Table E-1. Neuropsychological Test Scores (Mean Corrected Values and SD) from Patients

Table e-1. Neuropsychological test scores (mean corrected values and SD) from patients with pediatric MS.

All pediatric Pediatric cognitively Pediatric p values

patients preserved patients cognitively

impaired patients n.s. Global IQ 97.6 (37.2) 100.1 (26.8) 94.5 (36.9) n.s. CDI 9.1 (6.0) 8.0 (5.4) 10.4 (6.7) n.s. FSS 29.9 (10.8) 30.3 (11.4) 29.3 (10.4)

Memory 0.008 SRT-LTS 51.1 (14.0) 57.0 (8.3) 44.0 (16.1) 0.01 SRT-CLTR 42.8 (16.6) 49.9 (13.0) 35.1 (17.5) 0.02 SRT-D 9.7 (2.4) 10.5 (1.4) 8.6 (2.9) 0.0001 SPART 23.5 (7.2) 27.7 (3.3) 18.7 (7.6) 0.004 SPART-D 8.4 (2.6) 9.6 (0.6) 6.9 (3.1)

Abstract/conceptual reasoning MCST perseverative 0.003 3.3 (4.6) 1.5 (2.4) 4.6 (5.7) responses Attention/concentration n.s. SDMT 49.8 (13.2) 53.4 (13.3) 46.2 (12.5) n.s. TMT-A 43.6 (5.5) 39.8 (10.6) 48.1 (19.3) 0.02 TMT-B 77.4 (44.0) 60.9 (21.8) 97 (55.4)

Language Phonemic verbal n.s. 30.2 (9.7) 31.4 (10.7) 29 (8.5) fluency test Semantic verbal 0.01 20.4 (6.4) 23.2 (5.8) 17.4 (5.7) fluency test n.s. IPT 9.9 (0.2) 10 (0) 9.8 (0.3) n.s. PCT 29.8 (0.5) 29.8 (0.3) 29.75 (0.5) n.s. Token test 34.8 (1.2) 35.0 (1.0) 34.6 (1.3) n.s. ODT 42.6 (4.4) 43.6 (3.5) 41.5 (5.1)

Abbreviations: IQ=intelligence quotient; CDI=Children Depression Inventory; FSS=Fatigue

Severity Scale; SRT-LTS=Selective Reminding Test-Long-Term Storage; SRT-CLTR=Selective

Reminding Test-Consistent Long-Term Retrieval; SPART=10/36 Spatial Recall Test;

SDMT=Symbol Digit Modalities Test; TMT-A/B=Trail Making Test A/B; SRT-D=Selective

Reminding Test-Delayed; SPART-D=10/36 Spatial Recall Test-Delayed; MCST=Modified Card

Sorting Test; IPT=Indication of Pictures Test; PCT=Phrase Comprehension Test; OD=Oral

Denomination Test.