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German Centre for Cardiovascular Research (DZHK) ANNUAL REPORT

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German Centre for Cardiovascular Research (DZHK) ANNUAL REPORT German Centre for Cardiovascular Research (DZHK) ANNUAL REPORT 2015 The DZHK is the largest research institution for cardiovascular diseases in Germany. Our goal is to promote scientific innovation and to bring it quickly into clinical application and to patient care in order to improve the prevention, diagnosis and treatment of cardiovascular diseases. Contents 3 Preface 4 1. The German Centre for Cardiovascular Research 5 2. Highlights in 2015 8 3. Research Strategy – Focus on Translation 10 4. Preclinical Research 13 5. Clinical Research 18 6. Research Highlights at the DZHK 28 7. Scientific Infrastructures and Resources at the DZHK 35 8. Cooperation and Scientific Exchange at the DZHK 40 9. External Cooperations 43 10. Promotion of Junior Scientists – the Young DZHK 46 11. The DZHK in the Public 52 12. Indicators of the Success of Translational Research at the DZHK 54 Facts and figures The German Centres for Health Research 57 Number of partners in the registered association 58 Finances and Staff 60 Scientific Achievements 67 Personalia, Prizes and Awards 69 Committees and Governance of the DZHK 71 Sites 75 Acronyms 82 Imprint 83 The German Centre for Cardiovascular Research | ANNUAL REPORT 2015 4 Preface In 2015, the DZHK once again recorded an excep- and promise to provide new knowledge and treatment tional growth. About 1,200 people now belong to our recommendations for important endemic diseases, such network: physicians, pharmacologists, physiologists, as heart failure and myocardial infarction. The coop- biologists, chemists, physicists, biostatisticians, ethicists erations between sites, between disciplines and even and many others. We incorporated the Cardiological within institutions have been intensified. The collabo- Competence Networks. In the clinical partner institu- ration with the Cardiological Competence Networks is tions study physicians, nursing staff and health informa- bringing forward new ideas. The number of scientific tion managers collaborate with dedication on our clinical publications continues to rise and their topics reflect the studies. The mission that unites everyone is translation strategic focus of the DZHK. Publications with several in cardiovascular research, i.e., transferring research re- DZHK partners have also risen. The appeal of the net- sults into clinical practice. It is probably the first time in work is also shown not least by the large interest in our Germany that so many people are working together for internal events, especially in our annual retreat, which is this purpose. The fact that people’s attention is drawn regularly overbooked. to the topic of translation in cardiovascular research and that they are motivated to make individual contributions We always have the patient in mind in all of that. The in their field is considered to be a very special achieve- efforts of the DZHK shall benefit them. An important ment and additional value of the DZHK. Among others, group for the DZHK are study participants – without this involves the development of new measures for pro- them clinical research would not be possible. In order to Preface moting junior scientists as well as establishing a unified ensure that they are well informed about what occurs study data management system that is not dependent with their data and biological samples, we have started on individual persons. to build an information platform for them that will go online in 2016. In 2015, our budget accrued to the planned sum of 41 million euro. Our network enables us to sensibly manage these funds and to specifically support excel- lence in translational approaches. Committees like the Translational Research Group and the Clinical Study Group discuss and review applications and advise ap- plicants of clinical studies and large preclinical projects. The committees gain a lot of experience in the process, especially where the inclusion of regulatory authorities and industrial partners in early phases of research proj- ects is concerned. This benefits the next applicant and eventually the whole of the DZHK. This kind of wealth of experience is an added value that can only emerge in a network like the DZHK and that can be established and shared in the long run. Thomas Eschenhagen Gerd Hasenfuß Thomas Sommer And our efforts are starting to pay off: large multicentre Chairman of the Executive Board Executive Board clinical DZHK studies have successfully been initiated Executive Board The German Centre for Cardiovascular Research | ANNUAL REPORT 2015 5 The German Centre for Cardiovascular Research (DZHK) 1. The DZHK The 1. For its multicentre clinical studies the DZHK has invested in the latest diagnostic units The German Centre for Cardiovascular Research | ANNUAL REPORT 2015 6 DZHK – a German Centre of Health Research The German Centre for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung, DZHK) is among the six German Centres for Health Research (Deutsche Zentren der Gesundheitsfor- schung, DZG) that are dedicated to the improvement of the prevention, diagnosis and treatment of endem- ic diseases. It was founded in 2011 upon the initia- tive of the German Federal Ministry of Education and Research (BMBF) and is funded jointly by the Federal Government (90 percent) and the govern- ments of those German states in which member institutions are headquartered (10 percent). The goal of the six German Centres for Health Research is to quickly bring results from basic research to clinical application. 1. The DZHK The 1. Mission and goals of the DZHK The DZHK focuses on translating new knowledge gained from cardiovascular research as rapidly as possible into clinical practice in order to improve the diagnosis, prevention and treatment of cardio- vascular diseases. This mission is of utmost clinical and health economic importance, because in the future the incidence of cardiovascular diseases will increase further as a result of the rising incidence of metabolic disorders (obesity, diabetes) and due to demographic change. In order to be able to implement this mission, the DZHK unites excellent basic researchers and clinical researchers from Where do we stand? seven sites in Germany. It promotes the cooperation between them with the goal to develop synergies The DZHK completed its fourth year of business op- and to thereby accelerate the process of translation. erations in 2015. Hence, after a successful start-up Above all, the DZHK invests its funds in previous phase, the phase of realisation could begin. In 2015, weak spots of the translation process. This is en- for this first time and as scheduled, the centre had at sured through a coordinated research strategy and its disposal the full budget of 41 million euro (2014: specific funding instruments. 14 million). The German Centre for Cardiovascular Research | ANNUAL REPORT 2015 7 In 2015, the sites have once again made outstanding are awarded internally in the scope of application investments in order to strengthen their infrastructure procedures and competition. Due to the increase and common resources (investment programme of funds, we carried out a total of 11 application 2015). They purchased major instrumentation for procedures in the funding lines Preclinical Research, basic research, clinical research and the DZHK Clinical Research and Promotion of Excellence in the Biobanking Project. In addition, the 17 clinical reporting year (2014: 2 application procedures). We member institutions standardised their infrastructure have launched the first major preclinical and clinical with a view to the conduct of multicentre clinical studies and were able to include the 500th patient in studies. In the OMICs Resource Project the DZHK November 2015. In addition, the excellence pro- commissioned the sequencing of 1,000 genomes of gramme to promote young translational researchers healthy individuals (cf. Chapter 6). Within the scope was initiated in 2015, here we were able to award 14 of partner-site funding, additional DZHK tenured grants and sponsorships and recruit two excellent professorships were awarded, which is an important junior scientist group leaders from abroad. contributory factor to reinforce and stabilise the work of the DZHK at its various sites. It is our goal to rank among the five leading cardio- vascular research centres in the world. According to DZHK strategy, 55 percent of the research funds are flexible, which means that they 1. The DZHK The 1. 2016 2010 2012 2014 2015 Selection Start Evaluation One of the 5 internationally Construction phase Implementation and delivery leading centres in CV research • Buildup of structures • Strategy adaptation • Scientific underpinning of CVD • Recruitment • Late translation projects • Research buildings • First-in-patient • Clinical studies impacting guidelines • New generation of physician scientists • International outreach Development of the DZHK since 2010 The German Centre for Cardiovascular Research | ANNUAL REPORT 2015 8 Highlights in 2015 JANUARY Start of supporting the Cardiological Compe- tence Networks by the DZHK APRIL Joint fair stand with the Competence Networks at the 81st annual meeting of FEBRUARY the German Cardiac Society Parliamentary evening 2. Highlights in 2015 in Highlights 2. of the six German Cent- res for Health Research (DZG) in Berlin MARCH Opening of the new MRI building in Göttingen JULY Selection of two DZHK junior scien- tist group leaders The German Centre for Cardiovascular Research | ANNUAL REPORT 2015 9 NOVEMBER Twelve centres participate in the TORCH registry,
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