<p>Table e-1. Neuropsychological test scores (mean corrected values and SD) from patients with pediatric MS.</p><p>All pediatric Pediatric cognitively Pediatric p values</p><p> patients preserved patients cognitively </p><p> impaired patients n.s. Global IQ 97.6 (37.2) 100.1 (26.8) 94.5 (36.9) n.s. CDI 9.1 (6.0) 8.0 (5.4) 10.4 (6.7) n.s. FSS 29.9 (10.8) 30.3 (11.4) 29.3 (10.4)</p><p>Memory 0.008 SRT-LTS 51.1 (14.0) 57.0 (8.3) 44.0 (16.1) 0.01 SRT-CLTR 42.8 (16.6) 49.9 (13.0) 35.1 (17.5) 0.02 SRT-D 9.7 (2.4) 10.5 (1.4) 8.6 (2.9) 0.0001 SPART 23.5 (7.2) 27.7 (3.3) 18.7 (7.6) 0.004 SPART-D 8.4 (2.6) 9.6 (0.6) 6.9 (3.1)</p><p>Abstract/conceptual reasoning MCST perseverative 0.003 3.3 (4.6) 1.5 (2.4) 4.6 (5.7) responses Attention/concentration n.s. SDMT 49.8 (13.2) 53.4 (13.3) 46.2 (12.5) n.s. TMT-A 43.6 (5.5) 39.8 (10.6) 48.1 (19.3) 0.02 TMT-B 77.4 (44.0) 60.9 (21.8) 97 (55.4)</p><p>Language Phonemic verbal n.s. 30.2 (9.7) 31.4 (10.7) 29 (8.5) fluency test Semantic verbal 0.01 20.4 (6.4) 23.2 (5.8) 17.4 (5.7) fluency test n.s. IPT 9.9 (0.2) 10 (0) 9.8 (0.3) n.s. PCT 29.8 (0.5) 29.8 (0.3) 29.75 (0.5) n.s. Token test 34.8 (1.2) 35.0 (1.0) 34.6 (1.3) n.s. ODT 42.6 (4.4) 43.6 (3.5) 41.5 (5.1)</p><p>Abbreviations: IQ=intelligence quotient; CDI=Children Depression Inventory; FSS=Fatigue </p><p>Severity Scale; SRT-LTS=Selective Reminding Test-Long-Term Storage; SRT-CLTR=Selective </p><p>Reminding Test-Consistent Long-Term Retrieval; SPART=10/36 Spatial Recall Test; </p><p>SDMT=Symbol Digit Modalities Test; TMT-A/B=Trail Making Test A/B; SRT-D=Selective </p><p>Reminding Test-Delayed; SPART-D=10/36 Spatial Recall Test-Delayed; MCST=Modified Card </p><p>Sorting Test; IPT=Indication of Pictures Test; PCT=Phrase Comprehension Test; OD=Oral </p><p>Denomination Test.</p>