Coagulation Disorders: Primary Hemostasis

MLAB 1227 Coagulation

Learning Objectives

At the end of this unit, the student should be able to:

1. Explain the pathophysiologic processes that cause thrombocytopenia.

2. List specific thrombocytopenic disorders caused by each process.

3. Compare ITP and thrombocytopenic purpura (TTP).

4. Discuss the characteristics of the inherited platelet membrane defects.

5. Summarize the differences between Bernard-Soulier syndrome and Glanzmann’s thrombasthenia.

6. Differentiate among the vascular disorders associated with purpura.

7. Define the terms thrombocytopenia and thrombocytosis.

8. Name the acquired coagulation disorders.

9. Define and differentiate between petechiae, purpura, ecchymosis and hematoma.

10. Identify laboratory tests that can be ordered to screen for abnormalities of the hemostatic system.

11. Explain the expected clinical outcomes when a patient has an abnormality of platelets or blood vessels.

12. Distinguish between primary and secondary(reactive) thrombocytosis.

13. Explain the effect of aspirin and its duration on platelet function.

14. Predict the type of bleeding symptoms in patients with disorders of primary hemostasis.

4/5/2018 MLAB 1227 Coagulation

15. Estimate the percentage of circulating platelets found in the spleen.

16. Identify expected laboratory results in patients with ITP.

17. Cite an example of a drug that causes thrombocytopenia.

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