DOCSLIB.ORG

Vitamin D and Cancer

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text

Load more

WORLD HEALTH ORGANIZATION INTERNATIONAL AGENCY FOR RESEARCH ON CANCER Vitamin D and Cancer IARC 2008 WORLD HEALTH ORGANIZATION INTERNATIONAL AGENCY FOR RESEARCH ON CANCER IARC Working Group Reports Volume 5 Vitamin D and Cancer - i - Vitamin D and Cancer Published by the International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372 Lyon Cedex 08, France © International Agency for Research on Cancer, 2008-11-24 Distributed by WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland (tel: +41 22 791 3264; fax: +41 22 791 4857; email: [email protected]) Publications of the World Health Organization enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal Copyright Convention. All rights reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. The mention of specific companies or of certain manufacturer’s products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. The authors alone are responsible for the views expressed in this publication. The International Agency for Research on Cancer welcomes requests for permission to reproduce or translate its publications, in part or in full. Requests for permission to reproduce or translate IARC publications – whether for sale or for noncommercial distribution – should be addressed to WHO Press, at the above address (fax: +41 22 791 4806; email: [email protected]). IARC Library Cataloguing in Publication Data IARC Working Group on Vitamin D Vitamin D and cancer / a report of the IARC Working Group on Vitamin D (IARC Working Group Reports ; 5) 1. Neoplasms – etiology 2. Neoplasms – prevention & control 3. Vitamin D – adverse effects 4. Vitamin D – therapeutic use 5. Risk Factors I. Title II. Series ISBN 978 92 832 2446 4 (NLM Classification: W1) ii Vitamin D and Cancer Working Group Membership International Scientists: Michaël John Barry, Massachusetts General Hospital, Harvard Medical School, USA (chair) Esther De Vries, Erasmus MC, The Netherlands Dallas English, University of Melbourne, Australia Edward Giovannucci, Harvard School of Public Health, USA Bodo Lehmann, Medical School "Carl Gustav Carus, Dresden University of Technology, Germany Henrik Møller, King's College London, School of Medicine, UK (co-chair) Paola Muti, Italian National Cancer Institute "Regina Elena," Italy Eva Negri, Istituto di Ricerche Farmacologiche "Mario Negri," Italy Julian Peto, London School of Hygiene and Tropical Medicine, UK Arthur Schatzkin, National Cancer Institute, Bethesda, USA Lars Vatten, Norwegian University of Science and Technology, Trondheim, Norway Stephen Walter, McMaster University, Hamilton, Canada Secretariat: Philippe Autier, IARC, Lyon, France (Working Group and Report coordinator) Mathieu Boniol, IARC, Lyon, France Graham Byrnes, IARC, Lyon, France Brian Cox, Otago Medical School, University of Otago, New Zealand Geneviève Deharveng, IARC, Lyon, France Jean François Doré, INSERM + IARC, Lyon Sara Gandini, European Institute of Oncology, Milano, Italy Mary Heanue, IARC, Lyon, France Mazda Jenab, IARC, Lyon, France Patrick Mullie, Jules Bordet Institute, Brussels, Belgium Mary Jane Sneyd, Otago Medical School, University of Otago, New Zealand Observer: Tahera Emilie van Deventer, World Health Organization, Geneva, Switerland Editorial assistance provided by: Asiedua Asante Anne-Sophie Hameau Elsa Labrosse Laurence Marnat Correspondence: Philippe Autier, MD, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon. Email: [email protected] Suggested citation:. IARC. Vitamin D and Cancer. IARC Working Group Reports Vol.5, International Agency for research on Cancer, Lyon, 25 November 2008. iii Vitamin D and Cancer iv Vitamin D and Cancer Contents List of chapters: Detailed contents..........................................................................................................................................................vi Terminology and abbreviations...................................................................................................................................x 1 – Summary overview of the report.......................................................................................................................... 1 2 – Objectives and format of the report...................................................................................................................... 3 3 – Sunlight and skin cancer: recall of essential issues........................................................................................... 5 4 – Sources of vitamin D............................................................................................................................................ 10 5 – Toxicity of vitamin D and long term health effects............................................................................................ 21 6 – Current recommendations for vitamin D intakes ............................................................................................. 29 7 – Determinants of vitamin D status ....................................................................................................................... 33 8 – Biological effects of vitamin D relevant to cancer............................................................................................. 52 9 – Ecological studies on sun exposure and cancer ............................................................................................. 59 10 – Observational studies on individual sun exposure and cancer.................................................................... 77 11 – Observational studies on dietary intakes of vitamin D and cancer.............................................................. 83 12 – Observational studies on serum 25-hydroxyvitamin D, cancer and all-cause mortality........................... 92 13 – Meta-analysis of observational studies on vitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma....................................................................................................100 14 – Randomised trials on vitamin D, cancer and mortality................................................................................113 15 – Vitamin D, cancer prognostic factors and cancer survival..........................................................................119 16 – Special topics: non-Hodgkin lymphoma and VDR genetic variants .........................................................122 16 – Special topics: non-Hodgkin lymphoma and VDR genetic variants .........................................................122 17 – Vitamin D and cancer in specific populations or conditions .......................................................................133 18 – Vitamin D: predictor or cause of cancer and of other chronic health conditions?....................................140 19 – Should recommendations for sun protection and vitamin D intakes be changed? ................................143 20 – Further research: a plea for new randomised trials on vitamin D..............................................................145 21 – Overall conclusions of the IARC Working Group on vitamin D and cancer.............................................148 References................................................................................................................................................................149 Annex Latitude of residence in Europe and serum 25-hydroxyvitamin D levels: a systematic review 201 v Vitamin D and Cancer Detailed contents 1 – Summary overview of the report............................................................................................................................... 1 2 – Objectives and format of the report .......................................................................................................................... 3 2.1 Background........................................................................................................................................ 3 2.2 Objectives of the report...................................................................................................................... 4 2.3 Format of the report........................................................................................................................... 4 2.4 Overview of the methodology used.................................................................................................... 4 3 – Sunlight and skin cancer: recall of essential issues ................................................................................................. 5 3.1 The skin cancer burden ..................................................................................................................... 5 3.2 Wavelengths of solar radiation relevant to skin cancer......................................................................5 3.3 Action spectra for sunburn, skin cancer and vitamin D synthesis.....................................................
Recommended publications
  • Loss of the NKX3.1 Tumorsuppressor Promotes the TMPRSS2-ERG

    Loss of the NKX3.1 Tumorsuppressor Promotes the TMPRSS2-ERG

    Thangapazham et al. BMC Cancer 2014, 14:16 http://www.biomedcentral.com/1471-2407/14/16 RESEARCH ARTICLE Open Access Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer Rajesh Thangapazham, Francisco Saenz, Shilpa Katta, Ahmed A Mohamed, Shyh-Han Tan, Gyorgy Petrovics, Shiv Srivastava and Albert Dobi* Abstract Background: In normal prostate epithelium the TMPRSS2 gene encoding a type II serine protease is directly regulated by male hormones through the androgen receptor. In prostate cancer ERG protooncogene frequently gains hormonal control by seizing gene regulatory elements of TMPRSS2 through genomic fusion events. Although, the androgenic activation of TMPRSS2 gene has been established, little is known about other elements that may interact with TMPRSS2 promoter sequences to modulate ERG expression in TMPRSS2-ERG gene fusion context. Methods: Comparative genomic analyses of the TMPRSS2 promoter upstream sequences and pathway analyses were performed by the Genomatix Software. NKX3.1 and ERG genes expressions were evaluated by immunoblot or by quantitative Real-Time PCR (qRT-PCR) assays in response to siRNA knockdown or heterologous expression. QRT-PCR assay was used for monitoring the gene expression levels of NKX3.1-regulated genes. Transcriptional regulatory function of NKX3.1 was assessed by luciferase assay. Recruitment of NKX3.1 to its cognate elements was monitored by Chromatin Immunoprecipitation assay. Results: Comparative analysis of the TMPRSS2 promoter upstream sequences among different species revealed the conservation of binding sites for the androgen inducible NKX3.1 tumor suppressor. Defects of NKX3.1, such as, allelic loss, haploinsufficiency, attenuated expression or decreased protein stability represent established pathways in prostate tumorigenesis.
  • Large-Area Coating of Previtamin D3 Based on Roll-To-Roll Processing

    Large-Area Coating of Previtamin D3 Based on Roll-To-Roll Processing

    coatings Article Large-Area Coating of Previtamin D3 Based on Roll-to-Roll Processing 1, 1, 1 1 1 Janghoon Park y, Yoonki Min y, Jongsu Lee , Hakyung Jeong , Youngwook Noh , Kee-Hyun Shin 2 and Dongjin Lee 2,* 1 Department of Mechanical Design and Production Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea; [email protected] (J.P.); [email protected] (Y.M.); [email protected] (J.L.); [email protected] (H.J.); [email protected] (Y.N.) 2 School of Mechanical Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea; [email protected] * Correspondence: [email protected]; Tel.: +82-2-450-0452 These authors contributed equally to this work. y Received: 22 August 2019; Accepted: 9 September 2019; Published: 11 September 2019 Abstract: We propose a roll-to-roll process for vitamin D3 patch production. A solution of 7-dehydrocholesterol is applied to a plastic film by roll-to-roll slot-die coating and dried by a far-infrared lamp. Upon exposure to ultraviolet B irradiation, these films are converted to previtamin D3 films. After heat-treating the previtamin D3 film, high-performance liquid chromatography measurements are performed using commercial vitamin D3 as a standard sample. The results confirm that vitamin D3 can be produced by large-area coating and post-treatment processes. Specifically, 3.16 0.746 mg of vitamin D is obtained through ultraviolet B irradiation and heat-treatment of ± 3 24.8 1.44 mg of coated 7-dehydrocholesterol. ± Keywords: slot-die coating; roll-to-roll (R2R); vitamin D3; ultraviolet B (UVB); high-performance liquid chromatography (HPLC) 1.
  • Additive Effects of Micrornas and Transcription Factors on CCL2 Production in Human White Adipose Tissue

    Additive Effects of Micrornas and Transcription Factors on CCL2 Production in Human White Adipose Tissue

    1248 Diabetes Volume 63, April 2014 Agné Kulyté,1 Yasmina Belarbi,1 Silvia Lorente-Cebrián,1 Clara Bambace,1 Erik Arner,1,2 Carsten O. Daub,3 Per Hedén,4 Mikael Rydén,1 Niklas Mejhert,1 and Peter Arner1 Additive Effects of MicroRNAs and Transcription Factors on CCL2 Production in Human White Adipose Tissue Adipose tissue inflammation is present in insulin- converged on the nuclear factor-kB pathway. In resistant conditions. We recently proposed conclusion, TF and miRNA-mediated regulation of a network of microRNAs (miRNAs) and transcription CCL2 production is additive and partly relayed by factors (TFs) regulating the production of the cell-specific networks in human adipose tissue that proinflammatory chemokine (C-C motif) ligand-2 may be important for the development of insulin (CCL2) in adipose tissue. We presently extended and resistance/type 2 diabetes. further validated this network and investigated if the Diabetes 2014;63:1248–1258 | DOI: 10.2337/db13-0702 METABOLISM circuits controlling CCL2 can interact in human adipocytes and macrophages. The updated subnetwork predicted that miR-126/-193b/-92a White adipose tissue (WAT) function plays an important control CCL2 production by several TFs, including role in the development of insulin resistance/type 2 di- v-ets erythroblastosis virus E26 oncogene homolog 1 abetes. Fat cells present in WAT secrete a number of (avian) (ETS1), MYC-associated factor X (MAX), molecules, collectively termed adipokines, which affect and specificity protein 12 (SP1). This was confirmed insulin sensitivity by autocrine and/or paracrine mecha- in human adipocytes by the observation that gene nisms (1,2). In insulin-resistant obese subjects, WAT silencing of ETS1, MAX, or SP1 attenuated CCL2 displays a chronic low-grade inflammation, which is production.
  • Daily Lifestyle Modifications to Improve Quality of Life And

    Daily Lifestyle Modifications to Improve Quality of Life And

    brain sciences Review Daily Lifestyle Modifications to Improve Quality of Life and Survival in Glioblastoma: A Review Sarah Travers and N. Scott Litofsky * Division of Neurosurgery, University of Missouri School of Medicine, Columbia, MO 65212, USA; [email protected] * Correspondence: [email protected] Abstract: Survival in glioblastoma remains poor despite advancements in standard-of-care treatment. Some patients wish to take a more active role in their cancer treatment by adopting daily lifestyle changes to improve their quality of life or overall survival. We review the available literature through PubMed and Google Scholar to identify laboratory animal studies, human studies, and ongoing clinical trials. We discuss which health habits patients adopt and which have the most promise in glioblastoma. While results of clinical trials available on these topics are limited, dietary restrictions, exercise, use of supplements and cannabis, and smoking cessation all show some benefit in the comprehensive treatment of glioblastoma. Marital status also has an impact on survival. Further clinical trials combining standard treatments with lifestyle modifications are necessary to quantify their survival advantages. Keywords: survival in glioblastoma; dietary restriction in glioblastoma; cannabis use in glioblastoma; supplementation in glioblastoma; glioblastoma health modifications Citation: Travers, S.; Litofsky, N.S. Daily Lifestyle Modifications to 1. Introduction Improve Quality of Life and Survival Glioblastoma remains the most aggressive and deadly form of primary brain tumor, in Glioblastoma: A Review. Brain Sci. with average survival rates ranging from 7.8 to 23.4 months after diagnosis [1]. Maximal 2021, 11, 533. https://doi.org/ surgical resection followed by radiation and temozolomide have become standard of 10.3390/brainsci11050533 care [2,3].
  • Method Development and Validation of Vitamin D2 and Vitamin D3 Using Mass Spectrometry

    Method Development and Validation of Vitamin D2 and Vitamin D3 Using Mass Spectrometry

    Method Development and Validation of Vitamin D2 and Vitamin D3 Using Mass Spectrometry Devon Victoria Riley A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science University of Washington 2016 Committee: Andrew Hoofnagle Geoffrey Baird Dina Greene Program Authorized to Offer Degree: Laboratory Medicine ©Copyright 2016 Devon V. Riley ii University of Washington Abstract Method Development and Validation of Vitamin D2 and Vitamin D3 Using Mass Spectrometry Devon V. Riley Chair of the Supervisory Committee: Associate Professor Andrew Hoofnagle, MD, PhD Vitamin D has long been known to maintain bone health by regulating calcium and phosphorous homeostasis. In recent years, scientists have discovered additional physiological roles for vitamin D. The complex interaction between the active vitamin D hormone and its metabolic precursors continues to be a rich area of research. Fundamental to this research is the availability of accurate and precise assays. Few published assays for vitamins D2 and D3 have contained sufficient details on method validation or performance characteristics. The liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay developed for this thesis has undergone a rigorous validation and proven to yield a sensitive and specific method that exceeds the capabilities of all previously published methods. Developing and validating a novel assay is often complicated by the lack of established acceptability standards. This thesis explores this challenge, specifically for establishing meaningful interpretations and qualification standards of the lower limit of the measuring interval. Altogether, future research focused on vitamins D2, D3 and the Vitamin D pathway can benefit from this robust LC-MS/MS assay and the associated quality parameters outlined in this thesis.
  • Abstract Mahapatra, Debabrata

    Abstract Mahapatra, Debabrata

    ABSTRACT MAHAPATRA, DEBABRATA. Vitamin D Receptor and Xenobiotic Interactions: Insights into the diversity and complexity of molecular interactions and their outcomes (Under the direction of Seth W. Kullman). The etiology of a significant number of human diseases including hypertension, cardiovascular disease, diabetes, obesity and cancer are in part associated with exposures to environmental contaminants. Recent trends in toxicological research indicate a growing interest in chemicals capable of disrupting the endocrine system. These chemicals comprise a range of natural and synthetic molecules that interact with nuclear hormone receptors altering signaling pathways regulating adverse effects in multiple organ systems, tissue and cell types. While the interaction of endocrine disrupting xenobiotics with nuclear receptors such as the Estrogen receptor (ER), Thyroid receptor (TR), Glucocorticoid receptor (GR) and Androgen receptor (AR) has been studied in detail, similar research involving xenobiotic interactions with the Vitamin D receptor (VDR) has remained underexplored. This dissertation examines the role of vitamin d receptor as a potential target of xenobiotic induced endocrine disruption and provides new insights into the possible mechanisms underlying the complex molecular interactions between VDR and select VDR agonists and antagonists. Chapter 1 tests the usefulness and importance of orthogonal assays for validation and confirmation of activity profiles of chemicals generated by the qHTS (Quantitative Highthroughput Testing)
  • Report Legal Research Assistance That Can Make a Builds

    Report Legal Research Assistance That Can Make a Builds

    EUROPEAN DIGITAL RIGHTS A LEGAL ANALYSIS OF BIOMETRIC MASS SURVEILLANCE PRACTICES IN GERMANY, THE NETHERLANDS, AND POLAND By Luca Montag, Rory Mcleod, Lara De Mets, Meghan Gauld, Fraser Rodger, and Mateusz Pełka EDRi - EUROPEAN DIGITAL RIGHTS 2 INDEX About the Edinburgh 1.4.5 ‘Biometric-Ready’ International Justice Cameras 38 Initiative (EIJI) 5 1.4.5.1 The right to dignity 38 Introductory Note 6 1.4.5.2 Structural List of Abbreviations 9 Discrimination 39 1.4.5.3 Proportionality 40 Key Terms 10 2. Fingerprints on Personal Foreword from European Identity Cards 42 Digital Rights (EDRi) 12 2.1 Analysis 43 Introduction to Germany 2.1.1 Human rights country study from EDRi 15 concerns 43 Germany 17 2.1.2 Consent 44 1 Facial Recognition 19 2.1.3 Access Extension 44 1.1 Local Government 19 3. Online Age and Identity 1.1.1 Case Study – ‘Verification’ 46 Cologne 20 3.1 Analysis 47 1.2 Federal Government 22 4. COVID-19 Responses 49 1.3 Biometric Technology 4.1 Analysis 50 Providers in Germany 23 4.2 The Convenience 1.3.1 Hardware 23 of Control 51 1.3.2 Software 25 5. Conclusion 53 1.4 Legal Analysis 31 Introduction to the Netherlands 1.4.1 German Law 31 country study from EDRi 55 1.4.1.1 Scope 31 The Netherlands 57 1.4.1.2 Necessity 33 1. Deployments by Public 1.4.2 EU Law 34 Entities 60 1.4.3 European 1.1. Dutch police and law Convention on enforcement authorities 61 Human Rights 37 1.1.1 CATCH Facial 1.4.4 International Recognition Human Rights Law 37 Surveillance Technology 61 1.1.1.1 CATCH - Legal Analysis 64 EDRi - EUROPEAN DIGITAL RIGHTS 3 1.1.2.
  • Acne Vulgaris and Intake of Selected Dietary Nutrients—A Summary of Information

    Acne Vulgaris and Intake of Selected Dietary Nutrients—A Summary of Information

    healthcare Review Acne Vulgaris and Intake of Selected Dietary Nutrients—A Summary of Information Aleksandra Podgórska †, Anna Pu´scion-Jakubik*,† , Renata Markiewicz-Zukowska˙ , Krystyna Joanna Gromkowska-K˛epkaand Katarzyna Socha Department of Bromatology, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, Mickiewicza 2D Street, 15-222 Białystok, Poland; [email protected] (A.P.); [email protected] (R.M.-Z.);˙ [email protected] (K.J.G.-K.); [email protected] (K.S.) * Correspondence: [email protected]; Tel.: +48-8574-854-69 † Contributed equally. Abstract: Acne vulgaris (AV) is a chronic disease that affects a significant percentage of the world’s population. Its development is influenced by both external and internal factors. The purpose of this review is to demonstrate the effect of basic nutrient intake on the exacerbation or alleviation of AV lesions. A retrospective review of publications in PubMed regarding diet therapy and the impact of individual nutrient intake on the skin condition of patients was conducted. Ingestion of products with a high glycaemic index may indirectly lead to sebum overproduction, which promotes infection with Cutibacterium acnes and causes inflammation. Consumption of certain dairy products may result Citation: Podgórska, A.; in skin deterioration caused by the presence of hormones in these products, i.e., progesterone and Pu´scion-Jakubik,A.; testosterone precursors. The beneficial effect of fatty acids on the skin is manifested by the reduction Markiewicz-Zukowska,˙ R.; Gromkowska-K˛epka,K.J.; Socha, K. in inflammation. Of significance in AV treatment are vitamins A, C, D, E and B, as well as mineral Acne Vulgaris and Intake of Selected elements zinc and selenium.
  • Far Infrared Radiation Exposure

    Far Infrared Radiation Exposure

    INTERNATIONAL COMMISSION ON NON‐IONIZING RADIATION PROTECTION ICNIRP STATEMENT ON FAR INFRARED RADIATION EXPOSURE PUBLISHED IN: HEALTH PHYSICS 91(6):630‐645; 2006 ICNIRP PUBLICATION – 2006 ICNIRP Statement ICNIRP STATEMENT ON FAR INFRARED RADIATION EXPOSURE The International Commission on Non-Ionizing Radiation Protection* INTRODUCTION the health hazards associated with these hot environ- ments. Heat strain and discomfort (thermal pain) nor- THE INTERNATIONAL Commission on Non Ionizing Radia- mally limit skin exposure to infrared radiation levels tion Protection (ICNIRP) currently provides guidelines below the threshold for skin-thermal injury, and this is to limit human exposure to intense, broadband infrared particularly true for sources that emit largely IR-C. radiation (ICNIRP 1997). The guidelines that pertained Furthermore, limits for lengthy infrared exposures would to infrared radiation (IR) were developed initially with an have to consider ambient temperatures. For example, an aim to provide guidance for protecting against hazards infrared irradiance of 1 kW mϪ2 (100 mW cmϪ2)atan from high-intensity artificial sources and to protect work- ambient temperature of 5°C can be comfortably warm- ers in hot industries. Detailed guidance for exposure to ing, but at an ambient temperature of 30°C this irradiance longer far-infrared wavelengths (referred to as IR-C would be painful and produce severe heat strain. There- radiation) was not provided because the energy at longer fore, ICNIRP provided guidelines to limit skin exposure wavelengths from most lamps and industrial infrared to pulsed sources and very brief exposures where thermal sources of concern actually contribute only a small injury could take place faster than the pain response time fraction of the total radiant heat energy and did not and where environmental temperature and the irradiated require measurement.
  • Annual Policy Report 2008

    Annual Policy Report 2008

    Annual Policy Report 2008 produced by the European Migration Network March 2011 The purpose of EMN Annual Policy Reports is to provide an overview into the most significant political and legislative (including EU) developments, as well as public debates, in the area of asylum and migration, with the focus on third-country nationals rather than EU nationals. This EMN Synthesis Report summarises the main findings of National Reports produced by twenty-three of the EMN National Contact Points (EMN NCPs) from Austria, Belgium, Czech Republic, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Poland, Portugal, Slovak Republic, Slovenia, Spain, Sweden and the United Kingdom. The EMN Synthesis Report, as well as the twenty-three National Reports upon which the synthesis is based, may be downloaded from http://emn.intrasoft- intl.com/Downloads/prepareShowFiles.do;?entryTitle=02. Annual Policy Report 2008 Several of the National Reports are also available in the Member States‟ national language, as well as in English. EMN Synthesis Report – Annual Policy Report 2008 CONTENTS 1. INTRODUCTION .......................................................................................................... 7 1.1 Methodology followed ........................................................................................ 7 2. POLITICAL AND INSTITUTIONAL DEVELOPMENTS ........................................ 9 2.1 General political developments ...........................................................................
  • Vitamin D and Its Analogues Decrease Amyloid- (A) Formation

    Vitamin D and Its Analogues Decrease Amyloid- (A) Formation

    International Journal of Molecular Sciences Article Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation Marcus O. W. Grimm 1,2,3,*,† ID , Andrea Thiel 1,† ID , Anna A. Lauer 1 ID , Jakob Winkler 1, Johannes Lehmann 1,4, Liesa Regner 1, Christopher Nelke 1, Daniel Janitschke 1,Céline Benoist 1, Olga Streidenberger 1, Hannah Stötzel 1, Kristina Endres 5, Christian Herr 6 ID , Christoph Beisswenger 6, Heike S. Grimm 1 ID , Robert Bals 6, Frank Lammert 4 and Tobias Hartmann 1,2,3 1 Experimental Neurology, Saarland University, Kirrberger Str. 1, 66421 Homburg/Saar, Germany; [email protected] (A.T.); [email protected] (A.A.L.); [email protected] (J.W.); [email protected] (J.L.); [email protected] (L.R.); [email protected] (C.N.); [email protected] (D.J.); [email protected] (C.B.); [email protected] (O.S.); [email protected] (H.S.); [email protected] (H.S.G.); [email protected] (T.H.) 2 Neurodegeneration and Neurobiology, Saarland University, Kirrberger Str. 1, 66421 Homburg/Saar, Germany 3 Deutsches Institut für DemenzPrävention (DIDP), Saarland University, Kirrberger Str. 1, 66421 Homburg/Saar, Germany 4 Department of Internal Medicine II–Gastroenterology, Saarland University Hospital, Saarland University, Kirrberger Str. 100, 66421 Homburg/Saar, Germany; [email protected] 5 Department of Psychiatry and Psychotherapy, Clinical Research Group, University Medical Centre Johannes Gutenberg, University of Mainz, Untere Zahlbacher Str. 8, 55131 Mainz, Germany; [email protected] 6 Department of Internal Medicine V–Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital, Kirrberger Str.
  • Eldecalcitol Is More Effective for Promoting Osteogenesis Than Alfacalcidol in Cyp27b1-Knockout Mice

    Eldecalcitol Is More Effective for Promoting Osteogenesis Than Alfacalcidol in Cyp27b1-Knockout Mice

    bioRxiv preprint doi: https://doi.org/10.1101/349837; this version posted June 18, 2018. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. Eldecalcitol is more effective for promoting osteogenesis than alfacalcidol in Cyp27b1-knockout Mice Short title: Osteogenic effect of eldecalcitol Yoshihisa Hirota1,2*¶, Kimie Nakagawa2¶, Keigo Isomoto2¶, Toshiyuki Sakaki3, Noboru Kubodera4, Maya Kamao2, Naomi Osakabe5, Yoshitomo Suhara6, Toshio Okano2* 1 Laboratory of Biochemistry, Department of Bioscience and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama 337-8570, Japan 2 Laboratory of Hygienic Sciences, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan 3 Department of Pharmaceutical Engineering, Faculty of Engineering, Toyama Prefectural University, Kurokawa, Imizu, Toyama 939-0398, Japan 4 International Institute of Active Vitamin D Analogs, 35-6, Sankeidai, Mishima, Shizuoka 411-0017, Japan 5 Food and Nutrition Laboratory, Department of Bioscience and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama 337-8570, Japan 6 Laboratory of Organic Synthesis and Medicinal Chemistry, Department of Bioscience and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology, 307 Fukasaku, Minuma-ku, Saitama 337-8570, Japan ¶ These authors contributed equally to this work. * Corresponding authors: Yoshihisa Hirota Tel.: +81-48-7201-6037; Fax: +81-48-7201-6011; E-mail: hirotay@ shibaura-it.ac.jp Toshio Okano Tel.: (81) 78-441-7524; Fax: (81) 78-441-7524; E-mail: [email protected] 1 bioRxiv preprint doi: https://doi.org/10.1101/349837; this version posted June 18, 2018.