Chromosomal Abnormalities & Karyotyping

Chromosomal Abnormalities & Karyotyping Post-AP DNA/Genetics Names ______

Part I: University of Arizona’s karyotyping site allows you to diagnose three patients based on their chromosome smears. Read the introduction first to answer some of the questions below and then diagnose the three patients based on their karyotypes. http://www.biology.arizona.edu/human_bio/activities/karyotyping/karyotyping.html

1. Explain the two variables scientists use to identify features of a chromosome and explain what the G-region consists of.

2. Based on Patient A’s case history ONLY, predict the results of this individual’s amniocentesis. ______

3. After completing Patient A’s karyotype, what can you conclude this person’s child will be afflicted with? ______

4. Based on Patient B’s case history ONLY, give a diagnosis. ______

5. After completing Patient B’s karyotype, what can you tell this patient? ______

6. Based on Patient C’s case history ONLY, give a diagnosis. ______

7. After completing Patient B’s karyotype, what can you tell this patient? ______

Part II: The University of Utah also has a great site about chromosomes. Use the link below and follow the directions to answer all of the questions.

http://learn.genetics.utah.edu/content/begin/traits/

If you feel like you need a refresher on chromosomes, click on ‘What is a Chromosome’ and go through the tutorial.

1. Click on “How do scientists read a chromosome”. List the 3 factors scientists use when reading and matching up chromosomes. 2. DRAW and EXPLAIN the following:

Metacentric Submetacentric Acrocentric

Explanation: Explanation: Explanation:

3. Hit the back button and then click on “Make a Karyotype”. Go ahead and see how good you are at this. Explain if you found this process easy or difficult and WHY.

______

Part III: Use the link below if you would like some extra practice on karyotypes.

http://bluehawk.monmouth.edu/~bio/karyotypes.htm