Supplementary 1
% Glucose uptake
v1: GLC <-> G6P abcdef <-> abcdef
% EMP-pathway v2: G6P <-> F6P abcdef <-> abcdef
v3: F6P <-> G3P + G3P abcdef <-> cba + def
v4: G3P <-> PEP abc <-> abc
v5: PEP <-> PYRCYT abc <-> abc
% PP-pathway and Phosphoketolase
v6: G6P <-> CO + P5P abcdef <-> a + bcdef
vx1: P5P <-> G3P + ACE abcde <-> abc + de
v7: P5P + P5P <-> S7P + G3P abcde + fghij <-> fgabcde + hij v8: S7P + G3P <-> F6P + E4P abcdefg + hij <-> abchij + defg
v9: P5P + E4P <-> F6P + G3P abcde + fghi <-> abfghi + cde
% Formation of AcCoA in the cytosol
v14: ACE <-> ACCOACYT ab <-> ab
% Anaplerotic reaction (cytosolic)
v15: PYRCYT + CO <-> OAACYT abc + d <-> abcd
% TCA-cycle
v16: PYRMIT <-> ACCOAMIT + CO abc <-> bc + a
v17: OAAMIT + ACCOAMIT <-> ICIT abcd + ef <-> dcbafe
v18: ICIT <-> AKG + CO abcdef <-> abcef + d
v19: AKG <-> FUM + CO abcde <-> bcde + a
% variable scrambling fraction
v20: FUM + FUM <-> OAAMIT + OAAMIT abcd + efgh <-> abcd + hgfe
v21: OAAMIT <-> FUM abcd <-> abcd
% Transports
v22: OAAMIT <-> OAACYT abcd <-> abcd
v24: PYRCYT <-> PYRMIT abc <-> abc
% Threonine / Serine / Glycine metabolism (all enzymes assumed to be cytosolic)
v25: G3P <-> SER abc <-> abc
v26: SER <-> GLY + C1 abc <-> ab + c
v27: OAACYT <-> THR abcd <-> abcd
v28: THR <-> GLY + ACA abcd <-> ab + cd
% Malic enzyme (oxaloacetate decarboxylation, mitochondrial)
v29: OAAMIT <-> PYRMIT + CO abcd <-> abc + d
% Drain of intermediates to macromolecules
v30: G6P <-> G6POUT abcdef <-> abcdef
v31: P5P <-> P5POUT abcde <-> abcde
v32: E4P <-> E4POUT abcd <-> abcd
v33: G3P <-> G3POUT abc <-> abc
v34: PEP <-> PEPOUT abc <-> abc
v35: PYRMIT <-> PYRMITOUT abc <-> abc
v36: PYRCYT <-> PYRCYTOUT abc <-> abc v37: OAACYT <-> OAACYTOUT abcd <-> abcd
v38: AKG <-> AKGOUT abcde <-> abcde
v39: ACCOACYT <-> ACCOACYTOUT ab <-> ab
v40: ACCOAMIT <-> ACCOAMITOUT ab <-> ab
v41: SER <-> SEROUT abc <-> abc
v42: GLY <-> GLYOUT ab <-> ab
v43: C1 <-> C1OUT a <-> a
v44: THR <-> THROUT abcd <-> abcd
net 0.0 200.0; exch = 0.0;
% CO2-evolution
v48: CO2 <-> CO2OUT a <-> a