Online Supplement 2: Genes in the Critical Region of Chromosome 2

Rogus JJ, Poznik GD, Pezzolesi M, Smiles A, Dunn J, Walker W, Wanic K,

Canani L, Araki S, Makita J, Warram JH, Krolewski AS (2007) High-density SNP genome wide linkage scan for susceptibility genes for diabetic nephropathy in type 1 diabetes: Discordant sib-pair approach.

Online Supplement 2: Genes in the critical region of chromosome 2

LOCUS NT_022135 22331914 bp DNA linear CON 29-AUG-2006 DEFINITION Homo sapiens chromosome 2 genomic contig, reference assembly. ACCESSION NT_022135 REGION: 1..22331914 VERSION NT_022135.15 GI:88953723

n Name Start End Cmpl LocusID Accession Product "similar to 60S ribosomal protein L22 (Heparin-binding 1) LOC727747 99190 99995 0 GeneID:727747 XR_015114.1 protein HBp15)" "BUB1 budding uninhibited by benzimidazoles 1 homolog 2) BUB1 103333 143587 1 GeneID:699 NM_004336.2 (yeast)" 3) ACOXL 264537 559844 0 GeneID:55289 NM_018308.1 "acyl-Coenzyme A oxidase-like" 4) FLJ44006 563845 579685 1 GeneID:400997 NM_001001696.1 "FLJ44006 protein" 5) BCL2L11 589233 632510 0 GeneID:10018 NM_207002.1 "BCL2-like 11 (apoptosis facilitator)" 6) LOC729312 641113 672011 0 GeneID:729312 XM_001129914.1 "hypothetical protein LOC729312" 7) PAFAH1P2 848661 >851029 0 GeneID:27002 - "[no mRNA]" 8) ANAPC1 1234561 1349664 1 GeneID:64682 NM_022662.2 "anaphase promoting complex subunit 1" 9) LOC729365 1349196 1349543 0 GeneID:729365 XM_001130045.1 "hypothetical protein LOC729365" 10) MERTK 1364114 1494868 0 GeneID:10461 NM_006343.2 "c-mer proto-oncogene tyrosine kinase" 11) LOC727816 1405802 1406536 1 GeneID:727816 XR_015151.1 "similar to Protein C14orf166" 12) TMEM87B 1520737 1582553 0 GeneID:84910 NM_032824.1 "transmembrane protein 87B" 13) FLJ37440 1603885 1653714 0 GeneID:129804 NM_153214.1 "hypothetical protein FLJ37440" 14) ZC3H8 1681362 1720573 1 GeneID:84524 NM_032494.1 "zinc finger CCCH-type containing 8" 15) ZC3H6 1775586 1799747 0 GeneID:376940 NM_198581.1 "zinc finger CCCH-type containing 6" 16) LOC727851 1833661 1899987 1 GeneID:727851 XM_001126138.1 "similar to RAN binding protein 2, transcript variant 1" 17) TTL 1947821 1997906 0 GeneID:150465 NM_153712.3 "tubulin tyrosine ligase" 18) POLR1B 2007536 2043331 0 GeneID:84172 NM_019014.3 "polymerase (RNA) I polypeptide B, 128kDa" 19) CHCHD5 2049959 2054540 0 GeneID:84269 NM_032309.2 "coiled-coil-helix-coiled-coil-helix domain containing 5" 20) SLC20A1 2111450 2129325 0 GeneID:6574 NM_005415.3 "solute carrier family 20 (phosphate transporter), member 1" 21) CKAP2L 2203367 2230109 1 GeneID:150468 NM_152515.2 "cytoskeleton associated protein 2-like" 22) IL1A 2239415 2250894 1 GeneID:3552 NM_000575.3 "interleukin 1, alpha" 23) IL1B 2295260 2302279 1 GeneID:3553 NM_000576.2 "interleukin 1, beta" 24) IL1F7 2378471 2384382 0 GeneID:27178 NM_173205.1 "interleukin 1 family, member 7 (zeta)" 25) IL1F9 2443529 2451150 0 GeneID:56300 NM_019618.2 "interleukin 1 family, member 9" 26) LOC727920 2446376 2446934 1 GeneID:727920 XR_015210.1 "similar to D-PCa-2 protein isoform c" "similar to polymerase (RNA) II (DNA directed) polypeptide 27) LOC442042 2461017 2461439 0 GeneID:442042 XR_016266.1 D isoform 1" 28) IL1F6 2471372 2473544 0 GeneID:27179 NM_014440.1 "interleukin 1 family, member 6 (epsilon)" 29) IL1F8 2487591 2518363 1 GeneID:27177 NM_173178.1 "interleukin 1 family, member 8 (eta)" 30) IL1F5 2524138 2530244 0 GeneID:26525 NM_012275.2 "interleukin 1 family, member 5 (delta)" 31) IL1F10 2533470 2541350 0 GeneID:84639 NM_032556.4 "interleukin 1 family, member 10 (theta)" 32) IL1RN 2583393 2599516 0 GeneID:3557 NM_173842.1 "interleukin 1 receptor antagonist" 33) PSD4 2639483 2668600 0 GeneID:23550 NM_012455.2 "pleckstrin and Sec7 domain containing 4" 34) PAX8 2681497 2744420 1 GeneID:7849 NM_003466.3 "paired box gene 8" 35) CBWD2 2903305 2961668 0 GeneID:150472 NM_172003.2 "COBW domain containing 2" 36) LOC642617 2911673 2913796 1 GeneID:642617 XR_016371.1 "hypothetical LOC642617" 37) FOXD4L1 2964583 2966832 0 GeneID:200350 NM_012184.3 "forkhead box D4-like 1" 38) LOC572558 3005525 3008153 1 GeneID:572558 - "[no mRNA]" 39) LOC729468 3018557 3037816 0 GeneID:729468 XM_001130346.1 "similar to phosphoglucomutase 5" 40) LOC729470 3049326 3053800 1 GeneID:729470 XM_001130356.1 "hypothetical protein LOC729470" 41) MGC52000 3049624 3064536 0 GeneID:375260 NM_198943.1 "CXYorf1-related protein" "similar to DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 42) LOC728007 3065652 3067075 1 GeneID:728007 XM_001127199.1 11 (CHL1-like helicase homolog, S. cerevisiae)" 43) RPL23AP7 3076967 3092587 1 GeneID:118433 - "[no mRNA]" 44) RABL2A 3092804 3108888 0 GeneID:11159 NM_007082.2 "RAB, member of RAS oncogene family-like 2A" 45) bA395L14.12 3123373 3124384 0 GeneID:150478 - "[no mRNA]" 46) LOC645529 3132741 3135370 1 GeneID:645529 XM_928549.2 "similar to Hypothetical acrosin-like protease" 47) SLC35F5 3179852 3222326 1 GeneID:80255 NM_025181.2 "solute carrier family 35, member F5" 48) LOC728055 3353719 3355825 0 GeneID:728055 XM_001127599.1 "hypothetical protein LOC728055" 49) ACTR3 3355459 3424089 0 GeneID:10096 NM_005721.3 "ARP3 actin-related protein 3 homolog (yeast)" 50) LOC440900 3444942 3472809 0 GeneID:440900 XM_498909.3 "hypothetical LOC440900" 51) LOC391428 3725545 3736676 1 GeneID:391428 XR_016980.1 "similar to selenophosphate synthetase" 52) LOC391429 4130206 4130586 0 GeneID:391429 XM_372954.1 "hypothetical LOC391429" 53) DPP10 4627654 5309858 0 GeneID:57628 NM_020868.2 "dipeptidyl-peptidase 10" 54) DDX18 7280177 7297875 0 GeneID:8886 NM_006773.3 "DEAD (Asp-Glu-Ala-Asp) box polypeptide 18" 55) LOC389024 7301502 7303702 0 GeneID:389024 XM_374003.3 "hypothetical LOC389024" 56) LOC645694 7324925 7369178 0 GeneID:645694 XR_017010.1 "hypothetical LOC645694" 57) CCDC93 7381069 7479619 1 GeneID:54520 NM_019044.3 "coiled-coil domain containing 93" 58) INSIG2 7553972 7575519 0 GeneID:51141 NM_016133.2 "insulin induced gene 2" 59) LOC645733 7648420 7652379 1 GeneID:645733 XM_001130623.1 "hypothetical LOC645733" 60) EN1 8307688 8313681 1 GeneID:2019 NM_001426.2 "engrailed homolog 1" 61) MARCO 8407667 8460158 0 GeneID:8685 NM_006770.3 "macrophage receptor with collagenous structure" 62) C1QL2 8621741 8624393 1 GeneID:165257 NM_182528.1 "complement component 1, q subcomponent-like 2" 63) STEAP3 8689306 8731150 0 GeneID:55240 NM_001008410.1 "STEAP family member 3" 64) LOC130355 8767723 8832240 1 GeneID:130355 NM_001017927.1 "hypothetical protein LOC130355" "diazepam binding inhibitor (GABA receptor modulator, acyl- 65) DBI 8832582 8838044 0 GeneID:1622 NM_020548.4 Coenzyme A binding protein)" 66) TMEM37 8897402 8902938 0 GeneID:140738 NM_183240.1 "transmembrane protein 37" 67) SCTR 8905343 8989830 1 GeneID:6344 NM_002980.1 "secretin receptor" 68) MGC33657 9009967 9122159 0 GeneID:200373 NM_001029996.1 "similar to hypothetical protein" 69) MGC10993 9144677 9147616 0 GeneID:80775 NM_030577.1 "hypothetical protein MGC10993" 70) LOC645955 9188700 9225484 1 GeneID:645955 XM_933296.2 "hypothetical LOC645955" "protein tyrosine phosphatase, non-receptor type 4 71) PTPN4 9225129 9442959 0 GeneID:5775 NM_002830.2 (megakaryocyte)" 72) EPB41L5 9478591 9644617 0 GeneID:57669 NM_020909.2 "erythrocyte membrane protein band 4.1 like 5" 73) LOC729669 9640393 9683819 1 GeneID:729669 XM_001130975.1 "hypothetical protein LOC729669" 74) FAM11B 9686776 9688906 1 GeneID:79134 - "[no mRNA]" "v-ral simian leukemia viral oncogene homolog B (ras related; 75) RALB 9718336 9760208 0 GeneID:5899 NM_002881.2 GTP binding protein)" 76) INHBB 9810921 9816896 0 GeneID:3625 NM_002193.1 "inhibin, beta B (activin AB beta polypeptide)" 77) FLJ14816 9929833 9931619 1 GeneID:84931 - "[no mRNA]" 78) LOC728197 10008407 10009837 1 GeneID:728197 XM_001128449.1 "hypothetical protein LOC728197" 79) GLI2 10257779 10457773 0 GeneID:2736 NM_005270.3 "GLI-Kruppel family member GLI2" 80) TFCP2L1 10686456 10750697 1 GeneID:29842 NM_014553.1 "transcription factor CP2-like 1" 81) CLASP1 10803277 11114974 1 GeneID:23332 NM_015282.1 "cytoplasmic linker associated protein 1" 82) LOC729742 11123971 11162223 1 GeneID:729742 XR_015643.1 "similar to 60S ribosomal protein L12" "similar to Nucleophosmin (NPM) (Nucleolar phosphoprotein 83) LOC440902 11174007 11178126 1 GeneID:440902 XR_017111.1 B23) (Numatrin) (Nucleolar protein NO38)" 84) MKI67IP 11192476 11202390 1 GeneID:84365 NM_032390.3 "MKI67 (FHA domain) interacting nucleolar phosphoprotein" 85) TSN 11221043 11233351 0 GeneID:7247 NM_004622.2 "translin" 86) LOC646179 11255963 11261854 0 GeneID:646179 XM_933456.2 "hypothetical LOC646179" 87) LOC728241 11669351 11670358 0 GeneID:728241 XM_001128741.1 "hypothetical protein LOC728241" 88) CNTNAP5 13490786 14380834 0 GeneID:129684 NM_130773.2 "contactin associated protein-like 5" 89) LOC150554 16020909 16023677 1 GeneID:150554 - "[no mRNA]" 90) GYPC 16121606 16162168 0 GeneID:2995 NM_016815.2 "glycophorin C (Gerbich blood group)" 91) LOC339760 16354695 16366042 0 GeneID:339760 XM_295058.5 "hypothetical LOC339760" 92) BIN1 16513529 16572786 1 GeneID:274 NM_139343.1 "bridging integrator 1" 93) FLJ16008 16649334 16671265 1 GeneID:339761 NM_001001665.2 "FLJ16008 protein" "excision repair cross-complementing rodent repair deficiency, 94) ERCC3 16722788 16759674 1 GeneID:2071 NM_000122.1 complementation group 3 (xeroderma pigmentosum group B complementing)" 95) MAP3K2 16770061 16808692 1 GeneID:10746 NM_006609.3 "mitogen-activated protein kinase kinase kinase 2" 96) LOC729861 16873751 16874218 0 GeneID:729861 XM_001131552.1 "hypothetical protein LOC729861" 97) PROC 16883939 16894740 0 GeneID:5624 NM_000312.1 "protein C (inactivator of coagulation factors Va and VIIIa)" 98) IWS1 16946312 16991966 1 GeneID:55677 NM_017969.1 "IWS1 homolog (S. cerevisiae)" 99) MYO7B 17001300 17103225 0 GeneID:4648 XM_929403.2 "myosin VIIB" 100) LIMS2 17103923 17130042 1 GeneID:55679 NM_017980.2 "LIM and senescent cell antigen-like domains 2" 101) GPR17 17111669 17118135 0 GeneID:2840 NM_005291.1 "G protein-coupled receptor 17" 102) SFT2D3 17166519 17169329 0 GeneID:84826 NM_032740.3 "SFT2 domain containing 3" 103) WDR33 17169730 17276667 1 GeneID:55339 NM_001006622.1 "WD repeat domain 33" 104) POLR2D 17312155 17323626 1 GeneID:5433 NM_004805.2 "polymerase (RNA) II (DNA directed) polypeptide D" 105) MGC4268 17327126 17350356 1 GeneID:83607 NM_031445.2 "hypothetical protein MGC4268" 106) LOC646509 17350800 17351525 0 GeneID:646509 XM_933667.2 "hypothetical LOC646509" 107) SAP130 17406718 17492789 1 GeneID:79595 NM_024545.2 "Sin3A-associated protein, 130kDa" 108) UGCGL1 17556707 17656917 0 GeneID:56886 NM_020120.2 "UDP-glucose ceramide glucosyltransferase-like 1" 109) HS6ST1 17732954 17784174 1 GeneID:9394 NM_004807.1 "heparan sulfate 6-O-sulfotransferase 1" 110) LOC151121 18707824 18708281 1 GeneID:151121 - "[no mRNA]" 111) LOC402102 18956690 18962283 0 GeneID:402102 XR_017234.1 "similar to peptidylprolyl isomerase A isoform 1" 112) LOC729958 19360329 19360901 0 GeneID:729958 XM_001131880.1 "hypothetical protein LOC729958" 113) LOC389033 19388357 19399812 1 GeneID:389033 XM_374010.4 "hypothetical LOC389033" 114) LOC150516 19445159 19448233 0 GeneID:150516 - "[no mRNA]" 115) LOC646674 19458287 19459547 0 GeneID:646674 XR_016918.1 "similar to single stranded DNA binding protein 3" 116) LOC440905 19492340 19516626 1 GeneID:440905 NM_001013711.1 "hypothetical protein LOC440905" 117) LOC653775 19514263 19517760 1 GeneID:653775 - "[no mRNA]" "similar to Prostate, ovary, testis expressed protein on 118) LOC728378 19539030 19586062 1 GeneID:728378 XM_001130062.1 chromosome 2" 119) CCDC74B 19604784 19610553 1 GeneID:91409 NM_207310.1 "coiled-coil domain containing 74B" "sphingomyelin phosphodiesterase 4, neutral membrane 120) SMPD4 19616903 19647088 1 GeneID:55627 NM_017951.1 (neutral sphingomyelinase-3)" 121) FLJ14346 19647625 19656222 0 GeneID:80097 NM_025029.2 "hypothetical protein FLJ14346" 122) LOC112714 19657240 19663956 1 GeneID:112714 NM_207312.1 "similar to alpha tubulin" 123) LOC729985 19668276 19669870 0 GeneID:729985 XM_001131964.1 "similar to CDC42-binding protein kinase beta" 124) LOC284988 19676353 19679301 1 GeneID:284988 XR_017252.1 "hypothetical LOC284988" "similar to Nucleolar complex protein 2 homolog (NOC2 125) LOC643276 19694845 19697601 0 GeneID:643276 XR_016954.1 protein homolog)" 126) LOC391436 19714155 19718089 0 GeneID:391436 - "[no mRNA]" 127) LOC646710 19754036 19759900 0 GeneID:646710 XR_017260.1 "hypothetical LOC646710" 128) CCDC115 19803738 19807844 1 GeneID:84317 NM_032357.2 "coiled-coil domain containing 115" "IMP4, U3 small nucleolar ribonucleoprotein, homolog 129) IMP4 19808411 19812119 0 GeneID:92856 NM_033416.1 (yeast)" "protein tyrosine phosphatase, non-receptor type 18 (brain- 130) PTPN18 19821540 19840066 0 GeneID:26469 NM_014369.2 derived)" 131) LOC646802 19905122 19906619 1 GeneID:646802 XR_017274.1 "similar to Protein C2orf14" "similar to Prostate, ovary, testis expressed protein on 132) LOC653269 19927602 19974782 1 GeneID:653269 XM_928585.2 chromosome 2, transcript variant 2" 133) LOC653275 19986589 19994102 0 GeneID:653275 XM_932990.2 "similar to cryptic, transcript variant 2" 134) CFC1 20058257 20065004 1 GeneID:55997 NM_032545.2 "cripto, FRL-1, cryptic family 1" "similar to Prostate, ovary, testis expressed protein on 135) LOC653781 20077028 20124081 0 GeneID:653781 XM_929706.2 chromosome 2" 136) LOC646761 20143879 20147393 0 GeneID:646761 - "[no mRNA]" 137) LOC730024 20155472 20170244 0 GeneID:730024 XR_015755.1 "similar to male sterility domain containing 1" 138) GPR148 20194645 20195831 0 GeneID:344561 NM_207364.1 "G protein-coupled receptor 148" 139) FLJ38377 20221035 20230581 0 GeneID:205147 NM_152698.1 "hypothetical protein FLJ38377" 140) CYCSP8 20242141 20242452 0 GeneID:360160 - "[no mRNA]" 141) LOC730032 20301842 20383005 0 GeneID:730032 XM_001132160.1 "hypothetical protein LOC730032" 142) ARHGEF4 20382146 20512758 0 GeneID:50649 NM_015320.2 "Rho guanine nucleotide exchange factor (GEF) 4" 143) LOC130074 20513371 20558914 1 GeneID:130074 NM_001009993.1 "hypothetical protein LOC130074" "pleckstrin homology domain containing, family B (evectins) 144) PLEKHB2 20570831 20819204 0 GeneID:55041 NM_001031706.1 member 2" "similar to Serine/threonine-protein kinase Nek2 (NimA- 145) LOC401007 20642531 20644693 1 GeneID:401007 XR_017052.1 related protein kinase 2) (NimA-like protein kinase 1) (HSPK 21)" 146) POTE2 20683846 20729086 0 GeneID:445582 NM_001005359.1 "protein expressed in prostate, ovary, testis, and placenta 2" "similar to hypothetical protein A230046P18; cDNA sequence 147) FLJ30428 20765464 20776861 0 GeneID:150519 XM_496597.3 BC055759, transcript variant 1" 148) LOC150786 20826610 20829653 1 GeneID:150786 - "[no mRNA]" 149) LOC730037 20852770 20857627 1 GeneID:730037 XM_001132172.1 "similar to Collagen alpha-2(XI) chain precursor" 150) LOC389043 20868396 20874544 0 GeneID:389043 XM_374012.3 "hypothetical gene supported by AK125982; BC042817" 151) GNAQP 20889145 20890579 1 GeneID:2777 - "[no mRNA]" 152) LOC401010 20907656 20910378 1 GeneID:401010 - "[no mRNA]" 153) LOC730041 20926167 20929131 0 GeneID:730041 XR_015761.1 "similar to ras-like protein TC10" 154) LOC646836 20935632 20937595 1 GeneID:646836 XM_929793.1 "similar to CDC42-binding protein kinase beta" 155) H2-ALPHA 20941616 20948429 0 GeneID:113457 NM_080386.1 "alpha-tubulin isotype H2-alpha" 156) FLJ41352 20957755 20987084 0 GeneID:150776 - "[no mRNA]" 157) CCDC74A 20993414 20999161 0 GeneID:90557 NM_138770.1 "coiled-coil domain containing 74A" 158) FKSG30 21091610 21093010 0 GeneID:440915 NM_001017421.1 "actin-like protein" 159) LOC391444 21112190 21123077 1 GeneID:391444 - "[no mRNA]" 160) LOC646863 21123190 21123546 1 GeneID:646863 XM_933979.1 "hypothetical LOC646863" "similar to Probable mitochondrial import receptor subunit 161) LOC389049 21147741 21189861 1 GeneID:389049 XR_017334.1 TOM40 homolog (Translocase of outer membrane 40 kDa subunit homolog) (Haymaker protein) (p38.5)" 162) C2orf27 21187986 21232901 0 GeneID:29798 NM_013310.3 "chromosome 2 open reading frame 27" 163) MGC50273 21260456 21267156 1 GeneID:408029 NM_214461.1 "MGC50273 protein" 164) LOC646880 21299098 21310754 1 GeneID:646880 - "[no mRNA]" 165) FLJ41821 21430226 21445368 1 GeneID:401011 NM_001001697.1 "FLJ41821 protein" 166) LOC730072 21459278 21475885 0 GeneID:730072 XM_001132293.1 "hypothetical protein LOC730072" 167) LOC730075 21503495 21504007 0 GeneID:730075 XM_001132300.1 "hypothetical protein LOC730075" 168) LOC730076 21550918 21570577 0 GeneID:730076 XR_015775.1 "similar to zinc finger protein 43 (HTF6)" 169) LOC554226 21598315 21627456 1 GeneID:554226 - "[no mRNA]" 170) LOC730085 21751290 21770252 1 GeneID:730085 XM_001132335.1 "hypothetical protein LOC730085" 171) LOC646915 21770283 21788384 0 GeneID:646915 XM_929878.2 "similar to zinc finger protein 285" 172) LOC339742 21814712 21819179 0 GeneID:339742 XM_929883.2 "hypothetical protein LOC339742" 173) GPR39 21882538 22111101 0 GeneID:2863 NM_001508.1 "G protein-coupled receptor 39" 174) LYPD1 22110348 22135700 1 GeneID:116372 NM_144586.3 "LY6/PLAUR domain containing 1"

LOCUS NT_077407 359898 bp DNA linear CON 29-AUG-2006 DEFINITION Homo sapiens chromosome 2 genomic contig, reference assembly. ACCESSION NT_077407 REGION: 1..359898 VERSION NT_077407.3 GI:88953517 n Name Start End Cmpl LocusID Accession Product 175) LOC442041 53341 57208 1 GeneID:442041 XR_016876.1 "similar to zinc finger protein 532" 176) LOC729248 76489 78110 0 GeneID:729248 XR_015487.1 "similar to zinc finger protein 499" "similar to LIM and senescent cell antigen-like domains 3, 177) LOC440895 79807 127534 1 GeneID:440895 XM_496582.3 transcript variant 1" 178) LOC729260 140203 166506 1 GeneID:729260 XM_001129783.1 "similar to LIM and senescent cell antigen-like domains 1" 179) LOC729540 207058 272653 1 GeneID:729540 XM_001133578.1 "similar to RAN binding protein 2, transcript variant 2" "similar to 60S ribosomal protein L22 (Heparin-binding 180) LOC645231 296151 328754 0 GeneID:645231 XM_928270.2 protein HBp15)"

n Name Start End Cmpl LocusID Accession Product 181) SEPT10 45361 116768 1 GeneID:151011 NM_144710.2 "septin 10" 182) ANKRD57 116877 121549 0 GeneID:65124 NM_023016.2 "ankyrin repeat domain 57" "similar to 60S ribosomal protein L22 (Heparin-binding protein 183) LOC402100 239245 271860 1 GeneID:402100 XM_377761.4 HBp15)" 184) RGPD5 295320 360248 0 GeneID:84220 NM_005054.2 "RANBP2-like and GRIP domain containing 5" 185) LIMS3 401254 409018 0 GeneID:96626 NM_033514.1 "LIM and senescent cell antigen-like domains 3" 186) GPAA1P1 486630 487649 0 GeneID:22945 - "[no mRNA]" 187) LOC645129 489421 491042 1 GeneID:645129 XR_016856.1 "similar to zinc finger protein 499" 188) LOC645135 510210 514077 0 GeneID:645135 XR_016857.1 "similar to zinc finger protein 532" 189) MALL 586432 618633 1 GeneID:7851 NM_005434.3 "mal, T-cell differentiation protein-like" 190) NPHP1 624873 707579 1 GeneID:4867 NM_207181.1 "nephronophthisis 1 (juvenile)" 191) LOC205251 714851 717439 1 GeneID:205251 - "[no mRNA]" LOCUS NT_022171 1917086 bp DNA linear CON 29-AUG-2006 DEFINITION Homo sapiens chromosome 2 genomic contig, reference assembly. ACCESSION NT_022171 REGION: 10256372..12173457 VERSION NT_022171.14 GI:88953465

n Name Start End Cmpl LocusID Accession Product 192) LOC729121 253647 256010 1 GeneID:729121 XM_001133094.1 "hypothetical protein LOC729121" 193) SLC5A7 416209 443658 0 GeneID:60482 NM_021815.2 "solute carrier family 5 (choline transporter), member 7" 194) SULT1C3 676865 695021 0 GeneID:442038 NM_001008743.1 "sulfotransferase family, cytosolic, 1C, member 3" 195) SULT1C1 718309 739585 0 GeneID:6819 NM_001056.3 "sulfotransferase family, cytosolic, 1C, member 1" 196) LOC151234 751908 783469 0 GeneID:151234 XM_930027.2 "hypothetical protein LOC151234" 197) SULT1C2 807635 817484 0 GeneID:27233 NM_006588.2 "sulfotransferase family, cytosolic, 1C, member 2" 198) GCC2 878850 939068 0 GeneID:9648 NM_014635.3 "GRIP and coiled-coil domain containing 2" 199) FLJ38668 939425 963889 1 GeneID:644903 NM_001039776.1 "similar to hypothetical protein MGC10701" 200) LIMS1 1017981 1114103 0 GeneID:3987 NM_004987.3 "LIM and senescent cell antigen-like domains 1" "similar to 60S ribosomal protein L10 (QM protein) (Tumor 201) LOC644911 1141929 1142570 1 GeneID:644911 XR_017525.1 suppressor QM) (Laminin receptor homolog)" 202) RANBP2 1149151 1214465 0 GeneID:5903 NM_006267.3 "RAN binding protein 2" 203) FLJ32745 1216433 1306061 0 GeneID:165055 NM_144978.1 "hypothetical protein FLJ32745" 204) EDAR 1324143 1419042 1 GeneID:10913 NM_022336.1 "ectodysplasin A receptor" 205) SH3MD4 1549982 1886023 0 GeneID:344558 XM_293090.6 "SH3 multiple domains 4" 206) LOC729164 1773430 1774708 1 GeneID:729164 XM_001133275.1 "hypothetical protein LOC729164" Online Supplement 1: Genes in the critical region of chromosome 19

n Name Start End Cmpl LocusID Accession Product 1) SYT5 5392 12643 1 GeneID:6861 NM_003180.2 "synaptotagmin V" 2) PTPRH 13539 41765 1 GeneID:5794 NM_002842.2 "protein tyrosine phosphatase, receptor type, H" 3) TMEM86B 59035 61555 1 GeneID:255043 NM_173804.3 "transmembrane protein 86B" 4) SAPS1 62070 90850 1 GeneID:22870 NM_014931.2 "SAPS domain family, member 1" 5) HSPBP1 94521 112651 1 GeneID:23640 NM_012267.2 "hsp70-interacting protein" 6) BRSK1 116457 144853 0 GeneID:84446 NM_032430.1 "BR serine/threonine kinase 1" "similar to fasting-inducible integral membrane protein 7) LOC284417 145150 157631 1 GeneID:284417 XM_209187.6 TM6P1 isoform 1" 8) SUV420H2 172187 180412 0 GeneID:84787 NM_032701.2 "suppressor of variegation 4-20 homolog 2 (Drosophila)" 9) COX6B2 181993 187105 1 GeneID:125965 NM_144613.4 "cytochrome c oxidase subunit VIb polypeptide 2 (testis)" 10) C19orf16 190432 195551 1 GeneID:284418 XM_371195.5 "chromosome 19 open reading frame 16" 11) IL11 196680 202737 1 GeneID:3589 NM_000641.2 "interleukin 11" 12) MDAC1 209127 210535 0 GeneID:147744 NM_139172.1 "MDAC1" 13) LOC388564 211535 218165 1 GeneID:388564 XM_498725.3 "hypothetical gene supported by BC052596" 14) RPL28 218223 224376 0 GeneID:6158 NM_000991.3 "ribosomal protein L28" 15) UBE2S 233574 239939 1 GeneID:27338 NM_014501.1 "ubiquitin-conjugating enzyme E2S" 16) LOC284296 261031 265233 1 GeneID:284296 NM_175908.3 "hypothetical protein LOC284296" 17) LOC729956 265446 283895 1 GeneID:729956 XM_001131873.1 "hypothetical protein LOC729956" 18) ISOC2 285279 293935 1 GeneID:79763 NM_024710.1 "isochorismatase domain containing 2" 19) LOC729957 293082 296844 1 GeneID:729957 XM_001131877.1 "hypothetical protein LOC729957" 20) ZNF628 308622 316773 0 GeneID:89887 NM_033113.1 "zinc finger protein 628" 21) KLP1 317517 319858 0 GeneID:57106 NM_020378.2 "K562 cell-derived leucine-zipper-like protein 1" 22) FLJ35258 350956 351373 0 GeneID:284297 NM_182571.2 "hypothetical protein 284297" 23) LOC646643 362023 377832 1 GeneID:646643 XM_001131886.1 "similar to protein kinase Bsk146" 24) ZNF579 409822 413110 1 GeneID:163033 NM_152600.1 "zinc finger protein 579" 25) FLJ14768 423669 431816 1 GeneID:84922 NM_032836.1 "hypothetical protein FLJ14768" 26) ZNF524 432653 435427 0 GeneID:147807 NM_153219.2 "zinc finger protein 524" 27) LOC147808 453030 456864 1 GeneID:147808 NM_203374.1 "similar to zinc finger protein" 28) ZNF580 473315 475759 0 GeneID:51157 NM_016202.2 "zinc finger protein 580" 29) ZNF581 475909 477912 0 GeneID:51545 NM_016535.3 "zinc finger protein 581" 30) CCDC106 479877 485450 0 GeneID:29903 NM_013301.2 "coiled-coil domain containing 106" 31) U2AF2 486339 507005 0 GeneID:11338 NM_001012478.1 "U2 small nuclear RNA auxiliary factor 2" 32) EPN1 507515 528056 0 GeneID:29924 NM_013333.2 "epsin 1" 33) NALP9 540721 570691 1 GeneID:338321 NM_176820.2 "NACHT, leucine rich repeat and PYD containing 9" 34) LOC342931 591303 595464 0 GeneID:342931 XM_292796.5 "similar to ret finger protein-like 1" 35) LOC729974 601436 605468 0 GeneID:729974 XM_001131933.1 "similar to ret finger protein-like 1" 36) NALP11 617688 664283 1 GeneID:204801 NM_145007.1 "NACHT, leucine rich repeat and PYD containing 11" 37) LOC646667 668673 684218 1 GeneID:646667 XM_929610.2 "similar to proline-rich glycoprotein (sgp158)" 38) NALP4 684310 714144 0 GeneID:147945 NM_134444.3 "NACHT, leucine rich repeat and PYD containing 4" 39) NALP13 728234 764600 1 GeneID:126204 NM_176810.1 "NACHT, leucine rich repeat and PYD containing 13" 40) NALP8 780121 820918 0 GeneID:126205 NM_176811.2 "NACHT, leucine rich repeat and PYD containing 8" 41) NALP5 832015 894099 0 GeneID:126206 NM_153447.2 "NACHT, leucine rich repeat and PYD containing 5" 42) LOC729982 909198 912987 0 GeneID:729982 XM_001131951.1 "hypothetical protein LOC729982" 43) LOC126208 919655 953572 1 GeneID:126208 NM_001002836.1 "hypothetical protein LOC126208" 44) ZNF444 973479 993185 0 GeneID:55311 NM_018337.2 "zinc finger protein 444" 45) GALP 1008312 1018067 0 GeneID:85569 NM_033106.1 "galanin-like peptide precursor" 46) LOC342933 1021981 1025268 1 GeneID:342933 XM_292723.5 "similar to zinc finger and SCAN domain containing 5" 47) LOC649137 1038350 1041492 0 GeneID:649137 XM_001131980.1 "similar to zinc finger and SCAN domain containing 5" 48) ZSCAN5 1053602 1060582 1 GeneID:79149 NM_024303.1 "zinc finger and SCAN domain containing 5" 49) LOC646698 1076335 1079789 0 GeneID:646698 XM_929644.2 "similar to zinc finger and SCAN domain containing 5" 50) LOC729994 1105061 1139651 0 GeneID:729994 XM_001131994.1 "hypothetical protein LOC729994" 51) LOC649186 1149575 1150177 1 GeneID:649186 XM_938252.1 "similar to vomeronasal 2, receptor, 14" "similar to Glycerol-3-phosphate dehydrogenase, 52) LOC729999 1152060 1154603 1 GeneID:729999 XR_015739.1 mitochondrial precursor (GPD-M) (GPDH-M) (mtGPD)" "similar to Complex I intermediate-associated protein 30, 53) LOC646709 1174726 1176157 1 GeneID:646709 XR_017681.1 mitochondrial precursor" 54) ZNF542 1200431 1211820 0 GeneID:147947 - "[no mRNA]" 55) ZNF582 1215571 1225812 1 GeneID:147948 NM_144690.1 "zinc finger protein 582" 56) ZNF583 1236641 1257323 0 GeneID:147949 NM_152478.1 "zinc finger protein 583" 57) ZNF667 1272123 1309666 1 GeneID:63934 NM_022103.2 "zinc finger protein 667" 58) ZNF471 1340135 1361193 0 GeneID:57573 NM_020813.1 "zinc finger protein 471" 59) ZFP28 1371240 1389093 0 GeneID:140612 NM_020828.1 "zinc finger protein 28 homolog (mouse)" 60) ZNF470 1397473 1411042 0 GeneID:388566 NM_001001668.2 "zinc finger protein 470" 61) SIGLECP15 1422245 1422782 1 GeneID:114189 - "[no mRNA]" 62) ZNF71 1427615 1456473 0 GeneID:58491 NM_021216.3 "zinc finger protein 71" 63) BC37295_3 1495876 1505169 1 GeneID:90485 NM_001005850.1 "hypothetical BC37295_3" 64) OR5AH1P 1593155 1593523 0 GeneID:79336 - "[no mRNA]" 65) ZIM2 1606843 1672998 1 GeneID:23619 NM_015363.3 "zinc finger, imprinted 2" 66) PEG3 1644726 1672987 1 GeneID:5178 NM_006210.1 "paternally expressed 3" 67) LOC646746 1670585 1671958 0 GeneID:646746 XM_929696.1 "similar to piccolo (presynaptic cytomatrix protein)" 68) USP29 1952432 1964217 0 GeneID:57663 NM_020903.2 "ubiquitin specific peptidase 29" 69) ZIM3 1966387 1977493 1 GeneID:114026 NM_052882.1 "zinc finger, imprinted 3" 70) DUXA 1984017 1999779 1 GeneID:503835 NM_001012729.1 "double homeobox A" 71) ZNF264 2023792 2051462 0 GeneID:9422 NM_003417.2 "zinc finger protein 264" 72) AURKC 2063300 2067839 0 GeneID:6795 NM_001015878.1 "aurora kinase C" 73) LOC390980 2085726 2094590 0 GeneID:390980 NM_001023563.1 "similar to Zinc finger protein 264" 74) ZNF460 2112856 2125729 0 GeneID:10794 NM_006635.2 "zinc finger protein 460" 75) ZNF543 2152800 2163067 0 GeneID:125919 NM_213598.1 "zinc finger protein 543" 76) ZNF304 2183598 2192189 0 GeneID:57343 NM_020657.1 "zinc finger protein 304" 77) ZNF547 2195802 2211850 0 GeneID:284306 NM_173631.2 "zinc finger protein 547" 78) ZNF548 2222141 2233709 0 GeneID:147694 NM_152909.2 "zinc finger protein 548" 79) ZNF17 2243470 2254094 0 GeneID:7565 NM_006959.1 "zinc finger protein 17" 80) ZNF749 2275701 2277776 0 GeneID:388567 NM_001023561.1 "zinc finger protein 749" 81) VN1R1 2287465 2288777 1 GeneID:57191 NM_020633.2 "vomeronasal 1 receptor 1" 82) DKFZp686I1569 2301877 2309861 1 GeneID:400720 NM_001024596.1 "similar to hypothetical protein FLJ23506" 83) ZNF419 2320056 2326971 0 GeneID:79744 NM_024691.2 "zinc finger protein 419" 84) MGC4728 2332232 2340449 0 GeneID:374928 NM_198542.1 "similar to hypothetical protein FLJ23233" 85) ZNF549 2359616 2373054 0 GeneID:256051 NM_153263.1 "zinc finger protein 549" 86) ZNF550 2379266 2388648 1 GeneID:162972 NM_001039654.1 "zinc finger protein 550" 87) ZNF416 2403857 2411166 1 GeneID:55659 NM_017879.1 "zinc finger protein 416" 88) ZIK1 2416551 2424681 0 GeneID:284307 NM_001010879.2 "zinc finger protein interacting with K protein 1" 89) ZNF530 2432176 2440555 0 GeneID:348327 NM_020880.2 "zinc finger protein 530" 90) ZNF134 2446551 2455647 0 GeneID:7693 NM_003435.2 "zinc finger protein 134" 91) ZNF211 2465507 2475059 0 GeneID:10520 NM_198855.1 "zinc finger protein 211" 92) ZSCAN4 2501226 2511428 0 GeneID:201516 NM_152677.1 "zinc finger and SCAN domain containing 4" 93) ZNF551 2514328 2522102 0 GeneID:90233 NM_138347.2 "zinc finger protein 551" 94) ZNF154 2533890 2541502 1 GeneID:7710 XM_001132208.1 "zinc finger protein 154 (pHZ-92)" 95) ZNF671 2552042 2559906 1 GeneID:79891 NM_024833.1 "zinc finger protein 671" 96) FLJ38288 2583134 2590448 0 GeneID:284309 NM_173632.2 "hypothetical protein FLJ38288" 97) ZNF586 2601961 2612868 0 GeneID:54807 NM_017652.1 "zinc finger protein 586" 98) ZNF552 2639375 2647204 1 GeneID:79818 NM_024762.2 "zinc finger protein 552" 99) ZNF587 2682192 2700876 0 GeneID:84914 NM_032828.1 "zinc finger protein 587" "similar to Ubiquitin-conjugating enzyme E2 C (Ubiquitin- 100) LOC730173 2700051 2701277 0 GeneID:730173 XR_016082.1 protein ligase C) (Ubiquitin carrier protein C) (UbcH10)" 101) LOC730051 2704553 2721337 1 GeneID:730051 XR_015766.1 "similar to Zinc finger protein 418" 102) ZNF417 2739137 2748867 1 GeneID:147687 NM_152475.1 "zinc finger protein 417" 103) ZNF418 2754175 2767663 1 GeneID:147686 NM_133460.1 "zinc finger protein 418" 104) NAG18 2761970 2772600 0 GeneID:57051 - "[no mRNA]" 105) LOC730055 2767106 2767665 1 GeneID:730055 XM_001132235.1 "hypothetical protein LOC730055" 106) ZNF256 2773124 2780000 1 GeneID:10172 NM_005773.2 "zinc finger protein 256" 107) LOC646820 2785409 2786815 1 GeneID:646820 XR_017330.1 "similar to ribosomal protein L19" 108) C19orf18 2790728 2806827 1 GeneID:147685 NM_152474.2 "chromosome 19 open reading frame 18" 109) ZNF606 2809363 2835637 1 GeneID:80095 NM_025027.3 "zinc finger protein 606" 110) ZSCAN1 2866357 2886922 0 GeneID:284312 NM_182572.2 "zinc finger and SCAN domain containing 1" 111) ZNF135 2891535 2901699 0 GeneID:7694 NM_003436.2 "zinc finger protein 135" 112) ZNF447 2916129 2930500 1 GeneID:65982 NM_023926.3 "zinc finger protein 447" 113) ZNF329 2958618 2983071 1 GeneID:79673 NM_024620.3 "zinc finger protein 329" 114) ZNF274 3015319 3045850 0 GeneID:10782 NM_016324.2 "zinc finger protein 274" 115) ZNF544 3061757 3096396 0 GeneID:27300 NM_014480.1 "zinc finger protein 544" 116) ZNF8 3111241 3128177 0 GeneID:7554 NM_021089.1 "zinc finger protein 8" 117) LOC113386 3137666 3147938 0 GeneID:113386 NM_138781.2 "similar to envelope protein" 118) HKR2 3159308 3174621 0 GeneID:342945 NM_181846.1 "GLI-Kruppel family member HKR2" 119) A1BG 3177467 3185780 1 GeneID:1 NM_130786.2 "alpha-1-B glycoprotein" 120) ZNF497 3186648 3195043 1 GeneID:162968 NM_198458.1 "zinc finger protein 497" 121) LOC116412 3199660 3213335 1 GeneID:116412 XM_375665.4 "hypothetical protein BC012365" 122) RPS5 3219559 3227094 0 GeneID:6193 NM_001009.3 "ribosomal protein S5" 123) LOC646862 3228380 3229783 0 GeneID:646862 XM_929820.1 "similar to ring finger protein 183" 124) ZNF584 3240986 3250617 0 GeneID:201514 NM_173548.1 "zinc finger protein 584" 125) ZNF132 3265105 3272512 1 GeneID:7691 NM_003433.2 "zinc finger protein 132" 126) FLJ45850 3283894 3290122 0 GeneID:388569 NM_207395.1 "FLJ45850 protein" 127) ZNF324 3299386 3305688 0 GeneID:25799 NM_014347.1 "zinc finger protein 324" 128) ZNF446 3308718 3313520 0 GeneID:55663 NM_017908.1 "zinc finger protein 446" 129) SLC27A5 3330628 3344272 1 GeneID:10998 NM_012254.1 "solute carrier family 27 (fatty acid transporter), member 5" 130) ZNF499 3345820 3351844 1 GeneID:84878 NM_032792.2 "zinc finger protein 499" 131) TRIM28 3376759 3383005 0 GeneID:10155 NM_005762.2 "tripartite motif-containing 28" 132) CHMP2A 3383856 3387409 1 GeneID:27243 NM_198426.1 "chromatin modifying protein 2A" "ubiquitin-conjugating enzyme E2M (UBC12 homolog, 133) UBE2M 3388002 3391258 1 GeneID:9040 NM_003969.2 yeast)" 134) MZF1 3394207 3405865 1 GeneID:7593 NM_198055.1 "myeloid zinc finger 1" 135) MGC2752 3407750 3416478 0 GeneID:65996 NM_023939.3 "hypothetical protein MGC2752" 136) LOC653789 3431379 3431744 0 GeneID:653789 XM_929847.2 "similar to 60S ribosomal protein L23a"