ACT 2019 Annual Meeting Program
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American College of Toxicology Program Phoenix, Arizona jw marriott desert ridge American College of Toxicology President’s Message n behalf of the American College of Toxicology and Council, it is my pleasure to welcome you to our 40th Annual Meeting in sunny Phoenix, Arizona, at the JW Marriott Desert Ridge. We trust you will enjoy the venue and environs as much as you will be intrigued by the science and pleased by the collegial atmosphere of the meeting. oThis 40th meeting since the founding of ACT in 1977, with the first Annual Meeting being held in 1979, is a very special one commemorating our history and success. We will host a special celebration at 5:30 pm on Sunday highlighting the past 40 years and featuring people who contributed to events instrumental in shaping the College to its present form. All registrants are welcome and encouraged to attend this celebratory event being held immediately before the Welcome Reception. The American College of Toxicology is a society of professionals from industry, government, and academia. The mission of the College is to educate, lead, and serve scientists by promoting an exchange of information and perspectives on safety assessment and new developments related to applied toxicology. The Annual Meeting is the heart of ACT. This week, you will discover why the meeting has become the preferred venue for practicing toxicologists. This November gathering brings together a community of toxicologists at a small venue conducive to idea exchange, professional networking, and continuing education. Our first-rate Scientific Sessions are member driven and organized to maximize learning opportunities. The welcoming and collegial atmosphere of the Annual Meeting is a hallmark of ACT. In addition to Sunday events, including Continuing Education courses, the 5:30 pm ACT 40th Annual Meeting Anniversary Program, and 7:00 pm Welcome Reception, this 40th Annual Meeting includes a wide-ranging scientific program. There will be Plenary speakers on Monday and Tuesday; the popular Poster Session with Wine and Cheese; our Awards Ceremony and Luncheon with a distinguished, award-winning speaker; and extensive Symposia, Workshops, and professional networking events. The ACT Exhibition offers you the opportunity to meet with industry partners, suppliers of the latest in technology and services, in an intimate and very convenient setting—all under one roof. Our exhibitors offer the College a tremendous amount of finan- cial support, and I encourage you to visit with them and thank them for being a part of our Annual Meeting. We encourage you to download the Annual Meeting Mobile App (ACT Annual Meeting) to connect with fellow attendees, read the details about our Scientific Sessions, and learn more about ACT. If this is a new scientific meeting for you, we are excited to welcome you and trust you will discover for yourself why the collegial atmosphere of our Annual Meeting has made it the preferred venue for practicing toxicologists and those who wish to be. If you’ve attended our Annual Meeting before, welcome back! We thank our ACT members for their continued involvement and support of the College. Lastly, if you’ve attended our Annual Meetings before but are not an ACT member, you are encouraged to join our membership to become involved in making this College and Annual Meeting even better in the future. Sincerely, David R. Compton, PhD, DABT 2018–2019 ACT President 11190 Sunrise Valley Drive, Suite 300, Reston, VA 20191 Telephone: 703.547.0875 • Fax: 703.438.3113 • Email: [email protected] • Website: www.actox.org Program Content PROGRAM CONTENT ABSTRACTS President’s Welcome ................... Inside Cover ACT Poster Presentations .............................79 Schedule of Events Overview .......................2 100 Series—General Toxicology ............79 200 Series—Regulatory Toxicology ......91 GENERAL INFORMATION 300 Series—Safety Evaluation Phoenix, Arizona ...............................................7 Nonpharmaceuticals .............................94 400 Series—Toxicology Methods ..........96 Venue ....................................................................7 500 Series—Safety Evaluation Getting around Town ......................................7 Pharmaceuticals ................................... 106 Registration .........................................................7 Author Index ...................................................116 Internet Access ...................................................7 Photography Policy ..........................................7 EXHIBIT INFORMATION Posters ..................................................................7 Exhibitor-Hosted Programs .......................123 Solicitation Policy ..............................................7 Exhibit Hall Map ............................................125 Mobile Event App .............................................7 Exhibitor Directory .......................................127 Badge Scanning .................................................7 Map of Meeting Space ....................................9 REFERENCE Special Events ...................................................11 Council Listing ................................................149 2019 Awards ......................................................14 Committee Listings ......................................151 ACT Headquarters ........................................154 PROGRAM AGENDA Welcome New Members ............................155 Continuing Education Courses 2019 Corporate Members ...........................156 Morning CE Courses ...................................19 ACT Past Presidents ......................................157 Afternoon CE Courses ................................25 ACT Charter Members .................................157 Scientific Sessions ACT Distinguished Fellows ........................157 Monday Morning Sessions .......................31 ACT Endowment Contributors .................158 Monday Afternoon Sessions ...................40 Tuesday Morning Sessions .......................51 Tuesday Afternoon Sessions ....................57 Wednesday Morning Sessions ................67 Wednesday Afternoon Sessions .............73 Chairperson and Speaker Index .................76 All text and graphics are © 2019 by the American College of Toxicology. All rights reserved. No text or graphics may be copied or used without written Americanpermission College from the Americanof Toxicology College 40th of Toxicology. Annual For Meeting further information,2019 please contact ACT Headquarters. 1 Saturday, November 16 3:00 PM–5:00 PM Registration Open Grand Sonoran Foyer 5:00 PM–7:00 PM ACT Council Meeting Desert Conference Suite VII Sunday, November 17 7:00 AM–8:00 AM CE Continental Breakfast (CE course registrants only.) Grand Sonoran Foyer 7:00 AM–6:00 PM Registration Open Grand Sonoran Foyer 8:00 AM–11:30 AM CE 1—Study Director Training Part A: At the Intersection of Regulations and Wildflower A Project Management Overview CE 2—Basic Immunology and New Approaches for Immunotoxicology Testing Grand Sonoran E CE 3—Leading as the Toxicologist in Pharma: Advancing the Project Grand Sonoran D with a Cross-Functional Team CE 4—Toxicological Approaches to Nonmutagenic and Mutagenic Grand Sonoran F Pharmaceutical Impurities CE 5—Optimizing Toxicologic Pathology Data for Toxicologists: 10 Concepts with Grand Sonoran G Recommended Practices 9:30 AM–10:00 AM CE Refreshment Break (CE course registrants only.) Grand Sonoran Foyer 11:30 AM–1:00 PM Lunch on Your Own 11:30 AM–12:30 PM New Member Mingle (By invitation only.) Wildflower Terrace 11:45 AM–12:45 PM IJT Editorial Board Meeting (By invitation only.) Pinnacle Peak 3 12:00 Noon–12:55 PM Exhibitor-Hosted Program: Strategies for Screening Nonhuman Primates in Gene Grand Sonoran H Therapy Studies Presented by: Altasciences Exhibitor-Hosted Program: Charles River’s Fast Facts Competition Grand Sonoran K Presented by: Charles River Exhibitor-Hosted Program: Nonclinical Safety Evaluation of Oncolytic Viruses Grand Sonoran J Presented by: Southern Research Exhibitor-Hosted Program: Toxicologic Pathology Support in China Grand Sonoran I Presented by: WuXi AppTec 1:00 PM–4:30 PM CE 6—Study Director Training Part B: Understanding the Science Wildflower A CE 7—Safety Testing of Gene and Cell Therapy: Perspective from Industry, CROs, and Grand Sonoran E Regulators CE 8—Regulatory Meeting Preparation and Conduct: US, EU, and China Grand Sonoran D CE 9—Metabolites: What Do I Need to Know? Grand Sonoran F CE 10—What's New with Nonclinical ICH Guidances? Grand Sonoran G 1:00 PM–5:00 PM Speaker Ready Room Open Pinnacle Peak 1 2:00 PM–6:00 PM Exhibition and Poster Set Up Exhibit Hall 2:30 PM–3:00 PM CE Refreshment Break (CE course registrants only.) Grand Sonoran Foyer 4:00 PM–4:45 PM Furst Award Competition Poster Set Up (Invited student travel grant recipients only.) Pinnacle Peak 2 5:00 PM–6:30 PM Furst Award Competition (Invited student travel grant recipients only.) Pinnacle Peak 2 5:30 PM–7:00 PM 40th Annual Meeting Anniversary Program—Reliving the History of ACT Grand Saguaro (Open to all attendees.) 7:00 PM–8:30 PM Welcome Reception—Party Like It’s 1979 Sunset Lawn (Ticketed event. Purchase deadline November 10.) 2 American College of Toxicology 40th Annual Meeting 2019 Monday, November 18 7:00 AM–8:00 AM Continental Breakfast Grand Sonoran Foyer 7:00 AM–5:00 PM Registration Open Grand Sonoran Foyer 7:00 AM–4:00 PM Speaker Ready Room Open Pinnacle Peak 1 8:00 AM–8:55 AM Plenary