Nephrology Clinical Laboratory Research Compendium

The Nephrology Clinical Laboratory at Cincinnati Children’s Hospital Medical Center has expanded its clinical testing menu to now offer testing on a research basis. The CAP and CLIA certified laboratory operates under Good Clinical Laboratory Practice principles to ensure testing can be used to support findings of clinical trials.

CONTACT US Our state of the art laboratory offers a broad testing menu to support research and pharmaceutical projects. We have the capability to perform traditional For more information on research or ELISA’S, multiplexing using the MSD Meso discovery, luminex magnetic bead clinical testing, please contact us at: assays, nephelometry and clinical chemistry. Phone: 513-636-4530 [email protected] The Nephrology Clinical Laboratory Research Compendium offers clinical chemistry, therapeutic drug monitoring, immunology, complement quantitation, www.cincinnatichildrens.org function and activation, specialty proteins and testing for various forms of thrombotic microangiopathies.

COMPLEMENT SPECIALTY TESTING Autoantibody Testing Complement Components • Factor H Autoantibody (Quantitative) • C3 Nephritic Factor • C1 inhibitor (quantitative) • Factor B Autoantibody • C1q • C2 Functional Testing • C3 • CH50 • C4 • Alternative Pathway Functional Assay • C5 • MBL Pathway Functional Assay • C6 • C1 inhibitor Functional Assay • C7 • C8 Complement Activation Fragments • C9 • Complement Bb • Factor B • Complement Ba • Factor H • • Factor I • C3c • • C3d • C4 Binding Protein • • MBL • C4d • iC3b • SC5b-9 SERUM PROTEINS (NEPHELOMETRY) • ADNase B • CDT (Carbohydrate • Prealbumin • β2- • Deficient ) • RBP (Retinol Binding Protein) • β2-Microglobulin urine • Albumin Urine • • sTfR (Soluble Transferrin • β trace protein • ASO • Ferritin Receptor) • Ig/light chain, type kappa • Cystatin C • Fibrinogen • Transferrin (for %CDT • Ig/light chain, type lambda • • calculation) • Ig/light chain, type kappa • High Sensitivity CRP • • Transferrin urine (CardioPhase® hsCRP) • Homocysteine • Transferrin urine • Ig/light chain, type lambda • α1-Antitrypsin • Lipoprotein(a) • α1-Acid urine • AT-III • Myoglobin • α1-Microglobulin urine • Plasminogen • α2-

TTP TDM IMMUNOLOGY • ADAMTS13 Activity • Eculizumab Level • PLA2R Autoantibody • IgM • COVID19 IgG Titer • ADAMTS13 • Cyclosporine Level (CsA C0) • IgG • IgM CSF • COVID19 IgG • ADAMTS13 Inhibitor • Cyclosporine Level (CsA C2) • IgG CSF • IgA • COVID19 IgA • Sirolimus Level • IgG urine • IgE • COVID19 IgM • Tacrolimus Level • IgG subclasses 1-4 • Rheumatoid factor • Mycophenolic Acid (MPAT)

BIOMARKERS • Endothelin-1 • Glucose • Angiotensin 1-9 • Neutrophil Gelatinase-Associated • Microalbumin • Angiotensin I Lipocalin (NGAL) • Vascular Endothelial Growth Factor • Angiotensin II • Kidney Injury Molecule-1 (KIM-1) (VEGF) • Anigiopoitien I • Creatinine • Intracellular Adhesion Molecule 1 • Anigiopoitien I • Macrophage Chemoattractant (CD54) • Angiotensin converting enzyme-1 Protein-1 (MCP-1) • Vascular Cell Adhesion Molecule 1 (ACE 1) • Liver Fatty Acid Binding Protein (CD106) • Angiotensin converting enzyme-2 (LFABP) • Fibroblast Growth Factor 23 (FGF23) (ACE 2) • Transforming Growth Factor-beta 1 • Matrix Metalloproteinase 9 (MMP9) • ACE activity (TGFβ-1) • N-acetyl Glucosaminidase (NAG) • Von Willebrand Factor protein VFW • Uromodulin (Tamm-Horsfall protein) • Renin • Plasminogen activator inhibitor-1 (PAI-1) • Alpha-1 antitrypsin • Aldosterone • Tissue plasminogen activator (T-PA) • Alpha-1 acid glycoprotein • Adiponectin • Cytokeratin 18 (M65) (M30) () • Interluekin 6 IL-6 • Human CD163 • Hepcidin-25 • Interluekin 18 IL-18 • Human anti-endothelial cell antibody • Troponin T • MCP1 AECA • Vitamin D binding protein • Matrix Metalloproteinase 7 (MMP7) • Adiponectin • Angiotensin 1-7

The above list is not a comprehensive list of biomarkers. Please contact us for special projects and specific testing needs.

Call for sample processing and shipping instructions at 513-636-4530.

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