Research Output

1 Research outputListing of Research outputGalectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan RecognitionDelaine, T., Collins, P., MacKinnon, A., Sharma, G., Stegmayr, J., Rajput, V. K., Mandal, S., Cumpstey, I., Larumbe, A., Salameh, B. A., Kahl-Knutsson, B., van Hattum, H., van Scherpenzeel, M., Pieters, R. J., Sethi, T., Schambye, H., Oredsson, S., Leffler, H., Blanchard, H. & Nilsson, U. J. 15 Sep 2016In : Chembiochem : a European journal of chemical biology.17, 18, p. 1759-177012 p.Research output: Contribution to journal› ArticleA Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3- glycan Interactions in a Pulmonary Fibrosis ModelRajput, V. K., MacKinnon, A., Mandal, S., Collins, P., Blanchard, H., Leffler, H., Sethi, T., Schambye, H., Mukhopadhyay, B. & Nilsson, U. J. 8 Sep 2016In : Journal of Medicinal Chemistry.59, 17, p. 8141-81477 p.Research output: Contribution to journal› ArticleThe state of lung cancer research: A global analysisAggarwal, A., Lewison, G., Idir, S., Peters, M., Aldige, C., Boerckel, W., Boyle, P., Trimble, E. L., Roe, P., Sethi, T., Fox, J. & Sullivan, R. Jul 2016In : Journal of Thoracic Oncology.11, 7, p. 1040-105011 p.Research output: Contribution to journal› ArticleLung cancer stem cells-characteristics, phenotypeHardavella, G., George, R. & Sethi, T.Jun 2016In : Translational Lung Cancer Research.5, 3, p. 272-2798 p.Research output: Contribution to journal› ArticleBiomarkers for precision medicine in airways diseaseRooney, C.& Sethi, T.1 Jun 2015In : Annals of the New York Academy of Sciences.1346, 1, p. 18-3215 p.Research output: Contribution to journal› ArticleMicrodroplet digital PCR: Detection and quantitation of biomarkers in archived tissue and serial plasma samples in patients with lung cancerGao, F., Pfeifer, E., Farah, H., Karampini, E., Dua, D., Kamal, N., Cane, P., Tobal, K., Sethi, T., Spicer, J.& McCaughan, F.1 Jan 2015In : Journal of Thoracic Oncology.10, 1, p. 212-2176 p.Research output: Contribution to journal› ArticleAtorvastatin as a stable treatment in bronchiectasis: a randomised controlled trialMandal, P., Chalmers, J. D., Graham, C., Harley, C., Sidhu, M. K., Doherty, C., Govan, J. W., Sethi, T., Davidson, D. J., Rossi, A. G. & Hill, A. T. Jun 2014In : The lancet. Respiratory medicine.2, 6, p. 455-4639 p.Research output: Contribution to journal› ArticleDesign, synthesis, And applications of galectin modulators in human healthMackinnon, A., Chen, W. S., Leffler, H., Panjwani, N., Schambye, H., Sethi, T.& Nilsson, U. J. 27 Apr 2014Carbohydrates as Drugs.Seeberger, P. H. & Rademacher, C. (eds.). Springer International Publishing, p. 95-12127 p.(Topics in Medicinal Chemistry; vol. 12)Research output: Chapter in Book/Report/Conference proceeding› ChapterCD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonistSarvi, S., Mackinnon, A. C., Avlonitis, N., Bradley, M., Rintoul, R. C., Rassl, D. M., Wang, W., Forbes, S. J., Gregory, C. D. & Sethi, T.1 Mar 2014In : Cancer Research.74, 5, p. 1554-156512 p., N/AResearch output: Contribution to journal› ArticleGalectin-3 regulates hepatic progenitor cell expansion during liver injuryHsieh, W-C., Mackinnon, A. C., Lu, W-Y., Jung, J., Boulter, L., Henderson, N. C., Simpson, K. J., Schotanus, B., Wojtacha, D., Bird, T. G., Medine, C. N., Hay, D. C., Sethi, T., Iredale, J. P. & Forbes, S. J. 2014In : Gut.10 p.Research output: Contribution to journal› ArticleImproving care for patients with lung cancer in the UKSethi, T., Lim, E., Peake, M., Field, J., White, J., Nicolson, M., Faivre-Finn, C., Cane, P., Reynolds, J., Møller, H.& Pinnock, H. Dec 2013In : Thorax.68, 12, p. 1181-11855 p.Research output: Contribution to journal› ArticleInhibition of galectin-3 reduces atherosclerosis in apolipoprotein E-deficient miceMacKinnon, A. C., Liu, X., Hadoke, P. W., Miller, M. R., Newby, D. E. & Sethi, T.Jun 2013In : Glycobiology.23, 6, p. 654-66310 p.Research output: Contribution to journal› ArticleHistologic assessment of tumor-associated CD45(+) cell numbers is an independent predictor of prognosis in small cell lung cancerWang, W., Hodkinson, P., McLaren, F., Mackean, M. J., Williams, L., Howie, S. E. M., Wallace, W. A. H. & Sethi, T.Jan 2013In : Chest.143, 1, p. 146-1516 p.Research output: Contribution to journal› ArticleTreatments in idiopathic pulmonary fibrosis: time for a more targeted approach?Mahendran, S.& Sethi, T.Oct 2012In : QJM.105, 10, p. 929-9346 p., N/AResearch output: Contribution to journal› ArticleSmall cell lung cancer tumour cells induce regulatory T lymphocytes, and patient survival correlates negatively with FOXP3+ cells in tumour infiltrateWang, W., Hodkinson, P., McLaren, F., MacKinnon, A., Wallace, W., Howie, S. & Sethi, T.15 Sep 2012In : International Journal of Cancer.131, 6, p. E928-E93710 p.Research output: Contribution to journal› ArticleLoss of the integrin-activating transmembrane protein Fam38A (Piezo1) promotes a switch to a reduced integrin-dependent mode of cell migrationMcHugh, B. J., Murdoch, A., Haslett, C. & Sethi, T.5 Jul 2012In : PloS one.7, 7, 7 p., e40346Research output: Contribution to journal› ArticleTubular atrophy and interstitial fibrosis after renal transplantation is dependent on galectin-3Dang, Z., MacKinnon, A., Marson, L. P. & Sethi, T.15 Mar 2012In : Transplantation.93, 5, p. 477-4848 p.Research output: Contribution to journal› ArticleRegulation of Transforming Growth Factor-beta 1-driven Lung Fibrosis by Galectin-3MacKinnon, A. C., Gibbons, M. A., Farnworth, S. L., Leffler, H., Nilsson, U. J., Delaine, T., Simpson, A. J., Forbes, S. J., Hirani, N., Gauldie, J. & Sethi, T.1 Mar 2012In : American Journal of Respiratory and Critical Care Medicine.185, 5, p. 537 - 54610 p.Research output: Contribution to journal› ArticleLy6C(hi) Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung FibrosisGibbons, M. A., MacKinnon, A. C., Ramachandran, P., Dhaliwal, K., Duffin, R., Phythian-Adams, A. T., van Rooijen, N., Haslett, C., Howie, S. E., Simpson, A. J., Hirani, N., Gauldie, J., Iredale, J. P., Sethi, T.& Forbes, S. J. 1 Sep 2011In : American Journal of Respiratory and Critical Care Medicine.184, 5, p. 569 - 58113 p.Research output: Contribution to journal› ArticleThe Epithelial Cell and Lung Cancer: The Link between Chronic Obstructive Pulmonary Disease and Lung CancerRooney, C. & Sethi, T.Feb 2011In : Respiration.81, 2, p. 89 - 10416 p.Research output: Contribution to journal› ArticleThe molecular and cellular biology of lung cancer: identifying novel therapeutic strategiesMacKinnon, A. C., Kopatz, J. & Sethi, T.Sep 2010In : British Medical Bulletin.95, 1, p. 47-6115 p.Research output: Contribution to journal› ArticleIntegrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulumMcHugh, B. J., Buttery, R., Lad, Y., Banks, S., Haslett, C. & Sethi, T.1 Jan 2010In : Journal of Cell Science.123, 1, p. 51-6111 p.Research output: Contribution to journal› ArticleThe regulation of inflammation by galectin-3Henderson, N. C. & Sethi, T.Jul 2009In : Immunological Reviews.230, 1, p. 160-17112 p.Research output: Contribution to journal› ArticleHuman dendritic cells produce TGF-beta 1 under the influence of lung carcinoma cells and prime the differentiation of CD4+CD25+Foxp3+ regulatory T cellsDumitriu, I. E., Dunbar, D. R., Howie, S. E., Sethi, T.& Gregory, C. D. 1 Mar 2009In : Journal of Immunology.182, 5, p. 2795-280713 p.Research output: Contribution to journal› ArticleTargeting V1A-vasopressin receptors with [Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapiesMacKinnon, A. C., Tufail-Hanif, U., Wheatley, M., Rossi, A. G., Haslett, C., Seckl, M. & Sethi, T.Jan 2009In : British Journal of Pharmacology.156, 1, p. 36-4712 p.Research output: Contribution to journal› ArticleTargeting growth factors in lung cancerHodkinson, P. S., Mackinnon, A. & Sethi, T.May 2008In : Chest.133, 5, p. 1209-168 p.Research output: Contribution to journal› ArticleRegulation of alternative macrophage activation by galectin-3MacKinnon, A. C., Farnworth, S. L., Hodkinson, P. S., Henderson, N. C., Atkinson, K. M., Leffler, H., Nilsson, U. J., Haslett, C., Forbes, S. J. & Sethi, T.15 Feb 2008In : Journal of Immunology.180, 4, p. 2650-89 p.Research output: Contribution to journal› ArticleGalectin-3 expression and secretion links macrophages to the promotion of renal fibrosisHenderson, N. C., Mackinnon, A. C., Farnworth, S. L., Kipari, T., Haslett, C., Iredale, J. P., Liu, F-T., Hughes, J. & Sethi, T.Feb 2008In : American Journal of Pathology.172, 2, p. 288-9811 p.Research output: Contribution to journal› ArticleGalectin-3 reduces the severity of pneumococcal pneumonia by augmenting neutrophil functionFarnworth, S. L., Henderson, N. C., Mackinnon, A. C., Atkinson, K. M., Wilkinson, T., Dhaliwal, K., Hayashi, K., Simpson, A. J., Rossi, A. G., Haslett, C. & Sethi, T.Feb 2008In : American Journal of Pathology.172, 2, p. 395-40511 p.Research output: Contribution to journal› ArticleMammalian NOTCH-1 activates beta1 integrins via the small GTPase R-RasHodkinson, P. S., Elliott, P. A., Lad, Y., McHugh, B. J., MacKinnon, A. C., Haslett, C. & Sethi, T.28 Sep 2007In : Journal of Biological Chemistry.282, 39, p. 28991-2900111 p.Research output: Contribution to journal› ArticleCritical role of c-jun (NH2) terminal kinase in paracetamol- induced acute liver failureHenderson, N. C., Pollock, K. J., Frew, J., Mackinnon, A. C., Flavell, R. A., Davis, R. J., Sethi, T.& Simpson, K. J. Jul 2007In : Gut.56, 7, p. 982-9909 p.Research output: Contribution to journal› ArticlePhospholipase C epsilon suppresses integrin activationLad, Y., McHugh, B., Hodkinson, P. S., Mackinnon, A. C., Haslett, C., Ginsberg, M. H. & Sethi, T.6 Oct 2006In : Journal of Biological Chemistry.281, 40, p. 29501-2951212 p.Research output: Contribution to journal› ArticleGalectin-3 regulates myofibroblast activation and hepatic fibrosisHenderson, N. C., Mackinnon, A. C., Farnworth, S. L., Poirier, F., Russo, F. P., Iredale, J. P., Haslett, C., Simpson, K. J. & Sethi, T.28 Mar 2006In : Proceedings of the National Academy of Sciences of the United States of America.103, 13, p. 5060-56 p.Research output: Contribution to journal› ArticleCD98hc (SLC3A2) interaction with beta 1 integrins is required for transformationHenderson, N. C., Collis, E. A., Mackinnon, A. C., Simpson, K. J., Haslett, C., Zent, R., Ginsberg, M. & Sethi, T.24 Dec 2004In : Journal of Biological Chemistry.279, 52, p. 54731-5474111 p.Research output: Contribution to journal› ArticleSerum from patients with fulminant hepatic failure causes hepatocyte detachment and apoptosis by a beta(1)-integrin pathwayNewsome, P. N., Tsiaoussis, J., Masson, S., Buttery, R., Livingston, C., Ansell, I., Ross, J. A., Sethi, T., Hayes, P. C. & Plevris, J. N. Sep 2004In : Hepatology.40, 3, p. 636-64510 p.Research output: Contribution to journal› ArticleSmall cell lung cancer: the importance of the extracellular matrixButtery, R. C., Rintoul, R. C. & Sethi, T.Jul 2004In : International Journal of Biochemistry and Cell Biology.36, 7, p. 1154-11607 p.Research output: Contribution to journal› Article[D-Arg6, D-Trp7,9, NmePhe8]-substance P (6-11) activates JNK and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanismMacKinnon, A. & Sethi, T.2003In : METHODS IN MOLECULAR MEDICINE.74, p. 299-3079 p.Research output: Contribution to journal› ArticleSphingosine kinase: a point of convergence in the action of diverse neutrophil priming agentsMacKinnon, A. C., Buckley, A., Chilvers, E. R., Rossi, A. G., Haslett, C. & Sethi, T.1 Dec 2002In : Journal of Immunology.169, 11, p. 6394-4007 p.Research output: Contribution to journal› ArticleCross-Linking CD98 Promotes Integrin-like Signaling and Anchorage-independent GrowthRintoul, R. C., Buttery, R. C., Mackinnon, A. C., Wong, W. S., Mosher, D., Haslett, C. & Sethi, T.1 Aug 2002In : Mol Biol Cell.13, 8, p. 2841-285212 p.Research output: Contribution to journal› ArticleIntegrins and extracellular matrix: a novel mechanism of multidrug resistanceElliott, T. & Sethi, T.Aug 2002In : EXPERT REVIEW OF ANTICANCER THERAPY.2, 4, p. 449-45911 p.Research output: Contribution to journal› ArticleExtracellular matrix regulation of drug resistance in small-cell lung cancerRintoul, R. C. & Sethi, T.Apr 2002In : Clinical Science.102, 4, p. 417-248 p.Research output: Contribution to journal› ArticleThe above report is produced using the following setupOrdered by: null

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