<p> COMPARISON OF BIOCHEMICAL PARAMETERS AMONG THE GENOTYPE GROUPS OF THE SNP STUDIED IN PHPT SUBJECTS</p><p>Comparison of biochemical parameters among the three genotypes of OPG 163 A/G rs3102735 in PHPT patients</p><p>OPG 163 A/G rs3102735 Median and range p A 10.7 (8.7-13.5) A Total calcium (mg/dL) 0.041 (+) A 11.0 (8.5-14.5) G G 10.5 (9-13) G A 1.50 (1.21-2.7) A Ionized calcium (mM) 0.198 A 1.50 (1.20- G 1.96) G 1.40 (1.31-1.51) G A 17 (3-93) A 25-OH-Vitamin D (ng/mL) 0.252 A 18 (4-47) G G 15 (8-24) G A 80 (20-373) A Alkaline Phosphatase 0.723</p><p>(U/L) A 87 (45-302) G G 88 (46-191) G A 4.8 (0.01-12.4) A Serum OPG (pmol/L) 0.735 A 4.9 (2.01-10.00) G G 3.9 (2.39-5.6) G A 55 (11-255) A P1NP (µg/L) 0.826 A 53 (16-140) G G 63 (17-155) G A 0.829 (0.044-2.853) A β Crosslaps (ng/mL) 0.506 A 0.762 (0.192-2.182) G G 1.041 (0.333-3.208) G A 32 (5-79) A Bone Alkaline 0.081 Phosphatase (U/L) A 33 (12-84) G G 49 (19-85) G A 31 (7-126) A <0.001 Osteocalcin (ng/mL) AG-GG A 29 (7-67) <0.001 G AA-GG G 79 (19-175) <0.001 G</p><p>Comparison of biochemical parameters among the three genotypes of OPG 245 T/G rs3134070 in PHPT patients </p><p>OPG 245 T/G rs3134070 Median and range p TT 10.7 (8.7-13.5) 0.011 Total calcium (mg/dL) T 10.9 (8.5-14.5) GG-TT= G 0.012 G 12.9 (11.7-13) GG-TG= G 0.032 TT 17.0 (3-93) 25-OH-Vitamin D T 17.5 (6.6-39.7) 0.702 (ng/mL) G G 14.5 (12.0-17.0) G TT 1.47 (1.21-2.07) Ionized calcium (mM) T 1.51 (1.20-1.96) 0.565 G G 1.51 G TT 81 (20-373) Alkaline Phosphatase T 89 (55-156) 0.301 (U/L) G G 122,5 (54-191) G TT 4.8 (0.01-12.42) Serum OPG (pmol/L) T 5.1 (3.72-9.2) 0.957 G G 4.8 (4.00-5.6) G TT 54 (11-255) P1NP (µg/L) T 62 (18-110) 0.204 G G 91 (27-155) G TT 0.816 (0.44-2.853) 0.033 β Crosslaps (ng/mL) T 0.726 (0.192- GG-TT= G 1.342) 0.035 G 1.77 (0.333-3.208) GG-TG = G 0.029 TT 33 (5-84) Bone Alkaline Phosphatase T 35 (12-63) 0.196 (U/L) G G 52 (19-85) G TT 30.5 (7-126) <0.001 Osteocalcin (ng/mL) T 30.6 (7.2-67) GG-TT<0.001 G GG-TG<0.001 G 175 G</p><p>Comparison of biochemical parameters among the three genotypes of OPG 1181 G/C rs2073618 in PHPT patients </p><p>OPG 1181 G/C rs2073618 Median and range p</p><p>GG 10.9 (9.1-14.5) Total calcium (mg/dL) GC 10.7 (8.5-13) 0.438 CC 10.8 (9-13) GG 17 (3-50) 25-OH-Vitamin D (ng/mL) GC 17 (4-93) 0.892 CC 17 (3-55) GG 1.47 (1.20-1.96) Ionized calcium (mM) GC 1.47 (1,25-1.79) 0.254 CC 1.48 (1.21-2.07) GG 83 (21-191) Alkaline Phosphatase (U/L) GC 87 (20-373) 0.162 CC 73 (29-302) GG 5.0 (0.01-11.53) Serum OPG (pmol/L) GC 4.7 (1.21-10) 0.566 CC 4.7 (2.1-12.42) GG 63 (21-155) P1NP (µg/L) GC 52 (18-255) 0.518 CC 51 (11-142) GG 0.977 (0.210-3.208) β Crosslaps (ng/mL) GC 0.777 (0.192-2.500) 0.044 CC 0.747 (0.044-3.208) GG 39 (12-85) 0.016 Bone Alkaline Phosphatase (U/L) GC 31 (5-84) GG-GC=0.01 GG-CC=0.018 CC 31 (12-72) GG 39 (9-175) 0.009 Osteocalcin (ng/mL) GC 27 (7-62) GG-GC=0.004 CC 30 (7-80) Comparison of biochemical parameters among the three genotypes of RANKL rs2277438 in PHPT patients</p><p>RANKL rs2277438 Median and range p A 10.8 (9-14.5) Total calcium (mg/dL) A 0.339 A 10.6 (8.5-11.8) G G 10.5 (10-10.9) G A 17 (3-93) 25-OH-Vitamin D (ng/mL) A 0.594 A 17 (4-55) G G 15 (12-21) G A 1.47 (1.20-2.07) Ionized calcium (mM) A 0.351 A 1.44 (1.20-1.74) G G 1.48 (1.37-1.57) G A 82 (20-373) Alkaline Phosphatase A 0.956 (U/L) A 82 (21-339) G G 76 (45-111) G A 4.85 (0.01-11.44) Serum OPG (pmol/L) A 0.411 A 4.77 (1.21-12.42) G G 5.63 (4.3-7.5) G A 53 (11-192) P1NP (µg/L) A 0.954 A 55 (10-255) G G 52 (39-68) G A 0.808 (0.117- β Crosslaps (ng/mL) A 3.208) 0.847 A 0.776 (0.044- G 2.853) G 0.867 (0.600- G 1.228) A 33 (5-86) Bone Alkaline Phosphatase A 0.122 (U/L) A 31 (12-80) G G 44 (36-55) G A 30 (7-175) Osteocalcin (ng/mL) A 0.975 A 30 (6-126) G G 26 (14-44) G</p>