BIOGRAPHICAL SKETCH Provide the following information for the Senior/key personnel and other significant contributors. Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE Raj Paul Wadwa, MD Assistant Professor of Pediatrics eRA COMMONS USER NAME (credential, e.g., agency login) WADWA_P EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, include postdoctoral training and residency training if applicable.) DEGREE INSTITUTION AND LOCATION MM/YY FIELD OF STUDY (if applicable) Northwestern University, Evanston, IL B.S. 1993 Biomedical Engineering Northwestern University, Feinberg School of M.D. 1996 Medicine Medicine, Chicago, IL

The Ohio State University/ Children’s Hospital, Residency 1996-1999 Pediatrics Columbus, OH Pediatric Endocrinology University of Cincinnati/ Cincinnati Children’s Fellowship 2000-2003 Hospital Medical Center, Cincinnati, OH

University of Colorado at Denver and Health Certificate 2003-2005 Public Health Sciences Sciences Center, Denver, CO

A. Personal Statement My primary research focus is on identification of risk factors for cardiovascular disease in youth with type 1 diabetes with the goal of prevention of vascular complications of type 1 diabetes. I have a background in pediatric endocrinology, with specific training and expertise in pediatric diabetes. My prior research experience includes work with epidemiological studies of cardiovascular disease risk in young adults with type 1 diabetes (CACTI) and epidemiological studies of diabetes in youth (SEARCH for Diabetes in Youth). In the last 6 years, I have worked with investigators from the SEARCH for Diabetes in Youth study to carry out ancillary studies (SEARCH CVD) focusing on non-invasive measurement of vascular function to assess the risk of developing cardiovascular disease in youth with diabetes, age 10-25 years. At this time, I am the PI for a JDRF funded study of macrovascular disease risk factors in adolescents with type 1 diabetes compared to non-diabetic control subjects. The proposed project will recruit from this cohort. In summary, I have a demonstrated record of successful and productive research projects in collaboration with local and national colleagues. My expertise and experience have prepared me to serve as a contributing investigator in the proposed project.

B. Positions and Honors 1999-2000 Chief Resident, The Ohio State University, Dept. of Pediatrics/ Children’s Hospital, Columbus, OH 2005-present Medical Director, Colorado ADA Camp for Children with Diabetes 2005-2010 Member, Leadership Council of the American Diabetes Association, Colorado Chapter 2008 President, Leadership Council of the American Diabetes Association, Colorado Chapter 2010 Member, Youth Information and Resources Subcommittee, American Diabetes Association, national organization 2010 Travel Grant Award- International Society for Pediatric and Adolescent Diabetes Annual Meeting

2003-2011 Assistant Professor of Pediatrics Barbara Davis Center for Childhood Diabetes University of Colorado Denver, Aurora, CO

2011-present Associate Professor of Pediatrics Barbara Davis Center for Childhood Diabetes University of Colorado Denver, Aurora, CO

Professional Societies 1996-present American Academy of Pediatrics 2000-2003 Lawson Wilkins Pediatric Endocrine Society 2002-present The Endocrine Society 2003-present American Diabetes Association 2004-present American Heart Association 2008-present International Society for Pediatric and Adolescent Diabetes

C. Selected Peer-reviewed Publications Most relevant to the current application (selected from 21 peer-reviewed publications)

1. Wadwa RP. Kinney GL. Maahs DM. Snell-Bergeon J. Hokanson JE. Garg SK. Eckel RH. Rewers M. (2005). Awareness and treatment of dyslipidemia in young adults with type 1 diabetes. Diabetes Care, 28(5), 1051-6. PMID 15855566.

2. Wadwa RP. Kinney GL. Ogden L. Snell-Bergeon J. Maahs DM. Cornell E. Tracy RP. Rewers M. (2006). Soluble Interleukin-2 Receptor as a Marker for Progression of Coronary Artery Calcification in Type 1 Diabetes. Int J Biochem Cell Biol, 38: 996-1003. PMID 16271309.

3. Kretowski A, McFann K, Hokanson JE, Maahs D, Kinney G, Snell-Bergeon JK, Wadwa RP, Eckel RH, Ogden LG, Garg S, Li J, Cheng S, Erlich HA. Rewers M. (2007). Polymorphisms of The Renin- Angiotensin System Genes Predict Progression of Subclinical Coronary Atherosclerosis. Diabetes, 56(3), 863-71. PMID 17327458.

4. Urbina EM. Wadwa RP. Davis C. Snively B. Dolan LM. Daniels SR. Hamman RF. Dabelea D. (2010). Arterial Stiffness in Children with Diabetes Mellitus Differs by Measurement Site and Sex. J Pediatr, 156(5):731-7, 737.e1. PMID 20097360.

5. Wadwa RP. Urbina EM. Anderson AM. Hamman RF. Dolan LM. Rodriguez BL. Daniels SR. Dabelea D. for the SEARCH study group. (2010). Measures of arterial stiffness in youth with type 1 and type 2 diabetes: the SEARCH for Diabetes in Youth study. Diabetes Care, 33(4), 881-6. PMC2845046.

Additional recent publications of importance to the field (in chronological order)

6. Maahs DM. Ogden LG. Kinney GL. Wadwa P. Snell-Bergeon JK. Dabelea D. Hokanson JE. Ehrlich J. Eckel RH. Rewers M. (2005). Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation, 111(6), 747-53.

7. Maahs DM. Kinney GL. Wadwa P. Snell-Bergeon JK. Dabelea D. Hokanson JE. Ehrlich J. Garg S. Eckel RH. Rewers M. (2005). Hypertension prevalence, awareness, treatment, and control in an adult type 1 diabetes population and a comparable general population. Diabetes Care, 28(2): 301-306 8. Maahs DM. Maniatis A. Nadeau K. Wadwa RP. McFann K. Klingensmith GJ. (2005). Total Cholesterol and High Density Lipoprotein Levels in Pediatric Subjects with Type 1 Diabetes Mellitus. J Pediatr, 147(4), 544-6.

9. Kretowski A, Hokanson JE, McFann K, Kinney GL, Snell-Bergeon JK, Maahs DM, Wadwa RP, Eckel RH, Ogden LG, Garg SK, Li J, Cheng S, Erlich HA, Rewers M. (2006). The apolipoprotein A-IV Gln360His polymorphism predicts progression of coronary artery calcification in patients with type 1 diabetes. Diabetologia, 49(8):1946-54. PMID 16770585.

10. Maahs DM. Wadwa RP. McFann K. Nadeau K. Williams MR. Eckel RH. Klingensmith GJ. (2007). Longitudinal lipid screening and use of lipid-lowering medications in pediatric type 1 diabetes. J Pediatr, 150(2), 146-50, 150.e1-2. PMID 17236891.

11. Maahs DM. Ogden L. Snell-Bergeon J. Kinney G. Wadwa RP. Hokanson JE. Dabelea D. Kretowski A. Eckel RH. Rewers M. (2007). Determinants of Serum Adiponectin in Persons with and without Type 1 Diabetes. Am J Epidemiol, 166(6), 731-40. PMID: 17591595.

12. Maahs DM. Snell-Bergeon JK. Kinney GL. Wadwa RP. Garg SK. Ogden LG. Rewers M. (2007). ACE/ARB Treatment in Type 1 Diabetes Subjects with Albuminuria is Associated with Lower Odds of Progression of Coronary Artery Calcification. J Diabetes Complications, 21(5), 273-9. PMID 17825750

13. Guy J. Ogden L. Wadwa RP. Hamman RF. Mayer-Davis EJ. Liese AD. D'Agostino R Jr. Marcovina S. Dabelea D. (2009). Lipid and Lipoprotein Profiles in Youth with and Without Type 1 Diabetes: The SEARCH Case-Control Study. Diabetes Care, 32(3), 416-20. PMC2646019

14. Gendelman N. Snell-Bergeon JK. McFann K. Kinney G. Wadwa RP. Bishop F. Rewers M. Maahs DM. (2009). Prevalence and Correlates of Depression in Persons with and without Type 1 Diabetes. Diabetes Care, 32(4), 575-9. PMC2660458

15. Orlando VA. Johnson LR. Wilson AR. Maahs DM. Wadwa RP. Bishop FK. Dong F. Morrato E. (2010). Oral health knowledge and behaviors among adolescents with type 1 diabetes. International Journal of Dentistry, 942124. Epub 2010 May 13. PMC2871184

16. Maahs DM, Prentice N, McFann K, Snell-Bergeon JK, Jalal D, Bishop FK, Aragon B, Wadwa RP. Age and Sex Influence Cystatin C in Adolescents With and Without Type 1 Diabetes. Diabetes Care. 2011 Sep 16. [Epub ahead of print] PubMed PMID: 21926294

D. Research Support

Ongoing Research Support 11-2007-694 Wadwa (PI) 9/01/07-8/31/12 Juvenile Diabetes Research Foundation Determinants of macrovascular disease in adolescents with type 1 diabetes The goals of this study are to describe the prevalence of traditional and non-traditional cardiovascular disease risk factors in adolescents with type 1 diabetes compared to non-diabetic similar age adolescents and follow changes in these risk factors over two years. Role: PI

U01 DK60782 Gottlieb (PI) 10/01/09-4/30/14 NIH, NIDDK Type 1 Diabetes Prevention Trial (TrialNet) The goal of this study is to conduct a series of clinical trials aiming to prevent or reverse type 1 diabetes. Role: Investigator 2U08DP000247 Dabelea (PI) 09/30/10 - 09/29/15 Centers for Disease Control SEARCH for Diabetes in Youth 3: Colorado Center This is one of five centers designated by CDC to set-up a national registry of childhood diabetes. Researchers will ascertain, register, characterize, and conduct follow-up of diabetes and complications of diabetes in youth aged 0-19 with an emphasis on Type 1a (autoimmune), Type 2 and other forms of diabetes in Colorado and American Indian communities Role: Co-Investigator

NN 2211-1800 Wadwa (PI) 12/15/09- 11/30/11 Novo Nordisk Liraglutide: A randomized, double-blinded, placebo controlled trial to assess safety/tolerability, pharmacokinetics & pharmacodynamics of liraglutide in pediatric (10-17 year olds) and adult subjects with type 2 diabetes Role: Site PI

Completed Research Support R01 HL61753 Rewers (PI) 09/01/99-08/31/08 NIH, NHLBI Subclinical Heart Disease in Insulin-Dependent Diabetes; Coronary Artery Calcification in Type 1 Diabetes The goals of this study are to determine prevalence, risk factors and progression of coronary calcification in type 1 diabetic patients and controls. Role: Investigator (2006-07)

JDRF 22-2006-1109 Chase (PI) 09/01/2006-8/31/2011 Development of Algorithms for a Prototype Closed Loop Insulin Pump The major goal of this project is to develop algorithms to enable the development of an artificial pancreas system by using Continuous Glucose Monitors together with Insulin Pump technology. Role: Investigator (2006-07)

31898 Maahs / Wadwa (Co-PIs) 10/1/06- 12/31/10 Merck Medical School Grant Clinical Trial of Zocor and Vytorin in Adolescents with Type 1 Diabetes Role: Co-PI (no salary support) The goals of this study are to determine the safety and efficacy of two lipid-lowering medications in adolescents with type 1 diabetes and elevated LDL cholesterol levels

1 R01 DK078542 Dabelea (PI) 9/22/09- 8/31/11 NIH, NIDDK Sub Clinical Cardiovascular Disease (CVD) in Youth with Type 1 Diabetes: SEARCH CVD The major goals of this project are to advance our understanding of the natural history of early CVD in youth and will provide insights into the mechanisms from which strategies to prevent or limit vascular disease in individuals can be developed. Role: Co-Investigator