Voltage coatings, thus a non-destructive Tencor surface profilometer to characterization test set up is used to way to view a sample. The ZYGO measure the step height of features evaluate devices post wire bonding NewView 6300, an interferometric on wafers and a high-powered and pre-integration into test set microscope with dynamic MEM’s optical Nikon microscope allowing ups on the lab bench. Dicing and capability, has a heating and cooling users to capture still or video images scribing capabilities are available stage that allows testing under from the sample or wafer. outside of the cleanroom facilities. controlled temperature and the viewing and measurement in-situ. Dry etching processes available in Precision Measurement Surface roughness, morphology, and the OPF cleanroom include plasma Laboratory (PML) displacement can all be measured etching, reactive ion etching, and using this instrument. The Zeiss a deep reactive ion etch. As part PML is comprised of two Supra 55VP FESEM, in addition to of equipment upgrades last year, laboratories located in the basement imaging using secondary electron a new, more robust backing pump of the Photonics Center. In one of detectors, is also capable of imaging was installed to function with the the lab spaces, a JEOL SEM with thin TEM samples using a STEM existing software and infrastructure imaging, Cathodoluminescence detector, providing atomic contrast on the vacuum system. In addition (CL), and Energy Dispersive information using a backscattered to dry etching, both acid and Spectrometer (EDS) are available electron detector and chemical separate solvent hoods are available for use. The EDS allows validation composition using EDS. It is also to complete wet chemical etching or of elemental composition and equipped with an EBSD (Electron cleaning and lift-off. The HF vapor surface contaminants in selected Backscatter Diffraction) detector etch system, where the vapor system locations over the surface of the which gives information on the is used to release oxide films, has sample. The Cathodoluminescence crystalline structure and grain addressed safety issues so the user (CL) monochromator allows the boundary orientations on polished does not have to handle liquid HF. detection of energy released in the materials. A hot and cold stage is This system accommodates small visible spectrum from electrons in also available for in-situ work in the pieces of wafers as well as four and an atom returning to their original SEM chamber. Both the Supra 40VP six-inch full wafers. energy level after being excited by and 55VP have e-beam blankers the bombardment of electrons from to allow for e-beam writing of A majority of the research the e-beam in the SEM. nanoscale structures. laboratories at Boston University use thin film deposition systems. The second laboratory space The Focused Ion Beam/ Thermal oxide furnaces, evaporators includes: a Veeco (formerly Digital Transmission Electron and sputtering systems all provide Instruments) Atomic Force Microscope Facility (FTF) students with the ability to learn Microscope (AFM) a Pico-Force about different coating processing AFM System, a Zeiss Supra 40VP The FIB/TEM Facility, also located methodologies and how to measure Field Emission Scanning Electron in the basement, is comprised of the films deposited after processing. Microscope (FESEM), a Zygo two separate rooms with capabilities Thus, new users have undergone NewView 6300 and a Zeiss Supra to measure material composition, qualification and training on the 55VP FESEM. The Pico-Force image surface morphology, and Angstrom instrument. Increased AFM System enables accurate force micro/nano machined materials. research in coatings required a high measurements and manipulation This laboratory houses a FEI temperature-annealing furnace of biological or material samples Quanta 3D Field Emission Gun that covers both low and high at the pico-Newton level, including Focused Ion Beam (FEG FIB) temperature annealing that has also inter- and intramolecular forces, system in one room and a FEI been located in the cleanroom. for applications ranging from drug Tecnai Osiris 200kV S/TEM in the discovery to basic molecular-scale second room. Wire bonding, wedge bonding, or research. The Zeiss Supra 40VP The FEI Quanta 3D FEG FIB is ANNUAL REPORT 2018 - 43 a powerful tool with a resolution of 1.2 nm in the HiVac mode, 2.9 nm in LoVac mode, 7 nm with the FIB column. The tool has a wide variety of detectors including: Everhart Thornley detector (EDT), continuous dynode multiplier (CDEM), ion induced secondary electron (SE) imaging, backscattered electron detector (BSED), low vacuum secondary electron detector (LVSED), gaseous analytical solid-state back scattered electron detector (ESEM GAD), high contrast detector (vCD), annular STEM detector (bright field (BF), dark-field (DF), and high-angle annular dark field (HAADF) modes), Oxford Instruments Energy Dispersive Spectrometry (EDS). The system also includes gas injector modules (GIS) and an Omniprobe micromanipulator can be used for TEM sample preparation and lift-out. For research applications and to study in situ dynamic behavior of materials at different humidity (up to 100% RH) and temperatures (-10 °C to 1000 °C), an additional Peltier/Heating Stage Control Kit can be used.

The FEI Tecnai Osiris TEM system specifications state a TEM point resolution of 0.25 nm, line 0.102 nm, extended to 0.16 nm with TrueImage™ software, and STEM HAADF 0.18 nm. The system includes Super-X EDX detection system, SDD technology, windowless, shutter-protected, X-FEG Electron Source and also includes EFTEM with EELS and a Gatan CCD. The Bright Field/Dark Field Detector on the TEM allows users the capability to align and overlay all of the images from the TEM itself, the EELS and EDS.

The neighboring sample preparation room contains the tools needed for making sections for TEM viewing. Included in this preparation room is a cut off saw, a sample core, a polisher, and an ion tool for final thinning of TEM samples. The equipment can be used by any trained users who wish to prepare sample for TEM and SEM usage. 44 - BOSTON UNIVERSITY PHOTONICS CENTER

8 Saint Mary’s Street, Suite 936 Boston, MA 02215 www.bu.edu/photonics

Front and Back Page Photos: Christopher McIntosh