Fundamentals of Pathophysiology

Fundamentals of Pathophysiology CELL3560.01/6560.01, CRN 32010, 32011. MWF 1:00-1:50, RB 113A Spring 2016

Textbook: Pathophysiology of Disease, An Introduction to Clinical Medicine, 7th Ed. (2014),Hammer & McPhee.

This class is a focuses on cellular and molecular mechanisms of pathology. The course follows an organ-system approach. The semester is organized around surveying the different organ systems, doing a brief review of that organ’s physiology, and discussing some of the pathologies faced by that organ system.

The power point slides are posted on black board prior to each lecture. The lecture notes are summarized below each slide. If you print the file in “notes page” mode, you’ll get both the slide and the notes.

There are four non-cumulative tests, including the final. Each test is weighted equally for the final grade. Student attendance and participation is included in grading consideration. Make-up exams are not allowed without a medical excuse (in writing). Prior arrangements must be made with instructor if an exam is missed due to travel plans for professional program entrance interviews. There are no extra-credit projects, no tests are dropped (please do not ask).

Graduate students will make presentations during the course of the semester. Presentations account for 17% of the final grade.

Course Goals: Students will gain a fundamental understanding of the basic cellular dysfunctions that underlie pathophysiology.

Learning Objectives:

1. Students will understand the basic physiology at the organ and cellular levels of the different organ systems of the human body.

2. Students will understand how pathology disrupts the function of the organ systems.

3. Students will be prepared to perform well on the physiology section of the MCAT. 1. M 1/11 1. Introduction

2. W 1/13 2. Blood Cells & Immunity; Chapters 33, 34, 35 from Guyton’s Medical Physiology

3. F 1/15 3. Disorders of the Immune System I; Chapter 3

4. W 1/20 4. Disorders of the Immune System II; Chapter 3

5. F 1/22 5. Infectious Diseases I; Chapter 4

6. M 1/25 6. Infectious Diseases II; Chapter 4

7. W 1/27 7. Blood Disorders I; Chapter 6

8. F 1/29 8. Blood Disorders II; Chapter 6

9. M 2/1 Student Presentation I: AIDS. Where are we now? Reading; Controlling the HIV/AIDS Epidemic: Current Status and Global Challenges, Frontiers in Immunology, 2012.

10. W 2/3 Test I

11. F 2/5 9. Neoplasia I; Chapter 5 12. W 2/10 no class

13. F 2/12 10. Neoplasia II; Chapter 5

14. M 2/15 11. Nervous System I; Chapter 7

15. W 2/17 12. Nervous System II; Chapter 7

16. F 2/19 13. Nervous System III; Chapter 7

17. M 2/22 14. Skin Disorders; Chapter 8

18. W 2/24 Student Presentation II: Screening for Cancer. Reading; Precision medicine for cancer with next-generation functional diagnostics, Nature Reviews Cancer, 2015.

19. F 2/26 Test II

20. M 2/29 15. Pulmonary I; Chapter 9

21. W 3/2 16. Pulmonary II; Chapter 9

22. F 3/4 17. Cardiovascular I; Chapter 10, 11

23. M 3/7 18. Cardiovascular II; Chapter 10, 11 24. W 3/9 19. Cardiovascular III; Chapter 10, 11

25. F 3/11 20. Disorders of the Adrenal Medulla; Chapter 12

26. M 3/14 21. Renal Disease; Chapter 16

27. W 3/16 Student Presentation III, COPD. Reading, Chronic Obstructive Pulmonary Disease, Nature Reviews Disease Primers, 2015

28. F 3/18 Student Presentation IV, Venous Thrombosis, Reading, Venous Thrombosis, Nature Reviews Disease Primers, 2015

29. W 3/30 Test III

30. F 4/1 22. Gastrointestinal Disease I; Chapter13

31. M 4/4 23. Liver Disease; Chapter 14

32. W 4/6 24. Disorders of the Pancreas I; Chapter 15 & 18

33. F 4/8 25. Disorders of the Pancreas II; Chapter 15 & 18

34. M 4/11 26. Inflammatory Rheumatic Diseases; Chapter 24

35. W 4/13 27. Disorders of the Hypothalamus and Pituitary I; Chapter 19 36. F 4/15 28. Disorders of the Hypothalamus and Pituitary II; Chapter 19

37. M 4/18 29. Sex, Gender and Fertility Chapter 22, 23

38. W 4/20 Student Presentation V, Type II Diabetes. Reading; Type II Diabetes Mellitus, Nature Reviews Disease Primers, 2015

39. F 4/22 Student Presentation VI, Menopause. Reading; Menopause, Nature Reviews Disease Primers, 2015

40. M 4/25 Open

Final Exam: April 29, 2016