<p> KASS count*</p><p>Pss Nev Acd Hos Mum KEGG Pathway Sub-pathway Hyma Dome t e i a u</p><p>Metabolism Carbohydrate metabolism 322 297 275 331 324 318 248</p><p>Energy metabolism 208 157 121 188 177 177 160</p><p>Lipid metabolism 204 167 183 183 315 319 154</p><p>Nucleotide metabolism 182 167 158 185 196 196 164</p><p>Amino acid metabolism 314 252 235 293 303 303 202</p><p>Metabolism of other amino acid 64 61 52 69 72 71 56</p><p>Glycan biosynthesis and metabolism 152 135 146 143 262 259 140</p><p>Metabolism of cofactors and vitamins 133 105 102 122 144 142 89</p><p>Terpenoids and polyketides 24 34 25 39 26 24 23</p><p>Biosynthesis of secondary metabolites 33 21 24 22 29 25 21</p><p>Xenobiotics biodegradation 92 69 70 83 103 98 62</p><p>Genetic information Transcription 158 161 125 165 174 174 162 processing </p><p>Translation 348 352 284 371 389 389 375</p><p>Folding, sorting and degradation 309 313 275 330 405 405 319</p><p>Replication and repair 148 147 171 179 216 211 151</p><p>Environmental information Membrane transport 25 processing</p><p>Signal transduction 533</p><p>Signaling molecules and interaction 67</p><p>Cellular processes Transport and catabolism 255 226 229 249 412 412 229</p><p>Cell motility 71 54 63 69 148 145 59</p><p>Cell growth and death 277 246 243 270 408 403 261</p><p>Cell communication 159 137 140 141 321 318 148</p><p>Organismal systems Immune system 322</p><p>Endocrine system 200</p><p>Circulatory system 52</p><p>Digestive system 158</p><p>Excretory system 69</p><p>Nervous system 298</p><p>Sensory system 30 Development 76</p><p>Environmental adaptation 52</p><p>Human diseases Cancers: overview 250</p><p>Cancers: specific types 297</p><p>Immune diseases 31</p><p>Neurodegenerative diseases 275</p><p>Substance dependence 95</p><p>Cardiovascular diseases 81</p><p>Endocrine and metabolic diseases 20</p><p>Infectious diseases: bacterial 253</p><p>Infectious diseases: viral 394</p><p>Infectious diseases: parasitic 89 Table S3. KEGG metabolic pathway analysis of the P. strigosa transcriptome comparing the number of transcripts for each sub-pathway between representative species.</p><p>* Number of transcripts for each representative species; Psst, Pseudodiploria strigosa; Neve, Nematostella vectensis; Acdi, Acropora digitifera; Hyma, Hydra magnipapillata; Hosa, Homo sapiens; Mumu, Mus musculus; Dome, Drosophila melanoganster.</p>