20:00 Informal Gathering of Invited Speakers and Chairs in the Hotel

SCIENTIFIC PROGRAM

Saturday, February 9, 20:00 Informal gathering of invited speakers and chairs in the Hotel

Sunday, February 10, 2008

08:30-9:30 Registration and Distribution of Meeting Material

09:30-9:40 Opening Remarks: Abdussalam Azem

Session I

STRUCTURE, BIOGENESIS AND FUNCTION OF MEMBRANE PROTEINS

(Chairman – Eitan Bibi (Weizmann Institute

09:40-10:20 Nathan Nelson (Tel Aviv University) Molecular evolution of perfection and imperfection

10:20-11:00 Ronald Kaback (University of California, Los Angeles) How to stop worrying and learn to love the permease.

11:00-11:40 Gunnar von Heijne (Stockholm University) The membrane protein world: looking for the simple answers.

11:40- 12:20 Coffee break

12:20- 13:20 Wolfgang Junge (Osnabrück University) From Light to ATP: the Beauty of Simplicity

13:20- 14:00 Etana Padan (Hebrew University) NhaA: structure driven studies of function and regulation of a Na+/H+ antiporter

14:00-16:00 Lunch & Posters

Session I: Continued

Chairman- Shimon Schuldiner (Hebrew University)

16:00-16:40 Susan G. Amara (Pittsburgh University) The ins and outs of neurotransmitter transporters.

16:40-17:20 Ernest M. Wright (University of California Los Angeles) Imaging glucose transporters in mice and men. 17:20-18:00 Coffee break

18:00-19:00 Keynote Lecture Sir John E. Walker (MRC; Nobel laureate) Oxygen, energy and life.

Monday, February 11, 2008

Session II

UNRAVELING COMPLEX BIOLOGICAL SYSTEMS BY GENETICS AND STRUCTURAL STUDIES

Chairman- Andrea Melandri (University of Bologna)

09:00-09:40 Andreas Engel (Biozentrum, Basel) Observing membrane proteins in ice and water.

09:40-10:20 Satoshi Murakami (Institute of Scientific and Industrial Research, Osaka University) Multidrug recognition and pumping by bacterial multidrug efflux transporter - A structural view

10:20-11:00 Reinhold Herrmann (University of Munich) Organelle Biology and Eukaryotism

11:00-11:30 Coffee break

Chairman- Chanoch Carmeli (Tel Aviv University)

11:30-12:10 Jean-David Rochaix (University of Geneva) To be announced

12:10-12:50 Sabeeha Merchant (University of California Los Angeles) Inorganic building blocks of the photosynthetic apparatus.

12:50- 13:30 Charles F. Yocum (University of Michigan) Photosynthetic oxygen evolution: organization and reactivity of the active site.

13:30-15:30 Lunch & Posters

Session II: Continued

Chairman- Guenther Hauska (University of Regensburg)

15:30-16:10 James Barber (Imperial College) The Big Bang of evolution and the engine of life.

16:10-16:50 Shuguang Zhang ( MIT) Designer lipid-like peptide surfactants for studying membrane proteins.

16:50-17:30 William F. Martin (Düsseldorf University) Some thoughts on early evolution and the role of hydrogen.

18:00-19:00 Keynote Lecture Hartmut Michel (MPI Frankfurt; Nobel laureate) To be anounced

19:30 Wine and Cheese evening – All the registered participants are invited

Tuesday, February 12, 2008

Session III

CELLULAR DYNAMICS

Chairman- Ophry Pines (Hebrew University)

09:00-09:40 Randy W. Schekman (University of California Berkeley) Protein sorting and disease.

09:40-10:20 Howard Riezman (University of Geneva) The intimate relationship between sterols and sphingolipids

10:20-11:00 Steve Karlish (Weizmann institute) P-type cation pumps- structure and mechanism

11:30-12:10 Walter Neupert (University of Munich) Putting together a complex organelle that comes in many shapes: the mitochondrion

12:10-12:50 Ada E. Yonath ( Weizmann Institute) The amazing ribosome.

12:50-15:00 Lunch & Posters Session III: Continued

Chairman- Maciej Nalecz (UNESCO and Nencki Institute)

15:00-15:40 Joseph Schlessinger (Yale University) Cell signaling by receptor tyrosine kinases: From bench to bedside.

15:40-16:20 Yossi Shiloh (Tel Aviv University) ATM as a crossroad of the complexity of the DNA damage response – A blessing in disguise.

16:20-16:50 Coffee break.

16:50-17:50 Keynote lecture Avram Hershko (Technion Haifa; Nobel laureate) The ubiquitin system for protein degradation and its roles in cell cycle control

17:50 Concluding remarks: Gottfried Schatz