Brief Resume of the Study

From, DR SREEKUMAR.C.R Preliminary MD (AYU) Scholar Department of P G Studies in Swastha Vritta S.D.M. College of Ayurveda and hospital P.B No 164, Hassan- 573201 To, The Registrar RajivGandhiUniversity of Health Sciences, Bangalore, Karnataka.

Through: The Principal and Head of the Department of P.G. Studies in Swasthavritta S.D.M.College of Ayurveda and Hospital Hassan – 573 201

Respected Sir, Sub: Submission of completed Performa for Registration of subject for Dissertation.

I request you to kindly register the below mentioned subject against my name for the submission of the dissertation to the Rajiv Gandhi University of Health Sciences, Bangalore for partial fulfillment of M.D. (Ayurveda).

Title ofDissertation: “A Study on the Efficacy of Mridweekadi avaleha in Karshya”

Herewith I am enclosing a completeProforma of synopsis for registration of subject for dissertation. Thanking you,

Place: Hassan, Yours faithfully, Date: (Sreekumar.C.R)

1 RAJIVGANDHIUNIVERSITY OF HEALTH SCIENCES, BANGALORE, KARNATAKA.

ANNEXURE – II

COMPLETED PROFORMA FOR REGISTRATION OF SUBJECT FOR DISSERTATION.

1. NAME OF THE CANDIDATE : SREEKUMAR.C.R AND ADDRESS PRELIMINARY MD AYURVEDA,

IN BLOCK LETTERS) DEPARTMENT OF PG STUDIES IN SWASTHAVRITTA, S.D.M.C.A & H. HASSAN - 573201.

PERMANENT ADDRESS : S/O DR.T.K.RAJAGOPALAN CHAITHANYA (H) OORAMANA.P.O RAMAMANGALAM (VIA) MUVATTUPUZHA ERANAKULAM DISTRICT KERALA STATE PIN-686730

02. NAME OF THE INSTITUTE : S.D.M.COLLEGE OF AYURVEDA & HOSPITAL, HASSAN – 573 201.

03. COURSE OF STUDY: M.D. (AYURVEDA), SWASTHAVRITTA. & SUBJECT

04. DATE OF ADMISSION TO : THE COURSE

05. TITLE OF DISSERTATION : “A STUDY ON THE EFFECT OF MRIDWEEKADI AVALEHA IN KARSHYA”

2 0.6BRIEF RESUME OF THE STUDY.

6.1 NEED FOR THE STUDY. Ati Krusha is one among the kuposhanajanya vyadhi. Kuposhanajanya vyadhi occurs due to the lack of nutrients in diet. Vegavarodha i.e. suppression of natural urges like hunger4, thirst, sleep etc which affects the general health status and ratri jagarana is also a reason for krushata.4Kriyaatiyoga (vamana, virechana atiyoga) also lead to krishata.

Krusharogi with hinabala are more prone for diseases such as pliha, kshaya, kasa, swasa, gulma, arsha, udara, and grahani etc. Shareerika bala as well as sexual activities of krisha rogi is hampered due to the above said reasons and the person get exhausted very soon even after doing small works. Ayurveda aims for the prevention, promotion and maintenance of health, Swasthavritta being a specialty in Ayurveda deals with proper life style, Ahara-Vihara and Rasayana which are basic for maintaining and promotion of health. A person who becomes krusha due to intake of ruksha ahara etc should be treated with bala-vardhaka, bramahana and vajeekaraka Aushadhi10

Mridvika is having madhura rasa sitala and snigdha guna and is having brahmana and vrishya properties.5 Masha is having guru, snigdha and ushna guna, madhura rasa and having santarpana, balya, vrishya and vatahara properties.5 Ashvagandha is having laghu and snigdha guna, madhura-kashaya rasa and vata- kapha Shamaka, balya, vrishya and rasayana properties.5 Tila is having madhura, tikta, kashaya and katu rasa, snigdha, balya and ushna guna.

Nagara is having madhura and katu vipaka, it is having vrishya, kapha- vataghna, snehana, hridya and deepana properties.5 Karshya is associated with Agni mandya, Vata vriddhi and dhatu kshaya. As a coumpound preparation, each drug targets each of the above said aspects of the disease besides being Brihmana, Balya and Vrishya, thus yielding more effect than a single drug therapy.

3 Above said drugs in avaleha form may act as effective remedy to overcome the problems faced by the adults suffering from Karshya as these drugs are bruhmana, vrishya, madhura rasa and balya in nature. So here an effort is made to see the efficacy of avaleha prepared with above said drugs in preventing complication and improving nutritional status of Karshya patients.

6.2 REVIEW OF LITERATURE: . Karshya is one among the Kuposhna Janya Vyadhi, which comes under Apatarpana Vyadhi. Atikrusha is included under Asta Nindita Pursha. Krushata is caused due to Rukshannapana, increased activity of Sharirika, Manasika, and Vachika Kriyas and also due to Shoka, Vega avarodha, Vriddhavasta, Vataprakruti, and by Dirghakaalina Roga.1, 6 The person who is Krusha will have Sushka Sphik, Udara, and Griva and also they have less Mamsa in the body. The joints will be more prominent as well as the peripheral veins.1, 10 The Krusha are more susceptible for diseases and there will be Kshaya of Snehamsha in the body, Kshaya of Agni, Nidra, Indriya Shakti, Shukra, Oja, and Swara. Characteristically Krusha person gets pain in Basti, Hrudya Janga, and also in Trika and Ura Pradesh.10 According to Chikitsa Siddanta of Krusha, Laghu, Santarpan and Brumhana Chikitsa can be adopted.1 The Krusha people will need madhura, Snigdha, Ushna, and Laghu Guna property drugs and diet in their treatment.3 Krusharogi is treated with brahmana and vrishya drugs like ashwagandha, vidari etc.3

Ashvagandha is having Laghu and Snigdha Guna, madhur Vipaka and Kapha Vatashamaka property. Ashvagandha act as Balya, Brumahaniya and Rasayana.5 Mridweeka is having madhura rasa sitala and snigdha guna and is having brahmana and vrishya properties.8, 5 Masha is having guru, snigdha and ushna guna madhura rasa and having santarpana, balya, vrishya and vatahara properties.5 Tila is having madhura, tikta, kashaya and katu rasa, snigdha, balya and ushna guna.5 Nagara is having madhura and katu vipaka, it is having vrishya, kapha vataghna, snehana, hridya and deepana properties.5

4 Guda is having madhura rasa; it helps in the production of rakta, meda, mamsa shukra, majja and bala. Main preparation of above said drugs like Ashvagandha ghrita9, Ashvagandha rasayana, Asvagandha avalehya, drakshadi leha, tiladi rasayana, can be used in Karshya.6, 8, 9

PREVIOUS RESEARCHES

1) Gaidone Hrishikesh: Karshya Chiktsa Siddanta ke Pariprekshya mein Brimhaneeya Dashemani ka Pryogika Adhyayana, Smt K.G .M Punarvasu Ayurveda College Mumbai. Mumbai university in 2002 2) Jat S.L : Ashvamalaki yoga ka Karshya par Rasayana Prabhava., National Institute of Ayurveda Rajasthan University Jaipur in 1996 3) Sharma Kishori Lal: Rasa Dhatu Ksaya Janya Karshya roga ke Pariprekshya mein katipaya Brmhaneeya Drvyo ka Prabhavatamaka Adhyayana, National Institute of Ayurveda Rajasthan University Jaipur in 2003 4) Maddinamath.V.S:Rasayana and effect of Chyavanaprash on Karshya, Government Ayurvedic Medical College Mysore. Mysore university in 1975 5) Namajoshi. M : Concept of Brumhana w.s.r. to Karshya Institute for Post Graduate Teaching and Research in Ayurveda , Gujarat Ayurveda University Jamnagar in 1994. 6) Dhyani. M.P: Sthaulya evam Karshya. Institute for Post Graduate Teaching and Research in Ayurveda , GujaratAyurvedaUniversityJamnagar in 1967 7) Tonni Sanjeev Shivappa: A study on effect of Kushumanda avaleha on Karshya, Shri Dharamasthala Manjunateshwar College of Ayurveda and Hospital Hassan, Rajeev Gandhi University of Health Sciences Bangalore.

5 OBJECTIVES OF THE STUDY 1) To evaluate the effect of Mridweekadi avaleha in improving the nutritional status in karshya.

07. MATERIALS AND METHODS.

7.1 SOURCE OFDATA: Subjectsfrom OPD and IPD of SDM College of Ayurveda and Hospital, Hassan will be selected for this study.

7.2 : MATERIALS Emaciated subjects will be selected irrespective of sex; caste and religion between the age group of 18-40 years, exhibiting less body weight

7.3:DIAGNOISTIC CRITERIA Subjects with BMI below 18 kg/m2

7.4 INCLUSION CRITERIA: 1. Subjectswho are having Body Mass Index below 18kg/m2 irrespective of sex. 2. Subjects between the age group of 18 – 40 years, exhibiting less body weight

7.5 EXCLUSION CRITERIA: Krushata secondary to any illness such as Tuberculosis Infection and other systemic illness are excluded from the study.

6 7.6 STUDY GROUPS: It will be a clinical study with two groups, each group comprising of 15 patients.

GROUP A–Trial group contains 15 patients who will be administered Mridweekadi avaleha 16gms in two divided doses before food with Luke warm milk.

GROUP B- Control group contains 15 Subjects who will be given placebo capsule half an hour before food with Luke warm milk.

Mridweekadiavaleha Ingridients: Mridweeka, Masha, Ashvagandha, Tila, Nagara and Guda.

7.7ASSESSMENT CRITERIA: 1. Improvement in signs and symptoms of Karshya 2. Changes in weight &BMI 3. Changes in circumference of chest, mid arm, abdomen, mid-thigh. 4. Changes in waist hip ratio.

7.8FOLLOW UP STUDY Follow up study will be done after one month of the treatment.

7.9LABORATORYINVESTIGATIONS: 1. Blood routine 2. Serum protein 3. Serum albumin

7 8.0. LIST OF REFERENCES. 1) Charka Samhita translated by Achrya Vidyadhara shukla and Ravidatta Tripathy.Volume-1, 2002 edition, Sutrastana 21 chapter, shloka no 3, 11, 12, 15, 16, 20, 30-34. Page no 300-304. 2) Astanga Sangraha translated by Dr. Ravidatta Tripathy 1999 edition Sutrastana Sutrastana 11 chapter shloka no 2, page no 234. 3)Sushruta Shamita volume one Hindi translated by Dr. Ambikadattashastri, and Dr.Pranjivan Manikchand Mehata 2005 edition Sutra stana 35 Chapter Shloka no 40,41. Page no 135. 4) CharkaSamhita translated by Achrya Vidyadhara shukla and Ravidatta Tripathy. Volume-1, 2002 edition, Sutrastana 22 chapter, shloka no25, 26, 28 &38. Page no 313,314. 7th Chapter, 20th shloka. Page no 123. 5) Kaideva Nigantu Hindi Translated By AchryaPriyavat Sharma and Guruprasad Sharma. Page no 193. 2006 edition. OushdiVarga 309, 14, 345 shloka no. 1044- 1046, 298-304, 1150-1152. Dhanyavarga 33,46 shloka no. 56-58, 80-83. 6) BhavaPraksha Volume One Hindi Translated by Brahma Shankar Mishra and Rupalalji Vaishya. 2002 year 10th Edition. Page no 393 Guduhi varga 97, Volume 2 Karshadhikar 40, page no 412,413. Rasayanadhikar73 page no 721- 723. 7) Baghel M.S. Reaserches in Ayurveda. Jamnagar: Mridu ayurvedic publications and sales; 2005 8) CharkaSamhita translated by Achrya Vidyadhara shukla and Ravidatta Tripathy. Volume-1, 2002 edition, sutrastana 27th chapter, shloka no 125 & 126. Page no. 401 9) Bharata baishaja ratnakara part 1, Compliedby Vaidya Nagindas chhaganlal shah. Page no 62-63. 10) Astanga Sangraha translated by Dr. Ravidatta Tripathy 1999 edition Sutrastana Sutrastana 24 chapter. Shloka no 3, 10, 11, 47-55, 67. Page no 434, 435, 441, 442, 444.

8 9. SIGNATURE OF CANDIDATE:

10. REMARKS OF GUIDE :

11. NAMES AND DESIGNATION OF

11.1 GUIDE : DR. SHIVAKUMAR READER DEPT. OF PG STUDIES IN SWASTHAVRITTA, SDMCA&H, HASSAN.

11.2 SIGNATURE :

11.4. H.O.D. : DR. T.B .TRIPATHY PROFFESOR &HOD, DEPT. OF PG STUDIES IN SWASTHAVRITTA, SDMCA & H, HASSAN

12 SIGNATURE :

12.1 REMARK OF CHAIRMAN: & PRINCIPAL:

12.2 SIGNATURE :