R. Stan Williams Professor, Obstetrics and Gynecology Chief, Division of Reproductive Endocrinology and Infertility Medical Director, Women's Health at Magnolia Parke and Women's Health at Shands Medical Plaza Medical Director, In Vitro Fertilization Program University of Florida College of Medicine Department of Obstetrics and Gynecology 1600 SW Archer Road Room M-302 Gainesville, FL 32610 PHONE: 352-392-5680 FAX: 352-392-9724

Education and Training INSTITUTION AND LOCATION DEGREE YEAR(s) FIELD OF STUDY University of North Carolina, Chapel Hill, NC B.A. 1975 Zoology University of North Carolina, Chapel Hill, NC M.D. 1979 Medicine Medical University of SC, Charleston, SC Residency 1979-1983 OB/GYN University of Louisville, Louisville, KY Fellowship 1986-1988 Reproductive

Dr. Williams has been active in both clinical and basic research. Clinically he has been involved with multiple clinical trials in the area of menopause, hot flashes, osteoporosis and infertility. His basic research has been in collaboration with Nasser Chegini, PhD and Ken Drury, PhD and has included research involving the pathophysiology of leiomyomas, endometriosis, and adhesion formation, as well as FISH in preimplantation genetic diagnosis.

Selected peer-reviewed publications (in chronological order) Williams RS. Infertility care in the New Millennium. House Calls (Alachua Co. Medical Society) September - October 2000.

Evenson LJ, Drury KC, Kovalinskaia L, Williams RS. Repeated FISH (Fluorescence in Situ Hybridization) in Human Amniocytes and Fibroblasts for Preimplantation Genetic Diagnosis. Journal of the Association of Genetic Technology. 26:96-98, 2000.

Kipersztok S, Man L, Drury KC, Williams RS, Rhoton-Vlasak AS. Use of Intracytoplasmic Sperm Injection (ICSI) in In-Vitro Fertilization (IVF) Cycles with Failed or Poor Fertilization. Reproductive Technologies. Reproductive Technologies 10: 311-313, 2001.

Chegini N, Kotseos K, Chunfeng M, Patel A, Williams RS, Diamond M, Holmdahl L, Skinner K. Differential Expression of Integrin v and ß3 in Serosal Tissue of Human Intraperitoneal Organs and Adhesion. Fertility and Sterility. 75:791-796, 2001.

PHS 398 (Rev. 05/01) Page ____ Chegini C, Rhoton-Vlasak A, Williams RS. Expression of Matrix Metalloproteinase-26 and Tissue Inhibitor of Matrix Metalloproeinase-3 and -4 in Endometrium Throughout the Normal Menstrual Cycle and Alteration in Users of Levonorgestrel Implants Who Experience Bleeding. Fertil and Steril 80:3; 2003

Williams RS, Hillard JB, DeVane G, Yeko T, Kipersztok S, Rhoton-Vlasak A, Sistrom C. A Prospective, Randomized, Multicenter Study Comparing the Efficacy of Recombinant FSH vs. Recombinant FSH with Ganirelix During Superovulation/IUI Therapy. American Journal of Obstetrics and Gynecology 191:648-653, 2004.

Levins E, Williams RS. Current Opinions and understandings of Menopausal Women Toward Hormone Replacement Therapy. American Journal of Obstetrics and Gynecology 191:641-647, 2004

Williams CA, Wallace MR, Drury KC, Kipersztok S, Edwards RK, Williams RS, Gray BA, Zori RT. Blood Lymphocyte Chimerism Associated with In Vitro Fertilization and Monochorionic Dizygous Twinning. Human Reproduction 19(12):2816-2821, 2004.

Jordan C, Belar CD, Williams RS. Anonymous Oocyte Donation: A Follow-Up Analysis of Donors’ Experiences. Journal of Psychosomatic Obstetrics and Gynecology 25(2):145-151, 2004.

Luo X, Ding L, Xu J, Williams RS, Chegini N. Leiomyoma and Myometrial Gene Expression Profiles and Their Response to Gonadotropin Releasing Hormone Analogue (GnRHa) Therapy and Modulation During GnRHa Treatment In Vitro. Endocrinology 146(3):1074-1096, 2005.

Rhoton-Vlasak A, Chegini N, Hardt N, Williams RS. Histologic Characteristics and Altered Expression of Interleukins (IL) IL-13 and IL-15 in Endometria of Levonorgestrel Users with Different Bleeding Patterns. Fertility and Sterility 83:3,659-665, 2005.

Barnabei VM, Cochrane BB, Aragaki A, Nygaard I, Williams RS, et al. Menopausal Symptoms and Treatment-Related Effects of Estrogen and Progestin in the Women’s Health Initiative. Obstetrics and Gynecology 105:5, 1063-1073, 2005.

Williams RS, Christie D, Sistrom C. Assessment of the Understanding of the Risks and Benefits of Hormone Replacement Therapy (HRT) in Primary Care Physicians. American Journal of Obstetrics and Gynecology 193:2, 551-558, 2005.

Levens E, Luo X, Ding L, Williams RS, Chegini N. Fibromodulin is Expressed in Leiomyoma and Myometrium and Regulated by Gonadotropin Releasing Hormone Analogue (GnRHa) Therapy and TGFß Through Smad and MAPK-Mediated Signaling. Molecular Human Reproduction. 11:7, 489-494, 2005.

PHS 398 (Rev. 05/01) Page ____ Kovalinskaia l, Song L, Al-Katanani Y, Williams RS, Drury KC. Rapid 2-Round FISH for Aneuploidy Screening of 9 Chromosomes (X,Y,13,15,16,17,18,21,22) Using Microwave Technology. Clinical Embryologist 9:1, 13-21, 2006.

Luo X, Levens E, Williams RS, Chegini N. The Expression of Abl Interactor 2 (Abi-2) in Leiomyoma and Myometrium and Regulation by Gonadotropin Releasing Hormone Analogue and TGF-B . Human Reproduction 6:1380-6, 2006.

Li R, Luo X, Pan Q, Zineh I, Archer D, Williams RS, Chegini N. Doxycycline Alters the Expression of Inflammatory and Immune Related Cytokines and Chemokines in Human Endometrial Cells: Implication in Dysfunctional Uterine Bleeding . Human Reproduction, 10:2555-63, 2006.

Research Support

Xanodyne – A Randomized, Prospective Study for the Treatment of Menorrhagia 2006-2007 PI - 1%

Wyeth- The effect of Dose Titration and Dose Tapering on the Tolerability of 2006- 2007 DVS SR in Women with Vasomotor Symptoms Associated with Menopause PI - 5%

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