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791 Index a – – pyridyldiimine-ligated Fe and Co complexes acceptor materials molecular design and 540–542 engineering 662 alkynylindoles 740 – fullerene-based acceptors 662–669 allenoates and electron-deficient alkenes, – non-fullerene-based acceptors 669–671 phosphine-catalyzed reaction mechanisms of acenes 760–761 574–577 Actinomycetales 157 Alstonia actinophylla 54 actinomycete bacteria 166 Alzheimer’s disease 785 actinophyllic acid 54–56 amides formation 506–508 Actinotalea fermentans 155 amination and halogenation, asymmetric acylimine and acyliminium ions 747 351–352 acyl transfer method 230 2-amino-2-deoxyglycosides 188 aerobic oxidation mechanistic study anion–π-interactions 529–530 – mechanistic characterization anomeric/gauche effect 414 – – kinetic investigations 629–634 anthradithiophene (ADT) 762 – recent progress 627–629 aplykurodinone-1 60–62 agelagalastatin 184 aqueous ascorbate procedure 253 agostic interaction 290 Arixtra (fondaparinux) 196 Agrobacterium sp. 194 aromatic hydrazide and amide oligomers aldol reaction 367–371 487–497 alkane metathesis 284 alkene polymerization, cooperative catalysis in Arthrobacter protophormiae 205 393–394 arylamide oligomers alkene polymerization, novel catalysis for – flexible 492 537–538 – modified 494–497 – early transition metal complexes 544 arylazides 111 – – chelating bis(phenoxy)-ligated group 4 metal aryl dienyl ketones Nazarov cyclization complexes 549–551 mechanism 580–583 – – phenoxyimine-ligated group 4 metal ascorbate 252 complexes 544–549 Aspergillus fumigatus 46 – – pyridylamine-ligated Hf complexes aspidophytine 43 551–553 aspirin 714 – late transition metal complexes 538 asymmetric allylic alkylation (AAA) 344–345, – – diimine-ligated Ni and Pd complexes 346 538–540 asymmetric anti-Mannich reactions 588–590 – – phenoxyimine-ligated Ni complexes asymmetric organocatalysis 378, 379 542–544 – early status of 377–378 Organic Chemistry – Breakthroughs and Perspectives, First Edition. Edited by Kuiling Ding and Li-Xin Dai. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2012 by Wiley-VCH Verlag GmbH & Co. KGaA.

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Synthesis of Indole and Oxindole Derivatives Incorporating Pyrrolidino, Pyrrolo Or Imidazolo Moieties
From DEPARTMENT OF BIOSCIENCES AT NOVUM Karolinska Institutet, Stockholm, Sweden SYNTHESIS OF INDOLE AND OXINDOLE DERIVATIVES INCORPORATING PYRROLIDINO, PYRROLO OR IMIDAZOLO MOIETIES Stanley Rehn Stockholm 2004 All previously published papers have been reproduced with permission from the publishers. Published and printed by Karolinska University Press Box 200, SE-171 77 Stockholm, Sweden © Stanley Rehn, 2004 ISBN 91-7140-169-5 Till Amanda Abstract The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties. Pyrrolidino-2-spiro-3’-oxindole derivatives have been prepared in high yielding three-component reactions between isatin, α-amino acid derivatives, and suitable dipolarophiles. Condensation between isatin and an α-amino acid yielded a cyclic intermediate, an oxazolidinone, which decarboxylate to give a 1,3-dipolar species, an azomethine ylide, which have been reacted with several dipolarophiles such as N- benzylmaleimide and methyl acrylate. Both N-substituted and N-unsubstituted α- amino acids have been used as the amine component. 3-Methyleneoxindole acetic acid ethyl ester was reacted with p- toluenesulfonylmethyl isocyanide (TosMIC) under basic conditions which gave (in a high yield) a colourless product. Two possible structures could be deduced from the analytical data, a pyrroloquinolone and an isomeric ß-carboline. To clarify which one of the alternatives that was actually formed from the TosMIC reaction both the ß- carboline and the pyrroloquinolone were synthesised. The ß-carboline was obtained when 3-ethoxycarbonylmethyl-1H-indole-2-carboxylic acid ethyl ester was treated with a tosylimine. An alternative synthesis of the pyrroloquinolone was performed via a reduction of a 2,3,4-trisubstituted pyrrole obtained in turn by treatment of a vinyl sulfone with ethyl isocyanoacetate under basic conditions.
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Highly Efficient Endo'- Selective Synthesis of (Dispiro 3,2
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IV. the Synthesis of (±)-Horsfiline
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