Comparison of Biochemical Parameters Among the Genotype Groups of the Snp Studied in Phpt

COMPARISON OF BIOCHEMICAL PARAMETERS AMONG THE GENOTYPE GROUPS OF THE SNP STUDIED IN PHPT SUBJECTS

Comparison of biochemical parameters among the three genotypes of OPG 163 A/G rs3102735 in PHPT patients

OPG 163 A/G rs3102735 Median and range p A 10.7 (8.7-13.5) A Total calcium (mg/dL) 0.041 (+) A 11.0 (8.5-14.5) G G 10.5 (9-13) G A 1.50 (1.21-2.7) A Ionized calcium (mM) 0.198 A 1.50 (1.20- G 1.96) G 1.40 (1.31-1.51) G A 17 (3-93) A 25-OH-Vitamin D (ng/mL) 0.252 A 18 (4-47) G G 15 (8-24) G A 80 (20-373) A Alkaline Phosphatase 0.723

(U/L) A 87 (45-302) G G 88 (46-191) G A 4.8 (0.01-12.4) A Serum OPG (pmol/L) 0.735 A 4.9 (2.01-10.00) G G 3.9 (2.39-5.6) G A 55 (11-255) A P1NP (µg/L) 0.826 A 53 (16-140) G G 63 (17-155) G A 0.829 (0.044-2.853) A β Crosslaps (ng/mL) 0.506 A 0.762 (0.192-2.182) G G 1.041 (0.333-3.208) G A 32 (5-79) A Bone Alkaline 0.081 Phosphatase (U/L) A 33 (12-84) G G 49 (19-85) G A 31 (7-126) A <0.001 Osteocalcin (ng/mL) AG-GG A 29 (7-67) <0.001 G AA-GG G 79 (19-175) <0.001 G

Comparison of biochemical parameters among the three genotypes of OPG 245 T/G rs3134070 in PHPT patients

OPG 245 T/G rs3134070 Median and range p TT 10.7 (8.7-13.5) 0.011 Total calcium (mg/dL) T 10.9 (8.5-14.5) GG-TT= G 0.012 G 12.9 (11.7-13) GG-TG= G 0.032 TT 17.0 (3-93) 25-OH-Vitamin D T 17.5 (6.6-39.7) 0.702 (ng/mL) G G 14.5 (12.0-17.0) G TT 1.47 (1.21-2.07) Ionized calcium (mM) T 1.51 (1.20-1.96) 0.565 G G 1.51 G TT 81 (20-373) Alkaline Phosphatase T 89 (55-156) 0.301 (U/L) G G 122,5 (54-191) G TT 4.8 (0.01-12.42) Serum OPG (pmol/L) T 5.1 (3.72-9.2) 0.957 G G 4.8 (4.00-5.6) G TT 54 (11-255) P1NP (µg/L) T 62 (18-110) 0.204 G G 91 (27-155) G TT 0.816 (0.44-2.853) 0.033 β Crosslaps (ng/mL) T 0.726 (0.192- GG-TT= G 1.342) 0.035 G 1.77 (0.333-3.208) GG-TG = G 0.029 TT 33 (5-84) Bone Alkaline Phosphatase T 35 (12-63) 0.196 (U/L) G G 52 (19-85) G TT 30.5 (7-126) <0.001 Osteocalcin (ng/mL) T 30.6 (7.2-67) GG-TT<0.001 G GG-TG<0.001 G 175 G

Comparison of biochemical parameters among the three genotypes of OPG 1181 G/C rs2073618 in PHPT patients

OPG 1181 G/C rs2073618 Median and range p

GG 10.9 (9.1-14.5) Total calcium (mg/dL) GC 10.7 (8.5-13) 0.438 CC 10.8 (9-13) GG 17 (3-50) 25-OH-Vitamin D (ng/mL) GC 17 (4-93) 0.892 CC 17 (3-55) GG 1.47 (1.20-1.96) Ionized calcium (mM) GC 1.47 (1,25-1.79) 0.254 CC 1.48 (1.21-2.07) GG 83 (21-191) Alkaline Phosphatase (U/L) GC 87 (20-373) 0.162 CC 73 (29-302) GG 5.0 (0.01-11.53) Serum OPG (pmol/L) GC 4.7 (1.21-10) 0.566 CC 4.7 (2.1-12.42) GG 63 (21-155) P1NP (µg/L) GC 52 (18-255) 0.518 CC 51 (11-142) GG 0.977 (0.210-3.208) β Crosslaps (ng/mL) GC 0.777 (0.192-2.500) 0.044 CC 0.747 (0.044-3.208) GG 39 (12-85) 0.016 Bone Alkaline Phosphatase (U/L) GC 31 (5-84) GG-GC=0.01 GG-CC=0.018 CC 31 (12-72) GG 39 (9-175) 0.009 Osteocalcin (ng/mL) GC 27 (7-62) GG-GC=0.004 CC 30 (7-80) Comparison of biochemical parameters among the three genotypes of RANKL rs2277438 in PHPT patients

RANKL rs2277438 Median and range p A 10.8 (9-14.5) Total calcium (mg/dL) A 0.339 A 10.6 (8.5-11.8) G G 10.5 (10-10.9) G A 17 (3-93) 25-OH-Vitamin D (ng/mL) A 0.594 A 17 (4-55) G G 15 (12-21) G A 1.47 (1.20-2.07) Ionized calcium (mM) A 0.351 A 1.44 (1.20-1.74) G G 1.48 (1.37-1.57) G A 82 (20-373) Alkaline Phosphatase A 0.956 (U/L) A 82 (21-339) G G 76 (45-111) G A 4.85 (0.01-11.44) Serum OPG (pmol/L) A 0.411 A 4.77 (1.21-12.42) G G 5.63 (4.3-7.5) G A 53 (11-192) P1NP (µg/L) A 0.954 A 55 (10-255) G G 52 (39-68) G A 0.808 (0.117- β Crosslaps (ng/mL) A 3.208) 0.847 A 0.776 (0.044- G 2.853) G 0.867 (0.600- G 1.228) A 33 (5-86) Bone Alkaline Phosphatase A 0.122 (U/L) A 31 (12-80) G G 44 (36-55) G A 30 (7-175) Osteocalcin (ng/mL) A 0.975 A 30 (6-126) G G 26 (14-44) G