Table S2: Literature Search Terms and Results, Conducted by AKG

Table S2: Literature search terms and results, conducted by AKG Medli Search Terms Search Terms Results PubMed Results ne Search (((((randomized clinical trial) OR randomised clinical trial) OR randomized controlled trial) OR randomised controlled trial) randomized clinical 1 25307 OR randomized controlled trial.af. trial[MeSH Major Topic]) OR randomised clinical trial[MeSH #1 Major Topic] 404035 Search (((randomly) OR randomized clinical randomised) OR randomized) OR 2 trial.ab,cn,hw,kw,ot,p 25296 #2 random* 763429 t,sh,sl,ti,tw Search ((((trial) OR clinical trial) controlled clinical OR study) OR trial[MeSH Major 3 83971 trial.pt. #3 Topic]) OR trial[Title] 5761319 controlled clinical Search #2 OR #3 4 483908 #4 5909676 trial.af. #5 Search #2 AND #3 615072 5 clinical trial.af. 1489830 (randomized clinical Search #1 OR #5 6 trial or randomised 28430 #6 615137 clinical trial).af. Search ((polypill) OR polycap) OR randomized 7 677651 #7 polypill[MeSH Subheading] 150 controlled trial.af. Search (((drug combination) OR combination therapy) OR fixed (Trial or intervention 8 15858322 combination) OR fixed dose or Study).af. #8 combination 556650 #9 Search ((((antihypertensive) OR 260992 9 random*.af. 1613161 antihypertensive[MeSH Major Topic]) OR blood pressure medication) OR antihyperten*) OR blood pressure lowering medication Search (((drug) OR treatment) OR 10 8 and 9 1311829 #10 medication) OR agent 9243118 Search (((blood pressure) OR hypertension) OR 1 or 2 or 3 or 4 or 5 or hypertension[MeSH Major Topic]) 11 2177666 6 or 7 or 10 OR blood pressure[MeSH #11 Subheading] 670035 (polypill or Search #11 and #10 12 4293 #12 417573 polycap).af. #13 Search #12 AND #9 112866 13 antihypertensive.af. 161351 Search ((((hyperlipdaemia) OR hyperlipidemia) OR (Hypertension or high hyperlipidaemia[MeSH Major 14 930375 blood pressure).af. Topic]) OR hypercholesterolemia) #14 OR hypercholeterol* 67707 (treatment or Search #14 and #10 15 8671413 #15 42001 management).af. Search (((((antihyperlipidaemic) OR statin) OR anticholestremic) OR lipid lowering agent) OR antihyperlipidemic[MeSH Major 16 (drug or agent).af. 8731102 Topic]) OR anticholestermic[MeSH Major #16 Topic] 28461 #17 Search #16 AND #15 8065 17 14 and 15 and 16 143019 Search #8 AND (#17 OR #15) 18 13 or 17 256550 #18 AND (#16 OR #9) 1831 #19 Search #18 OR #7 1978 19 (anticholesteremic or 32589 antihyperlipidaemic or Lipid lowering).af. Search (((((((cardiovascular disease) OR cardiovascular[MeSH Major Topic]) OR coronary artery disease) OR coronary heart (hyperlipidaemia or disease) OR coronary heart 20 hyperlipidemia or 79664 disease[MeSH Major Topic]) OR high cholesterol).af. stroke) OR cerebrovascular disease) AND cerebrovascular #20 disease[MeSH Major Topic] 198959 Search (((((((compliance) OR adherence) OR persistence) OR safety) OR blood pressure) OR 21 15 and 16 and 20 16123 complianc*) OR adverse events) #21 OR cardiovascular outcome 1037794 #22 Search #21 OR #20 1213847 22 19 or 21 46500 #23 Search #22 AND #19 AND #6 336 23 18 and 22 8548 (drug combination or fixed cose Search (human) NOT animal 24 1316016 combination or #24 10987182 combination).af. Search (English) OR 25 23 and 24 1301 #25 English[Language] 19078152 #26 Search #23 AND #24 AND #25 323 26 12 or 25 5567 (cardiovascular disease or Search #26 AND #7 27 2549447 cardiovascular* or #27 16 coronary*).af. (cardiovascular disease or 28 2549447 cardiovascular* or coronary*).af. 29 11 and 26 and 28 523 (Human or Men or 30 17372214 women).af. (Human or Men or 31 17372214 women).af. English.lg. or 32 39431332 English.af. 33 29 and 31 and 32 398 blood pressure.lg. or 34 systolic.af. or 349418 diastolic.af. cholesterol.lg. or LDL.af. or total 35 879637 cholesterol.af. or lipid.af. safety.lg. or adverse reaction.af. or adverse 36 2405028 event.af. or advers*.af. compliance.lg. or complian*.af. or adherence.af. or pill 37 525280 count.af. or mediation possession ratio.af. or persistence.af. 38 34 or 35 or 36 or 37 3967701 39 33 and 38 345 remove duplicates 40 334 from 39 41 12 and 40 64 NB: No further references were found when Embase was searched