NAVBO's Vascular Biology Publication Alert s1

NAVBO's Vascular Biology Publication Alert

November 2017 Issue (papers published in October 2017)

NAVBO Members are highlighted in dark red

American Journal of Pathology Lili Feng, Meihua Ju, Kei Ying V Lee, Ashley Mackey, Mariasilvia Evangelista, Daiju Iwata, Peter Adamson, Kameran Lashkari, Richard Foxton, David Shima, Yin Shan Ng. A Proinflammatory Function of Toll-Like Receptor 2 in the Retinal Pigment Epithelium as a Novel Target for Reducing Choroidal Neovascularization in Age-Related Macular Degeneration. Am J Pathol., 187(10):2208–2221

Basel Sitohy, Sunghee Chang, Tracey E Sciuto, Elizabeth Masse, Mei Shen, Peter M Kang, Shou-Ching Jaminet, Laura E Benjamin, Rupal S Bhatt, Ann M Dvorak, Janice A Nagy, Harold F Dvorak. Early Actions of Anti-Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels. Am J Pathol., 187(10):2337–2347

Hyunjoo Kwon, Kyoungsub Song, Chang Han, Jinqiang Zhang, Lu Lu, Weina Chen, Tong Wu. Epigenetic Silencing of miRNA-34a in Human Cholangiocarcinoma via EZH2 and DNA Methylation: Impact on Regulation of Notch Pathway. Am J Pathol., 187(10):2288–2299

Volha V Malechka, Gennadiy Moiseyev, Yusuke Takahashi, Younghwa Shin, Jian-Xing Ma. Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy. Am J Pathol., 187(10):2222–2231

Biochemical Journal No vascular biology related publications this month

Blood No vascular biology related publications this month

Cancer Cell No vascular biology related publications this month

Cancer Research Qian Yan, Lingxi Jiang, Ming Liu, Dandan Yu, Yu Zhang, Yan Li, Shuo Fang, Yan Li, Ying-Hui Zhu, Yun-Fei Yuan and Xin-Yuan Guan. ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling. Cancer Res., 77(21):5831-5845

Moumita Chatterjee, Edgar Ben-Josef, Ryan Robb, Marall Vedaie, Star Seum, Krishnan Thirumoorthy, Kamalakannan Palanichamy, Matthew Harbrecht, Arnab Chakravarti and Terence M. Williams. Caveolae-Mediated Endocytosis Is Critical for Albumin Cellular Uptake and Response to Albumin-Bound Chemotherapy. Cancer Res., 77(21):5925-5937

Lisa M. Julian, Sean P. Delaney, Ying Wang, Alexander A. Goldberg, Carole Doré, Julien Yockell-Lelièvre, Roger Y. Tam, Krinio Giannikou, Fiona McMurray, Molly S. Shoichet, Mary-Ellen Harper, Elizabeth P. Henske, David J. Kwiatkowski, Thomas N. Darling, Joel Moss, Arnold S. Kristof and William L. Stanford. Human Pluripotent Stem Cell–Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis. Cancer Res., 77(20):5491-5502

Mark J. Bucsek, Guanxi Qiao, Cameron R. MacDonald, Thejaswini Giridharan, Lauren Evans, Brian Niedzwecki, Haichao Liu, Kathleen M. Kokolus, Jason W.-L. Eng, Michelle N. Messmer, Kristopher Attwood, Scott I. Abrams, Bonnie L. Hylander and Elizabeth A. Repasky. β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy. Cancer Res., 77(20):5639-5651

Cell Saharinen P, Leppänen VM, Alitalo K. SnapShot: Angiopoietins and Their Functions. Cell. 2017, 171(3):724- 724.e1

Clinical Science Lieke Jäkel, William E Van Nostrand, James A R Nicoll, David J Werring, Marcel M Verbeek. Animal models of cerebral amyloid angiopathy. Clin Sci (Lond)., 131(19):2469–88

Jessica Duncombe, Akihiro Kitamura, Yoshiki Hase, Masafumi Ihara, Raj N Kalaria, Karen Horsburgh. Chronic cerebral hypoperfusion: a key mechanism leading to vascular cognitive impairment and dementia. Closing the translational gap between rodent models and human vascular cognitive impairment and dementia. Clin Sci (Lond)., 131(19):2451–68

Narges Yazdekhasti, Corinna Brandsch, Frank Hirche, Julia Kühn, Anke Schloesser, Tuba Esatbeyoglu, Patricia Huebbe, Siegfried Wolffram, Gerald Rimbach, Gabriele I Stangl. Impact of chocolate liquor on vascular lesions in apoE-knockout mice. Clin Sci (Lond)., 131(20):2549–60

Dawn Thompson, Nicola Morrice, Louise Grant, Samantha Le Sommer, Emma K Lees, Nimesh Mody, Heather M Wilson, Mirela Delibegovic. Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR(-/-) mouse model of atherosclerosis. Clin Sci (Lond)., 131(20):2489–501

Zsanett Bahor, Jing Liao, Malcolm R Macleod, Alexandra Bannach-Brown, Sarah K McCann, Kimberley E Wever, James Thomas, Thomas Ottavi, David W Howells, Andrew Rice, Sophia Ananiadou, Emily Sena. Risk of bias reporting in the recent animal focal cerebral ischaemia literature. Clin Sci (Lond)., 131(20):2525–32

Santiago Martinez Sosa, Kenneth J Smith. Understanding a role for hypoxia in lesion formation and location in the deep and periventricular white matter in small vessel disease and multiple sclerosis. Clin Sci (Lond)., 131(20):2503–24

Development Bojan Gujas, Tiago M. D. Cruz, Elizabeth Kastanaki, Joop E. M. Vermeer, Teun Munnik, Antia Rodriguez-Villalon. Perturbing phosphoinositide homeostasis oppositely affects vascular differentiation in Arabidopsis thaliana roots. Development, 144: 3578-3589

Yixin Wang, Yi Jin, Maarja Andaloussi Mäe, Yang Zhang, Henrik Ortsäter, Christer Betsholtz, Taija Mäkinen, Lars Jakobsson. Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity. Development, 144: 3590-3601

Kelly J. Soady, Giusy Tornillo, Howard Kendrick, Valerie Meniel, Daria Olijnyk-Dallis, Joanna S. Morris, Torsten Stein, Barry A. Gusterson, Clare M. Isacke, Matthew J. Smalley. The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis. Development , 144: 3777-3788

Mike Adam, Andrew S. Potter, S. Steven Potter. Psychrophilic proteases dramatically reduce single-cell RNA- seq artifacts: a molecular atlas of kidney development. Development, 144: 3625-3632

Developmental Biology Kathleen Hübner, Kathrin S. Grassme, Jyoti Rao, Nina K. Wenke, Wiebke Herzog. Wnt signaling positively regulates endothelial cell fate specification in the Fli1a-positive progenitor population via Lef1. Dev Biol., 430(1):142-155

Hua Guo, Yana Kazadaeva, Fabian E. Ortega, Narasimaswamy Manjunath, Tushar J. Desai. Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung. Dev Biol., 430(1):214–223

Developmental Cell No vascular biology related publications this month

Developmental Dynamics No vascular biology related publications this month

EMBO No vascular biology related publications this month EMBO Reports No vascular biology related publications this month

FASEB Journal No vascular biology related publications this month

Genes & Development No vascular biology related publications this month

Journal of Biological Chemistry Gandhi T. K. Boopathy, Madhura Kulkarni, Sze Yuan Ho, Adrian Boey, Edmond Wei Min Chua, Veluchamy A. Barathi, Tom J. Carney, Xiaomeng Wang, and Wanjin Hong. Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis. J. Biol. Chem., 292:17760-17776

Qadeer Aziz, Yiwen Li, Naomi Anderson, Leona Ojake, Elena Tsisanova, and Andrew Tinker. Molecular and functional characterization of the endothelial ATP-sensitive potassium channel. J. Biol. Chem., 292:17587- 17597

Kai Song, Jianxin Fu, Jianhua Song, Brett H. Herzog, Kirk Bergstrom, Yuji Kondo, J. Michael McDaniel, Samuel McGee, Robert Silasi-Mansat, Florea Lupu, Hong Chen, Harini Bagavant, and Lijun Xia. Loss of mucin-type O- glycans impairs the integrity of the glomerular filtration barrier in the mouse kidney. J. Biol. Chem., 292:16491-16497

Astrid Rohrbeck, Markus Höltje, Andrej Adolf, Elisabeth Oms, Sandra Hagemann, Gudrun Ahnert-Hilger, and Ingo Just. The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg–Gly–Asp motif. J. Biol. Chem., 292:17668-17680

Weiming Ouyang, Pengfei Guo, Hui Fang, and David M. Frucht. Anthrax lethal toxin rapidly reduces c-Jun levels by inhibiting c-Jun gene transcription and promoting c-Jun protein degradation. J. Biol. Chem., 292:17919- 17927

Kariona A. Grabińska, Ban H. Edani, Eon Joo Park, Jan R. Kraehling, and William C. Sessa. A conserved C- terminal RXG motif in the NgBR subunit of cis-prenyltransferase is critical for prenyltransferase activity. J. Biol. Chem., 292:17351-17361

Hong Xie and M. Celeste Simon. Oxygen availability and metabolic reprogramming in cancer. J. Biol. Chem., 292:16825-16832

Xiangqiang Shao, Hyunook Kang, Timothy Loveless, Gyu Rie Lee, Chaok Seok, William I. Weis, Hee-Jung Choi, and Jeff Hardin. Cell–cell adhesion in metazoans relies on evolutionarily conserved features of the α-catenin·β- catenin–binding interface. J. Biol. Chem., 292:16477-16490

Jon A. Kenniston, Brandy M. Taylor, Gregory P. Conley, Janja Cosic, Kris J. Kopacz, Allison P. Lindberg, Stephen R. Comeau, Kateri Atkins, Jameson Bullen, Christopher TenHoor, Burt A. Adelman, Daniel J. Sexton, Thomas E. Edwards, and Andrew E. Nixon. Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody. J. Biol. Chem., 292:17449-17460

Journal of Cell Biology Yao J, Guihard PJ, Wu X, Blazquez-Medela AM, Spencer MJ, Jumabay M, Tontonoz P, Fogelman AM, Boström KI, Yao Y. Vascular endothelium plays a key role in directing pulmonary epithelial cell differentiation. J Cell Biol., 216(10): 3369-3385

Journal of Cell Science Liao Z, Kasirer-Friede A, Shattil SJ. Optogenetic interrogation of integrin αVβ3 function in endothelial cells. J Cell Sci.,130(20): 3532-3541

Journal of Clinical Investigation Kim J, Park DY, Bae H, Park DY, Kim D, Lee CK, Song S, Chung TY, Lim DH, Kubota Y, Hong YK, He Y, Augustin HG, Oliver G, Koh GY. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest., 127(10): 3877-3896 Chen M, Lei X, Shi C, Huang M, Li X, Wu B, Li Z, Han W, Du B, Hu J, Nie Q, Mai W, Ma N, Xu N, Zhang X, Fan C, Hong A, Xia M, Luo L, Ma A, Li H, Yu Q, Chen H, Zhang D, Ye W. Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents. J Clin Invest., 127(10): 3689-3701

Journal of Immunology No vascular biology related publications this month

Journal of Lipid Research Nemati R, Dietz C, Anstadt EJ, Cervantes J, Liu Y, Dewhirst FE, Clark RB, Finegold S, Gallagher JJ, Smith MB, Yao X, Nichols FC. Deposition and hydrolysis of serine dipeptide lipids of Bacteroidetes bacteria in human arteries: relationship to atherosclerosis. J Lipid Res., 58(10): 1999-2007

Molecular Biology of the Cell No vascular biology related publications this month

Nature Ulrich Elling, Reiner A Wimmer, Andreas Leibbrandt, Thomas Burkard, Georg Michlits, Alexandra Leopoldi, Thomas Micheler, Dana Abdeen, Sergei Zhuk, Irene M Aspalter, Cornelia Handl, Julia Liebergesell, Maria Hubmann, Anna- Maria Husa, Manuela Kinzer, Nicole Schuller, Ellen Wetzel, Nina van de Loo, Jorge Arturo Zepeda Martinez, David Estoppey, Ralph Riedl, Fengtang Yang, Beiyuan Fu, Thomas Dechat, Zoltán Ivics, Chukwuma A Agu, Oliver Bell, Dieter Blaas, Holger Gerhardt, Dominic Hoepfner, Alexander Stark, Josef M Penninger. A reversible haploid mouse embryonic stem cell biobank resource for functional genomics. Nature, 550(7674):114–8

John P Leach, Todd Heallen, Min Zhang, Mahdis Rahmani, Yuka Morikawa, Matthew C Hill, Ana Segura, James T Willerson, James F Martin. Hippo pathway deficiency reverses systolic heart failure after infarction. Nature, 550(7675):260–4

Thiet M Vu, Ayako-Nakamura Ishizu, Juat Chin Foo, Xiu Ru Toh, Fangyu Zhang, Ding Ming Whee, Federico Torta, Amaury Cazenave-Gassiot, Takayoshi Matsumura, Sangho Kim, Sue-Anne E S Toh, Toshio Suda, David L Silver, Markus R Wenk, Long N Nguyen. Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. Nature, 550(7677):524–8

Nature Cell Biology Miguel Ganuza, Trent Hall, David Finkelstein, Ashley Chabot, Guolian Kang, Shannon McKinney-Freeman. Lifelong haematopoiesis is established by hundreds of precursors throughout mammalian ontogeny. Nat Cell Biol., 19(10):1153–63

Nature Genetics Wei Zhao, Asif Rasheed, Emmi Tikkanen, Jung-Jin Lee, Adam S Butterworth, Joanna M M Howson, Themistocles L Assimes, Rajiv Chowdhury, Marju Orho-Melander, Scott Damrauer, Aeron Small, Senay Asma, Minako Imamura, Toshimasa Yamauch, John C Chambers, Peng Chen, Bishwa R Sapkota, Nabi Shah, Sehrish Jabeen, Praveen Surendran, Yingchang Lu, Weihua Zhang, Atif Imran, Shahid Abbas, Faisal Majeed, Kevin Trindade, Nadeem Qamar, Nadeem Hayyat Mallick, Zia Yaqoob, Tahir Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Khalid Mehmood, Naveeduddin Ahmed, Irshad Hussain Qureshi, Tanveer-Us- Salam, Wasim Iqbal, Uzma Malik, Narinder Mehra, Jane Z Kuo, Wayne H-H Sheu, Xiuqing Guo, Chao A Hsiung, Jyh- Ming J Juang, Kent D Taylor, Yi-Jen Hung, Wen-Jane Lee, Thomas Quertermous, I-Te Lee, Chih-Cheng Hsu, Erwin P Bottinger, Sarju Ralhan, Yik Ying Teo, Tzung-Dau Wang, Dewan S Alam, Emanuele Di Angelantonio, Steve Epstein, Sune F Nielsen, Børge G Nordestgaard, Anne Tybjaerg-Hansen, Robin Young, CHD Exome+ Consortium, Marianne Benn, Ruth Frikke-Schmidt, Pia R Kamstrup, EPIC-CVD Consortium, EPIC-Interact Consortium, Michigan Biobank, J Wouter Jukema, Naveed Sattar, Roelof Smit, Ren-Hua Chung, Kae-Woei Liang, Sonia Anand, Dharambir K Sanghera, Samuli Ripatti, Ruth J F Loos, Jaspal S Kooner, E Shyong Tai, Jerome I Rotter, Yii-Der Ida Chen, Philippe Frossard, Shiro Maeda, Takashi Kadowaki, Muredach Reilly, Guillaume Pare, Olle Melander, Veikko Salomaa, Daniel J Rader, John Danesh, Benjamin F Voight, Danish Saleheen. Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. Nat Genet., 49(10):1450– 7

Nature Medicine Meera Murgai, Wei Ju, Matthew Eason, Jessica Kline, Daniel W Beury, Sabina Kaczanowska, Markku M Miettinen, Michael Kruhlak, Haiyan Lei, Jack F Shern, Olga A Cherepanova, Gary K Owens, Rosandra N Kaplan. KLF4- dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis. Nat Med., 23(10):1176–90 Paul J Emmerson, Feng Wang, Yong Du, Qian Liu, Richard T Pickard, Malgorzata D Gonciarz, Tamer Coskun, Matthew J Hamang, Dana K Sindelar, Kimberly K Ballman, Lisa A Foltz, Avinash Muppidi, Jorge Alsina-Fernandez, Gavin C Barnard, Jason X Tang, Xilin Liu, Xudong Mao, Robert Siegel, John H Sloan, Pamela J Mitchell, Bei B Zhang, Ruth E Gimeno, Bei Shan, Xinle Wu. The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL. Nat Med., 23(10):1215–9

PNAS Konishi M, Sakaguchi M, Lockhart SM, Cai W, Li ME, Homan EP, Rask-Madsen C, Kahn CR. Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice. Proc Natl Acad Sci U S A., 114(40): E8478-E8487

Jiang Y, Lin X, Tang Z, Lee C, Tian G, Du Y, Yin X, Ren X, Huang L, Ye Z, Chen W, Zhang F, Mi J, Gao Z, Wang S, Chen Q, Xing L, Wang B, Cao Y, Sessa WC, Ju R, Liu Y, Li X. Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK. Proc Natl Acad Sci U S A., 114(40): 10737-10742

Sakabe M, Fan J, Odaka Y, Liu N, Hassan A, Duan X, Stump P, Byerly L, Donaldson M, Hao J, Fruttiger M, Lu QR, Zheng Y, Lang RA, Xin M. YAP/TAZ-CDC42 signaling regulates vascular tip cell migration. Proc Natl Acad Sci U S A., 114(41): 10918-10923

Vion AC, Kheloufi M, Hammoutene A, Poisson J, Lasselin J, Devue C, Pic I, Dupont N, Busse J, Stark K, Lafaurie- Janvore J, Barakat AI, Loyer X, Souyri M, Viollet B, Julia P, Tedgui A, Codogno P, Boulanger CM, Rautou PE. Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow. Proc Natl Acad Sci U S A., 114(41):E8675-E8684

Ajami NE, Gupta S, Maurya MR, Nguyen P, Li JY, Shyy JY, Chen Z, Chien S, Subramaniam S. Systems biology analysis of longitudinal functional response of endothelial cells to shear stress. Proc Natl Acad Sci U S A., 114(41): 10990-10995

Science Ali H Zahalka, Anna Arnal-Estapé, Maria Maryanovich, Fumio Nakahara, Cristian D Cruz, Lydia W S Finley, Paul S Frenette. Adrenergic nerves activate an angio-metabolic switch in prostate cancer. Science, 358(6361):321–6

Jing Wang, Mokarram Hossain, Ajitha Thanabalasuriar, Matthias Gunzer, Cynthia Meininger, Paul Kubes. Visualizing the function and fate of neutrophils in sterile injury and repair. Science, 358(6359):111–6

Member Submissions Matthew DeBerge, Xin-Yi Yeap, Shirley Dehn, Shuang Zhang, Lubov S Grigoryeva, Sol Misener, Daniele Procissi, Xin Zhou, Daniel C Lee, William A Muller, Xunrong Luo, Carla Rothlin, Ira Tabas, Edward B Thorp. MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair after Myocardial Ischemia Reperfusion Injury. Circ Res, 121(8):930-940

Peter Baluk, Li-Chin Yao, Julio C. Flores, Dongwon Choi, Young-Kwon Hong, and Donald M. McDonald. Rapamycin reversal of VEGF-C–driven lymphatic anomalies in the respiratory tract. JCI Insight, 2(16)

Ridker PM, MacFadyen JG, Thuren T, Everett BM, Libby P, Glynn RJ, CANTOS Trial Group. Effect of interleukin- 1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial. Lancet, 390(10105):1833-1842

Noelia Escobedo & Guillermo Oliver. The Lymphatic Vasculature: Its Role in Adipose Metabolism and Obesity. Cell Metab., 26(4):598-609

Robert J, Button EB, Yuen B, Gilmour M, Kang K, Bahrabadi A, Stukas S, Zhao W, Kulic I, Wellington CL. Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels. Elife, 6

Sanghez V, Luzzi A, Clarke D, Kee D, Beuder S, Rux D, Osawa M, Madrenas J, Chou TF, Kyba M, Iacovino M. Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation. PLoS One., 12(10):e0186818

K Fung, C Wang, S Nyegaard, B Heit, GD Fairn, WL Lee . SR-BI mediated transcytosis of HDL in brain microvascular endothelial cells is independent of caveolin, clathrin and PDZK1. Frontiers in Physiology, 8:841 Kochan K, Kus E, Szafraniec E, Wislocka A, Chlopicki S, Baranska M. Changes induced by non-alcoholic fatty liver disease in liver sinusoidal endothelial cells and hepatocytes: spectroscopic imaging of single live cells at the subcellular level. Analyst, 142(20):3948-3958

Smeda M, Przyborowski K, Proniewski B, Zakrzewska A, Kaczor D, Stojak M, Buczek E, Nieckarz Z, Zoladz JA, Wietrzyk J, Chlopicki S. Breast cancer pulmonary metastasis is increased in mice undertaking spontaneous physical training in the running wheel; a call for revising beneficial effects of exercise on cancer progression. Am J Cancer Res., 7(9):1926-1936

Corey S. Moran, Erik Biros, Smriti M. Krishna, Yutang Wang, Chris Tikellis, Susan K. Morton, Joseph V. Moxon, Mark E. Cooper, Paul E. Norman, Louise M. Burrell, Merlin C. Thomas, Jonathan Golledge. Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin- Converting Enzyme 2. Arterioscler Thromb Vasc Biol., 37:2195-2203

Libby P. Interleukin-1 Beta as a Target for Atherosclerosis Therapy: Biological Basis of CANTOS and Beyond. J Am Coll Cardiol., 70(18):2278-2289