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Adenosquamous Carcinoma of the Pancreas: a Case Report

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Adenosquamous Carcinoma of the Pancreas: a Case Report Medical Research Archives 2015 Issue 3 ADENOSQUAMOUS CARCINOMA OF THE PANCREAS: A CASE REPORT Keisha Brooks, MS, CT(ASCP)MB University of Tennessee Health Science Center [email protected] David W. Mensi, BS, SCT(ASCP) Trumbull Laboratory [email protected] There are no institutional, personal, or financial conflicts of interest associated with this submission. Abstract: Adenosquamous carcinoma of the pancreas is a rare and aggressive variant of ductal adenocarcinoma which presents both glandular and squamous morphologic features. A cytologic diagnosis of adenosquamous carcinoma on fine needle aspirate preparations is dependent on the identification of both malignant glandular and squamous components. Diagnosis of the malignancy is not particularly difficult if both glandular and squamous components are abundant; however, diagnostic challenges may occur when there is scant cellularity of one of the components, or if one of the components is absent. Because a primary squamous carcinoma of the pancreas is non-existent, a careful search and identification of glandular malignant cells is essential in cases that are squamous dominant. In this report a case of adenosquamous carcinoma is presented in which a fine needle aspirate was performed. The cytologic and histologic features are described. The cytology findings showed a two cell population of malignant squamous and glandular cells. The histologic findings also showed both glandular and squamous malignant cells, thus confirming the diagnosis of adenosquamous carcinoma. Keywords: Pancreas, Adenosquamous Carcinoma, Mucoepidermoid Carcinoma, Andenoacanthoma Copyright © 2015, Knowledge Enterprises Incorporated. All rights reserved. 1 Medical Research Archives 2015 Issue 3 1. CASE REPORT 2. CYTOLOGIC FINDINGS The patient is a 41 year old African The FNA produced a cellular American male with no family history of specimen consisting of a two cell pancreatic cancer. The patient has a history population of both glandular squamous of hypertension and obesity, but denied malignant cells. The malignant glandular any history of smoking or alcohol use. cells are composed of crowded and Clinical symptoms include jaundice, disorganized nuclei in which prominent nausea, and dark colored urine. A 100 anisonucleosis is present (Figure 1). The pound weight loss was also reported in the nuclei have irregular nuclear membranes initial diagnosis. and bland evenly distributed chromatin. A fine needle aspirate of the Prominent nucleoli were also observed, pancreas was performed, in which 30 mL and hyperchromasia was minimal. The of reddish fluid and multiple string-like cytoplasm had a foamy and vacuolated tissue fragments were collected and placed consistency, which is characteristic of in Cytolyte solution. One Thin Prep glandular cells. Figures 2 and 3 show preparation was prepared along with one malignant squamous cells, with cell block preparation. The results of the hyperchromatic nuclei and coarse pre-operative fine needle aspirate were chromatin. In comparison to the cytoplasm suggestive of adenosquamous carcinoma. of glandular cells, the malignant squamous A CT scan showed the location of cells have cytoplasm that is absent of the tumor in the head of the pancreas. It vacuolization, and is denser in appearance. was identified as large, approximately 7 cm, invading the duodenum and in close 3. HISTOLOGIC FINDINGS proximity to the portal vein. There was extensive perineural invasion. The tumor The gallbladder specimen showed also directly invaded into the pyloric moderately severe chronic cholecystitis antrum. A 12-hour and patchy moderate cholesterolosis, with pancreaticoduodenectomy was performed. no evidence of malignancy identified. The patient recovered from surgery and Histologic findings from the pancreas started adjuvant chemotherapy, but a revealed moderately differentiated repeat CT scan showed diffuse liver adenosuqmous carcinoma of the pancreas metastasis. The patient then began to 7 cm in size, involving most of the receive palliate chemotherapy with pancreatic head and uncinate process. The cisplatin and gemcitabine. The patient was tumor produced a large elongated 10x4 cm later switched to folfirinox due to the lack duodenal ulcer that extended into the of response to the previous chemotherapy pyloric antrum, just above the ampulla of treatments. Vater, which represented extrapancreatic The pancreaticoduodenectomy direct invasion. The ampulla of Vater was produced several specimens for pathologic intruded by a pushing margin of the tumor, diagnosis. The following histologic but did not show invasion into the mucosa. specimens were submitted: 1) Gallbladder, Four of twenty-six peripancreatic lymph 2) Pancreas, and 3) Duodenum. nodes were positive for malignancy. Two perigastric lymphnodes were negative for Copyright © 2015, Knowledge Enterprises Incorporated. All rights reserved. 2 Medical Research Archives 2015 Issue 3 metastasis. The gastric antrum showed 5. DISCUSSION moderately severe active chronic atrophic gastritis, but no evidence of metastasis. Adenosquamous carcinoma, also The histology figures presented in known as mucoepidermoid carcinoma and this case report are of the pancreas tissue adenoacanthoma is a rare variant of ductal specimen. Figure 4 shows the presence of adenocarcinoma of the pancreas 1,2. It malignant glands that are in close accounts for 1-4% of all exocrine proximity of one another. The cells in the pancreatic malignancies3,4,5. Due to its rare glands are columnar in shape with incidence, there is a scarcity of literature in luminous spaces. Figure 5 is a close-up regards to the correlation of clinical view of one of the glands, which illustrates features and patient outcomes. Common the presence of glandular cells with symptoms of adenosquamous carcinoma eccentrically placed nuclei and foamy include abdominal pain, jaundice, weight vacuolated cytoplasm. The nuclei show loss, and anorexia6,7. The prognosis for irregular nuclear membranes, moderate individuals with the malignancy is less hyperchromasia, coarse chromatin, and promising than the conventional pancreatic prominent nucleoli. Another area of the ductal adenocarcinoma, with a survival pancreas revealed malignant squamous rate of less than one year after surgery8. cells, as shown in Figures 6 and 7. Figure 6 Reported cases of pancreatic shows a flat sheet of malignant cells, with adenosquamous carcinoma show a higher squamous pearl formation. Figure 7 shows incidence in males over the age of sixty3. malignant squamous cells with However, a study conducted by Hsu et al. multinucleation, coarse chromatin, and of twelve cases of the disease found more prominent nucleoli. The cytoplasm also women affected by the malignancy with a has a thick consistency, when compared to mean age of 71 years6. Unlike other the cytoplasm of malignant glandular cells. findings in the literature that cite the head of the pancreas as the common location of 4. CONCLUSION the tumor3, Hsu et al also reported an even dissemination of the tumor in the head, In conclusion, adenosquamous body and tail of the organ6. carcinoma of the pancreas is a rare and Cytologically, the squamous aggressive tumor with a poor prognosis. component of the tumor consists of cells The diagnosis of the tumor depends on the with mostly eosinophilic cytoplasm and identification of both malignant squamous occasional squamous pearl formations9. and glandular cells. The reported case had Malignant squamous tumor cells may also a sufficient amount of both malignant show varying degrees of cellular components for an accurate diagnosis, and pleomorphism with an increased grade of the histologic findings further substantiated the tumor. Malignant squamous cells can the diagnosis. No patient follow-up or life appear as single lying cells, or in abnormal expectancy outcomes were available for syncytial groups with orangeophilic or the patient. It is known that the patient was basophilic cytoplasm10. The glandular given palliative chemotherapy treatment component shows variability of nuclear after the discovery of distant metastasis to size and shape, with a higher degree of the liver. nuclear hyperchromasia, nuclear Copyright © 2015, Knowledge Enterprises Incorporated. All rights reserved. 3 Medical Research Archives 2015 Issue 3 enlargement, coarse chromatin, and component12,13. It is imperative to correlate prominent nucleoli with an increase in cytologic and histologic findings along tumor the stage of the tumor. The cells with clinical history for proper patient have foamy vacuolated cytoplasm with management and treatment. eccentrically placed nuclei. Surgical resection is the customary The abundance of squamous treatment for adenosquamous carcinoma of component varies with this malignancy, the pancreas14,15. In a study of 415 patients and in some cases may present itself as a with adenosquamous carcinoma, Boyd et pure squamous carcinoma11. Because a al. 15 found patients with the malignancy primary squamous carcinoma of the were more likely to undergo surgical pancreas is non-existent, is it important to resection than those with pancreatic ductal identify the glandular component of the adenocarcinoma. In spite of the less than tumor to accurately diagnose favorable prognosis of adenosquamous adenosquamous carcinoma. Likewise, it is carcinoma, surgical resection offers the also necessary to rule out a metastatic patient a slightly higher chance of long pulmonary squamous carcinoma of the term survival. pancreas in cases of a scant glandular Figure
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