Balancing Heat and Flavor
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Technical Developments in the Use of Spices Dr David Baines Baines Food Consultancy Ltd
EUROPEAN SPICE ASSOCIATION GENERAL ASSEMBLY 2013 Technical Developments in the Use of Spices Dr David Baines Baines Food Consultancy Ltd Co-editor: Flavour Horizons TECHNICAL DEVELOPMENTS IN THE USE OF SPICES TOPICS: Recent health claims submitted to the EU for the use of spices Compounds in selected spices that have beneficial effects on health The use of spices to inhibit of carcinogen formation in cooked meats The growing use of spices in animal feeds Salt reduction using spices Interesting culinary herbs from Vietnam Recent Health Claims Submitted to the EU EU REGULATION OF HEALTH CLAIMS • The Nutrition and Health Claims Regulation, 1924/2006/EC is designed to ensure a high level of protection for consumers and legal clarity and fair competition for food business operators. • Claims must not mislead consumers; they must be, accurate, truthful, understandable and substantiated by science. • Implementation of this Regulation requires the adoption of a list of permitted health claims, based on an assessment by the European Food Safety Authority (EFSA) of the science substantiating the claimed effect and compliance with the other general and specific requirements of the Regulation. • This list of permitted health claims was adopted in May 2012 by the Commission and became binding on 14th December 2012. Food companies must comply from this date or face prosecution for misleading marketing. APPROVAL OF CLAIMS EU REGULATION OF HEALTH CLAIMS CLAIMS BY COMPONENT CLAIMS BY FUNCTION CLAIMS FOR SPICES – NOT APPROVED/ON HOLD SPICE CLAIM(S) Anise / Star Anise Respiratory Health, Digestive Health, Immune Health, Lactation Caraway Digestive Health, Immune Health, Lactation Cardamon Respiratory Health, Digestive Health, Immune Health, Kidney Health, Nervous System Health, Cardiovascular Health, Capsicum Thermogenesis, Increasing Energy Expenditure, Enhancing Loss of Calories, Body Weight Loss, Stomach Health, Reduction of Oxidative Stress, promotion of Hair Growth. -
Piperine-Pro-Nanolipospheres As a Novel Oral Delivery System of Ca
Piperine-pro-nanolipospheres as a novel oral delivery system of ca... https://www.ncbi.nlm.nih.gov/pubmed/28890215 PubMed Format: Abstract Full text links J Control Release. 2017 Nov 28;266:1-7. doi: 10.1016/j.jconrel.2017.09.011. Epub 2017 Sep 8. Piperine-pro-nanolipospheres as a novel oral delivery system of cannabinoids: Pharmacokinetic evaluation in healthy volunteers in comparison to buccal spray administration. Cherniakov I1, Izgelov D1, Barasch D1, Davidson E2, Domb AJ1, Hoffman A3. Author information Abstract Nowadays, therapeutic indications for cannabinoids, specifically Δ9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) are widening. However, the oral consumption of the molecules is very limited due to their highly lipophilic nature that leads to poor solubility at the aqueous environment. Additionally, THC and CBD are prone to extensive first pass mechanisms. These absorption obstacles render the molecules with low and variable oral bioavailability. To overcome these limitations we designed and developed the advanced pro-nanolipospheres (PNL) formulation. The PNL delivery system is comprised of a medium chain triglyceride, surfactants, a co-solvent and the unique addition of a natural absorption enhancer: piperine. Piperine was selected due to its distinctive inhibitory properties affecting both Phase I and Phase II metabolism. This constellation self emulsifies into nano particles that entrap the cannabinoids and the piperine in their core and thus improve their solubility while piperine and the other PNL excipients inhibit their intestinal metabolism. Another clear advantage of the formulation is that its composition of materials is approved for human consumption. The safe nature of the excipients enabled their direct evaluation in humans. -
Technical Document for Piperine Also Referred to As a BRAD
BIOPESTICIDES REGISTRATION ACTION DOCUMENT PIPERINE (PC Code 043501) U.S. Environmental Protection Agency Office of Pesticide Programs Biopesticides and Pollution Prevention Division Piperine Biopesticides Registration Action Document Piperine (PC Code 043501) TABLE OF CONTENTS I. Executive Summary.........................................................5 II. Overview .................................................................6 A. ACTIVE INGREDIENT OVERVIEW .......................................6 B. USE PROFILE .........................................................6 C. ESTIMATED USAGE ...................................................7 D. DATA REQUIREMENTS.................................................7 E. REGULATORY HISTORY ...............................................7 F. CLASSIFICATION ....................................................8 G. FOOD CLEARANCES/TOLERANCES .....................................8 III. Science Assessment .........................................................8 A. PHYSICAL/CHEMICAL PROPERTIES ASSESSMENT .......................8 1. Product Identity and Mode of Action .....................................8 a. Product Identity: ..................................................8 b. Mode of Action:...................................................8 2. Physical And Chemical Properties Assessment .............................8 B. HUMAN HEALTH ASSESSMENT........................................10 1. Toxicology Assessment ...............................................10 a. Acute Toxicity ...................................................11 -
Foods with an International Flavor a 4-H Food-Nutrition Project Member Guide
Foods with an International Flavor A 4-H Food-Nutrition Project Member Guide How much do you Contents know about the 2 Mexico DATE. lands that have 4 Queso (Cheese Dip) 4 Guacamole (Avocado Dip) given us so 4 ChampurradoOF (Mexican Hot Chocolate) many of our 5 Carne Molida (Beef Filling for Tacos) 5 Tortillas favorite foods 5 Frijoles Refritos (Refried Beans) and customs? 6 Tamale loaf On the following 6 Share a Custom pages you’ll be OUT8 Germany taking a fascinating 10 Warme Kopsalat (Wilted Lettuce Salad) 10 Sauerbraten (German Pot Roast) tour of four coun-IS 11 Kartoffelklösse (Potato Dumplings) tries—Mexico, Germany, 11 Apfeltorte (Apple net) Italy, and Japan—and 12 Share a Custom 12 Pfefferneusse (Pepper Nut Cookies) Scandinavia, sampling their 12 Lebkuchen (Christmas Honey Cookies) foods and sharing their 13 Berliner Kränze (Berlin Wreaths) traditions. 14 Scandinavia With the helpinformation: of neigh- 16 Smorrebrod (Danish Open-faced bors, friends, and relatives of different nationalities, you Sandwiches) 17 Fisk Med Citronsauce (Fish with Lemon can bring each of these lands right into your meeting Sauce) room. Even if people from a specific country are not avail- 18 Share a Custom able, you can learn a great deal from foreign restaurants, 19 Appelsinfromage (Orange Sponge Pudding) books, magazines, newspapers, radio, television, Internet, 19 Brunede Kartofler (Brown Potatoes) travel folders, and films or slides from airlines or your local 19 Rodkal (Pickled Red Cabbage) schools. Authentic music andcurrent decorations are often easy 19 Gronnebonner i Selleri Salat (Green Bean to come by, if youPUBLICATION ask around. Many supermarkets carry a and Celery Salad) wide choice of foreign foods. -
TRP Mediation
molecules Review Remedia Sternutatoria over the Centuries: TRP Mediation Lujain Aloum 1 , Eman Alefishat 1,2,3 , Janah Shaya 4 and Georg A. Petroianu 1,* 1 Department of Pharmacology, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates; [email protected] (L.A.); Eman.alefi[email protected] (E.A.) 2 Center for Biotechnology, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates 3 Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, The University of Jordan, Amman 11941, Jordan 4 Pre-Medicine Bridge Program, College of Medicine and Health Sciences, Khalifa University of Science and Technology, Abu Dhabi 127788, United Arab Emirates; [email protected] * Correspondence: [email protected]; Tel.: +971-50-413-4525 Abstract: Sneezing (sternutatio) is a poorly understood polysynaptic physiologic reflex phenomenon. Sneezing has exerted a strange fascination on humans throughout history, and induced sneezing was widely used by physicians for therapeutic purposes, on the assumption that sneezing eliminates noxious factors from the body, mainly from the head. The present contribution examines the various mixtures used for inducing sneezes (remedia sternutatoria) over the centuries. The majority of the constituents of the sneeze-inducing remedies are modulators of transient receptor potential (TRP) channels. The TRP channel superfamily consists of large heterogeneous groups of channels that play numerous physiological roles such as thermosensation, chemosensation, osmosensation and mechanosensation. Sneezing is associated with the activation of the wasabi receptor, (TRPA1), typical ligand is allyl isothiocyanate and the hot chili pepper receptor, (TRPV1), typical agonist is capsaicin, in the vagal sensory nerve terminals, activated by noxious stimulants. -
Targeting Angiogenesis by Phytochemicals
Arom & at al ic in P l ic a n d t Kadioglu et al., Med Aromat Plants 2013, 2:5 e s M Medicinal & Aromatic Plants DOI: 10.4172/2167-0412.1000134 ISSN: 2167-0412 ResearchReview Article Article OpenOpen Access Access Targeting Angiogenesis By Phytochemicals Onat Kadioglu, Ean Jeong Seo and Thomas Efferth* Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany Abstract Cancer is a major cause of death worldwide and angiogenesis is critical in cancer progression. Development of new blood vessels and nutrition of tumor cells are heavily dependent on angiogenesis. Thus, angiogenesis inhibition might be a promising approach for anticancer therapy. Anti-angiogenic small molecule and phytochemicals as a cancer treatment approach are focused in these main points; modes of action, adverse effects, mechanisms of resistance and new developments. Treatment with anti-angiogenic compounds might be advantageous over conventional chemotherapy due to the fact that those compounds mainly act on endothelial cells, which are genetically more stable and homogenous compared to tumor cells and they show lower susceptibility to acquired drug resistance (ADR). Targeting the VEGF (vascular endothelial growth factor) signalling pathway with synthetic small molecules inhibiting Receptor Tyrosine Kinases (RTKs) in addition to antagonizing VEGF might be a promising approach. Moreover, beneficial effect of phytochemicals were proven on cancer-related pathways especially concerning anti-angiogenesis. Plant phenolics being an important category of prominent phytochemicals affect different pathways of angiogenesis. Green tea polyphenols (epigallocatechin gallate) and soy bean isoflavones (genistein) are two examples involving an anti-angiogenic effect. -
Traditional Indonesian Rempah-Rempah As a Modern Functional Food and Herbal Medicine
Functional Foods in Health and Disease 2019; 9(4): 241-264 Page 241 of 264 Review Article Open Access Traditional Indonesian rempah-rempah as a modern functional food and herbal medicine Muhammad Sasmito Djati and Yuyun Ika Christina Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang 65145, East Java, Indonesia Corresponding author: Prof. Dr. Ir. Muhammad Sasmito Djati, MS., Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang 65145, East Java, Indonesia Submission date: October 19th, 2018, Acceptance Date: April 28th, 2019, Publication Date: April 30th, 2019 Citation: Djati M.S., Christina Y.I. Traditional Indonesian Rempah-rempah as a Modern Functional Food and Herbal Medicine. Functional Foods in Health and Disease 2019; 9(4): 241-264. DOI: https://doi.org/10.31989/ffhd.v9i4.571 ABSTRACT Rempah-rempah are endemic spices from Nusantara (Southeast Asia archipelago) that have been used traditionally as food flavoring for centuries. Traditionally, rempah-rempah has been processed in a variety of ways including boiled, fried, distilled, fermented, extracted, and crushed and mixed fresh with other foods. Foods flavored with rempah-rempah are served daily as beverages, hot drinks, snacks, and crackers. Nowadays, the consumption of synthetic ingredients was increased globally, but rempah-rempah was rarely used in food. In traditional medicine, various parts of rempah-rempah have been used in many countries for the treatment of a number of diseases. Unfortunately, information concerning the human health benefits of rempah-rempah is still limited. Therefore, a detailed ethnomedical, phytochemical review of the correlated chemical compounds of rempah-rempah was performed. This review summarizes the most recent research regarding the phytopharmaceutical actions of rempah-rempah like immunomodulatory, antioxidant, analgesic, digestive, carminative, and antibacterial effects, as well as other physiological effects. -
WE DELIVER a Piece of NATURE FRESH JAPANESE WASABI Agrodirect and Fresh Wasabi Are Inextricably Fresh Linked
WE DELIVER A piece OF NATURE FRESH JAPANESE WASABI AgroDirect and fresh wasabi are inextricably Fresh linked. Regardless of our other offerings, fresh wasabi is our core product, and it’s what we’re about us famous for. The history of wasabi (Wasabia japonica) begins over 1000 years ago in Japan. Wasabi AgroDirect was founded in 2010. CULTIVATION Thomas Bick has a degree in Business Studies and is a The cultivation of high-quality Japanese wasabi SIAL Trade Fair in Paris – Japan Pavilion former banker. He was inspired by friends living in Japan, is a painstaking task which takes place in the and fell in love with the country and Japanese cuisine higher mountain regions of Japan. Fresh spring water with its specific set of nutrients is (washoku). exclusively used for this purpose, and in this way AgroDirect has established itself over the years as a the plant can grow without being exposed to commercial business and importer of first-class and any fertilisers or pesticides. Climatic factors are very exclusive Japanese foods which embody traditional also important for successful cultivation. Japanese cuisine. Growing wasabi requires a great deal of time and We deliver specialties from Japan! effort, and there are several areas where it’s cultivated in Japan. Wasabi from the moun- Our products are cultivated by producers who can lay claim tainous regions of Shizuoka and Nagano is of a to a rich tradition. particularly high quality. We know our suppliers, and carefully nurture relationships We collaborate with the most celebrated growers with the producers and farmers we collaborate with. -
Case Presentations Paprika of Kalocsa – Hungary
SINER-GI project Montpellier Plenary meeting 6 – 7 September 2006 Case presentations Paprika of Kalocsa – Hungary : Liberalisation et europeanisation Allaire G. (INRA), Ansaloni M., Cheyns E. (CIRAD)1 Introduction and Outlines The Paprika case raises two interesting issues. One is the Europeanization of the regulation on geographical indications in Hungary and its relationship with European market integration. Hungary has presented two European PDO applications: “Kalocsa ground paprika” and “Szeged ground paprika” (or Szeged paprika), which are in the process of examination. The other is the transformation of the former socialist system in the context of liberalisation and Europeanization of the Hungarian economy. Both the national regulation and the local situations are in moves. We will present first the product and the market of paprika in general and then address the two issues. We will conclude using the proposed grid for the cases presentations. The Hungarian Paprika 1.1 The product2 Paprika is a red powder made from grinding the dried pods of mild varieties of the pepper plant (Capsicum annuum L.), also referred to as bell peppers. The small, round, red "cherry pepper," is used for producing some of the hotter varieties of paprika3. Paprika powder ranges from bright red to brown. Its flavour ranges from sweet and mild to more pungent and hot, depending on the type of pepper and part of the plant used in processing. Paprika should be considered a semi-perishable product. There are many products made of paprika, pastas, creams, etc., which are also popular. 1 This note was written according to the studies made in the FP5 IDARI project (Integrated Development of Agriculture and Rural Institutions in Central and Eastern European Countries): - “Europeanization and the reality on the ground: Implementation of the European regulation on geographical indications for agricultural products in Hungary: The case of paprika”, by Matthieu Ansaloni (Steering Committee: Allaire G. -
Transient Receptor Potential (TRP) Channels in Haematological Malignancies: an Update
biomolecules Review Transient Receptor Potential (TRP) Channels in Haematological Malignancies: An Update Federica Maggi 1,2 , Maria Beatrice Morelli 2 , Massimo Nabissi 2 , Oliviero Marinelli 2 , Laura Zeppa 2, Cristina Aguzzi 2, Giorgio Santoni 2 and Consuelo Amantini 3,* 1 Department of Molecular Medicine, Sapienza University, 00185 Rome, Italy; [email protected] 2 Immunopathology Laboratory, School of Pharmacy, University of Camerino, 62032 Camerino, Italy; [email protected] (M.B.M.); [email protected] (M.N.); [email protected] (O.M.); [email protected] (L.Z.); [email protected] (C.A.); [email protected] (G.S.) 3 Immunopathology Laboratory, School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy * Correspondence: [email protected]; Tel.: +30-0737403312 Abstract: Transient receptor potential (TRP) channels are improving their importance in differ- ent cancers, becoming suitable as promising candidates for precision medicine. Their important contribution in calcium trafficking inside and outside cells is coming to light from many papers published so far. Encouraging results on the correlation between TRP and overall survival (OS) and progression-free survival (PFS) in cancer patients are available, and there are as many promising data from in vitro studies. For what concerns haematological malignancy, the role of TRPs is still not elucidated, and data regarding TRP channel expression have demonstrated great variability throughout blood cancer so far. Thus, the aim of this review is to highlight the most recent findings Citation: Maggi, F.; Morelli, M.B.; on TRP channels in leukaemia and lymphoma, demonstrating their important contribution in the Nabissi, M.; Marinelli, O.; Zeppa, L.; perspective of personalised therapies. -
Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies KEFAH MOKBEL, UMAR WAZIR and KINAN MOKBEL
ANTICANCER RESEARCH 39 : 5231-5259 (2019) doi:10.21873/anticanres.13720 Review Chemoprevention of Prostate Cancer by Natural Agents: Evidence from Molecular and Epidemiological Studies KEFAH MOKBEL, UMAR WAZIR and KINAN MOKBEL The London Breast Institute, Princess Grace Hospital, London, U.K. Abstract. Background/Aim: Prostate cancer is one of the Prostate cancer is the second cause of cancer death in men most common cancers in men which remains a global public accounting for an estimated 1.28 million deaths in 2018 (1, 2). health issue. Treatment of prostate cancer is becoming The incidence of prostate cancer has been increasing globally increasingly intensive and aggressive, with a corresponding with 1.3 million new cases reported in 2018 (3, 4). Prostate increase in resistance, toxicity and side effects. This has cancer is still considered the most common life-threatening revived an interest in nontoxic and cost-effective preventive malignancy affecting the male population in most European strategies including dietary compounds due to the multiple countries. In the UK, prostate cancer is the most common effects they have been shown to have in various oncogenic cancer among men accounting for 13% of all cancer deaths in signalling pathways, with relatively few significant adverse males. Furthermore, the incidence of prostate cancer in British effects. Materials and Methods: To identify such dietary men has increased by more than two-fifths (44%) since the components and micronutrients and define their prostate early 1990s (5). cancer-specific actions, we systematically reviewed the current Based on clinical stage, histological grade and serum levels literature for the pertinent mechanisms of action and effects of prostate-specific antigen (PSA), current treatment options on the modulation of prostate carcinogenesis, along with for prostate cancer include surgery, radiotherapy and/or relevant updates from epidemiological and clinical studies. -
[6]-Gingerol in Db/Db Mice
International Journal of Medicine and Medical Sciences. Vol. 1(12), pp. 536-544, December, 2009. Available online at http://www.academicjournals.org/ijmms ISSN 2006-9723 ©2009 Academic Journals Full Length Research Paper Anti-hyperglycaemic, lipid lowering and anti-oxidant properties of [6]-gingerol in db/db mice Amar Bahadur Singh1, Akanksha2, Nilendra Singh3, Rakesh Maurya2 and Arvind Kumar Srivastava1* 1Biochemistry Division, Central Drug Research Institute, Lucknow-226001, India. 2Medicinal and Process Chemistry Division, CDRI, Lucknow-226001, India. 3Pharmacology Division CDRI, Lucknow-226001, India. Accepted 3 August, 2009 In the present study, we investigated the blood glucose lowering, lipid lowering and antioxidant effect of [6]- gingerol in type 2 diabetic db/db mice. Treatment of db/db mice with [6]-gingerol (100 mg/kg bw) for 12 days significantly (p<0.05) lowered fasting blood glucose and improved the glucose tolerance in db/db mice. Oral administration of [6]-gingerol also significantly (p < 0.05) decreased plasma triglycerides (TG), total cholesterol (TC), free fatty acid (FFA), low-density lipoprotein cholesterol (LDL-C) and plasma insulin concentration. In addition, [6]-gingerol significantly (p < 0.05) reduces the content of hydrogen peroxide or suppresses the reactive oxygen species (ROS) generation and restores the enzyme activity of catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) in db/db mice. These findings suggest that [6]-gingerol exhibits a significant potential as an anti-hyperglycaemic, lipid lowering and anti- oxidant agent for the treatment of type 2 diabetes. Key words: Antihyperglycaemic, antioxidant, antilipidemic, reactive oxygen species, db/db mice, [6]-gingerol. INTRODUCTION Diabetes mellitus is a chronic metabolic disease which stress, which is believed to be a pathogenetic factor in now afflicts approximately 3% of the world population.