International Symposium on Natural Products

Chemistry and Chemical Biology 2012

Hangzhou, China November 23-26, 2012 Organizers Zhejiang University, China The Management Commission of Hangzhou Economic and Technological Development Zone, China Nagoya University, Japan

Sponsors Zhejiang University of Technology, China National Natural Science Foundation of China (NSFC) Asian Chemical Biology Initiative Japan Society for the Promotion of Science (JSPS) Baicao Traditional Chinese Medicine Co., Ltd.

Covered Topics 1. Isolation and Structure Elucidation of Natural Products 2. Chemosynthesis and Biosynthesis of Natural Products 3. Chemical Biology and Related Areas 4. Drug Discovery and Development

Organization Honorary Chairmen Prof. Yinchu Shen (Member of the Chinese Academy of Engineering, Zhejiang University of Technology)

I Chairmen Prof. Jianhua Qi (Zhejiang University) Prof. Daisuke Uemura (Nagoya University)

Academic Committee Chairmen of the Academic Committee Prof. Makoto Ojika (Nagoya University) Prof. Yongzhou Hu (Zhejiang University)

Members of the Academic Committee Prof. Su Zeng Prof. Yongping Yu Prof. Zhujun Yao Prof. Weike Su Prof. Zhengwei Fu Prof. Jianhua Qi

Organizing Committee Chairmen of Organizing Committee Prof. Jianhua Qi (Zhejiang University) Prof. Motonari Uesugi (Kyoto University) Prof. Yongping Yu (Zhejiang University)

Members of Organizing Committee Jianhua Bi Liming Wang Junmin Li Weiguang Shan Jianzhong Chen Liurong Chen Chen Zhang Ping Wang Rong Sheng Hongbin Zou

Secretariat Secretary-general Prof. Ping Wang (Zhejiang University of Technology)

Members of Secretariat Zhijun Zhu Wei Liu Lan Xiang Tao Liu Wendai Jing Xingyi Zhu Jie Xie Qinying Yan

II Schedule November 23th Registration 12:00- Yuanzheng Qizhen Hotel

November 24th Meeting Hall 349, College of Pharmaceutical Sciences, Zhejiang University Morning Session 8:45-9:05 Opening Remarks 9:05-9:25 Group Photo 9:25-9:30 Memorial Speech for Professor Youji Sakagami 1. 9:30-10:05 Topic: Intriguing natural products from marine sources Speaker: Prof. Daisuke Uemura (Faculty of Science, Kanagawa University, Japan) Moderator: Prof. Zhujun Yao 2. 10:05-10:40 Topic: The achievements of professor Youji Sakagami, a pioneer of plant and microbial peptide hormone researches Speaker: Prof. Makoto Ojika (Graduate School of Bioagricultural Sciences, Nagoya University, Japan) Moderator: Prof. Zhujun Yao 3. 10:40-11:15 Topic: Sexual reproduction inducers of Phytophthora (Dedicated to the late professor Youji Sakagami) Speaker: Prof. Jianhua Qi (College of Pharmaceutical Sciences, Zhejiang University, China) Moderator: Prof. Toshio Nishikawa 4. 11:15-11:50 Topic: Peptide isoprenylation Speaker: Dr. Masahiro Okada (College of Bioscience and Biotechnology, Chubu

III University, Japan) Moderator: Prof. Toshio Nishikawa

12:00-13:30 Lunch

Afternoon Session 5. 13:30-14:05 Topic: Mining functional organic compounds from nature Speaker: Prof. Renxiang Tan (Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, China) Moderator: Prof. Makoto Ojika 6. 14:05-14:40 Topic: Integrative approach for target identification of bioactive compounds Speaker: Prof. Hiroyuki Osada (Chemical Biology Core Facility, RIKEN ASI, Japan) Moderator: Prof. Makoto Ojika 7. 14:40-15:15 Topic: Biosynthesis-based natural product discovery Speaker: Prof. Wen Liu (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China) Moderator: Dr. Masahiro Okada

15:15-15:35 Tea Break

8. 15:35-16:10 Topic: Biology-oriented study of natural products: unnatural dual-functional abeo- taxanoids Speaker: Prof. Zhujun Yao (School of Chemistry and Chemical Engineering, Nanjing University, China) Moderator: Dr. Masahiro Okada 9. 16:10-16:45

IV Topic: Synthetic studies on natural products by means of RCM Speaker: Prof. Tohru Fukuyama (Graduate School of Pharmaceutical Sciences, Nagoya University) (Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan) Moderator: Prof. Renxiang Tan

18:00- Banquet

November 25th Meeting Hall 349, College of Pharmaceutical Sciences, Zhejiang University Morning Session 1. 8:45-9:20 Topic: Total synthesis of 13-oxyingenol and its natural derivative Speaker: Prof. Hideo Kigoshi (Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Japan) Moderator: Prof. Hirokazu Kawagishi 2. 9:20-9:55 Topic: Synthesis of guanidine-containing natural products Speaker: Prof. Toshio Nishikawa (Graduate School of Bioagricultural Sciences, Nagoya University, Japan) Moderator: Prof. Hirokazu Kawagishi 3. 9:55-10:30 Topic: Chemical diversity and the bioactive compounds from marine invertebrates inhabited in South China Sea Speaker: Prof. Wenhan Lin (State Key Laboratory of Natural and Biomimetic Drugs, Peking University, China) Moderator: Prof. Motonari Uesugi 4. 10:30-11:05 Topic: Anti-parasitic agents from marine organisms Speaker: Prof. Yoichi Nakao (School of Advanced Science and Engineering, Waseda University, Japan)

V Moderator: Prof. Motonari Uesugi 5. 11:05-11:40 Topic: The angel’s wing mystery-Attempt to disclose the molecular mechanism of acute encephalopathy caused by eating angel’s wing oyster mushroom (Sugihiratake) Speaker: Prof. Hirokazu Kawagishi (Graduate School of Science and Technology, Shizuoka University, Japan) Moderator: Prof. Wenhan Lin

12:00-13:30 Lunch

Afternoon Session 6. 13:30-14:05 Topic: Ajmaline biosynthesis: from alkaloid structure to enzyme structure Speaker: Prof. Joachim Stöckigt (College of Pharmaceutical Sciences, Zhejiang University, China) Moderator: Prof. Wen Liu 7. 14:05-14:40 Topic: Small molecules that block fat synthesis Speaker: Prof. Motonari Uesugi (Institutes for Integrated Cell-Material Sciences (WPI- iCeMS) and for Chemical Research (ICR), Kyoto University, Japan) Moderator: Prof. Wen Liu 8. 14:40-15:15 Topic: Analogues of cyclic ADP-ribose and their functions to regulate calcium signal pathway Speaker: Prof. Liangren Zhang (School of Pharmaceutical Sciences, Peking University, China) Moderator: Prof. Joachim Stöckigt

15:15-15:35 Tea Break

VI 9. 15:35-16:10 Topic: Food signals and circadian rhythm Speaker: Prof. Zhengwei Fu (College of Biological and Environmental Engineering, Zhejiang University of Technology, China) Moderator: Prof. Joachim Stöckigt 10. 16:10-16:45 Topic: Small molecules targeting mitochondrial UQCRB Speaker: Prof. Ho Jeong KWON (Chemical genomics NRL, Department of Biotechnology, Yonsei University, Korea) Moderator: Prof. Hideo Kigoshi 11. 16:45-17:20 Topic: S-3, a Spiraea diterpenoid derivative with potent anti-tumor activity Speaker: Prof. Xiaojiang Hao (The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China) Moderator: Prof. Hideo Kigoshi

17:20-17:30 Closing Remarks

18:00- Banquet

November 26th Excursion