<p> SCIENTIFIC PROGRAM</p><p>Saturday, February 9, 20:00 Informal gathering of invited speakers and chairs in the Hotel </p><p>Sunday, February 10, 2008</p><p>08:30-9:30 Registration and Distribution of Meeting Material</p><p>09:30-9:40 Opening Remarks: Abdussalam Azem</p><p>Session I</p><p>STRUCTURE, BIOGENESIS AND FUNCTION OF MEMBRANE PROTEINS</p><p>(Chairman – Eitan Bibi (Weizmann Institute</p><p>09:40-10:20 Nathan Nelson (Tel Aviv University) Molecular evolution of perfection and imperfection</p><p>10:20-11:00 Ronald Kaback (University of California, Los Angeles) How to stop worrying and learn to love the permease.</p><p>11:00-11:40 Gunnar von Heijne (Stockholm University) The membrane protein world: looking for the simple answers.</p><p>11:40- 12:20 Coffee break</p><p>12:20- 13:20 Wolfgang Junge (Osnabrück University) From Light to ATP: the Beauty of Simplicity</p><p>13:20- 14:00 Etana Padan (Hebrew University) NhaA: structure driven studies of function and regulation of a Na+/H+ antiporter</p><p>14:00-16:00 Lunch & Posters</p><p>Session I: Continued</p><p>Chairman- Shimon Schuldiner (Hebrew University)</p><p>16:00-16:40 Susan G. Amara (Pittsburgh University) The ins and outs of neurotransmitter transporters.</p><p>16:40-17:20 Ernest M. Wright (University of California Los Angeles) Imaging glucose transporters in mice and men. 17:20-18:00 Coffee break</p><p>18:00-19:00 Keynote Lecture Sir John E. Walker (MRC; Nobel laureate) Oxygen, energy and life.</p><p>Monday, February 11, 2008</p><p>Session II</p><p>UNRAVELING COMPLEX BIOLOGICAL SYSTEMS BY GENETICS AND STRUCTURAL STUDIES</p><p>Chairman- Andrea Melandri (University of Bologna)</p><p>09:00-09:40 Andreas Engel (Biozentrum, Basel) Observing membrane proteins in ice and water.</p><p>09:40-10:20 Satoshi Murakami (Institute of Scientific and Industrial Research, Osaka University) Multidrug recognition and pumping by bacterial multidrug efflux transporter - A structural view</p><p>10:20-11:00 Reinhold Herrmann (University of Munich) Organelle Biology and Eukaryotism</p><p>11:00-11:30 Coffee break</p><p>Chairman- Chanoch Carmeli (Tel Aviv University)</p><p>11:30-12:10 Jean-David Rochaix (University of Geneva) To be announced</p><p>12:10-12:50 Sabeeha Merchant (University of California Los Angeles) Inorganic building blocks of the photosynthetic apparatus.</p><p>12:50- 13:30 Charles F. Yocum (University of Michigan) Photosynthetic oxygen evolution: organization and reactivity of the active site.</p><p>13:30-15:30 Lunch & Posters</p><p>Session II: Continued</p><p>Chairman- Guenther Hauska (University of Regensburg)</p><p>15:30-16:10 James Barber (Imperial College) The Big Bang of evolution and the engine of life.</p><p>16:10-16:50 Shuguang Zhang ( MIT) Designer lipid-like peptide surfactants for studying membrane proteins.</p><p>16:50-17:30 William F. Martin (Düsseldorf University) Some thoughts on early evolution and the role of hydrogen.</p><p>17:30-18:00 Coffee break</p><p>18:00-19:00 Keynote Lecture Hartmut Michel (MPI Frankfurt; Nobel laureate) To be anounced </p><p>19:30 Wine and Cheese evening – All the registered participants are invited</p><p>Tuesday, February 12, 2008</p><p>Session III</p><p>CELLULAR DYNAMICS</p><p>Chairman- Ophry Pines (Hebrew University)</p><p>09:00-09:40 Randy W. Schekman (University of California Berkeley) Protein sorting and disease.</p><p>09:40-10:20 Howard Riezman (University of Geneva) The intimate relationship between sterols and sphingolipids</p><p>10:20-11:00 Steve Karlish (Weizmann institute) P-type cation pumps- structure and mechanism</p><p>11:00-11:30 Coffee break</p><p>11:30-12:10 Walter Neupert (University of Munich) Putting together a complex organelle that comes in many shapes: the mitochondrion</p><p>12:10-12:50 Ada E. Yonath ( Weizmann Institute) The amazing ribosome.</p><p>12:50-15:00 Lunch & Posters Session III: Continued</p><p>Chairman- Maciej Nalecz (UNESCO and Nencki Institute)</p><p>15:00-15:40 Joseph Schlessinger (Yale University) Cell signaling by receptor tyrosine kinases: From bench to bedside.</p><p>15:40-16:20 Yossi Shiloh (Tel Aviv University) ATM as a crossroad of the complexity of the DNA damage response – A blessing in disguise.</p><p>16:20-16:50 Coffee break.</p><p>16:50-17:50 Keynote lecture Avram Hershko (Technion Haifa; Nobel laureate) The ubiquitin system for protein degradation and its roles in cell cycle control</p><p>17:50 Concluding remarks: Gottfried Schatz</p>