Online Figure Legend

MS ID#: NEUROLOGY/2004/086488

ONLINE FIGURE LEGEND

Figure (E)F-1. (A) The pedigree structure of the PD3 family; affected individuals are shown as filled symbols and the arrow points to the proband on which complete sequencing analysis was performed and the G2019S LRRK2 mutation was found. (B) DNA sequence fluorescent chromatogram of the

G2019S mutation observed in PD3 proband 5527 (III:2) (sequence around the mutation site is shown, with the arrow pointing to heterozygous substitutions).

Figure (E)F-2. (A) The pedigree structure of the PD4 family. Affected individuals are shown as filled symbols and the arrow points to the proband on which complete sequencing analysis was performed and I1371V dardarin mutation was found; Mut - heterozygous mutation (B) DNA sequence fluorescent chromatogram of the I1371V LRRK2 mutation observed in proband 4862 (II:3) (sequence around the mutation site is shown, with the arrow pointing to heterozygous substitutions).