ETM 4 December 2014
ETMRC (2014) 3rd Meeting Scottish Government Health Directorates Chief Scientist Office
Experimental and Translational Medicine Research Committee
Minute of the meeting of the ETMRC on 4 December 2014 held in Conference Rooms A&B, St Andrew’s House, Edinburgh, at 9:30 am.
Present: Scottish Government: Professor Elaina Collie-Duguid Dr Alan McNair Professor Eleanor Davies Dr Tom Barlow Professor Sarah Howie Ms Diane Brockie Dr Faisel Khan Professor Alistair Leanord Dr Andrew McIntosh Professor Alisdair MacLullich Dr Simon Powis Dr Russell Petty Professor Philip Rowe Professor Donald Salter Professor Calum Sutherland
Ms Barbara Lamb (Lay Member) Ms Joanna McGregor (Lay Member)
Dr Carl Goodyear (Observer)
1. Apologies for absence and intimations Professor Siddarthan Chandran, Professor Fiona Denison and Professor Keith Muir.
2. Approval of minutes of ETMRC meeting held on 6 June 2014 The minutes of the meeting were approved.
3. Matters arising from the ETMRC meeting held on 4 December 2014 - full details of the 8 successful applications from the meeting are attached at Annex A.
4. Final Reports
4.1 Professor Heather Cubie, NHS Lothian (CZB/4/658)
Long-Term Follow-Up Of HPV Vaccination In Women Attending First Cervical Smear - Role And Development Of HPV Testing
Speakers – Davies – Petty - McIntosh
1 ETM 4 December 2014
The Committee graded the as report as Excellent
4.2 Professor Ian Reid, University of Aberdeen (ETM/6)
The Use Of Ketamine As An Anaesthetic During Electroconvulsive Therapy (ECT) For Depression: Does It Improve Treatment Outcome?
Speakers – McIntosh – Denison – Rowe
The Committee graded the as report as Good
4.3 Mr Grant Stewart, University of Edinburgh (ETM/37)
Scottish Collaboration On Translational Research into Renal Cell Cancer (SCOTRRCC): Proteomic Reconstruction Of Molecular Pathways To Predict Renal Cell Cancer Recurrence And Response To Treatment.
Speakers - Petty – Collie-Duguid - Salter
The Committee graded the as report as Good
4.4 Dr Duncan Porter, NHS Greater Glasgow (ETM/40)
Scottish Early Rheumatoid Arthritis (SERA) Bio-Bank From An Inception Cohort Of Patients With Newly Diagnosed Rheumatoid Arthritis
Speakers – Sutherland – Howie - MacLullich
The Committee graded the as report as Excellent
4.5 Dr Russell Petty, University of Aberdeen (ETM/116)
Qualification of Predictive Biomarkers for Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy in Oesophagogastric Carcinoma (Translational Cancer Oesophagus Gefitinib Study- TRANSCOG)
Speakers – MacLullich – Howie - Salter
The Committee graded the as report as Excellent
4.6 Professor Christian Schwarzbauer, University of Aberdeen (ETM/127)
Quantitative Neuroimaging In Disorders Of Consciousness Caused By Acquired Brain Injury
Speakers – Muir – McIntosh – Howie
2 ETM 4 December 2014
The Committee graded the as report as Good
4.7 Professor Sarah Howie, University of Edinburgh (ETM/145)
Cervical HPV Infection In Vaccinated And Unvaccinated Women– New Markers Of Infection, Immunity And Disease.
Speakers – Collie-Duguid – Chandran - Khan
The Committee graded the as report as Good
4.8 Dr Nik Hirani, University of Edinburgh (ETM/153)
Characterisation And Modulation Of Monocyte/Macrophage Lineage Cells In Idiopathic Pulmonary Fibrosis
Speakers – Khan– Rowe – Davies
The Committee graded the as report as Good
4.9 Dr John Plevris, University of Edinburgh (ETM/182)
Tissue Engineering Of 3D Human Hepatic Organotypic Model Using Novel Cell Biomatrix And Brioreactor Enabling Technologies For Pharmaceutical Applications.
Speakers – Rowe – Salter - Sutherland
The Committee graded the as report as Excellent
4.10 Dr Marie Boyd, University of Strathclyde (ETM/194)
Investigations Of Very High Energy Electron Tumour Therapy Based On Laser- Plasma Wakefield Accelerators
Speakers – Salter – Petty - Muir
The Committee graded the as report as Good
4.11 Professor Peter Ghazal, University of Edinburgh (ETM/202)
High Accuracy, Low Volume Host-Directed Detection Of Neonatal Sepsis
Speakers – Leanord – Collie-Duguid - Khan
The Committee graded the as report as Good
3 ETM 4 December 2014
4.12 Dr David Griffith, University of Edinburgh (ETM/221)
Persisting Inflammation Following Critical Illness: Prevalence, Relationship To Physical Recovery, And Exploration Of Defects In Inflammatory Resolution Pathways.
Speakers – Chandran – MacLullich - Denison
The Committee graded the as report as Good
4.13 Dr Kate Templeton, NHS Lothian (ETM/250)
MICAP: Microbiological Investigation of Community Acquired Pneumonia
Speakers –Leanord – Collie-Duguid - Denison
The Committee graded the as report as Good
5. Applications
5.1 Professor Iain McEwan. University of Aberdeen (ETM/382) Antiandrogen Therapy In Prostate Cancer: Impact Of Auto-Regulation Of The Androgen Receptor Gene And Receptor Point Mutations. Speakers – Davies – Sutherland - Howie
The committee recommended funding for this project
5.2 Professor Kenneth McColl, Dr James Going. University of Glasgow (ETM/385) H. Pylori Infection And Acid Secretory Function Of Entire Gastric Mucosa And Of Mucosa Close To The Gastroesophageal Junction In Healthy Volunteers Speakers – Salter – Petty – McIntosh
The committee did not recommend funding for this project
5.3 Dr Peter Barlow, Dr Craig Stevens. Napier University (ETM/389) Cathelicidins As Novel Therapeutic Antiviral Agents In Rhinovirus Infection
Speakers – Howie – Chandran - Leanord
4 ETM 4 December 2014
The committee recommended funding for this project
5.4 Dr Edmund Chan,Professor Hing Leung. University of Strathclyde (ETM/393) Defining The Biomarker Potential And Downstream Transcriptional Signature Of Nuclear Receptor Binding Proteins In Prostate Cancer Speakers – Sutherland – Petty – Collie-Duguid
The committee did not recommend funding for this project
5.5 Dr Elaine Nimmo, Professor Jack Satsangi, Professor David Wilson. University of Edinburgh (ETM/395) Characterisation Of Genetic And Epigenetic Alterations In The VMP1/Mir21 Region In Crohn's Disease - Implications For Pathogenesis And Translation To Clinical Application Speakers – MacLullich – Khan – Howie
The committee recommended funding for this project
5.6 Professor David Fitzpatrick, Dr Hemant Bangani, Dr Andrew Wood. University of Edinburgh (ETM/396)
Assessing The Potential Of Crispr/Cas9 Genome Editing Technology For Ex Vivo And In Vivo Therapeutic Correction Using Phenylketonuria As A Model Speakers – Collie-Duguid – Muir - Sutherland
The committee did not recommend funding for this project
5.7 Dr Calum Sutherland, Dr Ashleigh Duthie, Professor Simon Lovestone, Professor John Geddes. University of Dundee (ETM/401) Preliminary Evaluation Of The Therapeutic Potential Of Lithium In Mild Cognitive Impairment Speakers – MacLullich – McIntosh – Muir
The committee recommended funding for this project
5 ETM 4 December 2014
5.8 Professor James Scobbie, Dr Joanne Cleland. Queen Margaret University (ETM/402) Ultrasound Visual Biofeedback Treatment For Speech Sound Disorders In Children Speakers – Denison – Howie - Salter
The committee recommended funding for this project
5.9 Professor George MacFarlane, Dr Nigel Reynolds. University of Dundee (ETM/403) Resistant Starch And Non-Starch Polysaccharide (Dietary Fibre) Intake In Relation To The Structure And Metabolic Activities Of The Colonic Microbiome In Older People Speakers – MacLullich – Leanord – Chandran
The committee recommended funding for this project
5.10 Professor Anthony Chalmers, Dr Natividad Gomez-Roman University of Glasgow (ETM/405) Mitochondrial Poisoning As A Novel Strategy To Overcome Radiation Resistance Of Glioblastoma
Speakers – Petty – Salter - Chandran
The committee recommended funding for this project
5.11 Dr Dana Dawson, Dr Ornella Rimoldi, Professor Andy Welch, Professor Matteo Zanda, Professor Michael Frenneaux. University of Aberdeen (ETM/409) Metabolic Pathways In Acute Stress Induced (Tako-Tsubo) Cardiomyopathy Speakers – Khan – Davies – Chandran
The committee did not recommend funding for this project
5.12 Dr Stefan Siebert, Professor Iain McInnes, Professor Stuart Ralston, Dr Neil Basu, Professor Ian Ford, Dr Neil McKay University of Glasgow (ETM/414)
Towards A Predictive Molecular Taxonomy For Psoriatic Arthritis
Speakers – Salter – Chandran – MacLullich
The committee recommended funding for this project
6 ETM 4 December 2014
5.13 Dr Veronique Vitart, Dr Danny Mitry, Mr David Charteris, Professor Harry Campbell, Dr Aman Chandra University of Edinburgh (ETM/416)
Geneic Study Of Primary Rhematogenous Retinal Detachment: Building On The Scottish National Study Resource
Speakers – Collie-Duguid – McIntosh - Sutherland
The committee did not recommend funding for this project
6. Any other business
7. Date of next meeting Friday 5 June 2015, conference rooms A&B, St. Andrew’s House, Edinburgh, 9:30 am.
Annex A Matters arising from the minutes of the ETMRC meeting held on 4 December 2014
3.1 Professor Iain McEwan. University of Aberdeen (ETM/382) Antiandrogen Therapy In Prostate Cancer: Impact Of Auto-Regulation Of The Androgen Receptor Gene And Receptor Point Mutations. . A funding letter has now been issued.
Start 01/03/2015 Completion 28/02/17 2015-16 2016-17 2017-18 Total 11,396 110,363 99,025 220,784
3.2 Dr Peter Barlow, Dr Craig Stevens. Napier University (ETM/389) Cathelicidins As Novel Therapeutic Antiviral Agents In Rhinovirus Infection
A funding letter has now been issued.
Start 01/05/2015 Completion 30/04/2017 2015-16 2016-17 2017-18 Total 76,294 81,136 5,722 163,152
7 ETM 4 December 2014
3.3. Dr Elaine Nimmo, Professor Jack Satsangi, Professor David Wilson. University of Edinburgh (ETM/395) Characterisation Of Genetic And Epigenetic Alterations In The VMP1/Mir21 Region In Crohn's Disease - Implications For Pathogenesis And Translation To Clinical Application .
A funding letter has now been issued.
Start 01/03/2015 Completion 31/08/2017 2015-16 2016-17 2017-18 Total 35,581 94,290 95,127 224,998
3.4. Dr Calum Sutherland, Dr Ashleigh Duthie, Professor Simon Lovestone, Professor John Geddes. University of Dundee (ETM/401) Preliminary Evaluation Of The Therapeutic Potential Of Lithium In Mild Cognitive Impairment
A funding letter has now been issued.
Start 01/04/2015 Completion 31/03/2016 2015-16 Total 113,793 113,793
3.5 Professor James Scobbie, Dr Joanne Cleland. Queen Margaret University (ETM/402) Ultrasound Visual Biofeedback Treatment For Speech Sound Disorders In Children.
A funding letter has now been issued.
Start 01/04/2015 Completion 30/09/2016 2015-16 2016-17 Total 93,217 45,206 138,423
3.6 Professor George MacFarlane, Dr Nigel Reynolds. University of Dundee (ETM/403) Resistant Starch And Non-Starch Polysaccharide (Dietary Fibre) Intake In Relation To The Structure And Metabolic Activities Of The Colonic Microbiome In Older People A funding letter has now been issued.
8 ETM 4 December 2014
Start 01-02-2015 Completion 31-01-2017 2015-16 2016-17 2017-18 Total 18,247 112,400 93,736 224,383
3.7 Professor Anthony Chalmers, Dr Natividad Gomez-Roman University of Glasgow (ETM/405) Mitochondrial Poisoning As A Novel Strategy To Overcome Radiation Resistance Of Glioblastoma
A funding letter has now been issued.
Start 01-02-2015 Completion 31-01-2017 2015-16 2016-17 2017-18 Total 62,365 88,335 74,573 225,273
3.8 Dr Stefan Siebert, Professor Iain McInnes, Professor Stuart Ralston, Dr Neil Basu, Professor Ian Ford, Dr Neil McKay University of Glasgow (ETM/414)
Towards A Predictive Molecular Taxonomy For Psoriatic Arthritis
A funding letter has now been issued.
Start 01-04-2015 Completion 31-03-2018 2015-16 2016-17 2017-18 Total 75,549 75,549 75,549 226,647
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