<p>Supplementary 1</p><p>% Glucose uptake</p><p> v1: GLC <-> G6P abcdef <-> abcdef</p><p>% EMP-pathway v2: G6P <-> F6P abcdef <-> abcdef</p><p> v3: F6P <-> G3P + G3P abcdef <-> cba + def</p><p> v4: G3P <-> PEP abc <-> abc</p><p> v5: PEP <-> PYRCYT abc <-> abc</p><p>% PP-pathway and Phosphoketolase</p><p> v6: G6P <-> CO + P5P abcdef <-> a + bcdef</p><p> vx1: P5P <-> G3P + ACE abcde <-> abc + de</p><p> v7: P5P + P5P <-> S7P + G3P abcde + fghij <-> fgabcde + hij v8: S7P + G3P <-> F6P + E4P abcdefg + hij <-> abchij + defg</p><p> v9: P5P + E4P <-> F6P + G3P abcde + fghi <-> abfghi + cde</p><p>% Formation of AcCoA in the cytosol</p><p> v14: ACE <-> ACCOACYT ab <-> ab</p><p>% Anaplerotic reaction (cytosolic)</p><p> v15: PYRCYT + CO <-> OAACYT abc + d <-> abcd</p><p>% TCA-cycle</p><p> v16: PYRMIT <-> ACCOAMIT + CO abc <-> bc + a</p><p> v17: OAAMIT + ACCOAMIT <-> ICIT abcd + ef <-> dcbafe</p><p> v18: ICIT <-> AKG + CO abcdef <-> abcef + d</p><p> v19: AKG <-> FUM + CO abcde <-> bcde + a</p><p>% variable scrambling fraction</p><p> v20: FUM + FUM <-> OAAMIT + OAAMIT abcd + efgh <-> abcd + hgfe</p><p> v21: OAAMIT <-> FUM abcd <-> abcd</p><p>% Transports </p><p> v22: OAAMIT <-> OAACYT abcd <-> abcd</p><p> v24: PYRCYT <-> PYRMIT abc <-> abc</p><p>% Threonine / Serine / Glycine metabolism (all enzymes assumed to be cytosolic)</p><p> v25: G3P <-> SER abc <-> abc</p><p> v26: SER <-> GLY + C1 abc <-> ab + c</p><p> v27: OAACYT <-> THR abcd <-> abcd</p><p> v28: THR <-> GLY + ACA abcd <-> ab + cd</p><p>% Malic enzyme (oxaloacetate decarboxylation, mitochondrial)</p><p> v29: OAAMIT <-> PYRMIT + CO abcd <-> abc + d</p><p>% Drain of intermediates to macromolecules</p><p> v30: G6P <-> G6POUT abcdef <-> abcdef</p><p> v31: P5P <-> P5POUT abcde <-> abcde</p><p> v32: E4P <-> E4POUT abcd <-> abcd</p><p> v33: G3P <-> G3POUT abc <-> abc</p><p> v34: PEP <-> PEPOUT abc <-> abc</p><p> v35: PYRMIT <-> PYRMITOUT abc <-> abc</p><p> v36: PYRCYT <-> PYRCYTOUT abc <-> abc v37: OAACYT <-> OAACYTOUT abcd <-> abcd</p><p> v38: AKG <-> AKGOUT abcde <-> abcde</p><p> v39: ACCOACYT <-> ACCOACYTOUT ab <-> ab</p><p> v40: ACCOAMIT <-> ACCOAMITOUT ab <-> ab</p><p> v41: SER <-> SEROUT abc <-> abc</p><p> v42: GLY <-> GLYOUT ab <-> ab</p><p> v43: C1 <-> C1OUT a <-> a</p><p> v44: THR <-> THROUT abcd <-> abcd</p><p> net 0.0 200.0; exch = 0.0;</p><p>% CO2-evolution</p><p> v48: CO2 <-> CO2OUT a <-> a</p>