Rajan K. Thakkar

CURRICULUM VITAE Rajan K. Thakkar

Address 4107 Stannage Close New Albany, OH 43054

Telephone 614-580-1216 Email [email protected]

EDUCATION Undergraduate The Ohio State University, Columbus, OH BS, Biology, 2002

Medical School The Ohio State University, Columbus, OH MD, 2006

POSTGRADUATE TRAINING Internship: Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI: General Surgery, 2006-2007 Residency: Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI: General Surgery, 2008-2013 Research Fellowship: Armand D. Versaci Research Scholar in Surgical Sciences/Warren Alpert Medical School of Brown University/Rhode Island Hospital, Mentor Alfred Ayala, PhD. 2008-2010 Clinical Fellowship: Nationwide Children’s Hospital/The Ohio State University, Columbus, OH: Pediatric Surgery 2013-2015

HONORS AND AWARDS The Ohio State University Trustees Scholarship 1998- 2002 The Ohio State University Undergraduate Research Scholarship 2001 Gold Humanism Honor Society 2005 Armand D. Versaci Research Scholar In Surgical Sciences 2008 Finalist Rhode Island Hospital New Investigator Award Competition 2009 Alpha Omega Alpha Honor Society 2009 1st Place Rhode Island Committee on Trauma Basic Science Paper 2010 2nd Place Region 1 Committee on Trauma Basic Science Paper 2010 Brian Dorman Award for Best Clinical Science Research Paper 2012 Brown University Department of Surgery Outstanding Resident Physician 2013 Pediatric Critical Care and Trauma Scientist Development Program Travel Award 2014 Nationwide Children’s Hospital Resident of the Year Award 2015 Best Poster Award, American Pediatric Surgical Association Annual Meeting 2016 Golden Apple Teaching Award, Nationwide Children's Hospital 2016

PROFESSIONAL LICENSES & BOARD CERTIFICATIONS USMLE Step 1 2003 USMLE Step 2 CK and CS 2005 USMLE Step 3 2007 Rhode Island Physician limited license 2007-2013 Ohio State Medical Board Full license 2013-present American Board of Surgery General Surgery Qualifying Exam 2013 American Board of Surgery General Surgery Certifying Exam 2013 American Board of Surgery Pediatric Surgery Qualifying Exam 2015 American Board of Surgery Pediatric Surgery Certifying Exam 2016

CLINICAL CERTIFICATIONS Basic Life Support 2004 - present Advanced Cardiac Life Support 2004 - present Advanced Trauma Life Support 2006 - present Neonatal Resuscitation Program Provider 2013 - present Advanced Burn Life Support 2013 – present Pediatric Advanced Life Support 2014 - 2016

HOSPITAL APPOINTMENTS Member Department of Surgery Residency Selection Committee Rhode Island Hospital/Brown University 2009 - 2010 Member Surgical Education Committee Rhode Island Hospital/Brown University 2011 - 2013 Member Pediatric Surgery Residency Selection Committee Nationwide Children’s Hospital 2014 Associate Trauma Medical Director Nationwide Children’s Hospital 2015

2 Associate Burn Director Nationwide Children’s Hospital 2015 Assistant Professor of Clinical Surgery The Ohio State University College of Medicine 2016

MEMBERSHIP IN SOCIETIES American College of Surgeons (active Associate Fellow) 2006 - present Gold Humanism Honor Society 2006 - present Alpha Omega Alpha 2009 - present American Pediatric Surgical Association Resident Member 2014 - present American Academy of Pediatrics Resident (Candidate) Member 2014 - present American Burn Association 2015 - present Central Ohio Pediatric Society 2015 - present Pediatric Trauma Society 2015 - present

SPECIFIC TEACHING RESPONSIBILITIES

Pediatric Surgery Tutorials (PST) Vascular Anomalies October 7, 2015 Teratomas and Other Germ Cell Tumors January 27, 2016 Teratomas and Other Germ Cell Tumors August 17, 2016

Invited Lectures Pediatric Torso Trauma Presented at Critical Care Medicine Lecture Series, NCH March 22, 2016 Update on Trauma Surgery Presented at Lounge and Learn series, NCH April 1, 2016 Update on Trauma Surgery Presented at Anaesthesia Grand Rounds, NCH May 11, 2016 Chest Tube Management Presented at Pediatric Emergency Medicine Conference, NCH May 24, 2016 Pediatric Oral Board Prep Presented at Oral Board Review Conference, OSU May 25, 2016

Mentoring/Advising Training Dates Training Positions

3 Medical Students (Advising, Research Mentoring)

Research Zachary Diltz 2015 - present M1 Primary Project: Lymphocyte Depression in Trauma and Burns

Morgan Johnson 2016 - present M2 Primary Project: Chemical Burn Case Report

High School Students Tanish Gandhi 2015 Student (Interview) Student clinic shadowing June 6-August 15, 2016

Cassie Williams 2016 Student (Interview)

Residents Daniel Lodwick 2016 - present Primary Project: Lymphocyte Depression and Postoperative Abscess after Appendectomy in Children

Folasade Imeokparia 2016 – present Primary Project: Safety and Efficacy of Uninterrupted Perioperative Enteral Feeding in Pediatric Burn Patients

BOOK CHAPTERS

1. Thakkar RK and Francios Luks. Surgical Conditions Presenting During Fetal Development: Textbook of Clinical Pediatrics, Second Edition. New York: Springer, 2011. 2. Thakkar RK et al. Sepsis and the Immune Response: Essential Immunology for Surgeons. Oxford, UK, Oxford University Press, 2011. 3. Lopez J, Thakkar RK, Abantanga F. Initial Assessment and Resuscitation of the Trauma Patient. Paediatric Surgery: A Comprehensive Text for Africa. Hershey, PA: Global Help, 2016. 4. Groner J, Thakkar RK, Ogirima M. Musculoskeletal Trauma. Paediatric Surgery: A Comprehensive Text for Africa. Hershey, PA: Global Help, 2016.

PUBLICATIONS IN PEER REVIEWED JOURNALS

1. Perl M, Chung CS, Perl U, Thakkar RK, Lomas-Niera J, Ayala A. Therapeutic Accessibility of Caspase-Mediated Cell Death as a Key Pathomechanism in Indirect Acute Lung Injury. Critical Care Med. 2010 Apr; 38(4): 1179-86. doi: 10.1097/CCM.0b013e3181d4563f. 2. Heffernan DS, Thakkar RK, Monaghan SF, Ravindran R, Adams CA Jr, Kozloff MS, Gregg SC, Connolly MD, Machan JT, Cioffi WG. Normal Presenting Vital

4 Signs are Unreliable in geriatric blunt trauma victims. Journal of Trauma. 2010 Oct; 69( 4):813-20. doi: 10.1097/TA.0b013e3181f41af8. 3. Thakkar RK, Chung CS, Chen Y, Monaghan SF, Lomas-Neira J, Heffernan DS, Cioffi WG, Ayala A. Local Tissue Expression of the Cell Death Ligand, FasL, Plays a Central Role in the Development of Extra-Pulmonary Acute Lung Injury. Shock. 2011 Aug; 36(2):138-43. doi: 10.1097/SHK.0b013e31821c236d. 4. Heffernan DS, Vera R, Monaghan SF, Thakkar RK, Kozloff MS, Connolly MD, Gregg SC, Machan JT, Harrington DT, Adams CA, Cioffi WG. Impact of SocioEthnic Factors on Outcomes Following Traumatic Brain Injury. Journal of Trauma. 2011 Mar; 70(3):527-34. doi: 10.1097/TA.0b013e31820d0ed7. 5. Monaghan SF, Heffernan DS, Thakkar RK, Machan JT, Reinert SE, Connolly MD, Gregg SC, Kozloff MS, Adams CA, Cioffi WG. The Development of a Urinary Tract Infection is Associated with Increased Mortality in Trauma Patients. Journal of Trauma. 2011 Dec; 71(6):1569-74. doi: 10.1097/TA.0b013e31821e2b8f. 6. Monaghan SF, Thakkar RK, Chung CS, Xin H, Lomas-Neira J, Heffernan DS, Cioffi WG, Ayala A. Mechanisms of Indirect Acute Lung Injury: A Novel Role for the Co-Inhibitory Receptor, Programmed Death-1, (PD-1). Annals of Surgery. 2012 Jan;255(1):158-64. doi: 10.1097/SLA.0b013e31823433ca. 7. Heffernan DS, Monaghan SF, Thakkar RK, Machan JT, Cioffi WG, Ayala A. Failure to Normalize Lymphopenia Following Trauma is Associated with Increased Mortality, Independent of the Leukocytosis Pattern. Critical Care. 2012 Jan 20;16(1):R12. doi: 10.1186/cc11157. 8. Monaghan SF, Thakkar RK, Tran ML, Huang X, Cioffi WG, Ayala A, Heffernan DS. Programmed Death 1 Expression as a marker for Immune and Physiological Dysfunction in the Critically Ill Surgical Patient. Shock. 2012 Aug;38(2):117-22. doi: 10.1097/SHK.0b013e31825de6a3. 9. Thakkar RK, Steigman S, Aidlen J, Luks F. Individualized Image Improves Efficiency in Laparoscopic Surgery. Journal of Laparoendoscopic and Advanced Surgical Techniques. 2012 Dec;22(10):1010-3. doi: 10.1089/lap.2012.0050. Epub Jun 25. 10. Thakkar RK, Monaghan SF, Adams CA, Stephen AH, Connolly MD, Gregg S, Cioffi WG, Heffernan DS. Empiric Antibiotics Pending BAL Results in Patients without Pneumonia Significantly Alters the Flora but not the Resistance Profile if a Subsequent Pneumonia Develops. Journal of Surgical Research. 2013 May 15; 181(2):323-8. doi: 10.1016/j.jss.2012.07.021. Epub 2012 Jul 26. 11. Heffernan DS, Monaghan SF, Thakkar RK, Tran ML, Chung CS, Gregory SH, Cioffi WG, Ayala A. Inflammatory Mechanisms in Sepsis: Elevated invariant Natural Killer T-Cell numbers in Mouse and their Modulatory effect on Macrophage Function. Shock. 2013 Aug;40(2):122-8. doi: 10.1097/SHK.0b013e31829ca519. 12. Lomas-Neira J, Venet F, Chung CS, Thakkar RK, Heffernan DS, Ayala A. Neutrophil-Endothelial Interactions Mediate Angiopoietin-2 associated Pulmonary Endothelial Cell Dysfunction in Indirect ALI in Mice. American Journal of Respiratory Cell and Molecular Biology. 2014 Jan;50(1):193-200. doi: 10.1165/rcmb.2013-0148OC.

5 13. Mahida JB, Thakkar RK, Walker J, Shen R, Kenney BD, Prasad V, Aldrink J. Solid Pseudopapillary Neoplasm of the Pancreas in Pediatric Patients: A case report and institutional case series. Journal of Pediatric Surgery Case Reports. 2015 Feb; 3(4):149-153. 14. Raval MV, Rust L, Thakkar RK, Kurtovic K, Nwomeh BC, Besner GE, Kenney BD. Development and Implementation of an Electronic Health Record Generated Surgical Handoff and Rounding Tool. Journal of Medical Systems. 2015 Feb;39(2):8. doi: 10.1007/s10916-015-0202-x. Epub 2015 Jan 29. 15. Rajan K. Thakkar and Marc P. Michalsky. Update on Bariatric Surgery in Adolescence. Current Opinion in Pediatrics. 2015 Jun;27(3):370-6. doi: 10.1097/MOP.0000000000000223 16. Huntington TJ, Thakkar RK, Boomer LA, Groner JI, Nwomeh BC. Evolving Roles of the Surgeon in the Management of Pediatric Trauma Resuscitation. Journal of Current Surgery Reports. 2015; 3(20): 19-27. 17. Huntington TJ, Brigode W, Thakkar RK, Raval MV, Teich S. A Case of Pediatric Cecal Diverticulitis Mimicking Acute Appendicitis. International Journal of Colorectal Disease. 2016 Jan; 31(1):147-8. doi: 10.1007/s00384-015- 2171-4. Epub 2015 Mar 3. 18. Muszynski J, Thakkar RK, Hall MW. Inflammation and Innate Immune Function in Critical Illness. Current Opinion in Pediatrics. 2016 Jun; 25(3):267- 73. doi: 10.1097/MOP.0000000000000352 19. Cromeens B, Leonard J, Governale L, Kirschner R, Pearson G, Levitt M, Wood R, Thakkar RK, Islam M, McKinney J, Whitaker E, Bryant J, Adler B, Ray W, Hoehne B, Besner G. The Separation of Pygopagus Conjoined Twins with Fused Spinal Cords and Imperforate Anus. Journal of Pediatric Surgery Case Reports. Accepted 2016 June 12. 20. Johnson S, Shi J, Xiang H, Groner JI, Thakkar RK, Fabia R, Besner GE, Wheeler KK. Inter-Facility Transfer of Pediatric Burn Patients from U.S. Emergency Departments. Burns. 2016 Aug 20. Pii: S0305-4179(16)30202-9. Doi: 10.1016/j.burns.2016.06.024.[Epub ahead of print]

ABSTRACTS (PUBSLISHED IN PEER REVIEWED JOURNALS)

1. Thakkar RK, Chung CS, Chen Y, Venet F, Ayala A. Local siRNA Knock down of Fas Ligand Leads to a Decrease in Inflammation and Neutrophil Recruitment following Indirect Acute Lung Injury. Journal Am College of Surgeons. 2009; S38. 2. Heffernan DS, Thakkar RK, Ravindran R, Adams CA, Kozloff MS, Gregg S, Cioffi WG. Normal Presenting Vital Signs are Unreliable in Geriatric Blunt Trauma Victims. Journal Am College of Surgeons. 2009; S38. 3. Lomas-Neira J, Venet F, Chung CS, Thakkar RK, Ayala, A. Divergent Effects of Early Neutralization vs. Sustained Suppression of Endothelial Cell Growth Factor, Angiopoetin (Ang)-2, in Hemorrhage Priming for Acute Lung Injury (ALI) following subsequent Septic Challenge. Cytokine. 2009; 48:1-2:pp106-107.

6 4. Monaghan SF, Heffernan DS, Thakkar RK, Reinert SE, Machan JT, Gregg S, Kozloff MS, Connolly MD, Adams CA, Cioffi WG. Urinary Tract Infections Significantly Worsen Outcomes in Trauma Patients: an Analysis of 8,842 Patients. Surg. Infect. 2010; 11:208-209. 5. Heffernan DS, Monaghan SF, Thakkar RK, Machan JT, Ayala A, Cioffi WG. Failure to Normalize Lymphocyte Reduction following Trauma is Associated with Increased Mortality, Independent of Leukocyte Pattern. Surg. Infect. 2010; 11:225. 1. Thakkar RK, Monaghan SF, Heffernan DS, Adams CA, Connolly MD, Gregg S, Kozloff MS, Cioffi WG. Empiric Antibiotics Pending BAL Results in Patients without Pneumonia Significantly Alters the Flora but not the Resistance Profile if a Subsequent Pneumonia Develops. Surg. Infect. 2010; 11:225. 2. Monaghan SF, Thakkar RK, Tran M, Huang X, Cioffi WG, Ayala A, Heffernan DS. Can we find better Markers for Immune and Physiological Dysfunction in the Critically Ill? The case for PD-1. Surg. Infect. 2010; 11:239. 3. Lomas-Neira J, Thakkar RK, Monaghan SF, Carter N, Ayala A, Heffernan DS. Is Angiopoietin-2 Elevated in Trauma Patients with Extra-Pulmonary ALI/ARDS? Surg. Infect. 2010; 11:252. 4. Thakkar RK, Chen Y, Chung CS, Monaghan SF, Cioffi WG, Ayala A. Local Tissue Expression of the Cell Death Ligand, FasL, Plays a Central Role in the Development of Acute Lung Injury. J. Amer. Col. Surg. 2010; 211(3):S52. 5. Monaghan SF, Thakkar RK, Chung CS, Chen Y, Huang X, Heffernan DS, Cioffi WG, Ayala A. Lack of Programmed Cell Death Receptor (PD)-1 Leads to Improved Survival in a Murine Model of Indirect Acute Lung Injury. J. Amer. Col. Surg. 2010 211(3):S46-S47. 6. Thakkar RK, Giles S, Capello T, Fabia R. Safety and Efficacy of Uninterrupted Perioperative Enteral Feeding in Pediatric Burn Patients. J. Burn Care Research. Supplement May/June 2016; 37 (5). 7. Nagpal A, Moore-Clingenpeel M, Thakkar RK, Fabia R, Lutmer J. Over- Resuscitation Following Acute Pediatric Burn Injury and Impact on Outcomes. J. Burn Care Research. Supplement May/June 2016; 37 (5). 8. Lodwick DL, Cooper JN, Kenney B, Deans KJ, Minneci PC, Thakkar RK. Lymphocyte Depression and Postoperative Abscess After Appendectomy in Children. Journal of Pediatric Surgery, Accepted 2016 Aug 1. 9. Johnson SA., Shi J, Groner JI, Thakkar RK, Fabia R, Besner GE, Xiang H, Wheeler KK. Inter-Facility Transfer of Pediatric Burn Patients from U.S. Emergency Departments. Burns, Accepted pending revision

PUBLICATIONS IN NON - PEER REVIEWED JOURNALS

1. Rajan K Thakkar and Gail E. Besner. The Acute Abdomen. Everything Matters: In Patient Care. Spring 2014; 27(2)13-14.

REVIEWER

7 1. Journal of Pediatric Surgery 2. Journal of Pediatric Surgery Case Reports 3. Nature Scientific Reports

PRESENTATIONS (ORAL)

1. Thakkar RK. Case presentation: Thoracic Outlet Syndrome; J. Murray Beardsley Surgeon-in-Chief Pro Tempore Lectureship Rhode Island Hospital/Brown University Department of Surgery; Dr. Julie Freischlag, May 14th 2007. 2. Thakkar RK, Heffernan DS, Adams CA, Kozloff M., Majercik S, Gregg S, Harrington DT, Cioffi WG. The Super-Elderly (>80 years old) Suffer Devastating Head Injury Outcomes Following Trauma when Compared with their Elderly Counterparts (65-79 years old). 4th Annual Academic Surgical Congress, February 4th, 2009, Fort Myers, FL. 3. Thakkar RK. Local Tissue Expression of the Cell Death Ligand, FasL, Plays a Central Role in the Development of Acute Lung Injury. 7th Annual Inflammation Research Symposium, September 24th-25th, 2009, Providence, RI. 4. Thakkar RK. Local siRNA Knock Down of Fas Ligand Leads to a Decrease in Inflammation and Neutrophil Recruitment Following Indirect Acute Lung Injury, 95th Annual American College of Surgeons Clinical Congress, October 11th-15th, 2009, Chicago, IL. 5. Monaghan SF (Presenter), Heffernan DS, Thakkar RK, Ravindran R, Adams CA, Kozloff MS, Gregg S, Cioffi WG. Normal Presenting Vital Signs are Unreliable in Geriatric Blunt Trauma Victims. 95th Annual American College of Surgeons Clinical Congress, October 11-15, 2009, Chicago, IL. 6. Thakkar RK. Local Tissue Expression of the Cell Death Ligand, FasL, Plays a Central Role in the Development of Acute Lung Injury. 17th Annual Rhode Island Hospital Finalist New Investigator Award Competition, October 20th, 2009, Providence, RI. 7. Thakkar RK (Presenter), Ravindran R, Heffernan DS, Monaghan SF, Adams CA, Cioffi WG. Penetrating Trauma in the Elderly: An Expression of Despair. 5th Annual Academic Surgical Congress, February 3rd, 2010, San Antonio, TX. 8. Monaghan SF (Presenter), Tran ML, Thakkar RK, Huang X, Cioffi WG, Ayala A, Heffernan DS. The development of secondary pneumonia induces differential pulmonary expression of ‘soluble isoforms’ of the novel inhibitory receptor PD-1 and its ligand, PD-L1. 8th World Congress on Trauma, Shock, Inflammation, and Sepsis – TSIS March 9-13, 2010, Munich, Germany. 1. Monaghan SF (Presenter), Thakkar RK, Heffernan DS, Adams CA, Cioffi WG. Urinary tract infections significantly worsen outcomes in trauma patients; an analysis of 8,841 patients. 30th Annual Surgical Infection Society meeting, April 17-20. 2010, Las Vegas, NV. 2. Thakkar RK (Presenter), Monaghan SF, Heffernan DS, Adams CA, Cioffi WG. Empiric antibiotics pending BAL results in patients without pneumonia significantly alters the flora but not the resistance profile if a subsequent

8 pneumonia develops. 30th Annual Surgical Infection Society meeting, April 17- 20. 2010, Las Vegas, NV. 3. Heffernan DS (Presenter), Monaghan SF, Thakkar RK, Adams CA, Cioffi WG. Failure to normalize lymphocyte reduction following trauma is associated with increased mortality, independent of the leukocytosis pattern. 30th Annual Surgical Infection Society meeting, April 17-20. 2010, Las Vegas, NV. 4. Monaghan S (Presenter), Thakkar RK, Chung CS, Chen Y, Huang X, Heffernan DS, Cioffi WG, Ayala A. Novel Regulatory Mechanisms of Indirect Acute Lung Injury: The Contribution of Programmed Death Receptor (PD)-1. 8th Annual Advances in Inflammation Research Symposium, Providence, RI, September 16, 2010. 5. Thakkar RK (Presenter), Chen Y, Chung CS, Monaghan SF, Cioffi WG, Ayala A. Local Tissue Expression of the Cell Death Ligand, FasL, Plays a Central Role in the Development of Acute Lung Injury. 96th Annual American College of Surgeons Clinical Congress, Washington, DC, October 6, 2010. 6. Monaghan S (Presenter), Thakkar RK, Chung CS, Chen Y, Huang X, Heffernan DS, Cioffi WG, Ayala A. Lack of Programmed Cell Death Receptor (PD)-1 leads to improved survival in a murine model of indirect acute lung injury. 96th Annual American College of Surgeons Clinical Congress, Washington, DC, October 7, 2010. 7. Thakkar RK (Presenter), Monaghan SF, Tran ML, Chung CS, Cioffi WG, Ayala A, Heffernan DS. Both CD3+ and GammaDelta T Lymphocytes are Reduced in SIRS following Trauma, but Show Different Rates of Recovery with Physiologic Resolution. Region One Finalist Resident Trauma Papers ACS Committee on Trauma, Boston, MA, November 8th 2010. 8. Thakkar RK. Case presentation: Carcinoid Syndrome; Henry Thomas Randall Distinguished Lectureship in Surgical Sciences Rhode Island Hospital/Brown University Department of Surgery; Dr. Christopher Ellison; April 15th 2011. 9. Thakkar RK., Steigman S., Aidlen J., Luks F (Presenter). L’individualisation de l’image augmente l’efficacité en coelioscopie. 20th Annual Meeting of the Groupe d'Etude de Coelioscopie Infantile; Tours, France, October 2011. 10. Thakkar RK., (Presenter), Steigman S., Aidlen J., Luks F. Individualized Image Improves Efficiency in Laparoscopic Surgery. 21st Annual Congress for Endosurgery in Children; San Diego, CA, March 8th 2012. 11. Thakkar RK. (Presenter) Case presentation: Sinistral Portal Hypertension; The DeLuca Lectureship. Rhode Island Hospital/Brown University Department of Surgery; Dr. Jay Wilson, October 16th 2012. 12. Thakkar RK. (Presenter) Extracorporeal Membrane Oxygenation: Past, Present, Future. Surgical Grand Rounds. Rhode Island Hospital/Brown University Department of Surgery: February 26th 2013. 13. Thakkar RK., (Presenter), Steigman S., Aidlen J., Luks F. Individualized Image Improves Efficiency in Laparoscopic Surgery. William Clatworthy Nationwide Children’s Hospital Visiting Professor; Dr. George Holcomb. September 9th 2013. 14. Raval MV (Presenter), Rust L, Thakkar RK, Kurtovic K, Nwomeh BC, Besner GE, Kenney BD. Development and Implementation of an Electronic Health

9 Record Generated Surgical Handoff and Rounding Tool. American Academy of Pediatrics, October 11th, 2014, San Diego, CA. 15. Lane VA (Presenter), Wood RJ, Thakkar RK, Deans KJ, Minneci PC, Levitt MA. Rectal atresia- Video presentation. American Pediatric Surgical Association, May 2, 2015, Ft. Lauderdale, FL. 16. Johnson S, Shi J, Xiang H, Groner J, Thakkar RK, Fabia R, Besner G, Wheeler KK. Factors Associated with Inter-Facility Transfer of Pediatric Burn Patients in U.S. Emergency Departments. 2015 Pediatric Trauma Society, November 6th, 2015, Scottsdale, AZ. 17. Lodwick DL, Cooper JN, Deans KJ, Minneci PC, Thakkar RK. Lymphopenia and Postoperative Abscess after Appendectomy in Children. Columbus Surgical Association, February 27th, 2016, Columbus, OH. 18. Wurster LA, Thakkar RK, Groner J. Improving Compliance with the ATLS Primary Assessment. Central Ohio Trauma Research Symposium, May 10th, 2016, Columbus, OH. 19. Talbot L, Fabia R, Groner J, Kenney B, Thakkar RK. Fever Trends and Efficacy of Early Broad Spectrum Antibiotic Therapy in Treatment of Pediatric Severe Burn Patients. Central Ohio Trauma Research Symposium, May 10th, 2016, Columbus, OH. 20. Fabia R, Thakkar RK, Giles S, Sales S. Non-Government Organizations Providing Burn-Related Education and Treatment in Developing Countries. International Society for Burn Injuries 2016 Congress, August 29th, 2016, Miami, FL. 21. Talbot L, Fabia R, Groner J, Thakkar RK, Kenney B. Early Fluid Overresuscitation Patterns in Severe Pediatric Burn Injuries and Influence on Outcomes. 75th Annual Meeting of The American Association for the Surgery of Trauma, September 14-17, 2016, Waikoloa, HI. 22. VerLee S, Buchanan L, Giles S, Groner J, Thakkar RK, Fabia R. Perceived Stress Response in Caregivers Following Pediatric Burn Injury. 44th Annual Eastern Great Lakes Conference, September 30, 2016, Akron, OH. 23. Wurster LA, Groner J, Thakkar RK. Standardizing the Initial Resuscitation of the Trauma Patient with the Primary Assessment Completion Tool (PACT) Using Video Review. 3rd Annual Meeting of the Pediatric Trauma Society, November 11, 2016, Nashville, TN. 24. Naik-Mathuria B, Rosenfeld E, Russell R, Maizlin I, Vogel A, Escobar M, Falcone R, Moody S, Juang D, St Peter S, Mooney D, Bendure L, Thakkar RK, Groner J, Klingner D, Polities S, Gosain A, Chotai P, Fenton S, Stevens A, Beaudin M, Carmant L, Chotai P, Gaines B, Papandria D. Non-Operative Management of High-Grade Pediatric Pancreatic Injuries: Contemporary Trends. 3rd Annual Meeting of the Pediatric Trauma Society, November 11, 2016, Nashville, TN. 25. Lopez J, Kelley-Quon L, Kerlek A, Luken M, McCracken K, Thakkar RK, Nwomeh B. Pediatric Perineal Trauma: A Ten-Year Retrospective Review. 12th Annual Academic Surgical Congress, February 8, 2017, Las Vegas, NV. 26. Diltz Z, Devine R, Wheeler K, Shi J, Xiang H, Fabia R, Hall MW, Thakkar RK. Late Relative Lymphopenia is Associated with an Increased Infection Rate in

10 Pediatric Burn Patients. 12th Annual Academic Surgical Congress, February 8, 2017, Las Vegas, NV.

PRESENTATIONS (POSTER)

1. Thakkar RK (Presenter), Lomas-Neira J, Venet F, Chen Y, Chung CS, Ayala A. The Comparative Contribution of Epithelial vs. Endothelial Fas/FasL Expression to the Onset of Extra-Pulmonary Acute Lung Injury from Sequential Hemorrhagic Shock and Sepsis. Lifespan/Rhode Island Hospital 16th Annual Research Celebration. September 20th, 2008, Providence, RI. 2. Heffernan DS (Presenter), Thakkar RK, Kozloff M, Gregg S, Adams CA, Cioffi WG. UTI in Elderly Trauma Patients: An Under Appreciated Risk for Trauma. Surgical Infection Societies of North America and Europe 3rd Combined Meeting, May 6-9, 2009, Chicago, IL. 3. Thakkar RK (Presenter), Chung CS, Chen Y, Venet F, Cioffi WG, Ayala A. Local Tissue Expression of the Cell Death Ligand, FasL, Plays a Central Role in the Development of Acute Lung Injury. Lifespan/Rhode Island Hospital 17th Annual Research Celebration. October 22nd 2009, Providence, RI. 4. Monaghan SF (Presenter), Heffernan DS, Thakkar RK, Ayala A. Is there a role for PD-1 Signaling in the Development of Indirect Lung Injury? Early Experience with a Mouse Model. Lifespan/Rhode Island Hospital 17th Annual Research Celebration. October 22nd 2009, Providence, RI. 5. Monaghan SF (Presenter), Tran ML, Thakkar RK, Huang X, Cioffi WG, Ayala A, Heffernan DS. The Development of Secondary Pneumonia Induces Differential Pulmonary Expression of ‘soluble isoforms’ of the Novel Inhibitory Receptor PD-1 and its Ligand, PD-L1. 8th World Congress on Trauma, Shock, Inflammation, and Sepsis – TSIS 2010, March 9-13, 2010, Munich, Germany. 6. Monaghan SF (Presenter), Thakkar RK, Tran ML, Huang X, Cioffi WG, Ayala A, Heffernan DS. Can we find better markers for Immune and Physiological Dysfunction in the Critically Ill? The case for PD-1. 30th Annual Surgical Infection Society meeting, April 17-20. 2010, Las Vegas, NV. 7. Lomas-Neira J (Presenter), Thakkar RK, Monaghan SF, Carter N, Ayala A, Heffernan DS. Is Angiopoietin-2 Elevated in Trauma Patients with Extra- Pulmonary ALI/ARDS? Presented at the 30th annual meeting of the Surgical Infection Society, April 17-20. 2010, Las Vegas, NV. 8. Kochar A (Presenter), Heffernan DS, Thakkar RK, Monaghan SF, Connolly MD, Kozloff MS, Gregg SC, Adams CA, Cioffi WG. Cumulative One Year Radiation Exposure in Geriatric Trauma Population. 69th Annual Meeting of the American Association for the Surgery of Trauma, September 22-25, 2010, Boston, MA 9. Thakkar RK (Presenter), Duron V, Blake B, Tucker C, Deviine J, Dannecker M, Muratore C. ECMO Simulation: A Pilot Project to Enhance Team Performance and Patient Outcomes. Lifespan/Rhode Island Hospital 19th Annual Research Celebration. October 27th, 2011, Providence, RI.

11 10. Raval MV (Presenter), Rust L, Thakkar RK, Kurtovic K, Nwomeh BC, Besner GE, Kenney BD. Development and Implementation of an Electronic Health Record Generated Surgical Handoff and Rounding Tool. Annual Meeting American Academy of Pediatrics. October 11th, 2014, San Diego, CA. 11. Lodwick DL, Cooper JN, Deans KJ, Minneci PC, Thakkar RK. Lymphocyte Depression as a Predictor of Postoperative Abscess after Appendectomy in Children. Columbus Surgical Society Meeting, February 27, 2016, Columbus, OH. 12. Thakkar RK, Giles S, Capello T, Fabia R. Safety and Efficacy of Uninterrupted Perioperative Enteral Feeding in Pediatric Burn Patients. American Burn Association Annual Meeting May 3-6, 2016, Las Vegas, NV. 13. Nagpal A, Moore-Clingenpeel M, Thakkar RK, Fabia R, Lutmer J. Over- Resuscitation Following Acute Pediatric Burn Injury and Impact on Outcomes. American Burn Association Annual Meeting May 3-6, 2016, Las Vegas, NV. 14. Talbot L, Fabia R, Kenney B, Groner J, Thakkar RK. Outcomes and Infectious Complications Associated with the use of 5% Albumin as a Resuscitative Fluid in Pediatric Severe Burn Patients. Central Ohio Trauma Research Symposium, May 10th, 2016, Columbus, OH. 15. Lodwick DL, Cooper JN, Deans KJ, Minneci PC, Thakkar RK. Lymphocyte Depression as a Predictor of Postoperative Abscess after Appendectomy in Children. 47th Annual Meeting of the American Pediatric Surgical Association. May 15-17, 2016, San Diego, CA. 16. Talbot LJ, Fabia R, Kenney B, Groner J, Thakkar RK. Association of Early Resuscitation with 5% Albumin Solution and Late Infectious Complications in Pediatric Severe Burn Patients. 75th Annual Meeting of The American Association for the Surgery of Trauma, September 14-17, 2016, Waikoloa, HI. 17. Talbot LJ, Fabia R, Groner J, Kenney B, Thakkar RK. Fever Trends and Utility of Early Broad Spectrum Antibiotic Therapy in Pediatric Severe Burn Patients. 75th Annual Meeting of The American Association for the Surgery of Trauma, September 14-17, 2016, Waikoloa, HI. 18. Kroczek K, Thakkar RK, Fabia R. Large Pediatric Burns, “Hot Topics” 2016. International Congress of Polish Society of Paediatric Surgeons, September 15- 17, 2016, Wroctaw, Poland. 19. Johnson M, Thakkar RK, Diefenbach K, Kenney B, Hogan M, Fabia R. Simultaneous Internal and External Chemical Injury in a Child. 44th Annual Eastern Great Lakes Conference, September 30, 2016, Akron, OH. 20. Wheeler K, Shi J, Xiang H, Thakkar RK, Groner J. Pediatric Trauma and Burn Patient Unplanned 30 Day Readmissions. 3rd Annual Meeting of the Pediatric Trauma Society, November 11, 2016, Nashville, TN. 21. Devine R, Hensley J, Popelka J, Steele L, Cihla J, Fabia R, Hall M, Thakkar RK. Systemic and Local Immune Function Following Pediatric Thermal Injury. 2016 Nationwide Children’s Hospital Research Institute Research Retreat, November 17, 2016, Columbus, OH.

12 OUTSIDE INVITED EVENTS

1. Eastern Great Lakes Burn Study Group 43rd Annual Conference, Columbus, Ohio Moderator, “Rehabilitation and Outpatient Care”. October 23, 2015. 2. Central Ohio Trauma System 2016 Trauma Research Symposium, Columbus, Ohio Judging Panel. May 10, 2016. 3. The Ohio State University 2016 Medical Student Summer Research Symposium, Columbus, Ohio Poster Judging Panel. October 31, 2016.

GRANTS

1. Rhode Island Foundation Grant #20113467; Interactive Multi-User Display System for Laparoscopic Surgery; Collaborator; $15,000 in direct costs – 2012- 2013. 2. NIH-LRP Grant submitted 11/2015 3. P50 (NIH) Grant submitted 1/25/2016 4. NHLBI-R34 TXA Grant; Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children (TIC-TOC); Site PI submitted 3/2016

QUALITY IMPROMVENT PROJECTS

1. Abdominal CT Protocol for Blunt Abdominal Trauma Level 2 Injuries Participant; PI Carla Coffey Nationwide Children’s Hospital 2. ATLS Primary Assessment Scoring Tool Participant, PI Lee Ann Wurster Nationwide Children’s Hospital 3. Management of Solid Organ Injury after Blunt Trauma PI, Rajan Thakkar Nationwide Children’s Hospital 4. Burn Fluid Resuscitation in the PICU Participant, PI Asish Nagphal Nationwide Children’s Hospital 5. Burn Fluid Resuscitation in the ER Participant, PI Lindsay Talbot Nationwide Children’s Hospital

ACTIVE RESEARCH PROTOCOLS

1. Lymphocyte Depression as a Predictor of Complications after Appendectomy for Complicated Appendicitis

13 PI Rajan Thakkar; Study Coordinator Daniel Lodwick IRB# IRB15-00217 2. Immunological Response to Burn Injury PI – Rajan Thakkar IRB#IRB15-00995 Internal Start up Funds 3. Does the Normalization of Immune Response Predict Outcomes in Pediatric Trauma PI – Rajan Thakkar IRB#IRB15-01017 4. Does the Normalization of Immune Response Predict Outcomes in Pediatric Burn Injury PI – Rajan Thakkar IRB#IRB15-01018 5. Active and Passive Virtual Reality Distraction for Pain Management during Pediatric Burn Dressing Changes PI – Rajan Thakkar IRB#IRB16-00444

ABSTRACTS SUBMITTED FOR CONFERENCES

1. Wheeler KK, Shi J, Xiang H, Nordin AB, Groner JI, Fabia R, Thakkar RK. Unplanned 30 Day Readmission Rates in Acutely Injured Pediatric Burn Patients. Submitted for American Burn Association 49th Annual Meeting, March 21-24, 2017, Boston, MA. 2. McCulloh CJ, Nordin A, Talbot L J, Fabia R, Thakkar RK. Accuracy of Pre- Hospital Care Providers in Determining Total Body Surfact Area Burned in Severe Pediatric Thermal Injury. Submitted for American Burn Association 49th Annual Meeting, March 21-24, 2017, Boston, MA. 3. Pennesi C, Thakkar RK, Kenney B, Ching C, Hewitt G, McCracken K. Preoperative Assessment Underestimates Complexity of Surgical Intervention Required for Successful Removal of Vaginal Foreign Object in a Patient Presenting with Prolonged Vaginal Bleeding. Submitted for 31st Annual Clinical & Research Meeting of the North American Society for Pediatric and Adolescent Gynecology, April 20-22, 2017, Chicago, IL. 4. Rosenfeld E, Klinkner D, Polites S, Escobar M, Pattyn A, Gaines B, Leeper C, Gosain A, Veras L, Russell R, Maizlin I, Campbell B, Thaker S, Wills H, Smith A, Stallion A, Waddell M, Peter S, Juang D, Thakkar RK, Drews J, Vogel A, Naik-Mathuria B. The Utility of ERCP in High-Grade Pediatric Pancreatic Trauma. Submitted for American Pediatric Surgical Association 17th Annual Meeting, May 4-7, 2017, Hollywood, FL. 5. Rosenfeld EH, Klinkner DB, Polites S, Escobar M, Pattyn A, Gaines B. Leeper C, Gosain A, Veras LV, Russell R, Maizlin I, Campbell B, Thaker S, Wills H, Smith A, Stallion A, Waddell M, St. Peter S, Juang D, Thakkar RK, Drews J, Vogel A, Naik-Mathuria BJ. Management and Outcomes of Pseudocysts Following Non-

14 Operative Management of Pancreatic Trauma in Children. Submitted for American Pediatric Surgical Association 17th Annual Meeting, May 4-7, 2017, Hollywood, FL.

4／6／2018