Table S3. KEGG Metabolic Pathway Analysis of the P. Strigosa Transcriptome Comparing The

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Table S3. KEGG Metabolic Pathway Analysis of the P. Strigosa Transcriptome Comparing The

KASS count*

Pss Nev Acd Hos Mum KEGG Pathway Sub-pathway Hyma Dome t e i a u

Metabolism Carbohydrate metabolism 322 297 275 331 324 318 248

Energy metabolism 208 157 121 188 177 177 160

Lipid metabolism 204 167 183 183 315 319 154

Nucleotide metabolism 182 167 158 185 196 196 164

Amino acid metabolism 314 252 235 293 303 303 202

Metabolism of other amino acid 64 61 52 69 72 71 56

Glycan biosynthesis and metabolism 152 135 146 143 262 259 140

Metabolism of cofactors and vitamins 133 105 102 122 144 142 89

Terpenoids and polyketides 24 34 25 39 26 24 23

Biosynthesis of secondary metabolites 33 21 24 22 29 25 21

Xenobiotics biodegradation 92 69 70 83 103 98 62

Genetic information Transcription 158 161 125 165 174 174 162 processing

Translation 348 352 284 371 389 389 375

Folding, sorting and degradation 309 313 275 330 405 405 319

Replication and repair 148 147 171 179 216 211 151

Environmental information Membrane transport 25 processing

Signal transduction 533

Signaling molecules and interaction 67

Cellular processes Transport and catabolism 255 226 229 249 412 412 229

Cell motility 71 54 63 69 148 145 59

Cell growth and death 277 246 243 270 408 403 261

Cell communication 159 137 140 141 321 318 148

Organismal systems Immune system 322

Endocrine system 200

Circulatory system 52

Digestive system 158

Excretory system 69

Nervous system 298

Sensory system 30 Development 76

Environmental adaptation 52

Human diseases Cancers: overview 250

Cancers: specific types 297

Immune diseases 31

Neurodegenerative diseases 275

Substance dependence 95

Cardiovascular diseases 81

Endocrine and metabolic diseases 20

Infectious diseases: bacterial 253

Infectious diseases: viral 394

Infectious diseases: parasitic 89 Table S3. KEGG metabolic pathway analysis of the P. strigosa transcriptome comparing the number of transcripts for each sub-pathway between representative species.

* Number of transcripts for each representative species; Psst, Pseudodiploria strigosa; Neve, Nematostella vectensis; Acdi, Acropora digitifera; Hyma, Hydra magnipapillata; Hosa, Homo sapiens; Mumu, Mus musculus; Dome, Drosophila melanoganster.

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