Dr.Rer.Nat.Dipl.-Ing. Zvonimir Koporc, (M.Sc., Ph.D.)

Curriculum vitae Dr.rer.nat.Dipl.-Ing. Zvonimir Koporc, (M.Sc., Ph.D.) birth: 30.03.1972. in Zagreb, Croatia address: Kalinovica 9, 10000, Zagreb, Croatia contact: e-mail: [email protected] tel: 00385 98 7333 48

Education: 2009 Habilitation (Docent), immunology, Division of biotechnology, University of Rijeka, Croatia 12.03.2006: Promotion Dr. rer.nat. TU-Vienna 2002-2006 Dr. rer.nat. TU-Vienna 1999 Austrian title of "Dipl.-Ing." 1992-1999 promotion 12.03.1999. Dipl.-Ing. of Food Technology and Biotechnology (study of biochemistry) University of Zagreb-Croatia 1997 Diploma work in BOKU Wien, „Institut für Lebensmitteltechnologie“ title of diploma work „Enzymatical synthesis of xylitol“

Scientific experience: 2009 (current) group leader, immunology, Division of Biotechnology, University of Rijeka, Croatia from 2008 (current) scientific expert evaluator for EU-FP7 Marie Curie Program 2007-2009 post-doc scientist – Division of Molecular Medicine, Institute of Ruđer Bošković, Croatia 2007 Cooperative work with National Institute of Biology, Slovenia, EU 2002-2006 Vienna General Hospital (AKH), Department of Surgery, Division of Transplantation, A.O. Univ. Prof. Dr.Thomas Wekerle TU-Vienna, Univ.Prof. Peter. C. Kubicek, Dissertation: Use of mobilized peripheral blood stem cells for the induction of mixed chimerism and tolerance) 2000-2001 Vienna General Hospital (AKH), Department of Pathophysiology, Univ. Prof. Dr. Jürg Graf /Ao. Univ. Prof. Dr. Renate Fuchs, Scientific coworker (“Wiss.

Curriculum Vitae Dr. DI Zvonimir Koporc 1 mitarbeiter”), Project: Comparative analysis of the mechanism of uncoating of three different picornaviruses 1999-2000 TU-Vienna, Department of Process Engineering, Eur.-Ing.DI.Dr. Richard Gapes, Scientific coworker (“Wiss. mitarbeiter”), Project 1:Aceton Butanol Fermentation Project 2: Production of Biodisel 1996-1997 BOKU Wien, Institut of Food technology and Biotechnology, Univ.Prof.Dr.Klaus D. Kulbe, Diploma work ; Enzymatical synthesis of xylitol

Awards:  Annual rektor award from University of Zagreb for best student work under title: „Bio-degradation of crude oil“ for year school year 1995/1996  Annual rektor award from University of Zagreb for best student work under title: „Enzymatical synthesis of xylitol“ for school year 1996/1997  Austrotransplant-Biotest-Preis BIOTEST prize year 2003 (Team work)  Poster award American Transplant Congress, Boston MA,USA 2004  Young Investigator Travel Award for “Basic Science Symposium of The Transplantation Society 2003”, Keystone, Colorado

Publications: 1. Blaha P, Bigenzahn S, Koporc Z, Schmid M, Langer F, Selzer E, Bergmeister H, Wrba F, Kurtz J, Kiss C, Roth E, Muehlbacher F, Sykes M, Wekerle T: The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood 101: 2886-2893, 2003 2. Wekerle T, Blaha P, Koporc Z, Bigenzahn S, Pusch M, Muehlbacher F: Mechanisms of tolerance induction through the transplantation of donor hematopoietic stem cells: central versus peripheral. Transplantation 75: 21S-25S, 2003 3. Koporc Z, Pree I, Bigenzahn S, Blaha P, Nierlich P, Fariborz E, Sykes M, Muehlbacher F, Wekerle T: Murine Mobilized Peripheral Blood Stem Cells Have a Lower Capacity than Bone Marrow to induce Mixed Chimerism and Tolerance. American Journal of Transplantation 8: 2025-2036, 2008 4. Blaha P, Bigenzahn S, Koporc Z, Sykes M, Muehlbacher F, Wekerle T: Short-term immunosuppression facilitates induction of mixed chimerism and tolerance Curriculum Vitae Dr. DI Zvonimir Koporc 2 after BMT without cytoreductive conditioning. Transplantation 80: 237-43, 2005 5. Bigenzahn S, Blaha P, Koporc Z, Pree I, Selzer E, Bergmeister H, Wrba F, Heusser C, Wagner K, Muehlbacher F, Wekerle T: The role of non-deletional tolerance mechanisms in a murine model of mixed chimerism with costimulation blockade. American Journal of Transplantation 5: 1237-1247, 2005 6. Koporc Z, Bigenzahn S, Blaha P, Fariborz E, Selzer E, Sykes M, Muehlbacher F, Wekerle T: Induction of Mixed Chimerism through Transplantation of CD45-Congenic Mobilized Peripheral Blood Stem Cells after Nonmyeloablative Irradiation. Biology of Blood and Marrow Transplantation 12: 284-292 , 2006 7. Pree I, Bigenzahn S, Fuchs D, Koporc Z, Nierlich P, Winkler C, Brandacher G, Sykes M, Muehlbacher F, Langer F, Wekerle T: CTLA4Ig PROMOTES THE INDUCTION OF HEMATOPOIETIC CHIMERISM AND TOLERANCE INDEPENDENTLY OF INDOLEAMINE-2,3-DIOXYGENASE (IDO). Transplantation 83(5):663-,2007 8. Nierlich P, Klaus C, Bigenzahn S, Pilat N, Koporc Z, Pree I, Baranyi U, Taniguchi M, Muehlbacher F, Wekerle T: NATURAL KILLER T (NKT) CELLS INHIBIT ENGRAFTMENT AND TOLERANCE INDUCTION AFTER NON-MYELOABLATIVE BONE MARROW TRANSPLANTATION, applied „Blood“ 2009

Oral presentations and posters: 1. Koporc Z, Blaha P, Bigenzahn S, Muehlbacher F, Sykes M, Wekerle T: Use of mobilized peripheral blood stem cells for the induction of mixed chimerism. Proc. Basic Sciences Symposium 2003 of The Transplantation Society 2003 2. Koporc Z, Blaha P, Bigenzahn S, Muehlbacher F, Sykes M, Wekerle T: Use of mobilized peripheral blood stem cells for the induction of mixed chimerism and tolerance. European Surgery Acta Chirurgica Austrianica 35 : 12 , 2003 3. Bigenzahn S, Blaha P, Koporc Z, Schmid M, Selzer E, Bergmeister H, Heusser C, Wagner K, Mühlbacher F, Wekerle T: : Influence of an anti-CD25 mAb on tolerance induction through BMT plus costimulation blockade. European Surgery Acta Chirurgica Austrianica 34: 17, 2002 4. Blaha P, Langer F, Bigenzahn S, Koporc Z, Selzer E, Bergmeister H, Mühlbacher F, Sykes M, Wekerle T: Minimal irradiation dose required for tolerance

Curriculum Vitae Dr. DI Zvonimir Koporc 3 induction through bone marrow transplantation with costimulation blockade . European Surgery Acta Chirurgica Austrianica 34: 18, 2002 5. Bigenzahn S, Blaha P, Koporc Z, Schmid M, Selzer E, Bergmeister H, Heusser C, Wagner K, Muehlbacher F, Wekerle T: Influence of an anti-CD25 mAb on tolerance induction through BMT with costimulation blockade. Journal of Heart and Lung Transplantation 22: 81, 2003 6. Bigenzahn S, Blaha P, Koporc Z, Selzer E, Bergmeister H, Heusser C, Wagner K, Muehlbacher F, Wekerle T: Anti-CD25 mAb treatment inhibits tolerance induction through BMT with costimulation blockade. American Journal of Transplantation 3: 455, 2003 7. Blaha P, Bigenzahn S, Koporc Z, Muehlbacher F, Sykes M, Wekerle T: Short-course immunosuppression allows a reduction in the cell dose required for tolerance induction in a model using BMT with costimulation blockade without cytoreduction. European Surgery Acta Chirurgica Austrianica 35: 12, 2003 8. Koporc Z, Blaha P, Bigenzahn S, Muehlbacher F, Sykes M, Wekerle T: Use of mobilized peripheral blood stem cells for the induction of mixed chimerism and tolerance. European Surgery Acta Chirurgica Austrianica 35: 12, 2003 9. Blaha P, Bigenzahn S, Koporc Z, Muehlbacher F, Takeuchi Y, Sykes M, Wekerle T: Peripheral deletion of alloreactive T cells in a tolerance model using BMT and costimulation blockade cannot be elicited by the transplantation of separated B cells or dendritic cells. European Surgery Acta Chirurgica Austrianica 35: 26, 2003 10. Bigenzahn S, Blaha P, Koporc Z, Selzer E, Wrba F, Heusser C, Wagner K, Muehlbacher F, Wekerle T: The role of regulation for induction and maintenance of tolerance through BMT plus costimulation blockade. European Surgery Acta Chirurgica Austrianica 35: 27, 2003 11. Bigenzahn S, Blaha P, Koporc Z, Muehlbacher F, Wekerle T: Progress towards clinical tolerance induction through mixed chimerism. European Surgery Acta Chirurgica Austrianica 35: 7, 2003 12. Blaha P, Bigenzahn S, Koporc Z, Schmid M, Langer F, Selzer E, Bergmeister H, Wrba F, Kurtz J, Kiss C, Roth E, Muehlbacher F, Sykes M, Wekerle T: The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. European Surgery Acta Chirurgica

Curriculum Vitae Dr. DI Zvonimir Koporc 4 Austrianica 36: 7-8, 2004 13. Blaha P, Bigenzahn S, Koporc Z, Muehlbacher F, Sykes M, Wekerle T: Transient immunosuppression allows a reduction in the cell dose required for tolerance induction through BMT with costimulation blockade without cytoreduction. Proc. Basic Sciences Symposium 2003 of The Transplantation Society 2003 14. Bigenzahn S, Blaha P, Koporc Z, Selzer E, Heusser C, Wagner K , Muehlbacher F, Wekerle T: The role of regulation for induction and maintenance of tolerance through BMT plus costimulation blockade. Proc. Basic Sciences Symposium 2003 of The Transplantation Society 2003 15. Koporc Z, Bigenzahn S, Blaha P, Muehlbacher F, Sykes M, Wekerle T: The use of Mobilized peripheral blood stem cells for the induction of mixed chimerism and tolerance. XX international congress of the transplantation society, Vienna-Austria Congress Abstracts Supplement to Transplantation 78: 131, 2004 16. Blaha P, Bigenzahn S, Koporc Z, Muehlbacher F, Sykes M, Wekerle T: Short-term immunosuppressive therapy improves chimerism and tolerance development in a model using bone marrow transplantation plus costimulation blockade without cytoreduction. XX international congress of the transplantation society, Vienna-Austria Congress Abstracts Supplement to Transplantation 78: 41, 2004 17. Koporc Z, Bigenzahn S, Blaha P, Wrba F, Muehlbacher F, Sykes M, Wekerle T: Mobilized peripheral blood stem cells show lower tolerogenic potential than bone marrow cells in recipients of costimulation blockade. American Journal of Transplantation 4: 324, 2004 18. Blaha P, Bigenzahn S, Koporc Z, Muehlbacher F, Sykes M, Wekerle T: Short-course immunosuppression facilitates chimerism and tolerance in a non- cytoreductive model using BMT and costimulation blockade. 6th International Conference on NEW TRENDS IN IMMUNOSUPPRESSION, Book of abstracts 42, 2004 19. Pree I, Bigenzahn S, Nierlich P, Koporc Z, Blaha P, Langer F, Selzer E, Fuchs D, Winkler C, Brandacher G, Sykes M, Muehlbacher F, Wekerle T: The role of Indoleamine 2,3-Dioxygenase (IDO) in a Murine CTLA4Ig-Based Mixed Chimerism Model. Clinical Immunology Supplement 1: 279, 2005 20. Koporc Z, Uporaba mobiliziranih krvotnih maticnih celic iz periferrne krvi (mPBSC) za indukcijo mesanega himerizma in tolerance, DELO-ZNANOST,26, 2007

Curriculum Vitae Dr. DI Zvonimir Koporc 5 Languages: Croatian mother language English fluent German good Russian basics

Curriculum Vitae Dr. DI Zvonimir Koporc 6