Annual Conference of the German-Swiss Association for Radiation Protection

(16.Juli 2007) Program:

Ion Beams in Biology and Medicine 11 th HCPMB-Workshop Annual conference of the German-Swiss Association for Radiation Protection Joint GAST Conference * invited speakers Wednesday, September 26 th , 2007 Radiation Safety Morning session Chairmen: G. Kraft (GSI), O. Jäkel (DKFZ) 9.00 - 9.15 J. Debus Welcome 9.15 - 10.00 E. Hall (Columbia)* The Impact of New Technologies on the Opening Lecture Incidence of Second Cancers in Radiotherapy 10.00 – 10.30 coffee 10.30 - 11.00 D. Schardt (GSI)* Neutrons and other secondary products 11.00 -11.30 A. Fuchs (PSI)* Radiation protection of personal & environment 11.30 - 12.00 G. Fehrenbacher (GSI)* Shielding design for Ion beam therapy 12.00 -12.30 J. Griebel (BFS Clinical research versus patient care: Legal München)* regulations for particle therapy 12.30 – 14.00 lunch Afternoon session Particle physics Chairmen: T. Otto (CERN), K. Henrichs (Siemens, München) 14:00 - 14.30 Eursch (IWB, München) Improved Radiation Protection for Manual Poster report 1: Tasks by the Use of an Immersive Camera N.N. System and the Technology of Augmented Reality M. Hultquist (Sweden) Secondary doses to patient in light ion therapy – Monte Carlo studies coupled with anthropomorphical phantoms. P. Kundrat (Czech -Probabilistic two-stage model of cell Republic) killing by ionizing radiation -Modeling the biological effectiveness of radiations of different qualities G. Dollinger (Universität Does radio biological effectiveness change der Bundeswehr) in laser driven ion therapy? 14.30 - 14.50 I. Gudowska (Sweden) Verification of the multiple scattering and energy for therapeutic light ion beams implemented in a semi-analytical pencil beam model and the MC code SHIELD- HIT; benchmark with experiments 14.50 - 15.10 I. Jadrníčková (Prague) Spectrometry of LET using track-etch detectors – Fragmentation studies and radiobiological effectiveness in heavier ion beams 15.10 - 15.30 Ö. Kartal (DKFZ, IMPS) Studying the secondary electron fluence in 12C ion beams by means of an extrapolation chamber 15.30 – 16.00 coffee Biology Session 1 16.00 - 16.20 B. Jakob (GSI) Dynamics of DNA double strand breaks detected by live cell microscopy indicates only limited cluster formation after high LET ionizing radiation. 16.20 - 16.40 V. Hable (UniBw Micro Irradiation of Living Cells at München) SNAKE 16.40 - 17.00 J. Splinter (GSI) Heavy Ions vs. UV Laser Microirradiation – Two systems to induce localized DNA lesions in living cells 17.00 - 17.20 Y. Schweinfurth (GSI) Measurements of DNA-double strand breaks after tumour therapy-related carbon irradiation and comparison with γH2AX analysis after induction of highly complex DNA-lesions 17.20 - 17.40 C. Baumstark-Khan Genotoxicity of Heavy Ions in (DLR) Recombinant Bacteria 17.40 - 18.00 S. Ritter (GSI) Cytogenetic damage induced in vivo by high and low LET radiation: follow up of radiotherapy patients Dinner session Reception, Industry Exhibition and poster viewing

Thursday, September 27 th , 2007 Physics + Dosimetry Morning session Chairmen: N. Saito (GSI), S. Brons (GSI, HIT) 9.00 - 9.30 J. Pawelke (FZD)* Therapy monitoring with PET techniques 9.30 - 9.50 F. Sommerer (CERN) Experiments and Simulations for In-beam PET Monitoring with Oxygen Beams 9.50 - 10.10 J. Kempe (Sweden) Analytical transport expressions and absorbed dose distribution of β+ emitters in light ion radiation therapy 10.10 – 10.40 coffee 10.40 - 11.10 C. Karger (DKFZ)* Dosimetry of Carbon RT Instrumentation 11.10 - 11.30 N. Bassler (DKFZ) Antiproton Radiation Dosimetry 11.30 - 12.00 M. Durante (Naples)* Radiobiology for space research 12.00 -12.20 O. Kavatsyuk (GSI) Particle-induced phosphene stimulation in heavy-ion tumor therapy 12.20 – 14.00 lunch Afternoon session Chairmen: Karger (DKFZ), Durante (Naples) 14:00 - 14.20 Maruyama (Japan) Analysis of the Factors that Disturb Dose Concentration in Carbon Beam Therapy 14.20 - 14.40 M. Rebisz (GSI) Diamond detectors for heavy-ion beams dosimetry 14.40 - 15.10 C. Bert (GSI) Integrated 3D Online Motion Compensation system for scanned carbon ion therapy 15.10 – 15.30 N. Saito (GSI) Technical improvement of the 3D-Online Motion Compensation System for scanned ion beam therapy 15.30 – 16.00 coffee 16.00 - 17.00 G. Kraft (GSI) Treatment of moving organs Round table (Moderator) C. Bert (GSI) S. Webb (Royal Marsden) S. Minohara (NIRS, Japan) 17.00 - 17.30 C. Bert (GSI) Gating with scanned carbon beams Poster report 2: K. Henkner (DKFZ) Monte Carlo Depth-Dose Calculations for N.N. different I-Values in Heavy Ion Therapy A. Schmidt (GSI) Cell survival studies in the presence of target motion 17.30 - 18.00 T. Haberer (HIT) Physical aspects of an ion application and Introduction to HIT facility Dinner session HIT guided tours / at the HIT facility barbecue

Friday, September 28 th , 2007 Morning session Radiobiology Chairmen: M. Beuve (IPNL, CNRS), G. Dollinger (Universität der Bundeswehr) 9.00 - 9.30 M. Löbrich (Homburg)* Molecular biology of ion beams 9.30 - 10.00 D. Bettega (Milano)* Cell transformation 10.00 – 10.30 coffee 10.30 - 11.00 M. Scholz (GSI)* Biological aspects of carbon RT 11.00 - 11.30 P. Peschke (DKFZ)* Normal tissue toxicity 11.30 - 12.00 Poster report 3: C. Hellweg (DLR) High-LET ion beams activate the N.N. transcription factor NF-κB in human cells J. Czub (Poland) Heavy ion radiobiological studies in the Bragg Peak region C. Fournier (GSI) Fate of human fibroblasts following exposure to low and high LET irradiation: senescence or genetic instability? C. Fürweger (Wien) Early Cellular Signalling after Exposure to Particles of High Linear Energy Transfer (LET) H. Hromčíkova(Czech Analysis of repair processes in different Republic) hamster cell lines exposed to carbon irradiation M. Davídková (Czech Effect of oxygen on DNA damage caused Republic) by ionizing radiation of different quality R. Lee (GSI) Estimating the genotoxic effects of Fe- ions: impact of cell cycle effects, apoptosis and intra-individual variability

12.00 - 12.30 M. Hollmark (Sweden) Comparison of radiobiological models for Poster report 4: light ion therapy N.N. M. Maalouf (France) Different cell death pathways for radio- sensitive and radio-resistant Head and Neck Squamous Carcinomas Cells exposed to high and low LET radiation: Implications for future clinical application in hadron therapy A. Meijer (Sweden) Apoptotic and cell cycle responses in the small cell lung cancer cell line U-1690 following exposure to different LET of boron and nitrogen ions T. Pouthier (GSI) Studies on bystander effect using the GSI heavy ion microbeam C. Schicker (GSI) OER Measurements in an Extended Volume 12.30 – 14.00 lunch Afternoon session Treatment planning Chairmen: M. Löbrich (Homburg), A .Friedl (LRZ Uni München) 14:00 - 14.20 C. Karger (DKFZ) Measurement of relative biological effectiveness (RBE) and fractionation ratios (α/β) after single and fractionated doses of carbon ions to the spinal cord of the rat 14.20 -14.40 T. Elsässer (GSI) Dependence of Cell Survival after Carbon irradiation on the α/β-ratio for photon irradiation – Implications of the Local Effect Model 14.40 - 15.00 M. Beuve (IPNL, CNRS) Theoretical limits of Local Effect Model 15.00 – 15.30 coffee 15.30 - 16.00 O. Jäkel (DKFZ)* Treatment planning for ion beams 16.00 - 16.30 M. Krämer (GSI)* Biological planning optimization 16.30 - 17.00 N.N. Protons 17.00 - 18.00 J. Debus (Moderator) Immobilisation techniques, necessity of a Round table H. Tsujii (NIRS, Japan) particle gantry B. Didinger (Heidelberg) R. Sweeney (Innsbruck) 19.00 Concert and reception at Social event Heidelberg Castle, free evening at the old town of Heidelberg

Saturday, September 29 th , 2007 Clinical results of Chairmen: D. Schulz-Ertner, Q. Li Morning session particle therapy 9.00 - 9.30 S. Rossi (CNAO)* Hospital-based therapy units for particle therapy 9.30 - 10.00 T. DeLaney (MGH Clinical results of proton RT in the USA Boston) (to be (MGH, Loma Linda) confirmed)* 10.00 – 10.30 coffee 10.30 - 11.00 E. Hug (PSI)* Clinical results of proton RT in Europe (PSI) 11.00 - 11.30 H. Tsujii (NIRS, Clinical results of carbon ion RT in Japan Japan)* 11.30 - 12.00 D. Schulz-Ertner Clinical results of carbon ion RT at GSI (Heidelberg)* 12.00 - 12.30 announcement 12.30 – 14.00 lunch Afternoon session Status reports Chairmen: J. Debus, E. Hug (PSI) 14.00 - 15.00 S. Rossi (CNAO) Pavia Q. Li (IMP, China) Lan Zhou U. Weber (RKA) Marburg T. Auberger Wiener Neustadt (Innsbruck,MedAustron) M. Bajard (Ètoile) Lyon R. Kampf (Uni Kiel) Kiel 15.00 – 15.30 coffee 15.30 - 17.00 P. Pommier (Lyon) Clinical indications for particle therapy, cost Round table J. DeLaney (MGH effectiveness of particle therapy Boston) (to be confirmed) T. Auberger (Innsbruck) D. Schulz-Ertner (Heidelberg) K.P. Thiele (KC Onkologie Düsseldorf) 17.00 J. Debus Closing speech