Jennifer Armstrong-Wells, MD, MPH

Armstrong-Wells

Revised: 8/2011

CURRICULUM VITAE

Name: Jennifer Armstrong-Wells, MD, MPH

Position: Assistant Professor 10/08-Present Director, Perinatal and Hemorrhagic Stroke Programs Department of Pediatrics, Section of Pediatric Neurology UCD Hemophilia & Thrombosis Center UCD Center for Women’s Health Research University of Colorado/Children’s Hospital Colorado

Assistant Adjunct Professor, Step 1 12/08-Present Division of Child Neurology Department of Neurology University of California, San Francisco

Address: Hemophilia & Thrombosis Center 13199 E. Montview Blvd., Suite 100 Aurora, CO 80045 303-724-0724 (office) 303-724-0947 (fax) [email protected]

EDUCATION: 2006-2008 University of California, San Francisco Fellow Child Neurology 2005-2006 University of California, San Francisco Resident Adult Neurology 2002-2004 University of California, San Francisco Resident Pediatrics 2000-2001 University of California, Berkeley M.P.H. Epidemiology 1997-2002 University of California, San Francisco M.D. Medicine 1991-1996 University of California, San Diego B.A. Cum Laude, Biological Anthropology, Archeology

LICENSES, CERTIFICATION: 2009 Diplomat in American Board of Psychiatry and Neurology (Child Neurology Board Certification) 2008 Medical Licensure, Colorado (active) 2004 Medical Licensure, California (active)

PRINCIPLE POSITIONS HELD:

2008-present University of Colorado, Denver Assistant Professor Pediatrics (Neurology)

OTHER POSITIONS HELD CONCURRENTLY:

2008-present University of California San Francisco Assistant Adjunct Professor of Neurology

HONORS AND AWARDS: 2010 UCD Department of Neurology excellence in inpatient teaching (by medical student Armstrong-Wells evaluations) 2010-2012 NIH Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) Scholar, UC Denver 2009-2011 Colorado Clinical and Translational Sciences Institute, Clinical Faculty Scholar 2009-present Designated neurologist, Sturge-Weber Foundation Center of Excellence 2008 Kaiser Award for Excellence in Research in Neuroscience, San Francisco Neurological Society 2007 Scholarship Recipient, Virginia Commonwealth University Pediatric Epilepsy Course, 2007 Chief Resident, UCSF Department of Neurology Residency 2007-2008 (Elected by faculty and residents of both adult and child neurology) Quebec City 2002 Alpha Omega Alpha 2002 Ralph W. Ellison National Award Nominee 2000 University Fellowship, UC Berkeley 1997 University Fellowship, UCSF 1991 Bank of America Award for Liberal Arts 1996 Departmental Honors, Anthropology, UC San Diego 1995 Golden Key National Honor Society 1991 Chancellor’s Merit Scholar, UC San Diego 1991-1996 Provost Honors, Warren College, UC San Diego 1991 Howard Hughes Fellow 1991 Hispanic National Merit Scholar Semi-Finalist

KEYWORDS/AREAS OF INTEREST: Child Neurology, Neurovascular/Stroke, Coagulation Disorders in Pregnancy and Perinatal Period, Neuro-Epidemiology, Neonatal Neurology, Rehabilitation, Medical Education, Health-Science Education, Mentorship, Minority Enrichment

PROFESSIONAL/CLINICAL ACTIVITIES: Director, Perinatal and Hemorrhagic Stroke Sections, Colorado Pediatric Stroke Program, University of Colorado, Denver: I started these clinical and research subsections in 2008. The Hemorrhagic Stroke Clinic started April 2009.

Pediatric Arterial Ischemic Stroke Clinic

Attending, Child Neurology Service, The Children’s Hospital Colorado (4 weeks per year)

PROFESSIONAL ORGANIZATIONS: 2008-present American Academy of Neurology – Stroke Section 2007-present Child Neurology Society 2002-2004 American Academy of Pediatrics 2007-present International Pediatric Stroke Study 2006-present American Heart Association – Stroke Council 2005-present American Academy of Neurology

SERVICE: 2011-present UCD Foundations of Doctoring Preceptor 2010-present UCD Stroke Council 2010-present UCD Center for Women’s Health Research 2009-present UCD Section of Child Neurology Clinical Research Committee 2009-present Sturge-Weber Foundation (TCH-designated neurologist) 2008-present UCD Fetal Medicine pre-delivery counseling Armstrong-Wells

2008-present UCD Stroke Research Interest Group Committee 2007 UCSF Medical School, Brain, Mind and Behavior Module – Apprentice Group Leader 2006-2008 Representative, UCSF Fellow’s Leadership and Advocacy Group 2006-2008 UCSF Child Neurology Interest Group Mentor 2002-2004 UCSF Medical Student Preceptor, Primary Care Pediatrics 2001-2002 UCSF Advanced Studies Steering Committee (Multidisciplinary committee focusing on medical education beyond the clinical core) 2000-2006 UCSF Integrated Clinical Studies Steering Committee (Multidisciplinary committee of physicians overseeing the re-structuring of the medical school clinical curriculum) 1998-2002 UCSF Medical School Admissions Committee

PRESENTATIONS and TEACHING: 2011 American Heart Association International Stroke Conference Moderator 2011 UCD Department of Neurology Grand Rounds 2011 UCD Perinatal Research Group, Research Presentation 2010 UCD, Neonatology Grand Rounds 2010 UCD, Neurology Resident Conference 2010 UCD, Child Neurology Fellow Conference 2010 The Children’s Hospital, EMS Conference 2010 UCD, Pediatrics Grand Rounds 2010 UCD, Department of Reproductive Sciences 2010 UCD Center for Women’s Health Research Summer Kick-off 2010 UCD Center for Women’s Health Research Fundraising Luncheon 2010 UCD Emergency Faculty 2007 UC San Diego Grand Rounds 2009 Poudre Valley Medical Center, Fort Collins, CO Grand Rounds 2008-present UCD Denver, Child Neurology Residency, Weekly AM Conference 2008-present Quarterly teaching session on pediatric stroke and neurovascular disease for TCH Child Neurology Residents Conference 2008-present UCD Department of Hematology Coagulation Conference (faculty and fellows - twice/month) 2008 UCSF, Neurology Grand Rounds 2008 San Francisco Neurological Society Annual Meeting, Monterey, CA 2008 UCSF Frontiers in Neurology and Neuroscience 2007 Fishman Research Symposium, UCSF 2007-2008 Curriculum development and teaching modules for UCSF Department of Neurology Residency Program, including new integrated neuroanatomy course (Instructor & course developer)

CME COURSES ATTENDED: 2011 American Heart Association International Stroke Conference 2011 Continuum, 18 hours 2010 American Heart Association International Stroke Conference 2010 Abbie Stoddard Lecture, The Children’s Hospital Colorado 2010 Child Neurology Society Annual Meeting 2009 American Heart Association International Stroke Conference 2009 American Neurological Association Course in Translational Neuroscience 2009 Abbie Stoddard Lecture, The Children’s Hospital Colorado 2009 Continuum, 20 hours 2008 Child Neurology Society Annual Meeting Armstrong-Wells

NATIONAL and GOVERNMENT SERVICE: 2009-present NIH/NINDS Stroke Common Data Elements, Biospecimens and Biomarkers Working Group

INTERATIONAL SERVICE: 2011-present Abstract Grader & Reviewer, American Heart Association International Stroke Conference (3-year term) 2011-present Co-Moderator, Stroke Special Interest Group, Child Neurology Society (3-year term) 2007-present International Pediatric Stroke Study

REVIEWER: 2010 Journal of Pediatrics 2010 American Academy of Neurology Continuum

PUBLICATIONS: 1. Jennifer Armstrong-Wells MD, MPH and Neil Goldenberg MD, PhD. Institution-Based Prospective Inception Cohort Studies In Neonatal Rare Disease Research. Seminars in Fetal and Neonatal Medicine. Aug 4, 2011 In press (epub ahead of print). 2. Adam Kirton MD, Jennifer Armstrong-Wells MD, MPH, Taeun Chang MD , Gabrielle deVeber MD, Michael J Rivkin MD, Marta Hernandez MD, Jessica Carpenter MD, Jerome Y Yager MD, John K Lynch DO, Donna M Ferriero MD for the IPSS Investigators. Symptomatic neonatal arterial ischemic stroke: The International Pediatric Stroke Study. Pediatrics. 2011. In press. 3. Stence NV, Fenton LZ, Goldenberg NA, Armstrong-Wells J, Bernard TJ. Craniocervical Arterial Dissection in Children: Diagnosis and Treatment. Current Treatment Options in Neurology. 2011:13 (6). In press. 4. Jennifer Armstrong-Wells, MD, MPH; Timothy J. Bernard, MD; Richard Boada, PhD; Marilyn Manco-Johnson, MD. Neurocognitive Outcomes after Neonatal Encephalopathy. NeuroRehabilitation, 2010 Jan 1; 26(1):27-33. 5. Timothy J. Bernard, MD; Laura Z. Fenton, MD; Susan D. Apkon, MD; Richard Boada, PhD; Greta N. Wilkening, PsyD; Charles Wilkinson, MD; Jennifer B. Soep, MD; Shelley D. Miyamoto, MD; Mark Tripputi, MS; Jennifer Armstrong-Wells, MD, M.P.H; Timothy A. Benke, MD, PhD; Marilyn J. Manco-Johnson, MD; Neil A. Goldenberg, MD, PhD. Biomarkers of Inflammatory Hypercoagulability in Childhood Arterial Ischemic Stroke: Prevalence and Association with Persistent/Progressive Cerebral Arteriopathy. J Pediatr. 2009 Dec 17. 6. Potter CA, Armstrong-Wells J, Fullerton HJ, Young WL, Higashida RT, Dowd CF, Halbach VV, Hetts SW. Neonatal Giant Pial Arteriovenous Malformation: Genesis or Rapid Enlargement in the Third Trimester. J Neurointerv Surg. 2009 Sep 5;1(1):151-153. 7. James S. Waldron, MD; Steven W. Hetts, MD; Jennifer Armstrong-Wells, MD, MPH; Christopher F. Dowd, MD; Heather J. Fullerton, MD, MAS; Nalin Gupta, MD, PhD; Michael T. Lawton, MD. Multiple Intracranial Aneurysms and Moyamoya Disease Associated with Microcephalic Osteodysplastic Primordial Dwarfism Type II: Surgical Considerations. Journal of Neurosurgery (Pediatrics), 2009 Nov;4(5):439-44. 8. Jennifer Armstrong-Wells, MD, MPH; Barbara Grimes, PhD; Stephen Sidney, MD, MPH; Daniel Kronish, MD; Stephen Shiboski, PhD; Robert J. Adams, MD; Heather J. Fullerton, MD, MAS. Utilization of Transcranial Doppler Ultrasonography Screening for Primary Stroke Prevention in Children with Sickle Cell Disease. Neurology, 2009 Apr 14;72(15):1316-21. 9. Jennifer Armstrong-Wells, MD, MPH; S. Claiborne Johnston, MD, PhD; Yvonne W. Wu, MD, MPH; Stephen Sidney, MD, MPH; Heather J. Fullerton, MD, MAS. Prevalence and Predictors of Perinatal Hemorrhage Stroke. Pediatrics, 2009;123:823-828. Armstrong-Wells

10. Timothy J. Bernard, MD; Neil A. Goldenberg, MD; Jennifer Armstrong-Wells, MD, MPH; Catherine Amlie-Lefond, MD; Heather J. Fullerton, MD, MAS. Treatment of Childhood Arterial Ischemic Stroke. Annals of Neurology, 2008;63:679-696. 11. Taeusch HW, Martinez AM, Partridge JC, Sniderman S, Armstrong-Wells J, Fuentes-Afflick E. Pain During Mogen or Plastibell Circumcision. Journal of Perinatology 2002;22(3):214-8.

Book Chapters Jennifer Armstrong-Wells, MD, MPH and Marilyn J. Manco-Johnson, MD (equal contributors). Inflammation and Thrombosis. In Neonatal Hematology, 2nd Edition, Pedro de Alarcon, Eric Werner, and Robert Christensen, editors. Cambridge University Press. In press.

Jennifer Armstrong-Wells, MD, MPH and Timothy J. Bernard, MD. Coma and Brain Death. In Pediatric Decision Making, 5th Edition, 2011, Stephen Berman, editor. Mosby Publishing.

Richard H. Haas, MB, BChir & Jennifer Armstrong-Wells, MD, MPH (equal contributors). Vascular Disease in Infants and Children. In Clinical Pediatric Neurology, 3rd Edition, 2009, Ronald B. David, MD, editor. Demos Medical Publishing, New York.

ABSTRACTS: Armstrong-Wells J, Post M, Hoover W, Winn V. Inflammatory Patterns in Placentas from Mothers with Preterm Premature Rupture of Membranes. Poster, BIRCWH Directors and Scholars Meeting 2011, Rockville, MD.

Armstrong-Wells J, Simpson M, Villalobos-Menuey E, Bernard TJ, Goldenberg NA, Manco-Johnson M. Thrombin and Plasmin Generation in Children Following Perinatal Arterial Ischemic Stroke. Poster, Child Neurology Society Annual Meeting 2011, Savannah, GA.

Hoover W, Bernard TJ, Goldenberg NA, Manco-Johnson M, Armstrong-Wells J. Follow-up neuroimaging in acute symptomatic perinatal arterial ischemic stroke: volumetic data. Poster, Child Neurology Society Annual Meeting 2011, Savannah, GA.

Schreiner T, Ross C, Armstrong-Wells J. Parent-Patient Quality of Life Perception in Children with Multiple Sclerosis. Poster, Child Neurology Society Annual Meeting 2011, Savannah, GA.

Armstrong-Wells J, Simpson M, Villalobos-Menuey E, Bernard TJ, Goldenberg NA, Manco-Johnson M. Thrombin and Plasmin Generation in Children Following Perinatal Arterial Ischemic Stroke. Poster, International Society of Thrombosis & Haemostasis Annual Meeting, Kyota, Japan, July 2011.

Kedia, S, Stence N, Armstrong-Wells J, Bernard T. Late Cytotoxic Edema in Two Children with Hemiplegia: Hemiplegic Migraine or Stroke? Poster, American Headache Society Annual Meeting, Washington D.C., June 2011.

Hoover W, Bernard TJ, Goldenberg NA, Manco-Johnson M, Armstrong-Wells J. Follow-up neuroimaging in acute symptomatic perinatal arterial ischemic stroke. Poster, International Stroke Conference 2011, Los Angeles, CA.

C. Keator, T. Bernard, J. Armstrong-Wells, N. Goldenberg, M. Manco-Johnson and K. Knupp Probability of Developing Epilepsy in Pediatric Arterial Ischemic Stroke. Poster, American Epilepsy Society Annual Meeting, 2010, San Antonio, TX. Armstrong-Wells

Profita T, Hoover W, Bernard TJ, Goldenberg NA, Manco-Johnson M, Armstrong-Wells J. Biomarkers of Hypercoagulability in Perinatal Arterial Ischemic Stroke. Poster, Child Neurology Society Annual Meeting, 2010, Providence, RI.

Kirton A, Armstrong-Wells J, Chang T, Rifkin M, Hernandez M, Carpenter J, Yager J, Lynch J, and Ferriero D for the Members of the IPSS. Neonatal arterial ischemic stroke: Findings from the International Pediatric Stroke Study. Presentation, Child Neurology Society Annual Meeting, 2010, Providence, RI.

Jennifer Armstrong-Wells, S. Claiborne Johnston, Yvonne W. Wu, Steven Sidney, Heather J. Fullerton. Prevalence and Predictors of Perinatal Hemorrhagic Stroke. Poster, Child Neurology Society Annual Conference, 2008, Santa Clara, CA.

Jennifer Armstrong-Wells, Barbara Grimes, PhD; Stephen Sidney, Daniel Kronish, Stephen Shiboski, Robert J. Adams, MD, Heather J. Fullerton, MD, MAS. Utilization of Transcranial Doppler Ultrasonography Screening for Primary Stroke Prevention in Children with Sickle Cell Disease. Poster, Child Neurology Society Annual Conference, 2008, Santa Clara, CA.

Jennifer Armstrong-Wells, S. Claiborne Johnston, Yvonne W. Wu, Steven Sidney, Heather J. Fullerton. Prevalence and Predictors of Perinatal Hemorrhagic Stroke. Oral Presentation, International Stroke Conference, 2007, New Orleans, LA.

Armstrong-Wells JL, Martinez AM, Escobar GJ, Gardner MN, Tico S. A Comparison Between an Inner-City County Hospital and a Health Maintenance Organization. Oral Presentation, Western Society of Pediatric Research, Oral Presentation, 1999, Carmel, CA.

MEDIA 2011 Sole Author, Perinatal Stroke and Hypoxic Ischemic Encephalopathy sections, Clinical Decision Support: Pediatrics, Decision Support in Medicine, LLC. Peer-reviewed, electronic media database for physicians (similar to an “app”).

2009-present NIH/NINDS Stroke Common Data Elements, Biospecimens and Biomarkers Working Group: http://www.commondataelements.ninds.nih.gov/Stroke.aspx

MENTORING/PRECEPTOR: 2011-present Whitney Hoover, UCD, Medical Student (research mentor) 2010-present Roxanne Martinez, UCD, Medical Student (UCD SOM Foundations of Doctoring - clinical preceptor) 2010-present John Binder, UCD, Pediatric Resident/Child Neurology Fellow (research mentor) 2010-present Andra Dingman, UCD, Pediatric Resident/Child Neurology Fellow (department mentor) 2009-present Taylor Profita, UCD, Medical Student (research mentor) 2009-2011 Teri Schreiner, MD, UCD, Child Neurology Fellow (department mentor) 2009-2011 Cassie Ross, UCD, Undergraduate (internship mentor)

TEACHING AIDS: Developer and moderator of the International Pediatric Stroke Study Listserv

University of Colorado, Denver, Subacute Stroke Protocol: Policy and Procedure Manual and Orderset Armstrong-Wells

RESEARCH SUPPORT:

1.) NIH Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) K12 at UC Denver Scholar 2010-2012 a. “In-Utero Inflammation in PPROM as a Biomarker in Perinatal Brain Injury” b. Examines the relationship of cytokines, coagulation disorders and placental pathology in pregnancies complicated by preterm premature rupture of membranes with perinatal stroke risk c. Mentored Grant – PI: Judy Regensteiner, PhD & Margaret (Peggy) Neville PhD and Mentor: Marilyn Manco-Johnson, MD & Virginia Winn, MD, PhD 2.) American Heart Association Pacific Mountain Affiliates Clinical Research Grant 2010-2012 (10CRP3670014) a. “In-Utero Inflammation as a Risk Factor in Perinatal Stroke” b. Examines the relationship of cytokines, coagulation disorders and placental pathology in pregnancies complicated by preeclampsia with perinatal stroke risk c. Mentor—Marilyn Manco-Johnson, MD (mentor) 3.) UCD Center for Women’s Health Research Junior Faculty Researcher Award 2010-2011 a. “Biomarkers of Hypercoagulability in Perinatal Brain Injury” b. Project support for biomarker assay validation of normal cord blood 4.) Colorado Clinical and Translational Sciences Institute: Child and Maternal Health Mentored Pilot Award 2010-present a. “In-Utero Inflammation as a Risk Factor for Symptomatic Perinatal Brain Injury” b. Studies serum cytokines in term/late preterm newborns that present within 72 hours of birth with seizure and/or encephalopathy, monitoring for evidence of brain injury (cerebral palsy) c. Mentored Pilot Grant – Marilyn Manco-Johnson, MD (mentor) 5.) TCH CTRC 2010-2013 a. 3 years ancillary funding and support services for the BIRCWH and AHA projects

RESEARCH PROGRAM: 1.) Biomarkers of Inflammation and Hypercoagulability in Perinatal Stroke and Brain Injury (PI) a. Prospective cohort study of pregnant women at risk for having a child with brain injury (PPROM, PROM, preeclampsia) studying biomarkers of inflammation and hypercoagulability in these mothers and their offspring, as well as placental analysis. b. Subset of case-control analysis of symptomatic perinatal stroke c. Normal control validation 2.) Anti-Epileptic Drug Prophylaxis in Children with Acute Hemorrhagic Stroke (PI) 3.) Psychosocial Outcomes after Childhood Hemorrhagic Stroke and Multiple Sclerosis Diagnosis (PI)

Other research collaborations: 1.) Site PI: The Impact of Seizures in Infants and Children with Ischemic Stroke (IPSS substudy) – PI, Gabrielle deVeber (SickKids, Toronto). 2.) Investigation of Biomarkers of Hypercoagulability and Inflammation in Childhood-onset AIS: Association with Stroke Etiology and Outcomes—PI, Timothy Bernard 3.) Co-I: Vascular Effects of Infection in Pediatric Stroke (VIPS) –PI, Heather Fullerton (UCSF) 4.) Co-I: Prospective, Inceptional Cohort Study of Individuals with Thrombotic Disorders (Thrombo-PICS) –PI, Marilyn Manco-Johnson 5.) Co-I: Prospective, Inceptional Cohort Study of Individuals with Bleeding Disorders (Hemo- PICS) –PI, Marilyn Manco-Johnson 6.) Co-I: CDC Thrombosis and Thrombophilia Registry –PI, Marilyn Manco-Johnson Armstrong-Wells

7.) Co-I: International Pediatric Stroke Study