CURRICULUM VITAE
Hector Mayani, Ph.D.
Personal Information date of birth 14 September 1960 place of birth Mexico City, Mexico nationality Mexican marital status Married; three sons
Mailing address Dr. Hector Mayani
Tallo 2, D-102,
San Pablo Tepetlapa, Coyoacan
Mexico City, 04620
MEXICO
Current Position Senior Research Scientist
Head, Oncology Research Unit
Oncology Hospital
National Medical Center, IMSS.
Mexico City, MEXICO
Phone (52-55) 5627 6959
Fax (52-55) 5761 0952
e-mail: [email protected] 2
Education
1980 - 1983 B.Sc. (Biology) National University of Mexico
Mexico City, MEXICO
1984 - 1986 M.Sc. (Cell Biology) National University of Mexico, Mexico City, MEXICO
1988 - 1992 Ph.D. (Medical Sciences) University of Alberta
Edmonton, Alberta, CANADA
Research Training
1987 - 1988 Visiting Researcher
(Professor Allan Jacobs’ Laboratory)
Department of Hematology
University of Wales College of Medicine
Cardiff, UNITED KINGDOM
1992 - 1994 Post-Doctoral Research Fellow
(Dr. Peter M Lansdorp´s Laboratory)
Terry Fox Laboratory
B.C. Cancer Research Centre
Vancouver, B.C., CANADA
Research Interests
Hematopoietic Stem/Progenitor Cell biology
Umbilical Cord Blood-derived hematopoietic cells
Hematopoiesis in hematological diseases (AML, CML, MDS, AA)
Hematopoietic microenvironment and Mesenchymal Stem Cells 3
Publications
1. Articles
1. Baines P, Mayani H, Bains M, Fisher J, Hoy T, Jacobs A (1988) Enrichment of CD34 (MY10)-positive myeloid and erythroid progenitors from human marrow and their growth in cultures supplemented with rhGM-CSF. Exp Hematol 16:785-789
2. Mayani H, Baines P, Jones A, Hoy T, Jacobs A (1989) Effects of rhGM- CSF on single CD34-positive haemopoietic progenitors from human bone marrow. Int J Cell Cloning 7:30-36
3. Mayani H, Baines P, Bowen DT, Jacobs A (1989). In-vitro growth of myeloid and erythroid progenitor cells from myelodysplastic patients in response to rhGM-CSF. Leukemia 3:29-32
4. Mayani H, Guilbert L, Janowska-Wieczorek A (1990) Modulation of erythropoiesis and myelopoiesis by exogenous erythropoietin in human long-term marrow cultures. Exp Hematol 18:174-179
5. Mayani H, Shen S, Guilbert L, Clark SC, Sych I, Janowska-Wieczorek A (1991) The effect of rhCSF-1 on human hemopoiesis in long-term cultures from patients with acute myelogenous leukemia. Leukemia 5:8- 13
6. Janowska-Wieczorek A, Mayani H, Shen S, Tupas J, Belch AR, Morrish DW, Miller GG, Turner AR (1991) Similarities in long-term cultures of blood and bone marrow from patients with acute myelogenous leukemia. Int J Cell Cloning 9:461-473
7. Mayani H, Guilbert L, Clark SC, Janowska-Wieczorek A (1991) Inhibition of hematopoiesis in normal human long-term marrow cultures treated 4
with recombinant human macrophage colony-stimulating factor. Blood 78:651-657
8. Mayani H, Guilbert L, Clark SC, Belch A, Janowska-Wieczorek A (1992) Composition and functional integrity of the in vitro hemopoietic microenvironment in acute myelogenous leukemia: Effect of macrophage colony-stimulating factor. Exp Hematol 20:1077-1084
9. Mayani H, Guilbert L, Sych I, Janowska-Wieczorek A (1992) Production of tumor necrosis factor-alpha in human long-term marrow cultures from normal subjects and patients with acute myelogenous leukemia: Effect of recombinant macrophage colony-stimulating factor. Leukemia 6:1148- 1154
10.Mayani H, Guilbert L, Janowska-Wieczorek A (1992) Biology of the hemopoietic microenvironment. Eur J Haematol 49:225-233
11.Mayani H, Guilbert L, Janowska-Wieczorek A (1993) Functional characterization of fibroblastic cells in human long-term marrow cultures from patients with acute myelogenous leukemia. Leukemia 7:1564-1569
12.Mayani H, Dragowska W, Lansdorp P (1993) Cytokine-induced selective expansion and maturation of erythroid versus myeloid progenitors from purified cord blood precursor cells. Blood 81:3252-3258
13.Lansdorp P, Dragowska W, Mayani H (1993) Ontogeny-related changes in proliferative potential of human hematopoietic cells. J Exp Med 178:787-791
14.Mayani H, Dragowska W, Lansdorp PM (1993) Characterization of functionally distinct subpopulations of CD34+ cord blood cells in serum- free long-term cultures supplemented with hematopoietic cytokines. Blood 82:2664-2672 5
15.Mayani H, Dragowska W, Lansdorp PM (1993) Lineage commitment in human hemopoiesis involves asymmetric cell division of multipotent progenitors and does not appear to be influenced by cytokines. J Cell Physiol 157:579-586
16.Mayani H (1993) Human Preleukemia: Cellular, Molecular and Clinical Aspects. Arch Med Res 24:317-325
17.Mayani H, Lansdorp PM (1994) Thy-1 expression is linked to functional properties of primitive hematopoietic progenitor cells from human umbilical cord blood. Blood 83:2410-2417
18.Watari K, Lansdorp PM, Dragowska W, Mayani H, Schrader J (1994) Expression of interleukin-1 gene in candidate human hematopoietic stem cells. Blood 84:36-43
19.Lansdorp PM, Dragowska W, Thomas T, Little MT, Mayani H (1994) Age related decline in proliferative potential of purified stem cell candidates. Blood Cells 20:376-381
20.Mayani H, Little MT, Dragowska W, Thornbury G, Lansdorp PM (1995) Differential effects of the hematopoietic inhibitors MIP-1, TGF and TNF on cytokine induced proliferation of subpopulations of CD34 + cells purified from cord blood and fetal liver. Exp Hematol 23:422-427
21.Mayani H, Lansdorp PM (1995) Proliferation of individual hematopoietic progenitors purified from umbilical cord blood. Exp Hematol 23:1453- 1462
22.Watari K, Mayani H, Lee F, Dragowska W, Lansdorp PM, Schrader J (1996) Expression of interleukin-1 and interleukin-1 converting enzyme genes in human hematopoietic stem and progenitor cells. J Clin Invest 97:1666-1674 6
23.Mayani H (1996) Composition and function of the hemopoietic microenvironment in human myeloid leukemia. Leukemia 10:1041-1047
24.Mayani H, Gutiérrez-Rodríguez M, Espinoza L, López-Chalini E, Huerta- Zepeda A, Flores E, Sánchez-Valle E, Luna-Bautista F, Valencia I, Ramírez OT (1998) Kinetics of hematopoiesis in Dexter-type long-term cultures established from human umbilical cord blood cells. Stem Cells 16:127-135
25.Mayani H, Lansdorp PM (1998) Biology of human umbilical cord blood- derived hematopoietic stem/progenitor cells. Stem Cells 16:153-165
26.Gómez-Morales E, Martínez-Jaramillo G, Sánchez-Valle E, Valencia I, Arana-Trejo RM, Castro MA, Pizzuto-Chavez J, Mayani H (1998) Deficient proliferation of myeloid, erythroid and multipotent progenitor cells in long-term marrow cultures from patients with aplastic anemia treated with immunosuppressive therapy. Am J Hematol 59:149-155
27.De León A, Mayani H, Ramírez OT (1998) Design, characterization and application of a minibioreactor for the culture of human hematopoietic cells under controlled conditions. Cytotechnology 28: 127-138.
28.Flores-Figueroa E, Gutiérrez-Espindola G, Guerrero-Rivera S, Pizzuto- Chavez J, Mayani H (1999) Hematopoietic progenitor cells from patients with myelodysplastic syndromes: In vitro colony growth and long-term proliferation. Leuk Res 23: 385-394
29.Martínez-Jaramillo G, Gómez-Morales E, Mayani H (1999) Effect of recombinant human Granulocyte-Macrophage Colony-Stimulating Factor in long-term marrow cultures from patients with aplastic anemia. Am J Hematol 61: 107-114 7
30.Gutiérrez-Rodríguez M, Reyes-Maldonado E, Mayani H (2000) Characterization of the adherent cells developed in Dexter-type long- term cultures from human umbilical cord blood. Stem Cells 18: 46-52
31.Martínez-Jaramillo G, Espinoza-Hernández L, Benítez-Aranda H, Mayani H (2000) Long-term proliferation in vitro of hematopoietic progenitor cells from children with congenital bone marrow failure: Effect of rhGM-CSF and rhEPO. Eur J Haematol 64: 173-181
32.Martínez-Jaramillo G, Sánchez-Valle E, Gómez-Morales E, Montesinos JJ, Valencia I, Pizzuto-Chavez J, Mayani H (2000) Sequential variations in the content of bone marrow colony-forming cells in individual patients with aplastic anemia before and after immunosuppressive therapy. Hematology 5: 247-255
33.Huerta-Zepeda A, Talavera A, Avilés A, Neri N, Mayani H (2000) In vitro hematopoiesis in patients with malignant lymphoma during active disease and at complete clinical remission after chemotherapy. Leuk Lymphoma 39: 613-624
34.Espinoza-Hernández L, Cruz-Rico J, Benítez-Aranda H, Martínez- Jaramillo G, Rodríguez-Zepeda MC, Vélez-Ruelas MA, Mayani H (2001) In vitro characterization of the hematopoietic system in pediatric patients with acute lymphoblastic leukemia. Leuk Res 25: 295-303
35.Martínez-Jaramillo G, Gómez-Morales E, Sánchez-Valle E, Mayani H (2001) Severe hematopoietic alterations in vitro in bone marrow transplant recipients who develop graft-versus-host disease. J Hematother Stem Cell Res 10: 347-354
36.De León A, Barba de la Rosa AP, Mayani H, Galindo E, Ramírez OT (2001) Two useful dimensionless parameters that combine physiological, operational and bioreactor design parameters for improved control of dissolved oxygen. Biotechnology Letters 23: 1051-1056 8
37.Martínez-Jaramillo G, Flores-Figueroa E, Gómez-Morales E, Sánchez- Valle E, Mayani H (2001) Tumor Necrosis Factor- levels in long-term marrow cultures from patients with aplastic anemia: Modulation by Granulocyte-Macrophage Colony-Stimulating Factor. Am J Hematol 68: 144-148
38.Flores-Guzmán P, Gutiérrez-Rodríguez M, Mayani H (2002) In vitro proliferation, expansion and differentiation of a CD34+ cell-enriched hematopoietic cell population from human umbilical cord blood in response to recombinant cytokines. Arch Med Res 33: 107-114
39.Flores-Figueroa E, Gutiérrez-Espíndola G, Montesinos JJ, Arana-Trejo RM, Mayani H (2002) In vitro characterization of hematopoietic microenvironment cells from patients with myelodysplastic syndromes. Leuk Res 26: 677-686
40.Martínez-Jaramillo G, Flores-Figueroa E, Sánchez-Valle E, Gómez- Morales E, Gutiérrez-Espíndola G, Montesinos JJ, Flores-Guzmán P, Chávez-González A, Alvarado-Moreno JA, Mayani H (2002) Comparative analysis of the in vitro proliferation and expansion of hematopoietic progenitors from patients with aplastic anemia and myelodysplasia. Leuk Res 26: 955:963.
41.Montesinos JJ, Sánchez-Valle E, Miranda-Peralta E, Gutiérrez-Romero M, Mayani H (2002) Effect of rhGM-CSF on the kinetics of hematopoiesis in long-term marrow cultures from patients with acute myelogenous leukemia. Leuk Lymphoma 43: 2383-2390.
42.Benítez Aranda H, Vélez-Ruelas MA, Díaz-Cárdenas S, Sánchez-Valle E, Xolotl-Castillo M, Dueñas-González MT, Mayani H (2002) Incidence of Aplastic Anemia in a defined subpopulation from México City. Hematology 7: 229-232. 9
43.Mayani H (2003) A glance into somatic Stem Cell biology: Basic principles, new concepts and clinical relevance. Arch Med Res 34: 3-15.
44.Luna-Bautista F, Sánchez-Valle E, Ayala-Sánchez M, Morales-Polanco M, Meillon-García L, Benítez-Bribiesca L, Mayani H (2003) Kinetics of hematopoiesis in bone marrow cultures from patients with chronic myeloid leukemia: Effect of recombinant cytokines in Dexter-Type long- term cultures. Hematology 8: 155-163.
45.Mayani H, Alvarado-Moreno JA, Flores-Guzman P (2003) Biology of human hematopoietic stem and progenitor cells present in circulation. Arch Med Res 34: 476-488.
46.Chávez-González MA, Rosas-Cabral A, Vela-Ojeda J, González JC, Mayani H (2004) Severe functional alterations in vitro in CD34+ cell subpopulations from patients with chronic myeloid leukemia. Leuk Res 28: 639-647
47.Martínez-Jaramillo G, Avilés A, Neri N, Huerta J, Madrigal-Velazquez M, Flores-Guzman P, Mayani H (2004) In vitro proliferation and expansion of hematopoietic progenitors from patients with Diffuse Large B-cell Lymphoma before and after chemotherapy. Leuk Lymphoma 45: 1247- 1254
48.Martínez-Jaramillo G, Flores-Guzmán P, Montesinos JJ, Quintana S, Bautista J, Sánchez-Valle E, Nambo MJ, Mayani H (2004) In vitro proliferation and expansion of hematopoietic progenitors present in mobilized peripheral blood from normal subjects and cancer patients. Stem Cells Dev 13: 382-389
49.Flores-Figueroa E, Arana-Trejo RM, Gutiérrez-Espíndola G, Pérez- Cabrera A, Mayani H (2005) Mesenchymal stem cells in Myelodysplastic Syndromes: Phenotypic and Cytogenetic characterization. Leuk Res 29: 215-224 10
50.Vela-Ojeda J, García-Ruiz Esparza MA, Reyes-Maldonado E, Jiménez- Zamudio L, García-Latorre E, Moreno-Lafont M, Estrada-García I, Mayani H, Montiel-Cervantes L, Tripp-Villanueva F, Ayala-Sánchez M, García-León LD, Borbolla-Escoboza JR (2005) CD4+ CD25+ lymphocyte and dendritic cell mobilization with intermediate doses of rhG-CSF in healthy donors. Stem Cells Dev 14: 310-316
51.Flores-Guzmán P, Flores-Figueroa E, Martínez-Jaramillo G, Mayani H (2005) In vitro characterization of two lineage-negative, CD34+ cell- enriched hematopoietic cell populations from human umbilical cord blood. Cytotherapy 7: 334-344
52.Vela-Ojeda J, García-Ruiz Esparza MA, Reyes-Maldonado E, Jiménez- Zamudio L, García-Latorre E, Moreno-Lafont M, Estrada-García I, Montiel-Cervantes L, Tripp-Villanueva F, Ayala-Sánchez M, García-León LD, Borbolla-Escoboza JR, Mayani H (2006) Clinical relevance of NK, NKT and dendritic cell dose in patients receiving G-CSF-mobilized peripheral blood allogeneic stem cell transplantation. Ann Hematol 85: 113-120
53.Chávez-González A, Ayala-Sánchez M, Sánchez-Valle E, Ruiz-Sánchez E, Arana-Trejo RM, Vela-Ojeda J, Mayani H (2006) Functional integrity in vitro of hematopoietic progenitor cells from patients with chronic myeloid leukemia that have achieved hematological remission after different therapeutic procedures. Leuk Res 30: 286-295
54.Madrigal-Velazquez M, Aviles A, Neri N, Huerta J, Martínez-Jaramillo G, Mayani H (2006) Ice, bcl-2, c-myc and p53 expression in different bone marrow cell populations from patients with Diffuse large B-cell lymphoma. Leuk Lymphoma 47: 665-673
55.Vela-Ojeda J, García-Ruiz Esparza MA, Reyes-Maldonado E, Jiménez- Zamudio L, García-Latorre E, Moreno-Lafont M, Estrada-García I, 11
Mayani H, Montiel-Cervantes L, Tripp-Villanueva F, Ayala-Sánchez M, García-León LD, Borbolla-Escoboza JR (2006) Peripheral blood mobilization of different lymphocyte and dendritic cell subsets with the use of intermediate doses of G-CSF in patients with non-Hodgkin´s lymphoma and multiple myeloma. Ann Hematol 85: 308-314
56.Flores-Guzman P, Martinez-Jaramillo G, Mayani H (2006) Growth kinetics of progenitor cell-enriched hematopoietic cell populations in long- term liquid cultures under continuous removal of mature cells. Cytotherapy 8: 299-307
57.Montesinos JJ, Sánchez-Valle E, Flores-Figueroa E, Martínez-Jaramillo G, Flores-Guzmán P, Miranda-Peralta E, Gutiérrez-Romero M, Mayani H (2006) Deficient proliferation and expansion in vitro of two bone marrow cell populations from patients with acute myeloid leukemia in response to hematopoietic cytokines. Leuk Lymphoma 47: 1379-1386
58.Vélez-Ruelas MA, Martínez-Jaramillo G, Arana-Trejo RM, Mayani H (2006) Hematopoietic changes during progression from Fanconi Anemia into Acute Myeloid Leukemia: Case report and brief review of the literature. Hematology 11: 331-334
59.Martinez A, Olarte I, Mergold MA, Gutiérrez M, Rozen E, Collazo J, Montesinos JJ, Mayani H, McCurdy DK, Ostrosky-Wegman P, Garrido- Guerrero E, Miranda EI (2007) mRNA expression of MAGE-A3 gene in leukemia cells. Leuk Res 31: 33-37
60.Martínez-Jaramillo G, Vela-Ojeda J, Sánchez-Valle E, Montesinos JJ, Mayani H (2007) In vitro functional alterations in the hematopoietic system of adult patients with acute lymphoblastic leukemia. Leuk Res 31: 83-89 12
61.Hernandez-Caballero ME, Mayani H, Montesinos JJ, Salamanca F, Peñaloza R (2007) In vitro leukemic cell differentiation and WT1 gene expression. Leuk Res 31:395-397
62.Alvarado-Moreno JA, Chavez-Gonzalez A, Cerbulo A, Arriaga L, Mayani H (2007) Cell cycle differences in vitro between primitive hematopoietic cell populations from adult and umbilical cord blood. Stem Cells Dev 16: 223-229
63.Novelo-Garza B, Limón-Flores A, Guerra-Marquez A, Luna-Bautista F, Montero I, Juan-Shum L, Sánchez-Valle E, Vélez-Ruelas MA, Mayani H (2008) Establishing a cord blood banking and transplantation program in Mexico: A single institution experience. Transfusion 48: 228-236
64.Flores-Figueroa E, Montesinos JJ, Flores-Guzmán P, Gutiérrez- Espíndola G, Castillo-Medina S, Arana-Trejo RM, Pérez-Cabrera A, Hernández-Estévez E, Arriaga L, Mayani H (2008) Functional analysis of Myelodysplastic Syndromes-derived Mesenchymal Stem Cells. Leuk Res 32: 1407-1416
65.Dorantes-Acosta E, Chávez-González A, Santos JI, Medina-Sanson A, Mayani H (2008) Defective in vitro growth of primitive hematopoietic cells from pediatric patients with acute myeloid leukemia. Pediatric Blood Cancer 51: 741-746
66.Vela-Ojeda J, Ruiz-Esparza MA, Padilla-González Y, Sánchez-Cortes E, García-Chávez J, Montiel-Cervantes L, Reyes-Maldonado E, Majluf-Cruz A, Mayani H (2009) Multiple myeloma-associated amyloidosis is an independent high-risk prognostic factor. Ann Hematol 88; 59-66
67.Montesinos JJ, Flores-Figueroa E, Castillo-Medina S, Flores-Guzman P, Orozco S, Mayani H (2009) Human mesenchymal stromal cells from adult and neonatal sources: comparative analysis of their morphology, 13
immunophenotype, differentiation patterns, and neural protein expression. Cytotherapy 11: 163-176
68.Mayani H, Flores-Figueroa E, Chavez-Gonzalez A (2009) In vitro biology of human myeloid leukemia. Leuk Res 33: 624-637
69.Flores-Guzman P, Flores-Figueroa E, Montesinos JJ, Martinez-Jaramillo G, Fernandez-Sanchez V, Valencia-Plata I, Alarcon-Santos G, Mayani H (2009) Individual and combined effects of Mesenchymal Stromal Cells and recombinant stimulatory cytokines on the in vitro growth of primitive hematopoietic cells from human umbilical cord blood. Cytotherapy 11: 886-896
70.Alvarado-Moreno A, Chávez-Gonzalez A, Cérbulo A, Arriaga L, Mayani H (2010) In vitro cell cycle dynamics of primitive hematopoietic cells from human umbilical cord blood. Hematology 15: 11-20
71.Mayani H (2010) Biological differences between neonatal and adult human hematopoietic stem/progenitor cells. Stem Cells Dev 19: 285-298
72.Vela-Ojeda J, Montiel-Cervantes L, Granados-Lara P, Reyes-Maldonado E, Garcia-Latorre E, Garcia-Chavez J, Majluf-Cruz A, Mayani H, Borbolla-Escoboza R, Garcia-Ruiz Esparza M (2010) Role of CD4+ CD25+ highFoxP3+ CD62L+ regulatory T cells and invariant NKT cells in human allogeneic hematopoietic stem cell transplantation. Stem Cells Dev 19: 333-340
73.Martínez-Jaramillo G, Vela-Ojeda J, Flores-Guzman P, Mayani H (2011) In vitro growth of hematopoietic progenitors and stromal bone marrow cells from patients with multiple myeloma. Leuk Res 35: 250-255
74.Guerra-Marquez A, Novelo-Garza B, Malagón-Martínez A, Limón-Flores A, Luna-Bautista F, Juan-Shum L, Montero-Ponce, Sánchez-Valle E, Peñaflor K, Vélez-Ruelas MA, Romero-Juárez Y, Mayani H (2011) Cord 14
blood banking and transplantation at the Mexican Institute of Social Security: The first five years. Transfusion 51: 328-332
75.Fernandez-Sanchez V, Pelayo R, Flores-Guzman P, Flores-Figueroa E, Villanueva-Toledo J, Garrido E, Ruiz-Sanchez E, Alvarez-Sanchez E, Mayani H (2011) In vitro effects of stromal cells expressing different levels of Jagged-1 and Delta-1 on the growth of primitive and intermediate CD34+ cell subsets from human cord blood. Blood Cells Mol Dis 47: 205-213
76.Mayani H (2011) Umbilical Cord Blood: Lessons learned and lingering challenges after more than twenty years of basic and clinical research. Arch Med Res 42: 645-651
77.Flores-Guzman P, Fernandez-Sanchez V, Valencia-Plata I, Arriaga- Pizano L, Alarcon-Santos G, Mayani H (2012) Comparative in vitro analysis of different hematopoietic cell populations from human cord blood: in search of the best option for clinically-oriented ex vivo cell expansion. Transfusion (in press)
2. Commentaries, editorials and letters 1. Flores-Figueroa E, Mayani H (2006) Chromosomal abnormalities in marrow stromal cells from myelodysplastic syndromes (MDS). Blood 108: 3948
2. Mayani H (2007) Abnormal stromal cells in myelodysplastic syndromes: Genomics presents further evidence. Leuk Res 31: 577-578
3. Mayani H (2010) Notch signaling: From stem cell expansion to improving cord blood transplantation. Expert Rev Hematol 3: 401-404 15
3. Book chapters 1. Mayani H, Kay R, Smith C, Lansdorp PM (1995) Thy-1 mediates inhibition of human hematopoietic cell proliferation. In: Leukocyte Typing V. White Cell Differentiation Antigens. S. Schlossman et al. eds. Oxford University Press. p.968-970
2. Lansdorp PM, Rebel V, Dragowska W, Little MT, Thomas T, Humphries K, Eaves C, Mayani H (1995) Proliferative and differentiation potential of neonatal and fetal hematopoietic stem cells. In: Ontogeny of Hematopoiesis. Aplastic Anemia. E. Gluckman & L. Coulombel, eds. Colloque INSERM/John Libbey Eurotex Ltd. Vol.235, p.49-52.
3. Mayani H (2001) In vitro biology of the hematopoietic system in myelodysplastic syndromes. In: Myelodysplastic Syndromes and Secondary Acute Myelogenous Leukemia- Directions for the New Millennium. Raza A & Mundle SD, eds. Kluwer Academic Publishers, p.25-43
4. Velasco I, Mayani H (2011) Stem Cells: Basic aspects and possible therapeutic applications. In: Topics in Animal and Plant Development: From cell differentiation to morphogenesis. Chimal-Monroy J, ed. Transworld Research Network, p.163-180
5. Mayani H (2011) Human Cord Blood-derived Hematopoietic Stem and Progenitor Cells: From Biology to Medicine. In: Stem Cells and Cancer Stem Cells, volume 3. Hayat MA, ed. Springer Science+Business Media, p. 63-73
Editorial activities Member of the Editorial Board of Leukemia Research (2004 – ) Member of Faculty of 1000 Medicine (2007 - ) Member of the Editorial Board of The Open Stem Cell Journal (2008 - ) 16
Guest editor: Archives of Medical Research 2003; vol. 34, number 6. Biology and Clinical Application of Hematopoietic Stem Cells
Reviewer for: Acta Haematologica; American Journal of Hematology; Archives of Medical Research; Blood; British Journal of Haematology; Experimental Hematology; Haematologica; Leukemia Research; PLoS One; Stem Cells; Stem Cells & Development; Stem Cells Reviews & Reports.
Scientific Societies (member) American Society of Hematology (ASH) American Association for the Advancement of Science (AAAS) International Society for Cellular Therapy (ISCT) International Society for Experimental Hematology (ISEH) Mexican Academy of Sciences (AMC) Mexican Association of Aplastic Anemia (AMAA) Mexican Society of Hematology (AMEH) Mexican Group for Stem Cell Research (GMICT) 17
Grants (as Principal Investigator) 1. Project: Characterization of the hematopoietic microenvironment in human myeloid leukemia Granting agency: National Council of Science and Technology (Mexico) Year: 1995 Amount granted: US $40,000.00
2. Project: Interactions between hematopoietic progenitors and stromal elements in long-term cultures from umbilical cord blood cells Granting agency: The Third World Academy of Sciences (European Community) Year: 1996 Amount granted: US $30,000.00
3. Project: In vitro expansion of hematopoietic progenitor cells from human umbilical cord blood Granting agency: Mexican Institute of Social Security (Mexico) Year: 1998 Amount granted: US $372,000.00
4. Project: Molecular and functional characterization of distinct subpopulations of hematopoietic progenitor cells in human myeloid leukemia Granting agency: National Council of Science and Technology (Mexico) Year: 2000 Amount granted: US $100,000.00
5. Project: Human umbilical cord blood as a source of hematopoietic and non- hematopoietic cells Granting agency: National Council of Science and Technology (Mexico) Year: 2002 Amount granted: US $640,000.00 18
6. Project: Expression of cell cycle regulatory molecules in cord-blood derived hematopoietic progenitor cells Granting agency: Mexican Institute of Social Security (Mexico) Year: 2005 Amount granted: US $30,000.00
7. Project: Leukemic stem cells Granting agency: National Council of Science and Technology (Mexico) Year: 2007 Amount granted: US $681,000.00
8. Project: In vitro characterization of hematopoietic stem and progenitor cells from pediatric patients with Acute Myeloid Leukemia Granting Agency: Terry Fox Foundation (Mexico Chapter) Year: 2007 Amount granted: US $40,000.00
9. Project: Leukemic Stem Cells Granting agency: Mexican Institute of Social Security (Mexico) Year: 2009 Amount granted: US $100,000.00
10. Project: Large-scale ex vivo expansion of human hematopoietic and mesenchymal stem cells Granting agency: Mexican Institute of Social Security (Mexico) Year: 2010 Amount granted: US $300,000.00 19
Graduate Students (Tutor) 1. Name of student: Eugenia Flores-Figueroa Degree granted: Master of Science School and Date: National University of Mexico; November 15th, 2000 Project title: The hematopoietic microenvironment in Myelodysplastic Syndromes
2. Name of student: Margarita Gutierrez-Rodriguez Degree granted: Doctor of Science School and date: National Institute of Technology (Mexico); June 29th 2000 Project title: Characterization of hematopoiesis in Dexter-type long-term cultures from umbilical cord blood cells
3. Name of student: María Alejandra Huerta-Zepeda Degree granted: Doctor of Science School and date: National University of Mexico; October 9th 2000 Project title: Characterization of the hematopoietic system in patients with Lymphoma
4. Name of student: Juan José Montesinos-Montesinos Degree granted: Doctor of Science School and date: National University of Mexico; December 11th, 2003 Project title: Effect of different hematopoietic cytokines on the in vitro proliferation and expansion of hematopoietic progenitor cells from patients with Acute Myeloid Leukemia
5. Name of student: Monica Madrigal-Velazquez Degree granted: Doctor of Science School and date: National University of Mexico; December 14th, 2005 Project title: Molecular characterization of bone marrow hematopoietic progenitors from patients with Diffuse Large B-cell Lymphoma 20
6. Name of student: Eugenia Flores-Figueroa Degree granted: Doctor of Science School and date: National University of Mexico; February 20th, 2006 Project title: In vitro studies on Mesenchymal Stem Cells from patients with Myelodysplastic Syndromes
7. Name of student: Patricia Flores-Guzman Degree granted: Doctor of Science School and date: National University of Mexico; August 22nd, 2006 Project title: In vitro proliferation and expansion of hematopoietic progenitor cells from human umbilical cord blood
8. Name of student: Antonieta Chavez-Gonzalez Degree granted: Doctor of Science School and date: National University of Mexico; February 23rd, 2007 Project title: Functional characterization of hematopoietic progenitor cells from patients with chronic myeloid leukemia
9. Name of student: Elisa Dorantes-Acosta Degree granted: Master of Science School and date: National University of Mexico; May 19th, 2009 Project title: In vitro characterization of hematopoietic stem and progenitor cells from pediatric patients with Acute Myeloid Leukemia
10. Name of student: Antonio Alvarado-Moreno Degree granted: Doctor of Science School and date: National University of Mexico; May 26th, 2009 Project title: Expression of cell cycle regulatory molecules in human hematopoietic progenitor cells from umbilical cord blood and adult mobilized peripheral blood 21
11. Name of student: Veronica Fernandez Sanchez Degree granted: Doctor of Science School and date: National University of Mexico; March 2nd, 2012 Project title: In vitro effects of stromal cells expressing Jagged-1 and Delta-1 on the proliferation, expansion and differentiation of different CD34+ cell subsets from human cord blood