Table I

Patient Sex Age Histology Location Bone infiltration Brain infiltration Previous therapy

1 F 57 Adenoid- cystic Skull base Petrous bone None S, RT, CT

2 M 47 SCC Auditory canal Posterior scull base None S, RT, CT

3 F 58 Esthesioneuroblastoma Anterior skull base Anterior skull base Frontal lobe S, RT, CT

4 M 75 SCC Maxillary sinus Maxillary sinus None None

5 M Chordoma Sella Sphenoid bone None S 61

6 F 48 SCC Naso- pharynx Anterior skull base None S

7 F 79 SCC None RT Sphenoid Sphenoid 8 F 24 Sarcoma None S, RT Cranio- facial Cranio- facial 9 F 55 SCC None S, RT Naso- pharynx Anterior skull base 10 M 47 SCC Frontal lobe S, RT Anterior skull base Cavum nasi

11 F 53 SCC Frontal lobe None Naso- pharynx Anterior skull base

12 M 73 SCC Frontal lobe None Naso- pharynx Anterior skull base

13 M 50 SCC Cerebellum RT Petrous bone Petrous bone 14 M 72 SCC Temporal lobe RT Skull base Sphenoid bone

15 M 45 Sarcoma Temporal lobe S, RT Cranio- facial Cranio- facial 16 F 54 Adenoid- cystic None S Skull base Petrous bone 17 M 57 SCC Frontal lobe S Naso- pharynx Anterior skull base 18 M 67 SCC None S, CT Naso- pharynx Anterior skull base 19 F 64 Sarcoma Frontal lobe S, RT Sphenoid Sphenoid 20 F 71 Adenoid- cystic None S Skull base Petrous bone 21 M 59 SCC Frontal lobe S, CT Sphenoid Sphenoid

F female, M male, SCC squamous cell cancer; S surgery, RT radiation therapy, CT chemotherapy