Supplementary Material 1 of the Manuscript Entitled

Supplementary material 1 of the manuscript entitled:

HYPERTENSION IN CHILDREN AND ADOLESCENTS ATTENDING A LIPID CLINIC by Francesco Martino1,MD, Paolo Emilio Puddu2,MD, FESC, FACC, Giuseppe Pannarale2,MD, Chiara Colantoni1,MD, Eliana Martino1,MD, Cristina Zanoni1, Francesco Barillà2,MD 1Lipid Research, Dipartimento di Pediatria e Neuropsichiatria Infantile;2Dipartimento di Scienze Cardiovascolari, Respiratorie, Nefrologiche, Anestesiologiche e Geriatriche, “Sapienza” Università di Roma, Rome, Italy

Please note that to interpret the following hypertension-corrected multiple correlation section (pages 2 to 8), the framed corresponding table from Italian acronyms to fully disclosed English significances, should be used.

Sex Gender Eta Age BMI Body Mass Index Ins Insulin level kg Weight h Height cv_h Waist-hip ratio Vita Waist circumference Fianc Hip circumference Bracc Middle-upper arm circumference PAS Systolic Blood Pressure PAD Diastolic Blood Pressure PASp Systolic Blood Pressure of the fathers PADp Diastolic Blood Pressure of the fathers PASm Systolic Blood Pressure of the mothers PADm Diastolic Blood Pressure of the mothers CT Total cholesterol HC Hypercholesterolemic subjects HDL HDL cholesterol nHDL Non-HDL cholesterol TG Triglycerides LDL LDL cholesterol BMIp Body Mass Index of the fathers BMIm Body Mass Index of the mothers glicemia Fasting blood glucose Insp Insulin level of the fathers Insm Insulin level of the mothers Vitap Waist circumference of the fathers Fiancp Hip circumference of the fathers Braccp Middle-upper arm circumference of the fathers Vitam Waist circumference of the mothers Fiancm Hip circumference of the mothers Braccm Middle-upper arm circumference of the mothers Creatinina Creatinine N_ureico Blood urea nitrogen (BUN) Uricemia Uric Acid pcr High sensitivity C-reactive protein (hsCRP)

1 Correlation Report Page/Date/Time 1 2/26/2013 4:00:20 PM Database Controlled For: GroupHT1

Pearson Correlations Section (Pair-Wise Deletion)

Sex Eta BMI Ins kg h Sex 1.000000 0.077460 0.076786 -0.092728 0.116133 0.079901 Eta 0.077460 1.000000 0.329086 0.408524 0.690838 0.861101 BMI 0.076786 0.329086 1.000000 0.590548 0.757246 0.379434 Ins -0.092728 0.408524 0.590548 1.000000 0.658304 0.471354 kg 0.116133 0.690838 0.757246 0.658304 1.000000 0.843581 h 0.079901 0.861101 0.379434 0.471354 0.843581 1.000000 cv_h 0.173931 -0.095859 0.694009 0.383186 0.377964 -0.041695 Vita 0.188406 0.503172 0.823426 0.627642 0.885930 0.640050 Fianc 0.074559 0.539564 0.796570 0.635241 0.895678 0.691644 Bracc 0.074787 0.514546 0.803860 0.624622 0.882686 0.665486 PAS 0.102624 0.318209 0.251194 0.232998 0.298775 0.271476 PAD -0.021261 0.092722 0.066554 0.117777 0.126955 0.112047 PASp -0.158792 0.032549 0.063699 0.140611 0.044350 0.026493 PADp -0.026634 0.031399 0.083220 0.087887 0.087267 0.080910 PASm -0.073577 -0.017566 0.032769 0.034677 0.011288 0.019573 PADm -0.046016 0.048735 0.040767 0.029280 0.047622 0.067975 CT -0.190990 -0.097923 -0.100621 -0.114697 -0.205249 -0.184654 HC -0.099541 -0.078366 -0.016613 -0.083841 -0.124180 -0.160786 HDL -0.066033 -0.094036 -0.300156 -0.290222 -0.305274 -0.174634 nHDL -0.171764 -0.068507 -0.004218 -0.021660 -0.108424 -0.130066 TG 0.006232 0.107616 0.340373 0.338803 0.281492 0.141566 LDL -0.167093 -0.091241 -0.064176 -0.079841 -0.161500 -0.159619 BMIp -0.025234 0.031647 0.339857 0.216762 0.231143 0.065541 BMIm 0.003336 -0.004355 0.288267 0.165597 0.202862 0.045246 glicemia 0.109976 0.153730 0.201035 0.177834 0.183538 0.133526 Insp 0.034720 0.139741 0.322216 0.265642 0.362397 0.206977 Insm 0.112712 0.007258 0.144884 0.062540 0.114405 0.048540 Vitap -0.042710 0.043898 0.261274 0.200531 0.194006 0.075983 Fiancp -0.038808 0.012723 0.155953 0.047758 0.063870 -0.000768 Braccp 0.019429 0.069125 0.157149 0.173968 0.149668 0.072619 Vitam -0.011343 -0.030777 0.280004 0.211330 0.192611 0.030466 Fiancm -0.019051 -0.041695 0.207955 0.092140 0.114000 0.002375 Braccm 0.036608 -0.028994 0.128263 0.065465 0.078723 -0.004962 Creatinina -0.025938 0.083354 0.057896 0.040684 0.114036 0.115711 N_ureico -0.122313 0.001515 0.010298 0.025139 0.018425 0.018582 Uricemia -0.080362 -0.017026 0.031626 0.003284 0.014466 -0.001761 pcr 0.022458 -0.056677 0.155275 0.072354 0.039485 -0.060574 Cronbachs Alpha = 0.030471 Standardized Cronbachs Alpha = 0.808706

2 Correlation Report Page/Date/Time 2 2/26/2013 4:00:20 PM Database Controlled For: GroupHT1

Pearson Correlations Section (Pair-Wise Deletion)

cv_h Vita Fianc Bracc PAS PAD Sex 0.173931 0.188406 0.074559 0.074787 0.102624 -0.021261 Eta -0.095859 0.503172 0.539564 0.514546 0.318209 0.092722 BMI 0.694009 0.823426 0.796570 0.803860 0.251194 0.066554 Ins 0.383186 0.627642 0.635241 0.624622 0.232998 0.117777 kg 0.377964 0.885930 0.895678 0.882686 0.298775 0.126955 h -0.041695 0.640050 0.691644 0.665486 0.271476 0.112047 cv_h 1.000000 0.705293 0.623301 0.614839 0.103951 0.044748 Vita 0.705293 1.000000 0.933864 0.914097 0.249828 0.110385 Fianc 0.623301 0.933864 1.000000 0.924570 0.243037 0.089112 Bracc 0.614839 0.914097 0.924570 1.000000 0.236178 0.086227 PAS 0.103951 0.249828 0.243037 0.236178 1.000000 0.433302 PAD 0.044748 0.110385 0.089112 0.086227 0.433302 1.000000 PASp 0.020246 0.016340 0.032589 0.032767 0.012493 0.074231 PADp 0.041019 0.072126 0.088782 0.082571 0.042277 0.203428 PASm 0.029733 0.023794 0.048940 0.062617 -0.034136 -0.083739 PADm 0.015819 0.043984 0.044044 0.065824 -0.024513 0.008093 CT -0.098826 -0.176053 -0.205660 -0.149576 0.023625 0.052681 HC -0.015785 -0.104880 -0.139881 -0.091882 0.109874 0.089539 HDL -0.315132 -0.370640 -0.338394 -0.334137 -0.058352 -0.041832 nHDL 0.002478 -0.057621 -0.098062 -0.042715 0.042893 0.066927 TG 0.345149 0.377664 0.344644 0.324278 0.039979 0.001352 LDL -0.004321 -0.119758 -0.133654 -0.077172 0.048427 0.082768 BMIp 0.286064 0.273231 0.269716 0.267468 0.079075 0.044688 BMIm 0.307138 0.287930 0.293773 0.273375 0.102268 -0.097255 glicemia 0.058820 0.160546 0.166879 0.143451 0.099855 -0.160008 Insp 0.158778 0.293987 0.268393 0.295572 0.114982 0.026327 Insm 0.155656 0.146996 0.153732 0.160493 0.138272 0.048003 Vitap 0.205273 0.218749 0.208499 0.191919 0.060128 0.011751 Fiancp 0.092355 0.066750 0.075926 0.064276 0.020306 0.002779 Braccp 0.183320 0.205698 0.187482 0.152674 0.069431 -0.052847 Vitam 0.322277 0.288668 0.276042 0.255336 0.085162 -0.039316 Fiancm 0.183345 0.158191 0.178542 0.187393 0.081457 0.026491 Braccm 0.200108 0.155801 0.154530 0.133491 0.050083 -0.110585 Creatinina -0.017222 0.063525 0.076187 0.066843 0.001793 -0.000971 N_ureico -0.028044 -0.004883 0.015422 0.049644 -0.014354 0.050603 Uricemia 0.016582 0.009766 0.018389 0.054760 0.053085 0.113152 pcr 0.160999 0.084855 0.066999 0.094400 0.054305 -0.046967 Cronbachs Alpha = 0.030471 Standardized Cronbachs Alpha = 0.808706

3 Correlation Report Page/Date/Time 3 2/26/2013 4:00:20 PM Database Controlled For: GroupHT1

Pearson Correlations Section (Pair-Wise Deletion)

PASp PADp PASm PADm CT HC Sex -0.158792 -0.026634 -0.073577 -0.046016 -0.190990 -0.099541 Eta 0.032549 0.031399 -0.017566 0.048735 -0.097923 -0.078366 BMI 0.063699 0.083220 0.032769 0.040767 -0.100621 -0.016613 Ins 0.140611 0.087887 0.034677 0.029280 -0.114697 -0.083841 kg 0.044350 0.087267 0.011288 0.047622 -0.205249 -0.124180 h 0.026493 0.080910 0.019573 0.067975 -0.184654 -0.160786 cv_h 0.020246 0.041019 0.029733 0.015819 -0.098826 -0.015785 Vita 0.016340 0.072126 0.023794 0.043984 -0.176053 -0.104880 Fianc 0.032589 0.088782 0.048940 0.044044 -0.205660 -0.139881 Bracc 0.032767 0.082571 0.062617 0.065824 -0.149576 -0.091882 PAS 0.012493 0.042277 -0.034136 -0.024513 0.023625 0.109874 PAD 0.074231 0.203428 -0.083739 0.008093 0.052681 0.089539 PASp 1.000000 0.630725 0.095643 0.085584 -0.001349 -0.042122 PADp 0.630725 1.000000 0.113172 0.204257 -0.049321 -0.061154 PASm 0.095643 0.113172 1.000000 0.586766 0.051270 0.015978 PADm 0.085584 0.204257 0.586766 1.000000 0.042994 -0.005806 CT -0.001349 -0.049321 0.051270 0.042994 1.000000 0.746306 HC -0.042122 -0.061154 0.015978 -0.005806 0.746306 1.000000 HDL -0.023456 -0.070864 -0.048441 -0.112797 0.197013 0.189220 nHDL 0.006270 -0.026837 0.067638 0.080215 0.947837 0.693678 TG -0.058560 -0.030620 0.051158 0.172476 0.086319 0.068040 LDL 0.035606 -0.002395 0.067658 0.063917 0.941032 0.692473 BMIp 0.240184 0.148243 0.129374 0.108570 -0.099512 -0.053922 BMIm 0.029953 0.057784 0.210825 0.092991 -0.051100 -0.056441 glicemia 0.013529 -0.026441 0.062802 0.089534 -0.020846 0.039339 Insp 0.114822 0.071432 -0.074621 0.053261 -0.106798 -0.076821 Insm 0.002566 0.088864 0.053720 -0.018099 -0.018075 -0.030038 Vitap 0.210321 0.160563 0.095811 0.129410 -0.120169 -0.063015 Fiancp 0.089069 0.060391 0.046212 0.109050 -0.052788 -0.000943 Braccp 0.124269 0.139234 0.039863 0.055303 -0.041275 -0.003327 Vitam -0.054984 0.048409 0.042924 0.010793 -0.038860 0.011771 Fiancm -0.048050 0.011604 0.084410 0.012109 -0.025437 0.017844 Braccm -0.006462 0.020901 0.073915 0.003907 -0.010177 0.059625 Creatinina -0.056350 0.006431 0.136534 0.116763 -0.086789 -0.115678 N_ureico 0.031005 0.093739 -0.074356 -0.044916 0.033399 -0.012238 Uricemia 0.069554 0.140649 0.014024 -0.021319 0.029193 0.035195 pcr 0.055561 0.048124 0.041125 -0.010039 0.050185 0.045257 Cronbachs Alpha = 0.030471 Standardized Cronbachs Alpha = 0.808706

4 Correlation Report Page/Date/Time 4 2/26/2013 4:00:20 PM Database Controlled For: GroupHT1

Pearson Correlations Section (Pair-Wise Deletion)

HDL nHDL TG LDL BMIp BMIm Sex -0.066033 -0.171764 0.006232 -0.167093 -0.025234 0.003336 Eta -0.094036 -0.068507 0.107616 -0.091241 0.031647 -0.004355 BMI -0.300156 -0.004218 0.340373 -0.064176 0.339857 0.288267 Ins -0.290222 -0.021660 0.338803 -0.079841 0.216762 0.165597 kg -0.305274 -0.108424 0.281492 -0.161500 0.231143 0.202862 h -0.174634 -0.130066 0.141566 -0.159619 0.065541 0.045246 cv_h -0.315132 0.002478 0.345149 -0.004321 0.286064 0.307138 Vita -0.370640 -0.057621 0.377664 -0.119758 0.273231 0.287930 Fianc -0.338394 -0.098062 0.344644 -0.133654 0.269716 0.293773 Bracc -0.334137 -0.042715 0.324278 -0.077172 0.267468 0.273375 PAS -0.058352 0.042893 0.039979 0.048427 0.079075 0.102268 PAD -0.041832 0.066927 0.001352 0.082768 0.044688 -0.097255 PASp -0.023456 0.006270 -0.058560 0.035606 0.240184 0.029953 PADp -0.070864 -0.026837 -0.030620 -0.002395 0.148243 0.057784 PASm -0.048441 0.067638 0.051158 0.067658 0.129374 0.210825 PADm -0.112797 0.080215 0.172476 0.063917 0.108570 0.092991 CT 0.197013 0.947837 0.086319 0.941032 -0.099512 -0.051100 HC 0.189220 0.693678 0.068040 0.692473 -0.053922 -0.056441 HDL 1.000000 -0.125771 -0.441407 -0.044094 -0.074199 -0.171644 nHDL -0.125771 1.000000 0.230878 0.966578 -0.076567 0.004117 TG -0.441407 0.230878 1.000000 0.039794 -0.008716 0.123184 LDL -0.044094 0.966578 0.039794 1.000000 -0.070853 -0.017343 BMIp -0.074199 -0.076567 -0.008716 -0.070853 1.000000 0.332003 BMIm -0.171644 0.004117 0.123184 -0.017343 0.332003 1.000000 glicemia 0.010126 -0.024397 0.141898 -0.069307 0.143550 0.113546 Insp -0.173167 -0.051754 0.118606 -0.085794 0.348681 0.203474 Insm -0.030036 -0.008504 0.020756 -0.005647 0.164570 0.100295 Vitap -0.072125 -0.098136 -0.005456 -0.097943 0.826294 0.232482 Fiancp 0.015520 -0.058452 -0.089435 -0.037305 0.606791 0.075666 Braccp -0.105695 -0.007401 0.176871 -0.042762 0.372043 0.250512 Vitam -0.131746 0.003523 0.115608 -0.018862 0.221186 0.741521 Fiancm -0.022032 -0.018563 -0.039930 -0.012133 0.226547 0.543679 Braccm -0.041815 0.003292 0.060664 -0.009202 0.108393 0.422965 Creatinina -0.035167 -0.076376 0.072212 -0.088441 -0.033064 -0.008037 N_ureico -0.028980 0.043253 -0.024371 0.045915 0.018357 0.015087 Uricemia -0.041033 0.042887 0.006179 0.043722 0.027917 -0.006816 pcr -0.144479 0.097765 0.023771 0.098360 0.126679 0.100814 Cronbachs Alpha = 0.030471 Standardized Cronbachs Alpha = 0.808706

5 Correlation Report Page/Date/Time 5 2/26/2013 4:00:20 PM Database Controlled For: GroupHT1

Pearson Correlations Section (Pair-Wise Deletion)

glicemia Insp Insm Vitap Fiancp Braccp Sex 0.109976 0.034720 0.112712 -0.042710 -0.038808 0.019429 Eta 0.153730 0.139741 0.007258 0.043898 0.012723 0.069125 BMI 0.201035 0.322216 0.144884 0.261274 0.155953 0.157149 Ins 0.177834 0.265642 0.062540 0.200531 0.047758 0.173968 kg 0.183538 0.362397 0.114405 0.194006 0.063870 0.149668 h 0.133526 0.206977 0.048540 0.075983 -0.000768 0.072619 cv_h 0.058820 0.158778 0.155656 0.205273 0.092355 0.183320 Vita 0.160546 0.293987 0.146996 0.218749 0.066750 0.205698 Fianc 0.166879 0.268393 0.153732 0.208499 0.075926 0.187482 Bracc 0.143451 0.295572 0.160493 0.191919 0.064276 0.152674 PAS 0.099855 0.114982 0.138272 0.060128 0.020306 0.069431 PAD -0.160008 0.026327 0.048003 0.011751 0.002779 -0.052847 PASp 0.013529 0.114822 0.002566 0.210321 0.089069 0.124269 PADp -0.026441 0.071432 0.088864 0.160563 0.060391 0.139234 PASm 0.062802 -0.074621 0.053720 0.095811 0.046212 0.039863 PADm 0.089534 0.053261 -0.018099 0.129410 0.109050 0.055303 CT -0.020846 -0.106798 -0.018075 -0.120169 -0.052788 -0.041275 HC 0.039339 -0.076821 -0.030038 -0.063015 -0.000943 -0.003327 HDL 0.010126 -0.173167 -0.030036 -0.072125 0.015520 -0.105695 nHDL -0.024397 -0.051754 -0.008504 -0.098136 -0.058452 -0.007401 TG 0.141898 0.118606 0.020756 -0.005456 -0.089435 0.176871 LDL -0.069307 -0.085794 -0.005647 -0.097943 -0.037305 -0.042762 BMIp 0.143550 0.348681 0.164570 0.826294 0.606791 0.372043 BMIm 0.113546 0.203474 0.100295 0.232482 0.075666 0.250512 glicemia 1.000000 0.180464 0.168407 0.137192 0.044430 0.112503 Insp 0.180464 1.000000 0.160730 0.317127 0.207108 0.110209 Insm 0.168407 0.160730 1.000000 0.053793 -0.008991 0.023209 Vitap 0.137192 0.317127 0.053793 1.000000 0.735886 0.302096 Fiancp 0.044430 0.207108 -0.008991 0.735886 1.000000 -0.111144 Braccp 0.112503 0.110209 0.023209 0.302096 -0.111144 1.000000 Vitam 0.166120 0.130090 0.090381 0.189386 0.024460 0.249203 Fiancm 0.144205 0.130422 0.087998 0.281131 0.405990 -0.294208 Braccm -0.038253 0.040211 0.047060 0.101211 0.016534 0.168312 Creatinina 0.058882 0.034111 -0.028208 0.002382 -0.117294 0.041190 N_ureico -0.221679 0.003475 -0.061646 -0.005058 0.037735 0.011601 Uricemia -0.147481 -0.027787 -0.038108 0.002920 0.014362 0.018412 pcr 0.188429 0.109138 0.063992 0.103573 -0.007414 0.045652 Cronbachs Alpha = 0.030471 Standardized Cronbachs Alpha = 0.808706

6 Correlation Report Page/Date/Time 6 2/26/2013 4:00:20 PM Database Controlled For: GroupHT1

Pearson Correlations Section (Pair-Wise Deletion)

Vitam Fiancm Braccm Creatinina N_ureico Uricemia Sex -0.011343 -0.019051 0.036608 -0.025938 -0.122313 -0.080362 Eta -0.030777 -0.041695 -0.028994 0.083354 0.001515 -0.017026 BMI 0.280004 0.207955 0.128263 0.057896 0.010298 0.031626 Ins 0.211330 0.092140 0.065465 0.040684 0.025139 0.003284 kg 0.192611 0.114000 0.078723 0.114036 0.018425 0.014466 h 0.030466 0.002375 -0.004962 0.115711 0.018582 -0.001761 cv_h 0.322277 0.183345 0.200108 -0.017222 -0.028044 0.016582 Vita 0.288668 0.158191 0.155801 0.063525 -0.004883 0.009766 Fianc 0.276042 0.178542 0.154530 0.076187 0.015422 0.018389 Bracc 0.255336 0.187393 0.133491 0.066843 0.049644 0.054760 PAS 0.085162 0.081457 0.050083 0.001793 -0.014354 0.053085 PAD -0.039316 0.026491 -0.110585 -0.000971 0.050603 0.113152 PASp -0.054984 -0.048050 -0.006462 -0.056350 0.031005 0.069554 PADp 0.048409 0.011604 0.020901 0.006431 0.093739 0.140649 PASm 0.042924 0.084410 0.073915 0.136534 -0.074356 0.014024 PADm 0.010793 0.012109 0.003907 0.116763 -0.044916 -0.021319 CT -0.038860 -0.025437 -0.010177 -0.086789 0.033399 0.029193 HC 0.011771 0.017844 0.059625 -0.115678 -0.012238 0.035195 HDL -0.131746 -0.022032 -0.041815 -0.035167 -0.028980 -0.041033 nHDL 0.003523 -0.018563 0.003292 -0.076376 0.043253 0.042887 TG 0.115608 -0.039930 0.060664 0.072212 -0.024371 0.006179 LDL -0.018862 -0.012133 -0.009202 -0.088441 0.045915 0.043722 BMIp 0.221186 0.226547 0.108393 -0.033064 0.018357 0.027917 BMIm 0.741521 0.543679 0.422965 -0.008037 0.015087 -0.006816 glicemia 0.166120 0.144205 -0.038253 0.058882 -0.221679 -0.147481 Insp 0.130090 0.130422 0.040211 0.034111 0.003475 -0.027787 Insm 0.090381 0.087998 0.047060 -0.028208 -0.061646 -0.038108 Vitap 0.189386 0.281131 0.101211 0.002382 -0.005058 0.002920 Fiancp 0.024460 0.405990 0.016534 -0.117294 0.037735 0.014362 Braccp 0.249203 -0.294208 0.168312 0.041190 0.011601 0.018412 Vitam 1.000000 0.590047 0.401064 -0.035936 0.021062 -0.002221 Fiancm 0.590047 1.000000 0.289072 -0.100407 -0.006203 0.000808 Braccm 0.401064 0.289072 1.000000 -0.123682 -0.011046 -0.039252 Creatinina -0.035936 -0.100407 -0.123682 1.000000 -0.051205 0.046388 N_ureico 0.021062 -0.006203 -0.011046 -0.051205 1.000000 0.545930 Uricemia -0.002221 0.000808 -0.039252 0.046388 0.545930 1.000000 pcr 0.081120 0.030485 -0.039732 0.018435 -0.001377 -0.075539 Cronbachs Alpha = 0.030471 Standardized Cronbachs Alpha = 0.808706

7 Correlation Report Page/Date/Time 7 2/26/2013 4:00:21 PM Database Controlled For: GroupHT1

Pearson Correlations Section (Pair-Wise Deletion)

pcr Sex 0.022458 Eta -0.056677 BMI 0.155275 Ins 0.072354 kg 0.039485 h -0.060574 cv_h 0.160999 Vita 0.084855 Fianc 0.066999 Bracc 0.094400 PAS 0.054305 PAD -0.046967 PASp 0.055561 PADp 0.048124 PASm 0.041125 PADm -0.010039 CT 0.050185 HC 0.045257 HDL -0.144479 nHDL 0.097765 TG 0.023771 LDL 0.098360 BMIp 0.126679 BMIm 0.100814 glicemia 0.188429 Insp 0.109138 Insm 0.063992 Vitap 0.103573 Fiancp -0.007414 Braccp 0.045652 Vitam 0.081120 Fiancm 0.030485 Braccm -0.039732 Creatinina 0.018435 N_ureico -0.001377 Uricemia -0.075539 pcr 1.000000 Cronbachs Alpha = 0.030471 Standardized Cronbachs Alpha = 0.808706