Research Output

Research output

Listing of Research output

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

Delaine, T., Collins, P., MacKinnon, A., Sharma, G., Stegmayr, J., Rajput, V. K., Mandal, S., Cumpstey, I., Larumbe, A., Salameh, B. A., Kahl-Knutsson, B., van Hattum, H., van Scherpenzeel, M., Pieters, R. J.,

Sethi, T.

, Schambye, H., Oredsson, S., Leffler, H., Blanchard, H. & Nilsson, U. J.

15 Sep 2016

Chembiochem : a European journal of chemical biology.

p. 1759-1770

Research output

Contribution to journal

Article

A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3- glycan Interactions in a Pulmonary Fibrosis Model

Rajput, V. K., MacKinnon, A., Mandal, S., Collins, P., Blanchard, H., Leffler, H.,

Sethi, T.

, Schambye, H., Mukhopadhyay, B. & Nilsson, U. J.

8 Sep 2016

Journal of Medicinal Chemistry.

p. 8141-8147

Research output

Article

The state of lung cancer research: A global analysis

Aggarwal, A.,

Lewison, G.

, Idir, S., Peters, M., Aldige, C., Boerckel, W., Boyle, P., Trimble, E. L., Roe, P.,

Sethi, T.

, Fox, J. & Sullivan, R.

Jul 2016

Journal of Thoracic Oncology.

p. 1040-1050

Research output

Article

Lung cancer stem cells-characteristics, phenotype

Hardavella, G.

, George, R. &

Sethi, T.

Jun 2016

Translational Lung Cancer Research.

p. 272-279

Research output

Article

Biomarkers for precision medicine in airways disease

Rooney, C.

Sethi, T.

1 Jun 2015

Annals of the New York Academy of Sciences.

p. 18-32

Research output

Article

Microdroplet digital PCR: Detection and quantitation of biomarkers in archived tissue and serial plasma samples in patients with lung cancer

Gao, F., Pfeifer, E., Farah, H., Karampini, E., Dua, D.,

Kamal, N.

, Cane, P., Tobal, K.,

Sethi, T.

Spicer, J.

McCaughan, F.

1 Jan 2015

Journal of Thoracic Oncology.

p. 212-217

Research output

Article

Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled trial

Mandal, P., Chalmers, J. D., Graham, C., Harley, C., Sidhu, M. K., Doherty, C., Govan, J. W.,

Sethi, T.

, Davidson, D. J., Rossi, A. G. & Hill, A. T.

Jun 2014

The lancet. Respiratory medicine.

p. 455-463

Research output

Article

Design, synthesis, And applications of galectin modulators in human health

Mackinnon, A., Chen, W. S., Leffler, H., Panjwani, N., Schambye, H.,

Sethi, T.

& Nilsson, U. J.

27 Apr 2014

Carbohydrates as Drugs.

Seeberger, P. H. & Rademacher, C. (eds.).

Springer International Publishing

p. 95-121

(Topics in Medicinal Chemistry; vol. 12)

Research output

Chapter in Book/Report/Conference proceeding

Chapter

CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist

Sarvi, S., Mackinnon, A. C., Avlonitis, N., Bradley, M., Rintoul, R. C., Rassl, D. M.,

Wang, W.

, Forbes, S. J., Gregory, C. D. &

Sethi, T.

1 Mar 2014

Cancer Research.

p. 1554-1565

Research output

Article

Galectin-3 regulates hepatic progenitor cell expansion during liver injury

Hsieh, W-C., Mackinnon, A. C., Lu, W-Y., Jung, J., Boulter, L., Henderson, N. C., Simpson, K. J., Schotanus, B., Wojtacha, D., Bird, T. G., Medine, C. N., Hay, D. C.,

Sethi, T.

, Iredale, J. P. & Forbes, S. J.

Research output

Article

Improving care for patients with lung cancer in the UK

Sethi, T.

, Lim, E., Peake, M., Field, J., White, J., Nicolson, M., Faivre-Finn, C.,

Cane, P.

, Reynolds, J.,

Møller, H.

& Pinnock, H.

Dec 2013

Thorax.

p. 1181-1185

Research output

Article

Inhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient mice

MacKinnon, A. C., Liu, X., Hadoke, P. W., Miller, M. R., Newby, D. E. &

Sethi, T.

Jun 2013

Glycobiology.

p. 654-663

Research output

Article

Histologic assessment of tumor-associated CD45(+) cell numbers is an independent predictor of prognosis in small cell lung cancer

Wang, W.

, Hodkinson, P., McLaren, F., Mackean, M. J., Williams, L., Howie, S. E. M., Wallace, W. A. H. &

Sethi, T.

Jan 2013

Chest.

p. 146-151

Research output

Article

Treatments in idiopathic pulmonary fibrosis: time for a more targeted approach?

Mahendran, S.

Sethi, T.

Oct 2012

p. 929-934

Research output

Article

Small cell lung cancer tumour cells induce regulatory T lymphocytes, and patient survival correlates negatively with FOXP3+ cells in tumour infiltrate

Wang, W.

, Hodkinson, P., McLaren, F., MacKinnon, A., Wallace, W., Howie, S. &

Sethi, T.

15 Sep 2012

International Journal of Cancer.

p. E928-E937

Research output

Article

Loss of the integrin-activating transmembrane protein Fam38A (Piezo1) promotes a switch to a reduced integrin-dependent mode of cell migration

McHugh, B. J., Murdoch, A., Haslett, C. &

Sethi, T.

5 Jul 2012

PloS one.

, e40346

Research output

Article

Tubular atrophy and interstitial fibrosis after renal transplantation is dependent on galectin-3

Dang, Z., MacKinnon, A., Marson, L. P. &

Sethi, T.

15 Mar 2012

Transplantation.

p. 477-484

Research output

Article

Regulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3

MacKinnon, A. C., Gibbons, M. A., Farnworth, S. L., Leffler, H., Nilsson, U. J., Delaine, T., Simpson, A. J., Forbes, S. J., Hirani, N., Gauldie, J. &

Sethi, T.

1 Mar 2012

American Journal of Respiratory and Critical Care Medicine.

p. 537 - 546

Research output

Article

Ly6C(hi) Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis

Gibbons, M. A., MacKinnon, A. C., Ramachandran, P., Dhaliwal, K., Duffin, R., Phythian-Adams, A. T., van Rooijen, N., Haslett, C., Howie, S. E., Simpson, A. J., Hirani, N., Gauldie, J., Iredale, J. P.,

Sethi, T.

& Forbes, S. J.

1 Sep 2011

American Journal of Respiratory and Critical Care Medicine.

p. 569 - 581

Research output

Article

The Epithelial Cell and Lung Cancer: The Link between Chronic Obstructive Pulmonary Disease and Lung Cancer

Rooney, C. &

Sethi, T.

Feb 2011

Respiration.

p. 89 - 104

Research output

Article

The molecular and cellular biology of lung cancer: identifying novel therapeutic strategies

MacKinnon, A. C., Kopatz, J. &

Sethi, T.

Sep 2010

British Medical Bulletin.

p. 47-61

Research output

Article

Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum

McHugh, B. J., Buttery, R., Lad, Y., Banks, S., Haslett, C. &

Sethi, T.

1 Jan 2010

Journal of Cell Science.

p. 51-61

Research output

Article

The regulation of inflammation by galectin-3

Henderson, N. C. &

Sethi, T.

Jul 2009

Immunological Reviews.

p. 160-171

Research output

Article

Human dendritic cells produce TGF-beta 1 under the influence of lung carcinoma cells and prime the differentiation of CD4+CD25+Foxp3+ regulatory T cells

Dumitriu, I. E., Dunbar, D. R., Howie, S. E.,

Sethi, T.

& Gregory, C. D.

1 Mar 2009

Journal of Immunology.

p. 2795-2807

Research output

Article

Targeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies

MacKinnon, A. C., Tufail-Hanif, U., Wheatley, M., Rossi, A. G., Haslett, C., Seckl, M. &

Sethi, T.

Jan 2009

British Journal of Pharmacology.

p. 36-47

Research output

Article

Targeting growth factors in lung cancer

Hodkinson, P. S., Mackinnon, A. &

Sethi, T.

May 2008

Chest.

p. 1209-16

Research output

Article

Regulation of alternative macrophage activation by galectin-3

MacKinnon, A. C., Farnworth, S. L., Hodkinson, P. S., Henderson, N. C., Atkinson, K. M., Leffler, H., Nilsson, U. J., Haslett, C., Forbes, S. J. &

Sethi, T.

15 Feb 2008

p. 2650-8

Research output

Article

Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis

Henderson, N. C., Mackinnon, A. C., Farnworth, S. L., Kipari, T., Haslett, C., Iredale, J. P., Liu, F-T., Hughes, J. &

Sethi, T.

Feb 2008

American Journal of Pathology.

p. 288-98

Research output

Article

Galectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil function

Farnworth, S. L., Henderson, N. C., Mackinnon, A. C., Atkinson, K. M., Wilkinson, T., Dhaliwal, K., Hayashi, K., Simpson, A. J., Rossi, A. G., Haslett, C. &

Sethi, T.

Feb 2008

American Journal of Pathology.

p. 395-405

Research output

Article

Mammalian NOTCH-1 activates beta1 integrins via the small GTPase R-Ras

Hodkinson, P. S., Elliott, P. A., Lad, Y., McHugh, B. J., MacKinnon, A. C., Haslett, C. &

Sethi, T.

28 Sep 2007

Journal of Biological Chemistry.

p. 28991-29001

Research output

Article

Critical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failure

Henderson, N. C., Pollock, K. J., Frew, J., Mackinnon, A. C., Flavell, R. A., Davis, R. J.,

Sethi, T.

& Simpson, K. J.

Jul 2007

p. 982-990

Research output

Article

Phospholipase C epsilon suppresses integrin activation

Lad, Y., McHugh, B., Hodkinson, P. S., Mackinnon, A. C., Haslett, C., Ginsberg, M. H. &

Sethi, T.

6 Oct 2006

p. 29501-29512

Research output

Article

Galectin-3 regulates myofibroblast activation and hepatic fibrosis

Henderson, N. C., Mackinnon, A. C., Farnworth, S. L., Poirier, F., Russo, F. P., Iredale, J. P., Haslett, C., Simpson, K. J. &

Sethi, T.

28 Mar 2006

Proceedings of the National Academy of Sciences of the United States of America.

p. 5060-5

Research output

Article

CD98hc (SLC3A2) interaction with beta 1 integrins is required for transformation

Henderson, N. C., Collis, E. A., Mackinnon, A. C., Simpson, K. J., Haslett, C., Zent, R., Ginsberg, M. &

Sethi, T.

24 Dec 2004

p. 54731-54741

Research output

Article

Serum from patients with fulminant hepatic failure causes hepatocyte detachment and apoptosis by a beta(1)-integrin pathway

Newsome, P. N., Tsiaoussis, J., Masson, S., Buttery, R., Livingston, C., Ansell, I., Ross, J. A.,

Sethi, T.

, Hayes, P. C. & Plevris, J. N.

Sep 2004

Hepatology.

p. 636-645

Research output

Article

Small cell lung cancer: the importance of the extracellular matrix

Buttery, R. C., Rintoul, R. C. &

Sethi, T.

Jul 2004

International Journal of Biochemistry and Cell Biology.

p. 1154-1160

Research output

Article

[D-Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism

MacKinnon, A. &

Sethi, T.

METHODS IN MOLECULAR MEDICINE.

p. 299-307

Research output

Article

Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents

MacKinnon, A. C., Buckley, A., Chilvers, E. R., Rossi, A. G., Haslett, C. &

Sethi, T.

1 Dec 2002

p. 6394-400

Research output

Article

Cross-Linking CD98 Promotes Integrin-like Signaling and Anchorage-independent Growth

Rintoul, R. C., Buttery, R. C., Mackinnon, A. C., Wong, W. S., Mosher, D., Haslett, C. &

Sethi, T.

1 Aug 2002

Mol Biol Cell.

p. 2841-2852

Research output

Article

Integrins and extracellular matrix: a novel mechanism of multidrug resistance

Elliott, T. &

Sethi, T.

Aug 2002

EXPERT REVIEW OF ANTICANCER THERAPY.

p. 449-459

Research output

Article

Extracellular matrix regulation of drug resistance in small-cell lung cancer

Rintoul, R. C. &

Sethi, T.

Apr 2002

Clinical Science.

p. 417-24

Research output

Article

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