RESEARCH ARTICLE Modification of Fear Memory by Pharmacological and Behavioural Interventions during Reconsolidation Janine Thome1*, Georgia Koppe3, Sophie Hauschild1, Lisa Liebke1, Christian Schmahl2,4, Stefanie Lis1‡, Martin Bohus1,5‡ 1 Institute of Psychiatric and Psychosomatic Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany, 2 Clinic for Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany, 3 Department of Theoretical Neuroscience, Central Institute of Mental Health, Medical a11111 Faculty Mannheim, University Heidelberg, Mannheim, Germany, 4 Department of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada, 5 Faculty of Health, University of Antwerp, Antwerp, Belgium ‡ These authors are shared last co-authors on this work. *
[email protected] OPEN ACCESS Abstract Citation: Thome J, Koppe G, Hauschild S, Liebke L, Schmahl C, Lis S, et al. (2016) Modification of Fear Memory by Pharmacological and Behavioural Background Interventions during Reconsolidation. PLoS ONE 11 (8): e0161044. doi:10.1371/journal.pone.0161044 Dysfunctional fear responses play a central role in many mental disorders. New insights in Editor: Michel Baudry, Western University of Health learning and memory suggest that pharmacological and behavioural interventions during Sciences, UNITED STATES the reconsolidation of reactivated fear memories may increase