Report to the NMU Academic Senate

REPORT TO THE NMU ACADEMIC SENATE from The Committee on Undergraduate Programs Chair: Lesley Putman First Reading: October 25, 2016

TABLE OF CONTENTS

1. Department of Biology (page 1-3) A. Course Changes 1. Change prerequisites for BI 218, BI 327, BI 406 and BI 418

2. Department of Chemistry (pages 3-7)

A. New Program 1. Medicinal Plant Chemistry Major

B. New Courses 1. CH 189, 289, 389 2. CH 420, CH 421

1. DEPARTMENT OF BIOLOGY

A. COURSE CHANGES: Change prerequisites for 4 courses.

PROPOSED BULLETIN COPY: BI 218 Introduction to Cell and Molecular Biology 4 cr. (3-0-3) Offered: Fall, Winter Prerequisites: BI 111 and either CH 107/108 or CH 111/112 or CH 111 and concurrent enrollment in CH 112 Introduction to the structure and function of prokaryotic and eukaryotic cells and the genes and the technologies used to study them. Laboratory work will include experiments using DNA, proteins and other biomolecules.

RATIONALE: Given the content covered in CH 111, students have sufficient background to begin understanding key concepts in Introduction to Cell and Molecular Biology. Taking CH 112 concurrently with BI 218 offers students the opportunity to simultaneously gain chemistry knowledge that will support their studies in Introduction to Cell and Molecular Biology.

CUP Report to the Senate October 25, 2016 Page 1 of 7 PROPOSED BULLETIN COPY: BI 327 Animal Physiology: 4 cr. (3-0-3) Offered: Fall Prerequisite: BI 111, BI 112 and CH 220 or CH 321. This course focuses on the physiological systems of invertebrates and vertebrates. The comparative method will be used to identify general physiological principles. The subject matter includes metabolism, respiration, circulation, temperature effects, water and solute regulation, and muscle and nerve physiology.

RATIONALE: Students are introduced to fundamental concepts about the chemistry of life in BI 111. The background provided in this course is sufficient for students to understand the physiological concepts in BI 327.

PROPOSED BULLETIN COPY: BI 406 Advanced Cell Biology 4 cr. (3-0-3) Offered: Winter Prerequisite: BI 111 and either BI 218 or CH 450, and CH 220 or CH 321, junior standing or instructor's permission. Structure and function of eukaryotic cells and organelles, with comparisons to selected features of prokaryotic cells. Topics include methods of study, compartmentalization of cells, cellular energetics, cell signaling, cytoskeletal proteins and the cell cycle. Laboratory work includes microscopy, tissue culture and isolation of cellular components.

RATIONALE: Students are introduced to fundamental concepts about the chemistry of life in BI 111, and these concepts are explored in more detail in BI 218. The level of organic chemistry covered in these courses is sufficient for students in BI 406. Students who enroll in BI 406 using CH 450 as a prerequisite will have completed and have a much greater knowledge of cellular chemistry; this course provides more than enough background for BI 406.

PROPOSED BULLETIN COPY: BI 418 Molecular Biology 4 cr. (2-0-4) Offered: Fall

2 Prerequisite: BI 312 (or BI 206 with instructor's permission) and CH 220 or CH 322, and credit or enrollment in CH 450, junior standing or instructor's permission. BI 218, and credit or enrollment in CH450, junior standing or instructor’s permission. Prokaryotic and eukaryotic gene structure and expression. Laboratories explore some of the techniques used for manipulating genes in vitro, including DNA isolation, DNA electrophoresis, subcloning and work with the bacteriophage. This course covers some of the theory and applications of biotechnology.

RATIONALE: 1.) BI 206 is no longer offered and therefore is being deleted from the prerequisite choices. 2.) When BI 418 was first offered, BI 312 was listed as a prerequisite so that students would have an introduction to topics of molecular genetics including DNA replication, RNA synthesis, and protein synthesis. Those topics are now covered in BI 218, Introduction to Cell and Molecular Biology

COSTS: There are no costs associated with any of these prerequisite changes.

2. Department of Chemistry

A. New Program

PROPOSED BULLETIN COPY: Medicinal Plant Chemistry Total Credits Required for Degree 120

Required Courses in Major 89-91

Chemistry CH 111 General Chemistry I 5 CH 112 General Chemistry II 5 CH 242 Quantitative Analysis 2 CH 315 Organic Chemistry I 3 CH 317 Organic Chemistry I Laboratory 1 CH 325 Organic Chemistry II 3 CH 327 Organic Chemistry II Laboratory 1 CH 435 Gas and Liquid Chromatography 2 CH 450 Biochemistry I 4 *CH 189 Medicinal Plant Chemistry Seminar I 1 *CH 289 Medicinal Plant Chemistry Seminar II 1 *CH 389 Medicinal Plant Chemistry Seminar III 1 *CH 420 Medicinal Plant Chemistry I 5 *CH 421 Medicinal Plant Chemistry II 5

CUP Report to the Senate October 25, 2016 Page 3 of 7 Biology BI 111 Introductory Biology: Principles 4 BI 112 Introductory Biology: Diversity 4 BI 230 Plant Kingdom 4 BI 431 Plant Physiology 4

Mathematics MA 171 Intro to Probability and Statistics 4

EEGS GC 100 Physical Geography 4 GC 202 Soils 4

Entrepreneurial Track 24 ACT 230 Principles of Accounting I 4 ACT 240 Principles of Accounting II 4 MGT 215 Entrepreneurship 4 FIN 351 Financial Management I 4 FIN 413 New Venture Finance: Capital Formation and Legal Issues 4 MKT 230 Introduction to Marketing or 4 MKT 310 Marketing for Entrepreneurship

Bio-analytical Track 22-23 CH 215 Chemistry of the Elements 4 CH 241 Chemical Equilibrium 3 CH 437 Atomic Spectrometry 1 BI 218 Intro to Cell and Molecular Biology 4 BI 312 Genetics 4 BI 412 Biostatistics 4 BI 433 Boreal Flora 2-3

* New courses

RATIONALE: The field of natural products chemistry, which involves the identification, isolation, and sometimes total synthesis of compounds biochemically produced in existing biota, has a long history of beneficial contributions to the field of medicine. Many pharmaceutical drugs originate from plant secondary metabolite compounds. There is currently a renewed and enthusiastic interest in medicinal plant chemistry as it relates to the herbal extract market and more recently to the emerging cannabis market. With increasing legitimacy and legality of medicinal plants nationwide, there is great demand for qualified technical personnel and great opportunity for the skilled entrepreneur.

Although there is a surge in businesses related to the marijuana economy, there is a major gap in educational opportunities available to prepare people to work in this field. There is graduate level research being done at universities such as the Native Medicinal Plants Program at the University of Kansas, the Center for Medicinal Cannabis Research at the University of California, San Diego, and the Humboldt Institute for Interdisciplinary Marijuana Research at Humboldt State University. There are also non-accredited, non-degree programs such as the successful Med Grow Cannabis College in Southfield Michigan and the traveling Oaksterdam University.

4 Additionally, there are some accredited universities that offer relevant course work on the subject such as the Medicinal Plant Program at the University of Massachusetts - Amherst, or a course specifically devoted to Marijuana Law at the University of Denver. However, there is currently no 4-year undergraduate program offered in the United States dedicated to this topic. Medicinal Plant Chemistry at NMU uniquely fills this gap and is simultaneously innovative and inevitable. NMU is in a position to create a flagship and model for other universities to follow, while simultaneously attracting the attention of prospective students from all states

This program will attract many new students to NMU, including a significant number of out-of- state and non-traditional students, the vast majority of whom will be drawn from a pool of prospective students otherwise minimally engaged in current recruiting efforts. This program will therefore boost enrollment without competing with existing programs for students already interested in NMU.

As noted, the focus of the Medicinal Plant Chemistry program will not be exclusive to cannabis. The broader field of natural products chemistry, as well as specific industries, such as herbal supplements and food chemistry, will also be addressed and could provide additional points for marketing. For example, interest in beer and brewing is and will continue to be strong in our state. The Medicinal Plant Chemistry program could provide a unique alternative to those prospective students interested in the fermentation programs at Central, Ferris, or Western, but who desire a stronger scientific foundation.

* Note: No illegal substances will be used in this program. There are plenty of legal medicinal plants that students can use in learning the techniques for extraction and analysis of plant compounds.

COSTS: This program absolutely requires an analytical instrument: an LC-MS (Liquid Chromatograph- Mass Spectrometer). The immense variety of molecular structures and properties found within the secondary metabolite class of natural products dictates an instrument with broad and robust analytical capabilities. The standard for such analysis is liquid chromatography-mass spectrometry.

This program was approved for Program Innovation Funds: LC-MS instrument $150,000 (one-time cost) adjunct/contingent faculty (0.25 FTE) $7,160 (Year 1) adjunct/contingent faculty (0.6 FTE) $16,380 (Year 2) $173,540 two-year evaluation period total

In addition, EEGS and Biology expressed concern about additional staffing for the courses that this program requires: GC 202, BI 230 and BI 431. We anticipate additional costs to support the courses required by this program as it becomes established.

B. New Courses 1. CH 189, 289, 389 2. CH 420, CH 421

PROPOSED BULLETIN COPY:

CUP Report to the Senate October 25, 2016 Page 5 of 7 CH 189 Medicinal Plant Chemistry Seminar I 1cr. (1-0-0) Offered: Winter Prerequisites: CH 111 (or concurrent enrollment) or instructor permisssion Seminar course involving discussion of articles related to Medicinal Plant Chemistry and presentations by peers and invited guests. This will be taken by students in their first year of the Medicinal Plant Chemistry program.

CH 289 Medicinal Plant Chemistry Seminar II 1 cr. (1-0-0) Offered: Winter Prerequisites: CH 189 or instructor permission Seminar course involving discussion of articles related to Medicinal Plant Chemistry and presentations by peers and invited guests. This will be taken by students in their second year of the Medicinal Plant Chemistry program.

CH 389 Medicinal Plant Chemistry Seminar III 1 cr. (1-0-0) Offered: Winter Prerequisites: CH 289 or instructor permission Seminar course involving discussion of articles related to Medicinal Plant Chemistry and presentations by peers and invited guests. This will be taken by students in their third year of the Medicinal Plant Chemistry program.

RATIONALE: These courses are meant to help students develop a cohort as they go through the Medicinal Plant Chemistry program. All students enrolled in CH 189, 289 and 389 will meet at the same time, in the same place. This will provide cohesion for the program as new students in the program will be able to interact with those who are in their second and third years of the program. Students in their second and third years will be able to mentor those who are just beginning. This structured mentoring system has the benefit of helping with retention of students and with successful completion of their degree.

PROPOSED BULLETIN COPY: CH 420 Medicinal Plant Chemistry I 5 cr. (3-0-6) Offered: Fall Prerequisites: BI 230, CH 389 and CH 435 (or concurrent enrollment in CH 435), or instructor permission. Structure and chemical properties of plant secondary metabolites, including alkaloids, terpenoids and flavonoids. Students will plan their research projects and will begin cultivation of the plants they will use. They will also learn about methods of extraction, analysis of plant secondary metabolites and principles of good laboratory practice (glp).

CH 421 Medicinal Plant Chemistry II 5 cr. (3-0-6) Offered: Winter Prerequisite: CH 420 Medicinal properties of plant secondary metabolites, including alkaloids, terpenoids and flavonoids. In the laboratory students will extract medicinal compounds from plants, analyze

6 them using various instrumental and chemical methods in order to complete their proposed project and present it to their peers.

RATIONALE: These are the capstone courses for the Medicinal Plant Chemistry program. Students will gain experience in planning a research project, carrying out the experimentation and analyzing and identifying compounds using instrumental methods including LC-MS. They will also gain experience in presenting their research to their peers. All of these skills will be beneficial for students in preparing them for a career in medicinal chemistry, analytical chemistry or going on to graduate school. The presentations given by these CH 421 students will be attended by the students in CH 189, 289 and 389 so they will benefit from hearing about projects done by other students in their program. This will hopefully give them ideas for projects they may want to do.

COSTS: See costs for program above.

CUP Report to the Senate October 25, 2016 Page 7 of 7