Cancer and Leukemia Group B (CALGB)

2018 年 4 月 7 日

Alliance for Clinical Trials in Oncology November 8, 2013 Intercontinental Chicago O’Hare Rosemont, IL Room TBD, 11:30am-2:30pm

Respiratory Committee

Chair: Everett E. Vokes, M.D. Vice-Chairs: Dennis Wigle (Surgery) Steven Schild (Radiation Oncology) Pasi Janne (Correlative Science) Jeff Crawford (CALGB) Alex Adjei (NCCTG)

1. Committee overview and protocol accrual–Everett Vokes and Xiaofei Wang

 Educational Updates: New since ASCO:

o WCLC-TBA

o ECCO- Update on vaccine trials – Beppe Giacone

2. Early Stage Non-Small Cell Lung Cancer and Surgical Studies- Dennis Wigle

 CALGB 140503: Lobectomy vs. limited resection – Nasser Altorki

 E 1505: Intergroup adjuvant bevacizumab study – Stephen Graziano

 Z41102- ALCHEMIST Personalized Adjuvant Therapy in Patients with

Completely Resected Non-Small Cell Lung Cancer –Geoffrey Oxnard, Pasi

Janne, Dennis Wigle, Ramaswamy Govindan

3. Stage III Non-Small Cell Lung Cancer-Steven Schild

 RTOG 1306: Personalized therapy for inoperable stage III NSCLC - Olwen

Hahn, Ramaswamy Govindan

 CALGB 31102: Hypofractionated XRT for stage III NSCLC - James Urbanic

4. Stage IV Non-Small Cell Lung Cancer 2018 年 4 月 7 日

 CALGB 30607: Sunitinib as maintenance therapy – Mark Socinski, Maria

Baggstrom

 CALGB 30801: Cox-2 inhibition in stage IV NSCLC – Martin Edelman

 SWOG 0819: Chemo-(bev) +/- cetuximab – Lyudmila Bazhenova

 CALGB 31002/ACCRUE: Erlotinib +/- bevacizumab for NSCLC patients with

EGFR mutation – Tom Stinchcombe

 E2512: A phase I/randomized phase II study of docetaxel with or without

AZD4547 in recurrent FGFR1-amplified squamous NSCLC. – Victoria Villaflor

 Rare genotypes trial– Geoffrey Oxnard, Pasi Janne

 Selumetinib – Bryan Schneider, Pasi Janne

 2nd line studies in NSCLC-Martin Edelman and subcommittee

 SWOG Squamous Master Protocol

5. Small Cell Lung Cancer

 CALGB 30610: Limited Stage Intergroup Trial– Jeffrey Bogart and Greg

Masters

 RTOG 0937 – Steve Schild

 Update on Sunitinib, nintendanib– Neal Ready, Jeff Crawford and

subcommittee

 Update on RTOG 0617- Jeffrey Bogart

6. Mesothelioma–Robert Kratzke, Hedy Kindler

 CALGB 30901 - Pemetrexed maintenance Study – Arkadiusz Dudek

7. Correlative Science-Pasi Janne

 Imaging modeling project – Michael Maitland

 Overview of current projects –Robert Kratzke, Stephen Graziano, Pasi

Janne 2018 年 4 月 7 日

8. Patient version of CTCAE being developed by NCI – Ethan Basch and Diana

Mehedint