Client Experience Guide Welcome to Our UK Facilities

Home , Glasbury, Hay Castle, Llangoed Hall, Llyswen, Radnorshire, Upper Boat Studios

Client Experience Guide Welcome to our UK facilities

From our four sites in South Wales, PCI’s European operations deliver a fully integrated Molecule to Market offering for our clients. Utilising leading edge technology and unparalleled expertise, PCI addresses global drug development needs at each stage of the product life cycle, for even the most challenging applications.

Hay on Wye Tredegar With extensive capability for both clinical and commercial With unparalleled capability in contained manufacture of packaging and labelling activities, the Hay-on-Wye site offers potent compounds, our Tredegar site excels as PCI’s centre clients a robust solution for primary and secondary packaging of excellence for drug manufacture. Significant investment of a variety of drug delivery forms. PCI’s expertise and in cutting edge technologies and world-class award- investments in leading packaging technologies create solutions winning facility design have enabled a truly market leading for speed-to-market and efficiency in drug supply. service for the development and manufacture of clinical and Scalable packaging technologies allow us to grow and commercial scale products. Services include formulation and evolve as project needs change through the product life analytical development, clinical trial supply, and commercial cycle, from early phase clinical development and growth into manufacturing of solid oral dose, powders, liquids and large scale clinical supply, commercial launch, and ongoing semisolids, supported by in-house packaging and labelling global supply. PCI offers bespoke packaging solutions for services and on-site laboratory services. challenging applications at its Hay facilities, including modified With over 35 years of experience in providing integrated environments for light and moisture sensitive products, drug development, PCI supports compounds from the earliest Cold Chain solutions for temperature sensitive products stages of development through to commercial launch and and biologics, specialist facilities for packaging of potent ongoing supply. Recognized for our regulatory and export compounds, as well as offering one of the largest controlled experience, our Tredegar site supplies global markets including drug vaults in all of Europe. Europe, the US, South America and Japan. With over 30 years of experience, the dedicated team at Hay prides itself on a breadth of knowledge and specialist expertise, Bridgend ensuring the best possible solutions for our clients. With considerable investment in specialist capability, PCI’s Bridgend location offers both extensive secondary packaging Treforest and labelling expertise coupled with unrivalled capability for Specialising in Clinical trial logistical services, PCI’s Treforest supporting an considerable range of Cold Chain and Ultra Cold facility is strategically located to take advantage of its UK Chain product needs, including the expertise and infrastructure geographic conveniences and proximity to both London and to support preparation, storage and global distribution of cell Cardiff in supplying investigational medicines to patients around therapies and Advanced Therapeutic Medicinal Products the world. Storage, distribution, and returns management of (ATMP) with cryogenic temperature requirements down to IMP materials all happens at this 23,000 sq.ft. purpose built -196ºC. The site also supports bespoke client needs with facility, stationed conveniently near the M4 corridor. custom solutions for each developing therapy, partnering with Our expertly trained and experienced associates handle clients to identify the optimal solution for each challenging thousands of shipments each year to investigational sites temperature sensitive application. located in over 100 countries around the world. Well versed Our dedicated experts are highly effective in addressing in the challenges of truly global clinical trial distribution, our specific customer challenge, providing clients both industry team in Treforest understands to the specific requirements for leading practices and innovative solutions in support of clinical each drug product, utilising cutting edge validated shipping development and global trial supply. PCI’s Bridgend team technologies and leveraging a trusted network of proven supports clients with an expert staff of highly skilled associates international couriers and depot networks. and extensive industry experience, versed in the needs of today’s clinical trial market.

2 PCI PHARMA SERVICES – Client Experience Guide www.pciservices.com Hay on Wye

Bangor Wrexham

Aberystwyth

Hay-on-Wye

Milford Haven Swansea Newport Cardiff

Treforest

Bangor Wrexham

Aberystwyth

Milford Haven

Treforest Newport Swansea Cardiff

Tredegar

Bangor Wrexham

Aberystwyth

Milford Haven Tredegar

Newport Swansea Cardiff

Bridgend

Bangor Wrexham

Aberystwyth

Milford Haven

Bridgend Newport Swansea Cardiff

www.pciservices.com PCI PHARMA SERVICES – Client Experience Guide 3 Hay-on-Wye

he town of Hay-on-Wye is located on the Welsh the name deriving from Norman origin, Hay or Haie, T and English borders and has an approximate meaning a fenced or hedged enclosure. In modern population of 1500 people. The town lies at the times, Hay is known throughout the world as ‘The Town northernmost point of the Brecon Beacons National of Books’, and is widely considered to be the second- Park, standing on the southern side of the River Wye. hand book capital of the world. Across the river to the north are the green hills of For ten days a year, 85,000 people come from all Radnorshire, to the south and west lies the glorious over the UK, Europe, America and the rest of the world range of the Black Mountains. To the east is the Golden to join a carnival celebration of ideas and stories at the Valley, part of the cultivated farmlands of Herefordshire. Hay Festival of Literature & the Arts. Writers, politicians, Hay is situated in some of the most varied and beautiful poets, scientists, comedians, philosophers and countryside the British Isles has to offer. musicians come together on the greenfield site to talk, In local terms, the town was known as ‘The Hay’, eat, think, drink and be merry!

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1. The Wye Valley in Autumn 2. Just one of the lovely statues decorating the Hay Literary Festival site 3. Llangorse Lake, Wales’ largest natural lake 4. Hay Bluff, Black Mountains 5. Book shop, Hay-on-Wye 6. Hay Literary Festival 7. Hay-on-Wye town centre 7

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1. Bike Park Wales, Gethin Woods 5 6 2. Millennium Stadium, Cardiff 3. Sir Tom Jones and Jessie J 4. Medieval Christmas Fayre, Caerphilly Castle 5. White Water Rafting, Cardiff Bay 6. University of South Wales 7. The Old Bridge, Pontypridd

6 PCI PHARMA SERVICES – Client Experience Guide www.pciservices.com Treforest

et in the beautiful Welsh countryside approximately making company, aimed to establish one or more S20 minutes from Cardiff, Treforest is historically trading estates in Wales. By the end of 1937, three connected to the mining of tin plate, dating back as far factories had been completed and occupied. During the as 1835. Today, the town is better known for its links Second World War these factories played a significant to the University of South Wales and this relationship part in the war effort, with the government requisitioning dates back to 1913 when the School of Mines was the buildings to provide supplies for the British troops. originally established. Famously, Treforest is also the birth place of the Today students from around the world come to musical legend Tom Jones, it is rumoured that Tom study, with Treforest being the university’s main and has an original telephone box from the town in his largest campus, playing host to the bulk of academic Californian home to remind him of his routes. Treforest departments and facilities. was also home to Upper Boat Studios - a television Established in Treforest in 1936, the Wales and studio complex where Doctor Who, Torchwood and The Monmouthshire Trading Estates Ltd., a non-profit Sarah Jane Adventures were filmed up until 2013.

www.pciservices.com PCI PHARMA SERVICES – Client Experience Guide 7 Tredegar

ituated at the north end of the Sirhowy Valley in It is also proud to host a unique gold post box to S South Wales, Tredegar is a vibrant town with a honour Gold medal winning Paralympic cyclist Mark unique history. The town has been in existence for Colbourne who claimed Wales’ first gold of the 2012 over 200 years and its past has been shaped by heavy London Paralympic Games. industry, particularly iron and coal. By far the most famous person to come from the In the 1800’s, Tredegar was a beautiful area amongst town was Aneurin Bevan. The son of a miner, Bevan forested hills with a few scattered farming homesteads. was a lifelong champion of social justice, rights of With the growth of the iron industry and the creation working people, and socialism. In 1945 Bevan was of the Tredegar Iron Company (TIC) in 1799, Tredegar appointed as Secretary of State for Health, with a remit turned into a 19th century boom town. that also covered housing. Bevan had responsibility The owners of the TIC were responsible for the for instituting a new National Health Service, paid for erection of many of the towns landmarks including the by a severe increase in marginal tax rates and with no town hall and the iconic town clock which has stood in fees paid at the point of delivery. He is recorded as ‘The Circle’ (originally Market Square) since 1858. having said of the NHS, “All I am doing is extending Many famous residents include the former leader to the entire population of Britain the benefits we had of the British Labour party, The Right Honourable, the in Tredegar for a generation or more. We are going to Lord Neil Kinnock and snooker ace, Ray Reardon. ‘Tredegar-ise’ you.”

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1. Mynydd Llangors 2. Bedwellty Pitts Incline Engine 3. Big Pit Coal Museum 4. Green Man Festival, Glanusk Estate 5. Monmouthshire Golf Club 4 5 6 6. Gold for Mark Colbourne 7. Abergavenny Food Festival 8. Aneurin Bevan, Tredegar’s most famous son

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1. Souther ndown Golf Club 2. MacArthurGlen Designer Outlet shopping centre 3. Porthcawl Elvis Festival 4. Mermaid Quay, Cardiff Bay 5. Cardiff Castle 6. The Stepping Stones at Ogmore Castle 7. Dunraven Bay on the Wales Coast Path 6

10 PCI PHARMA SERVICES – Client Experience Guide www.pciservices.com Bridgend

ituated in South Wales, 18-miles (29 km) west of War, a huge Royal Ordnance Factory was built and a S the capital Cardiff, Bridgend sits at a confluence massive underground armament store dug into the of three rivers, the River Ogmore, the Llynfi River and hill of Brackla. Subsequently this was converted into the Garw River. Named in the 15th Century, Bridgend a complex nuclear bunker, but since the end of the literally means ‘The main bridge on the River Ogmore’ Cold War, the communications pylon stands amongst after a stone bridge was built to connect (permanently) hundreds of fast-growing broadleaf trees - a peaceful each side of the River. Originally this bridge had four home for many species of wildlife. arches but in the 18th century a massive flood washed During the war, German prisoners of war were confined two of them away. The rest of the bridge still stands in a camp at Island Farm, to the west of the town. In and still remains a focal point of the town. 1945 a number of prisoners escaped, some reaching The Industrial Revolution brought prosperity and a the east coast of England before being recaptured. good communication system to Bridgend. Although Since the war, the face of Bridgend has changed with itself outside the rich coal seams, the mining valleys the ever-growing industrial complex. Ford and Sony of Ogmore and Llynfi sent their coal down by small have huge factories, and are the foremost employers, railways to meet Brunel’s main line. The present railway attracting workers from most of the surrounding areas. station incorporates part of the original building. Bridgend is also home to the headquarters of the South Just before the outbreak of the Second World Wales Police force.

www.pciservices.com PCI PHARMA SERVICES – Client Experience Guide 11 Aberdeen

A90

M90 EDINBURGH GLASGOW M8 A68 M74 A7 Newcastle A69 BELFAST

M6 A1 Isle of Man M62 M62 DUBLIN LIVERPOOL MANCHESTER M6 M1 A5 A470 BIRMINGHAM Aberystwyth M54 Cambridge M5 A487 A470 M50 M1 M11

M4 Swansea M4 BRISTOL LONDON CARDIFF M3 M25 Dover M20 Southampton M5 Exeter A38

A36 M6 M42 Hay on Wye Shrewsbury J8

EDINBURGH A483 GLASGOW Aberystwyth Birmingham Bangor J4a BELFAST Wrexham M40 A44 A483 J7 DUBLIN LIVERPOOL Worcester MANCHESTER Getting to our sites Hay-on-Wye Hereford J8 Aberystwyth BIRMINGHAM A40 M50 Abergavenny Cardiff Airport has direct and connecting flights Hay-on-Wye J11a Abergavenny LONDON A48 1. Hay CARDIFF BRISTOL Abergavenny from over 800 destinations worldwide. 2. Tredegar Milford Haven Gloucester B4351 from3. Treforest Swansea Clyro (A438)4. Bridgend Newport Llanelli Cwmbran Cardiff J24 J15 A40 J18a B4351 J32 Swansea M4 M4 DISTANCES BRIDGE STREET NEWPORT STREET Airport HAY BRIDGEND TREFOREST TREDEGAR WELSH TO SITES - ENGLISH Cardiff BORDER Bristol Birmingham Airport WYE END ROAD A36 M6 Bath M42 Distance to Hay: 84 Miles 68.8 miles River49.4 miles Wye 27.5 miles Wye Valley Business Park, J8 HAY POLICE STATION Shrewsbury Distance to Treforest: 125 Miles 110 km 79 km 44 km Hay-on-Wye, HR3 5PG, UK M5 BROADSTREET LION Distance to Bridgend: 129 Miles STREET A483 OLD BLACK LION HOTEL +44 (0) 1497 820 829 A39 Aberystwyth Birmingham BEAR ST Taunton Distance to Tredegar: 107 Miles HAY-ON-WYE A30 68.8 miles 18.8 miles 38.1 miles HAY CASTLE Salisbury J4a birminghamairport.co.uk BRIDGEND B4350 HARDWICKE ROAD 110 km BRECON BEACONS30 km 61 km M40 T OXFORD ROAD B4348 E NATIONAL PARK E A44 Bristol Airport R T S J7 SWAN-AT-HAY HOTEL A483 Worcester Distance to Hay: 78 Miles HR3 5PG H Hay-on-Wye often abbreviated to just “Hay”, is a small market town and community which lies on the Welsh side of C B4350 R Hay-on-Wye Distance to Treforest: 53 Miles 49.4 miles 18.8 miles U 20 miles the Welsh/English Border in the County of Powys. Often described as “the town of books”, it is the National Book Hereford J8 TREFOREST H 79 km 30 km C 32 km A40 Distance to Bridgend: 63 Miles GIPSY CASTLE LANE Town of Wales. The annual Hay Festival is a major international literary festival. M50 Distance to Tredegar: 64 Miles WYESIDE B4350 Abergavenny WELSH GARDEN J11a Abergavenny bristolairport.co.uk - ENGLISH A48 FOREST ROAD BORDER 27.5 miles 38.1 miles 20 miles FIRE STATION Abergavenny TREDEGAR GIPSYCASTLELANE Gloucester Cardiff Airport 44 km 61 km 32 km B4351 from Distance to Hay: 69 Miles FORESTROAD Clyro (A438) Llanelli Cwmbran J24 J15 A40 Distance to Treforest: 21 Miles B4350 BRECON BEACONS J32 J18a B4351 Swansea Distance to Bridgend: 18.5 Miles FOREST ROAD Hay-on-WyeNATIONAL PARK M4 M4 Coach, Bus and Rail BRIDGE STREET NEWPORT STREET Distance to Tredegar: 40 Miles B4350 from Blue Line WELSH National Rail Enquiries WELSH - ENGLISH Cardiff cardiff-airport.com Glasbury blueline-taxis.co.uk - ENGLISH BORDER Bristol Tel. 08457 484950 BORDER WYE END ROAD Bath London Heathrow Airport T: +44 (0) 1432 263000 +44 (0) 2072 785240 River Wye POLICE STATION Distance to Hay: 169 Miles Glasbury Taxis M5 BROAD STREET nationalrail.co.uk LION STREET Distance to Treforest: 141 Miles Hay-on-Wye OLD BLACK LION HOTEL A39 National Express Coaches HAY-ON-WYE BEAR ST Taunton Distance to Bridgend: 150 Miles T: +44 (0) 7966 017714 A30 Salisbury Tel. 08717 818178 B4350 HAY CASTLE Distance to Tredegar: 151 Miles HARDWICKE ROAD

Bridgend BRECON BEACONS OXFORD ROAD Overseas: +44 (0) 8717 818178 T B4348 E heathrowairport.com NATIONAL PARK E R Neil’s Executive Travel T nationalexpress.com S SWAN-AT-HAY HOTEL Manchester Airport T: +44 (0) 7780 441330 HR3 5PG H C B4350 Public Travel Information R Distance to Hay: 134 Miles U Email: [email protected] H Tel. 08712 002233 GIPSY CASTLE LANE C Distance to Treforest: 186 Miles Treforest Overseas: +44 (0) 8712 002233 WYESIDE B4350 Distance to Bridgend: 195 Miles WELSH Dragon Taxi GARDEN - ENGLISH traveline.info Distance to Tredegar: 173 Miles FOREST ROAD BORDER dragontaxis.com FIRE STATION manchesterairport.com GIPSY CASTLE LANE T: +44 (0) 2920 333333 Taxi Service FOREST ROAD Tredegar Drive BRECON BEACONS PCI are happy to arrange ground Tim’s Travel B4350 FOREST ROAD NATIONAL PARK When driving to any of PCI’s UK transport (taxis) on your behalf from Sara: +44 (0) 7958 791537 B4350 from facilities please use the following your arrival to any of our facilities. Gareth: +44 (0) 7958 791537 WELSH Glasbury - ENGLISH postcodes for SATNAV devices Please contact your meeting host Tim: +44 (0) 7944 299957 BORDER Hay on Wye - HR3 5PG in advance of your visit with details E: [email protected] Treforest - CF37 5UR of your journey, including flight Sullys Tredegar - NP22 3AA numbers, so we can make the T: +44 (0) 1495 723337 Bridgend - CF31 3RT necessary arrangements: E: [email protected]

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A90

M90 EDINBURGH GLASGOW M8 A68 M74 A7 Newcastle A69 BELFAST

M6 A1 Isle of Man M62 M62 DUBLIN LIVERPOOL MANCHESTER M6 M1 A5 A470 BIRMINGHAM Aberystwyth M54 Cambridge M5 A487 A470 M50 M1 M11

M4 Swansea M4 BRISTOL LONDON CARDIFF M3 M25 Dover M20 Southampton M5 Exeter A38

A36 M6 M42 Hay on Wye Shrewsbury J8

12 PCI PHARMA SERVICES – Client Experience Guide www.pciservices.com www.pciservices.com PCI PHARMA SERVICES – Client Experience Guide 13 A36 M6 M42 Treforest Shrewsbury J8 A483 Aberystwyth Birmingham Bangor J4a Wrexham M40 A44 A483 J7 Worcester Hereford J8 Aberystwyth A40 M50 J11a A48 Abergavenny Milford Haven Gloucester Treforest Newport Llanelli Cwmbran Swansea Treforest J24 J15 A40 Cardiff J18a from Pontypridd and Merthyr Tydfil J32 Swansea M4 M4 A36 M6 A4054 M42 Cardiff J8 Bristol ShrewsburyM6 Bath A36 Treforest Industrial Estate A483 M42 Aberystwyth ShrewsburyBirminghamJ8 Pontypridd, CF37 5UR, UK M5 A39 Aberystwyth A483 J4a TREFOREST +44 (0) 1443 846100 Taunton Birmingham M40 A30 A44 INDUSTRIAL Salisbury J4a A483 J7 WoM40rcester ESTATE A44 Hereford J8J7 Treforest (Welsh: Trefforest) is a village in the county borough of Rhondda Cynon Taf. The village is historically A40 A483 Worcester Treforest Estate Station CROCHENDY Hay-on-Wye M50 HEOL connected with the Crawshay family who established a major tinplate works in 1835. Treforest is now known for its Hereford J8 WILLOWFORD ROAD A470 A40 J11a MAIN AVENUE association with the University of South Wales, originally established as the School of Mines at Treforest in 1913. A48 Abergavenny M50 Abergavenny GloucesterJ11a from A48 Abergavenny Caerphilly Llanelli CwmbranAbergavenny J24 J15 A40 B4351 from Treforest Gloucester J32 J18a Clyro (A438) from Pontypridd and Merthyr Tydfil LlanelliSwansea Cwmbran CF37 5UR A4054 M4 J24 J15 M4A40 A468 J18a A4054 B4351 J32 Swansea M4Cardiff Bristol M4 BRIDGE STREET NEWPORT STREET WELSH Bath - ENGLISH Cardiff BORDER Bristol A4054 WYE END ROAD M5 from Bath River Wye POLICE STATION A39 M4 J32 TREFOREST TauntoM5n BROAD STREET and Cardiff LION A30 INDUSTRIAL STREET Salisbury OLD BLACK LION HOTEL A39 BEAR ST Taunton HAY-ON-WYEESTATE A30 HAY CASTLE Salisbury B4350 HARDWICKE ROAD

BRECON BEACONS T OXFORD ROAD B4348 Treforest Estate Station E NATIONAL PARK CROCHENDYE HEOL R WILLOWFORD ROAD T S SWAN-AT-HAY HOTEL A470 HR3 5PG H MAIN AVENUE C B4350

C from GIPSY CASTLE LANE Caerphilly WYESIDE B4350 WELSH GARDEN - ENGLISH FOREST ROAD BORDER CF37 5UR FIREA4054 STATION GIPSY CASTLE LANE A468

FOREST ROAD

B4350 BRECON BEACONS FOREST ROAD NATIONAL PARK A4054 B4350 from from WELSH Glasbury M4 J32 - ENGLISH BORDER and Cardiff

14 PCI PHARMA SERVICES – Client Experience Guide www.pciservices.com A36 M6 M42 Tredegar Shrewsbury J8 A483 Aberystwyth Birmingham Bangor J4a Wrexham M40 A44 A483 J7 Worcester Hereford J8 Aberystwyth A40 M50 Abergavenny Bush Bach J11a A48 Abergavenny Milford Haven Tredegar Abergavenny Tredegar Gloucester Newport Llanelli Swansea Cwmbran J24 J15 A40 Waundeg Cardiff J32 J18a Swansea M4 M4 NP22 3AA AD S RO Cardiff Ron Skinner & Sons LLEY 23-24 Tafarnaubach Industrial Bristol E VA Bath F TH A4048 Estate, Tredegar, Gwent, S O AD HE NP22 3AA, UK M5 Bryn Bach Primary School A39 +44 (0) 1495 711222 Taunton A465 A30 Salisbury A36 M6 M42 J8 CF31 3RT Shrewsbury Bryn Bach Park A unique valley town that can boast its own place in history. Tredegar is the birthplace of the National Health Service, A483 which was modelled on the Tredegar Medical Aid Society. Aneurin Bevan, the NHS’ founder, is Tredegar’s most famous Aberystwyth Birmingham son and when visiting Tredegar make sure that you take in the Bevan Trail. J4a Nags Head Inn M40 A465 A44 A483 J7 Worcester Hereford J8 A40 M50 Abergavenny Bush Bach J11a Abergavenny A48 Abergavenny Tredegar Gloucester Llanelli Cwmbran J24 J15 A40 Waundeg J32 J18a Swansea M4 M4 NP22 3AA AD S RO Cardiff Ron Skinner & Sons LLEY Bristol E VA Bath F TH A4048 S O AD HE M5 Bryn Bach Primary School A39 Taunton A465 A30 Salisbury

CF31 3RT Bryn Bach Park

Nags Head Inn A465

www.pciservices.com PCI PHARMA SERVICES – Client Experience Guide 15 A36 M6 M42 Bridgend Shrewsbury J8 A483 Aberystwyth Birmingham Bangor J4a Wrexham M40 A44 A483 J7 Worcester Hereford J8 Aberystwyth A40 M50 J11a A48 Abergavenny Milford Haven Gloucester WESTERN AVENUE Bridgend Newport Llanelli Cwmbran Swansea J24 J15 A40 Cardiff J32 J18a Swansea M4 M4 Biotec House, Western Ave., WESTERN AVENUE Bridgend Cardiff Bridgend Industrial Estate, Bristol A36 M6 Bath M42 Bridgend, Mid Glamorgan, Shrewsbury J8 CF31 3RT, UK M5 A483 A39 Aberystwyth Birmingham +44 (0) 1656 750550 Taunton KINGSWAY A30 Salisbury J4a M40 A44 J7 CHEPSTOW ROAD A483 Worcester CF31 3RT Bridgend is a beautiful region where history tumbles out to greet you around every corner. In fact it’s like Wales in miniature. Everything in close proximity. Castles, ancient inns, mysterious mansions, rugged coast and inspiring Hereford J8 A40 churches, all contained within 28 miles of coastal scenery that also includes villages, towns, history and legends. SOUTH WALES POLICE M50 J11a A473 NEW STREET CHEAPSID E A48 Abergavenny Gloucester WESTERN AVENUE Llanelli Cwmbran J24 J15 A40 COWBRIDGE ROAD J32 J18a Swansea M4 M4 WESTERN AVENUE Bridgend Cardiff Bristol Bath

M5 A39 Taunton KINGSWAY A30 Salisbury

CHEPSTOW ROAD CF31 3RT

SOUTH WALES POLICE

A473 NEW STREET CHEAPSID E

COWBRIDGE ROAD

16 PCI PHARMA SERVICES – Client Experience Guide www.pciservices.com Our favourite places to stay

The following hotels listed are all part of the PCI’s preferred hotels program.

Preferred hotels for Hay-on-Wye

Llangoed Hall Foyles of Glasbury Llyswen, Brecon Powys, LD3 0YP Glasbury on Wye, Hereford, HR3 5LH Tel.+44 (0) 1874 754525 Tel. +44 (0) 1497 847550 www.llangoedhall.co.uk www.foylesofglasbury.com Distance from Hay: 8.6 miles (15 minutes) Distance from Hay: 3.5 miles (6 minutes)

Preferred hotels for Treforest Preferred hotels for Tredegar

Bryn Meadows Golf, Hotel & Spa The Angel Abergavenny Ystrad Mynach, Caerphilly, CF82 7SN Abergavenny, Monmouthshire, NP7 5EN Tel. +44 (0) 1495 225590 Tel. +44 (0) 1873 857121 www.brynmeadows.co.uk www.angelabergavenny.com Distance from Tredegar: 13 miles Distance from Tredegar: 13.5 miles Distance from Treforest: 9 miles Distance from Treforest: 33 miles

www.pciservices.com PCI PHARMA SERVICES – Client Experience Guide 17 Preferred hotels for Bridgend

Cae Court Hotel The Vale Hotel 12 Merthyr Mawr Road North, Hensol Park, Hensol, CF72 8JY Bridgend, CF31 3NH Tel. +44 (0) 1443 667800 Tel. +44 (0) 1656 668866 www.vale-hotel.com www.caecourt.com Distance from Bridgend: 11 miles Distance from Bridgend: 2.1 miles (7 minutes)

Preferred hotels for Cardiff

Mercure Holland House Hotel The St Davids Hotel 24-26 Newport Road, Cardiff, CF24 0DD Havannah Street, Cardiff, CF10 5SD Tel. +44 (0) 2920 435000 Tel. +44 (0) 2920 454045 www.mercure.com www.thestdavidshotel.com Distance from Hay: 58 miles Distance from Hay: 58 miles Distance from Bridgend: 32 miles Distance from Tredegar: 33 miles Distance from Treforest: 10 miles Distance from Treforest: 11 miles Distance from Tredegar: 22 miles Distance from Bridgend: 21 miles

Wales has boutique hotels, smart city hotels, five-star luxury spa hotels, seaside hotels with infinity pools, gorgeous country house hotels with kitchen gardens. We’ve got hundreds of friendly B&Bs at the seaside, in the countryside, or half-way up a mountainside, we’ve got room – and rooms – for everyone.

18 PCI PHARMA SERVICES – Client Experience Guide www.pciservices.com Be adventurous, to us it’s second nature

Brecon Beacons of Brecon. They rise to 886 metres at Pen y Fan, the highest peak in southern Britain. With mountains and moorland, large standing stones The night skies are remarkable and have earned and castles, lively waterfalls and vibrant communities, the park recognition as an International “Dark Sky the Brecon Beacons National Park has masses to Reserve”. Every March, Brecon Beacons hosts the offer residents and visitors. It has a long and colourful Hay Dark Skies Festival where visitors have a unique history and a rich and varied mythology and culture. opportunity to view the stars from the darkest skies in The National Park is around 42 miles wide. In total, southern Britain. it covers approximately 520 square miles of South and The industrial heritage is magnificent, Blaenavon Mid Wales, just west of Herefordshire, and includes is classified as a UNESCO World Heritage Site. The parts of Powys, Carmarthenshire, Monmouthshire, rocks in the national park also tell their own story, Rhondda and Merthyr Tydfil. It gets its name from the They are so unique that part of the park has been Central Beacons, which dominate the skyline south designated a UNESCO Geopark.

www.pciservices.com PCI PHARMA SERVICES – Client Experience Guide 19 Brecon Beacons National Park Brecon LD3, United Kingdom Tel. +44 (0) 1874 624437 www.breconbeacons.org

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Castles, Parks and Gardens

1 Cyfarthfa Park Brecon Road, Merthyr Tydfil, CF47 8RE Tel. +44 (0) 1685 727371 www.cyfarthfa.com

2 Bedwellty House and Park Morgan Street, Tredegar, NP22 3XN Tel.: +44 (0) 1495 353370 www.bedwelltyhouseandpark.co.uk 3 4 3 Coity Castle Coity, Bridgend, CF35 6BH Tel. +44 (0) 1443 336000 www.cadw.wales.gov.uk/daysout/coitycastle

4 Tredegar House Park and Gardens Newport, Monmouthshire, NP10 8YW Tel. +44 (0) 1633 815880 www.nationaltrust.org.uk/tredegar-house

5 Cardiff Castle Castle Street, Cardiff, CF10 3RB Tel. +44 (0) 2920 878100 5 6 www.cardiffcastle.com

6 Hay on Wye Castle Hay Castle Trust, Hay-On-Wye Herefordshire, HR3 5DG Tel. +44 (0) 1497 820079 www.haycastletrust.org

www.pciservices.com PCI PHARMA SERVICES – Client Experience Guide 21 Other Activities

Mountain Biking & Caving Black Mountain Activities Three Cocks, Brecon, LD3 0SD Tel. +44 (0) 1497 847897 www.blackmountain.co.uk

Bike Hire Drovers Cycles Forest Rd, Hay-on-Wye, HR3 5EH Tel. +44 (0) 1497 822419 www.drovercycles.co.uk

Horse Riding Tregoyd Mountain Riders Tregoyd Farm, Brecon, LD3 0SP Tel. +44 (0) 1497 847351 www.tregoydriding.co.uk

Canoeing & Kayaking Paddles & Pedals Castle Street, Hay-on-Wye, HR3 5DF Tel. +44 (0) 1497 820604 www.canoehire.co.uk

Shopping Bridgend Designer Outlets The Derwen, Bridgend, CF32 9SU Tel. +44 (0) 1656 665700 www.mcarthurglen.com/uk/ bridgenddesigner-outlet/en/ St David Shopping Centre, Cardiff Bridge Street Arcade 11 St Davids Way, Cardiff, CF10 2EF Tel. +44 (0) 2920 367600 www.stdavidscardiff.com

Walking Leaping Stiles Temple Street, Llandrindod Wells, LD1 5HU Tel. +44 (0) 1597 826690 www.leapingstiles.co.uk

Golf Rhosgoch Golf & Leisure Club Rhosgoch, Paincastle, Builth Wells, Powys, LD2 3JY Tel. +44 (0) 1497 851251 rhosgoch-golf.co.uk The Vale Hotel Hensol Park, Hensol, CF72 8JY Tel. +44 (0) 1443 667800 www.vale-hotel.com Tredegar Park Golf Club Parc y Brain Road Rogerstone, Newport, NP10 9TG Tel. +44 (0) 1633 894433 www.tredegarparkgolfclub.co.uk

22 PCI PHARMA SERVICES – Client Experience Guide www.pciservices.com This interactive journey takes you and the Doctor on a spectacular adventure through time and space. Step through a crack in time and help the Doctor, armed with his Sonic Screwdriver to escape from his foes, fly the TARDIS and come face-to-face with some of the scariest monsters seen on screen including Daleks, Cybermen and Sontarans. Featuring exclusive filmed sequences with Peter Capaldi and packed with amazing special effects, this multi-sensory experience is fun for the family and fans alike. Distance from Hay: 61 miles Distance from Treforest: 10.5 miles Distance from Tredegar: 31 Miles Distance from Bridgend: 22 Miles

The Science and Discovery Centre

Techniquest’s mission is to engage people with science and to motivate them to learn more. This unique science centre offers interactive experiences that are accessible to all, and that have been enjoyed in its centre by over 4 million people since its inception in Cardiff in 1986. Distance from Hay - 66 Miles Distance from Treforest - 16 Miles Distance from Tredegar 37 Miles Distance from Bridgend 20 Miles

www.pciservices.com PCI PHARMA SERVICES – Client Experience Guide 23 Combining the expertise of

to create excellence in pharmaceutical outsourcing, from molecule to market

We’ve come together to create one expert team

PCI is an integrated full service provider and a trusted partner to leading companies in the global healthcare industry. We offer unparalleled expertise and experience in taking compounds from the earliest stages of development through to commercial launch, delivering speed to market and commercial success for our customers. Core services include: analytical services, formulation development, clinical trial supply, commercial manufacturing and packaging, QP services, supply chain management, storage and distribution.

HAY-ON-WYE TREDEGAR Wye Valley Business Park, 23-24 Tafarnaubach Industrial Estate, Hay-on-Wye, HR3 5 PG, UK Tredegar, Gwent, NP22 3AA, UK +44 (0) 1497 820 829 +44 (0) 1495 711222

TREFOREST BRIDGEND Treforest Industrial Estate, Biotec House, Western Avenue, Pontypridd, CF37 5UR, UK Bridgend Industrial Estate, Bridgend, +44 (0) 1443 846100 Mid Glamorgan, CF31 3RT, UK +44 (0) 1656 750550

PCI PHARMA SERVICES – Client Experience Guide